Effects of Inhibition of Nitric Oxide Synthase on Muscular Arteries During Exercise: Nitric Oxide Does Not Contribute to Vasodilation During Exercise or in Recovery.

abstract：:Background The interrelationships among the different stages of impaired glucose metabolism, insulin resistance, and hypertension are not fully understood. Methods and Results We investigated the impact of insulin resistance, plasma glucose, and serum immunoreactive insulin levels on hypertension in 19 166 participant...

journal_title：Journal of the American Heart Association

authors： Sasaki N,Ozono R,Higashi Y,Maeda R,Kihara Y

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:The incidence of abdominal aortic aneurysms (AAAs) will significantly increase during the next decade. Novel biomarkers, besides diameter, are needed for a better characterization of aneurysms and the estimation of the risk of rupture. Fibrin is a key protein in the formation of focal hematoma associated wit...

journal_title：Journal of the American Heart Association

authors： Botnar RM,Brangsch J,Reimann C,Janssen CHP,Razavi R,Hamm B,Makowski MR

更新日期：2018-05-30 00:00:00

abstract：:Background Atrial fibrillation (AF) has been shown to be associated with an increased risk of dementia as well as Alzheimer disease in observational studies. Whether this association reflects causal association is still unclear. The purpose of this study was to examine the causal association of AF with Alzheimer disea...

journal_title：Journal of the American Heart Association

authors： Pan Y,Wang Y,Wang Y

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:Experimental studies demonstrate that high aortic pressure in late systole relative to early systole causes greater myocardial remodeling and dysfunction, for any given absolute peak systolic pressure. METHODS AND RESULTS:We tested the hypothesis that late systolic hypertension, defined as the ratio of late...

journal_title：Journal of the American Heart Association

authors： Chirinos JA,Segers P,Duprez DA,Brumback L,Bluemke DA,Zamani P,Kronmal R,Vaidya D,Ouyang P,Townsend RR,Jacobs DR Jr

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:Vascular complications and abnormal platelet function contribute to morbidity and mortality in diabetes mellitus. We hypothesized that the Rho-related GTPase protein, Rac1, can influence both endothelial and platelet function and might represent a potential novel therapeutic target in diabetes mellitus. MET...

journal_title：Journal of the American Heart Association

authors： Schiattarella GG,Carrizzo A,Ilardi F,Damato A,Ambrosio M,Madonna M,Trimarco V,Marino M,De Angelis E,Settembrini S,Perrino C,Trimarco B,Esposito G,Vecchione C

更新日期：2018-04-06 00:00:00

abstract：:Background Obesity is a precursor to heart failure with preserved ejection fraction. Biomarkers that identify preclinical metabolic heart disease ( MHD ) in young obese patients would help identify high-risk individuals for heart failure prevention strategies. We assessed the predictive value of GAL3 (galectin-3), FST...

journal_title：Journal of the American Heart Association

authors： Gopal DM,Ayalon N,Wang YC,Siwik D,Sverdlov A,Donohue C,Perez A,Downing J,Apovian C,Silva V,Panagia M,Kolachalama V,Ho JE,Liang CS,Gokce N,Colucci WS

更新日期：2019-04-02 00:00:00

abstract：:Background Postpericardiotomy syndrome ( PPS ) is a common complication after cardiac surgery. However, large-scale epidemiological studies about the effect of procedure type on the occurrence of PPS and mortality of patients with PPS have not yet been performed. Methods and Results We studied the association of PPS o...

journal_title：Journal of the American Heart Association

authors： Lehto J,Kiviniemi T,Gunn J,Airaksinen J,Rautava P,Kytö V

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:The postnatal development of myofibrillar mechanics, a major determinant of heart function, is unknown in pediatric patients with tetralogy of Fallot and related structural heart defects. We therefore determined the mechanical properties of myofibrils isolated from right ventricular tissue samples from such ...

journal_title：Journal of the American Heart Association

authors： Elhamine F,Iorga B,Krüger M,Hunger M,Eckhardt J,Sreeram N,Bennink G,Brockmeier K,Pfitzer G,Stehle R

