Diversity, Equity, and Inclusiveness in Medicine and Cardiology: Next Steps for JAHA.

abstract：BACKGROUND:Among the growing numbers of patients with heart failure, up to one half have heart failure with preserved ejection fraction (HFpEF). The lack of effective treatments for HFpEF is a substantial and escalating unmet clinical need-and the lack of HFpEF-specific animal models represents a major preclinical barr...

journal_title：Journal of the American Heart Association

authors： Curl CL,Danes VR,Bell JR,Raaijmakers AJA,Ip WTK,Chandramouli C,Harding TW,Porrello ER,Erickson JR,Charchar FJ,Kompa AR,Edgley AJ,Crossman DJ,Soeller C,Mellor KM,Kalman JM,Harrap SB,Delbridge LMD

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Several studies have shown an inverse relationship between ideal cardiovascular health (CVH) and mortality. However, there are no studies that pool these data to show the shape of the relationship and quantify the mortality benefit from ideal CVH. METHODS AND RESULTS:We conducted a systematic internet liter...

journal_title：Journal of the American Heart Association

authors： Aneni EC,Crippa A,Osondu CU,Valero-Elizondo J,Younus A,Nasir K,Veledar E

更新日期：2017-12-21 00:00:00

abstract：:Background Whether physical activity is a determinant of peripheral artery disease (PAD) remains unclear. We therefore assessed the association of physical activity (amount and intensity) with subsequent risk of hospitalization with PAD and its severe form, critical limb ischemia, in the ARIC (Atherosclerosis Risk in ...

journal_title：Journal of the American Heart Association

authors： Lu Y,Ballew SH,Kwak L,Selvin E,Kalbaugh CA,Schrack JA,Matsushita K,Szklo M

更新日期：2019-11-05 00:00:00

abstract：:Background Type 2 diabetes mellitus is closely associated with metabolic risk factors that all contribute to impairment of the left ventricle. The implications of having type 2 diabetes mellitus with well-controlled metabolic risk factors compared to an increasing burden of uncontrolled metabolic risk factors on left ...

journal_title：Journal of the American Heart Association

authors： Jørgensen PG,Jensen MT,Biering-Sørensen T,Mogelvang R,Fritz-Hansen T,Vilsbøll T,Rossing P,Jensen JS

更新日期：2018-10-02 00:00:00

abstract：BACKGROUND:Black race has been shown to be a risk factor for amputation in peripheral artery disease (PAD); however, race has been argued to be a marker for socioeconomic status (SES) rather than true disparity. The aim of this study is to study the impact of race and SES on amputation risk in PAD patients. METHODS AN...

journal_title：Journal of the American Heart Association

authors： Arya S,Binney Z,Khakharia A,Brewster LP,Goodney P,Patzer R,Hockenberry J,Wilson PWF

更新日期：2018-01-12 00:00:00

abstract：BACKGROUND:Despite guideline recommendations, a significant number of patients with non-ST elevation myocardial infarction (NSTEMI) do not receive dual antiplatelet therapy (DAPT) before angiography "pretreatment." While there may be valid clinical reasons to not pretreat, such as concern for bleeding or multivessel di...

journal_title：Journal of the American Heart Association

authors： Shafiq A,Valle J,Jang JS,Qintar M,Gosch K,Cohen DJ,Singh M,Bach R,Spertus JA

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Postural tachycardia syndrome (POTS) is a disorder of chronic orthostatic intolerance accompanied by excessive orthostatic tachycardia. Patients with POTS commonly have comorbid conditions such as attention deficit hyperactivity disorder, depression, or fibromyalgia that are treated with medications that inh...

journal_title：Journal of the American Heart Association

authors： Green EA,Raj V,Shibao CA,Biaggioni I,Black BK,Dupont WD,Robertson D,Raj SR

更新日期：2013-09-03 00:00:00

abstract：BACKGROUND:Cardiac fibrosis occurs because of disruption of the extracellular matrix network leading to myocardial dysfunction. Angiotensin II has been implicated in the development of cardiac fibrosis. Recently, microRNAs have been identified as an attractive target for therapeutic intervention in cardiac pathologies;...