更新日期：2016-06-27 00:00:00

abstract：:Background Hydrogen sulfide (H2S) is an important endogenous physiological signaling molecule and exerts protective properties in the cardiovascular system. Cystathionine γ-lyase (CSE), 1 of 3 H2S producing enzyme, is predominantly localized in the vascular endothelium. However, the regulation of CSE in vascular endot...

journal_title：Journal of the American Heart Association

authors： Xia H,Li Z,Sharp TE 3rd,Polhemus DJ,Carnal J,Moles KH,Tao YX,Elrod J,Pfeilschifter J,Beck KF,Lefer DJ

更新日期：2020-10-20 00:00:00

abstract：:Background Cardiovascular disease incidence, prevalence, morbidity, and mortality have declined in the past several decades; however, disparities persist among subsets of the population. Notably, blacks have not experienced the same improvements on the whole as whites. Furthermore, frequent reports of relatively poore...

journal_title：Journal of the American Heart Association

authors： Islam SJ,Kim JH,Topel M,Liu C,Ko YA,Mujahid MS,Sims M,Mubasher M,Ejaz K,Morgan-Billingslea J,Jones K,Waller EK,Jones D,Uppal K,Dunbar SB,Pemu P,Vaccarino V,Searles CD,Baltrus P,Lewis TT,Quyyumi AA,Taylor H

更新日期：2020-05-05 00:00:00

abstract：:Background Patients with tetralogy of Fallot ( TOF ) remain at risk for cardiovascular events despite successful repair. Some of the current risk stratification tools require advanced imaging and invasive studies, and hence are difficult to apply to routine patient care. A recent study showed that QRS fragmentation ( ...

journal_title：Journal of the American Heart Association

authors： Egbe AC,Miranda WR,Mehra N,Ammash NM,Missula VR,Madhavan M,Deshmukh AJ,Farouk Abdelsamid M,Kothapalli S,Connolly HM

更新日期：2018-12-18 00:00:00

abstract：:Background Circulating proteins are exposed to vascular endothelial layer and influence their functions. Among them, adipsin is a member of the trypsin family of peptidases and is mainly secreted from adipocytes, monocytes, and macrophages, catalyzing the rate-limiting step of the alternative complement pathway. Howev...

journal_title：Journal of the American Heart Association

authors： Ohtsuki T,Satoh K,Shimizu T,Ikeda S,Kikuchi N,Satoh T,Kurosawa R,Nogi M,Sunamura S,Yaoita N,Omura J,Aoki T,Tatebe S,Sugimura K,Takahashi J,Miyata S,Shimokawa H

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:Hospital procedures have been associated with cognitive change in older patients. This study aimed to document the prevalence of mild cognitive impairment in individuals undergoing left heart catheterization (LHC) before the procedure and the incidence of cognitive decline to 3 months afterwards. METHODS AN...

journal_title：Journal of the American Heart Association

authors： Scott DA,Evered L,Maruff P,MacIsaac A,Maher S,Silbert BS

更新日期：2018-03-10 00:00:00

abstract：BACKGROUND:Cardiac mesenchymal cell (CMC) administration improves cardiac function in animal models of heart failure. Although the precise mechanisms remain unclear, transdifferentiation and paracrine signaling are suggested to underlie their cardiac reparative effects. We have shown that histone deacetylase 1 (HDAC1) ...

journal_title：Journal of the American Heart Association

authors： Moore JB 4th,Zhao J,Fischer AG,Keith MCL,Hagan D,Wysoczynski M,Bolli R

更新日期：2017-07-05 00:00:00

abstract：BACKGROUND:No data are available on the long-term performance of ultrathin strut biodegradable polymer sirolimus-eluting stents (BP-SES). We reported 2-year clinical outcomes of the BIOSCIENCE (Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Stent Versus Durable Polymer Everolimus-Eluting Stent for Percutaneous...

journal_title：Journal of the American Heart Association

authors： Zbinden R,Piccolo R,Heg D,Roffi M,Kurz DJ,Muller O,Vuilliomenet A,Cook S,Weilenmann D,Kaiser C,Jamshidi P,Franzone A,Eberli F,Jüni P,Windecker S,Pilgrim T

更新日期：2016-03-15 00:00:00

abstract：:Background For individuals with an out-of-hospital cardiac arrest (OHCA), survival may be influenced by the neighborhood in which the arrest occurs. Methods and Results Within the national CARES (Cardiac Arrest Registry to Enhance Survival) registry, we identified 169 502 patients with OHCA from 2013 to 2017. On the b...

journal_title：Journal of the American Heart Association

authors： Chan PS,McNally B,Vellano K,Tang Y,Spertus JA

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Although a stroke event often leads to work disability, diagnoses behind work disability before and after stroke are largely unknown. We examined the pre-event and postevent trends in diagnosis-specific work disability among patients of working age. METHODS AND RESULTS:We included all new nonfatal stroke ev...

journal_title：Journal of the American Heart Association

authors： Lallukka T,Ervasti J,Lundström E,Mittendorfer-Rutz E,Friberg E,Virtanen M,Alexanderson K

更新日期：2018-01-04 00:00:00

abstract：:Background While high levels of lipids and lipid variability are established risk factors for atherosclerotic cardiovascular disease, their roles in the development of atrial fibrillation (AF) are unclear, with previous studies suggesting a "cholesterol paradox." Methods and Results A nationwide population-based cohor...

journal_title：Journal of the American Heart Association

authors： Lee HJ,Lee SR,Choi EK,Han KD,Oh S

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:Longer QRS duration (QRSd) improves, but increased left ventricular (LV) end-diastolic volume (LVEDV) reduces, efficacy of cardiac resynchronization therapy (CRT). QRSd/LVEDV ratios differ between sexes. We hypothesized that in the EchoCRT (Echocardiography Guided Cardiac Resynchronization Therapy) trial enr...

journal_title：Journal of the American Heart Association

authors： Varma N,Sogaard P,Bax JJ,Abraham WT,Borer JS,Dickstein K,Singh JP,Gras D,Holzmeister J,Brugada J,Ruschitzka F

更新日期：2018-05-27 00:00:00

abstract：:Background It is uncertain whether there is an association between left ventricular (LV) ejection fraction ( LVEF ) or LV wall motion abnormality and embolic stroke of undetermined source ( ESUS ). Methods and Results We performed a retrospective, cross-sectional study of patients with acute ischemic stroke enrolled i...

journal_title：Journal of the American Heart Association

authors： Ramasamy S,Yaghi S,Salehi Omran S,Lerario MP,Devereux R,Okin PM,Gupta A,Navi BB,Kamel H,Merkler AE

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Cardiac sodium channel (NaV1.5) dysfunction contributes to arrhythmogenesis during pathophysiological conditions. Nav1.5 localizes to distinct subcellular microdomains within the cardiomyocyte, where it associates with region-specific proteins, yielding complexes whose function is location specific. We herei...

journal_title：Journal of the American Heart Association

authors： Rivaud MR,Agullo-Pascual E,Lin X,Leo-Macias A,Zhang M,Rothenberg E,Bezzina CR,Delmar M,Remme CA

更新日期：2017-12-08 00:00:00

abstract：:Background It has been suggested that endocardial and epicardial ablation of ventricular tachycardia ( VT ) improves outcome in arrhythmogenic right ventricular cardiomyopathy/dysplasia. We investigated our sequential approach for VT ablation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia i...

journal_title：Journal of the American Heart Association

authors： Mathew S,Saguner AM,Schenker N,Kaiser L,Zhang P,Yashuiro Y,Lemes C,Fink T,Maurer T,Santoro F,Wohlmuth P,Reißmann B,Heeger CH,Tilz R,Wissner E,Rillig A,Metzner A,Kuck KH,Ouyang F

更新日期：2019-03-05 00:00:00

abstract：:Background Myocarditis attributable to immune checkpoint inhibitor (ICI) therapy is a potentially fatal immune-related adverse event. Limited data have suggested an association between baseline and on-treatment absolute lymphocyte count (ALC) and neutrophil/lymphocyte ratio (NLR) and the development of other immune-re...

journal_title：Journal of the American Heart Association

authors： Drobni ZD,Zafar A,Zubiri L,Zlotoff DA,Alvi RM,Lee C,Hartmann S,Gilman HK,Villani AC,Nohria A,Groarke JD,Sullivan RJ,Reynolds KL,Zhang L,Neilan TG