journal_title：Journal of the American Heart Association

authors： Li L,Bounds KR,Chatterjee P,Gupta S

更新日期：2017-11-07 00:00:00

abstract：:Background Many observational studies and trials have shown that coronary artery bypass grafting improves the survival in patients with ischemic cardiomyopathy. However, these results are based on data generated from developed countries. Poor socioeconomic statuses, lack of uniformity in healthcare delivery, differenc...

journal_title：Journal of the American Heart Association

authors： Jose R,Shetty A,Krishna N,Chathoth V,Bhaskaran R,Jayant A,Varma PK

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:Neuregulin-1β (NRG-1β) is a growth factor critical for cardiac development and repair with therapeutic potential for heart failure. We previously showed that the glial growth factor 2 (GGF2) isoform of NRG-1β improves cardiac function in rodents after myocardial infarction (MI), but its efficacy in a large a...

journal_title：Journal of the American Heart Association

authors： Galindo CL,Kasasbeh E,Murphy A,Ryzhov S,Lenihan S,Ahmad FA,Williams P,Nunnally A,Adcock J,Song Y,Harrell FE,Tran TL,Parry TJ,Iaci J,Ganguly A,Feoktistov I,Stephenson MK,Caggiano AO,Sawyer DB,Cleator JH

更新日期：2014-10-23 00:00:00

abstract：:Background Cardiovascular disease incidence, prevalence, morbidity, and mortality have declined in the past several decades; however, disparities persist among subsets of the population. Notably, blacks have not experienced the same improvements on the whole as whites. Furthermore, frequent reports of relatively poore...

journal_title：Journal of the American Heart Association

authors： Islam SJ,Kim JH,Topel M,Liu C,Ko YA,Mujahid MS,Sims M,Mubasher M,Ejaz K,Morgan-Billingslea J,Jones K,Waller EK,Jones D,Uppal K,Dunbar SB,Pemu P,Vaccarino V,Searles CD,Baltrus P,Lewis TT,Quyyumi AA,Taylor H

更新日期：2020-05-05 00:00:00

abstract：:Background The 2013 American College of Cardiology/American Heart Association cholesterol guidelines recognize cardiovascular disease and diabetes mellitus but not chronic kidney disease ( CKD ) as high-risk conditions warranting statin therapy. Statin use may be lower for adults with CKD compared with adults with con...

journal_title：Journal of the American Heart Association

authors： Mefford MT,Rosenson RS,Deng L,Tanner RM,Bittner V,Safford MM,Coll B,Mues KE,Monda KL,Muntner P

更新日期：2019-01-22 00:00:00

abstract：:Background Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy. Current guidelines endorse management in expert centers, but patient socioeconomic status can affect access to specialty care. The effect of socioeconomic status and specialty care access on HCM outcomes has not been examined. Me...

journal_title：Journal of the American Heart Association

authors： Thomas A,Papoutsidakis N,Spatz E,Testani J,Soucier R,Chou J,Ahmad T,Darr U,Hu X,Li F,Chen ME,Bellumkonda L,Sumathipala A,Jacoby D

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:The presence and implications of abnormal arterial stiffness, a potential independent predictor of outcomes, in community-dwelling treated hypertensives is unknown. Furthermore, limited data exist regarding the risk of cardiovascular disease (CVD) associated with arterial stiffness across the entire range of...

journal_title：Journal of the American Heart Association

authors： Niiranen TJ,Kalesan B,Hamburg NM,Benjamin EJ,Mitchell GF,Vasan RS

更新日期：2016-10-26 00:00:00

abstract：:Background NT-proBNP (N-terminal pro-B-type natriuretic peptide) improves the discriminatory ability of risk-prediction models in type 2 diabetes mellitus (T2DM) but is not yet used in clinical practice. We assessed the discriminatory strength of NT-proBNP by itself for death and cardiovascular events in high-risk pat...