更新日期：2020-12-01 00:00:00

abstract：:Background Normal-flow, low-gradient severe aortic stenosis (NF-LG-SAS), defined by aortic valve area <1 cm2, mean gradient <40 mm Hg, and indexed stroke volume >35 mL/m2, is the most prevalent form of low-gradient aortic stenosis (AS). However, the true severity of AS and the management of NF-LG-SAS are controversial...

journal_title：Journal of the American Heart Association

authors： Chadha G,Bohbot Y,Rusinaru D,Maréchaux S,Tribouilloy C

更新日期：2019-10-01 00:00:00

abstract：:Background Exposure to chronic psychosocial stress is a risk factor for atherosclerosis-based cardiovascular disease. We previously demonstrated the increased expressions of cathepsin S (CatS) in atherosclerotic lesions. Whether CatS participates directly in stress-related neointimal hyperplasia has been unknown. Meth...

journal_title：Journal of the American Heart Association

authors： Wang H,Meng X,Piao L,Inoue A,Xu W,Yu C,Nakamura K,Hu L,Sasaki T,Wu H,Unno K,Umegaki H,Murohara T,Shi GP,Kuzuya M,Cheng XW

更新日期：2019-07-16 00:00:00

abstract：BACKGROUND:Sex-based differences in clinical presentation, pathophysiology, and outcomes of patients with acute chest pain are increasingly being recognized, but are not implemented in guidelines and clinical prediction tools. We evaluated the performance of the HEART score in women versus men, because sex-based differ...

journal_title：Journal of the American Heart Association

authors： Bank IEM,de Hoog VC,de Kleijn DPV,Pasterkamp G,Doevendans PA,den Ruijter HM,Dalmeijer G,Wildbergh TX,Mosterd A,Timmers L

更新日期：2017-06-21 00:00:00

abstract：BACKGROUND:Transseptal puncture is a critical step in achieving left atrial (LA) access for a variety of cardiac procedures. Although the mechanical Brockenbrough needle has historically been used for this procedure, a needle employing radiofrequency (RF) energy has more recently been approved for clinical use. We soug...

journal_title：Journal of the American Heart Association

authors： Hsu JC,Badhwar N,Gerstenfeld EP,Lee RJ,Mandyam MC,Dewland TA,Imburgia KE,Hoffmayer KS,Vedantham V,Lee BK,Tseng ZH,Scheinman MM,Olgin JE,Marcus GM

更新日期：2013-09-17 00:00:00

abstract：:Background Sex differences in the management of cardiovascular disease have been reported in secondary care. We conducted a systematic review with meta-analysis of systematically investigated sex differences in cardiovascular medication prescription among patients at high risk or with established cardiovascular diseas...

journal_title：Journal of the American Heart Association

authors： Zhao M,Woodward M,Vaartjes I,Millett ERC,Klipstein-Grobusch K,Hyun K,Carcel C,Peters SAE

更新日期：2020-06-02 00:00:00

abstract：:Background Laboratory studies demonstrate glucose-insulin-potassium (GIK) as a potent cardioprotective intervention, but clinical trials have yielded mixed results, likely because of varying formulas and timing of GIK treatment and different clinical settings. This study sought to evaluate the effects of modified GIK ...

journal_title：Journal of the American Heart Association

authors： Zhao K,Zhang Y,Li J,Cui Q,Zhao R,Chen W,Liu J,Zhao B,Wan Y,Ma XL,Yu S,Yi D,Gao F

更新日期：2020-03-17 00:00:00

abstract：BACKGROUND:Left ventricular noncompaction (LVNC) has since been classified as a primary genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present study was to identify the genetic spectrum using next-generation sequencing and to evaluate genotype-phenotype correlations in LVNC patient...

journal_title：Journal of the American Heart Association

authors： Wang C,Hata Y,Hirono K,Takasaki A,Ozawa SW,Nakaoka H,Saito K,Miyao N,Okabe M,Ibuki K,Nishida N,Origasa H,Yu X,Bowles NE,Ichida F,for LVNC Study Collaborators.

更新日期：2017-08-30 00:00:00