journal_title：Journal of the American Heart Association

authors： Malachias MVB,Jhund PS,Claggett BL,Wijkman MO,Bentley-Lewis R,Chaturvedi N,Desai AS,Haffner SM,Parving HH,Prescott MF,Solomon SD,De Zeeuw D,McMurray JJV,Pfeffer MA

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:In-stent hyperplasia (ISH) may develop in regions of low endothelial shear stress (ESS), but the relationship between the magnitude of low ESS, the extent of ISH, and subsequent clinical events has not been investigated. METHODS AND RESULTS:We assessed the association of poststent ESS with neointimal ISH an...

journal_title：Journal of the American Heart Association

authors： Shishido K,Antoniadis AP,Takahashi S,Tsuda M,Mizuno S,Andreou I,Papafaklis MI,Coskun AU,O'Brien C,Feldman CL,Saito S,Edelman ER,Stone PH

更新日期：2016-09-14 00:00:00

abstract：:Background Left ventricular assist devices (LVADs) generate electromagnetic interference that causes high-frequency noise artifacts on 12-lead ECGs. We describe the causes of this interference and potential solutions to aid ECG interpretation in patients with LVAD. Methods and Results Waveform data from ECGs performed...

journal_title：Journal of the American Heart Association

authors： Loring Z,Sen S,Black-Maier E,Atwater BD,Russell SD,DeVore AD,Piccini JP

更新日期：2020-08-18 00:00:00

abstract：:Background Sex differences in outcome have been reported in patients with congenital long QT syndrome. We aimed to report on the incidence of time-dependent life-threatening events in male and female patients with long QT syndrome with an implantable cardioverter defibrillator (ICD). Methods and Results A total of 60 ...

journal_title：Journal of the American Heart Association

authors： Younis A,Aktas MK,Rosero S,Kutyifa V,Polonsky B,McNitt S,Sotoodehnia N,Kudenchuk P,Rea TD,Arking DE,Goldenberg I,Zareba W

更新日期：2020-10-20 00:00:00

abstract：:Background Evidence suggests that enlarged perivascular spaces (PVSs) may represent a marker for cerebral small-vessel disease. We investigated whether vascular risk factors are correlated with visible PVS in older adults. Methods and Results This population-based study included 530 participants (age ≥60 years) who we...

journal_title：Journal of the American Heart Association

authors： Laveskog A,Wang R,Vetrano DL,Bronge L,Wahlund LO,Qiu C

更新日期：2020-08-18 00:00:00

abstract：:Background Ischemic heart disease continues to be a leading cause of mortality in patients. Extracellular vesicles (EVs) provide a potential for treatment that may induce collateral vessel growth to increase myocardial perfusion. Methods and Results Nineteen male Yorkshire pigs were given a high-fat diet for 4 weeks, ...

journal_title：Journal of the American Heart Association

authors： Scrimgeour LA,Potz BA,Aboul Gheit A,Shi G,Stanley M,Zhang Z,Sodha NR,Ahsan N,Abid MR,Sellke FW

更新日期：2019-08-06 00:00:00

abstract：:Background Congenital heart disease is common in patients with Trisomy 13 (T13) and Trisomy 18 (T18), but offering cardiac surgery to these patients has been controversial. We describe the landscape of surgical management across the United States, perioperative risk factors, and surgical outcomes in patients with T13 ...

journal_title：Journal of the American Heart Association

authors： Cooper DS,Riggs KW,Zafar F,Jacobs JP,Hill KD,Pasquali SK,Swanson SK,Gelehrter SK,Wallace A,Jacobs ML,Morales DLS,Bryant R 3rd

更新日期：2019-07-02 00:00:00

abstract：:Background Basal release of nitric oxide (NO) from the vascular endothelium regulates the tone of muscular arteries and resistance vasculature. Effects of NO on muscular arteries could be particularly important during exercise when shear stress may stimulate increased NO synthesis. Methods and Results We investigated ...

journal_title：Journal of the American Heart Association

authors： O'Gallagher K,Shabeeh H,Munir S,Roomi A,Jiang B,Guilcher A,Brett S,Chowienczyk P

更新日期：2020-08-18 00:00:00

abstract：BACKGROUND:The incidence of abdominal aortic aneurysms (AAAs) will significantly increase during the next decade. Novel biomarkers, besides diameter, are needed for a better characterization of aneurysms and the estimation of the risk of rupture. Fibrin is a key protein in the formation of focal hematoma associated wit...

journal_title：Journal of the American Heart Association

authors： Botnar RM,Brangsch J,Reimann C,Janssen CHP,Razavi R,Hamm B,Makowski MR

更新日期：2018-05-30 00:00:00

abstract：BACKGROUND:Oxidative stress is implicated in the etiology of coronary heart disease (CHD). New measures to capture oxidative stress are warranted. Fluorescent oxidation products (FlOPs) can be measured in plasma and have been shown to reflect levels of oxidative stress and to predict risk of CHD in men over 6 years of ...

journal_title：Journal of the American Heart Association

authors： Jensen MK,Wang Y,Rimm EB,Townsend MK,Willett W,Wu T

更新日期：2013-10-08 00:00:00

abstract：:Background Mortality is increased following a hospitalization for decompensated heart failure (HF), during which diuretics are usually intensified. It is unclear how risk is affected after outpatient intensification of diuretic therapy for HF. Methods and Results From nationwide administrative registers, we identified...

journal_title：Journal of the American Heart Association

authors： Madelaire C,Gustafsson F,Stevenson LW,Kristensen SL,Køber L,Andersen J,D'Souza M,Biering-Sørensen T,Andersson C,Torp-Pedersen C,Gislason G,Schou M

更新日期：2020-07-21 00:00:00

abstract：:Background Spontaneously hypertensive rats of the stroke-prone line (SHR-A3) develop hypertensive renal disease as a result of naturally occurring genetic variation. Our prior work identified a single-nucleotide polymorphism unique to SHR-A3 that results in truncation of the carboxy terminus of STIM1. The SHR-B2 line,...

journal_title：Journal of the American Heart Association

authors： Dhande IS,Zhu Y,Kneedler SC,Joshi AS,Hicks MJ,Wenderfer SE,Braun MC,Doris PA

更新日期：2020-03-03 00:00:00

abstract：:See Article Cammann et al. ...

journal_title：Journal of the American Heart Association

authors： Angelini P,Uribe C

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Current American Heart Association/American College of Cardiology guidelines recommend the GRACE (Global Registry of Acute Coronary Events) and TIMI (Thrombolysis in Myocardial Infarction) scores to assess myocardial infarction (MI) prognosis. Changes in the epidemiological characteristics of MI and the avai...

journal_title：Journal of the American Heart Association

authors： Gerber Y,Weston SA,Enriquez-Sarano M,Jaffe AS,Manemann SM,Jiang R,Roger VL

更新日期：2017-10-20 00:00:00

abstract：:Background Accurate assessments of sodium intake in children are important for the early prevention of cardiovascular disease. There is currently no accurate simple and feasible sodium intake approach for children. This study intends to validate the accuracy of 24-hour urinary sodium excretion (UNaV) estimation in chi...

journal_title：Journal of the American Heart Association

authors： Peng Y,Zhang Y,Li K,Liu L,Zhang S,Peng X

更新日期：2020-01-07 00:00:00

abstract：:Background Hyperkalemia has been associated with increased mortality in patients with myocardial infarction, but few data exist regarding hyperkalemia in cardiac intensive care unit ( CICU ) patients. We hypothesize that hyperkalemia is associated with increased mortality in unselected CICU patients. Methods and Resul...

journal_title：Journal of the American Heart Association

authors： Brueske B,Sidhu MS,Schulman-Marcus J,Kashani KB,Barsness GW,Jentzer JC

更新日期：2019-04-02 00:00:00