Abstract:
:Background The interrelationships among the different stages of impaired glucose metabolism, insulin resistance, and hypertension are not fully understood. Methods and Results We investigated the impact of insulin resistance, plasma glucose, and serum immunoreactive insulin levels on hypertension in 19 166 participants with different stages of impaired glucose metabolism (7114 normal fasting glucose/normal glucose tolerance, 3543 isolated impaired fasting glucose [IFG], 2089 isolated impaired glucose tolerance, 2922 IFG plus impaired glucose tolerance, and 3498 diabetes mellitus]) determined by 75-g oral glucose tolerance tests. Participants were recruited from examinees who finished a general health checkup for atomic bomb survivors between 1982 and 2017. The profiles of plasma glucose and immunoreactive insulin during oral glucose tolerance tests were assessed using the total area under the curve. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance. The rate of hypertension increased from 36.3% in participants with normal fasting glucose/normal glucose tolerance to 50.1%, 50.8%, 58.3%, and 63.8% in participants with isolated IFG, isolated impaired glucose tolerance, IFG plus impaired glucose tolerance, and diabetes mellitus, respectively. Homeostasis model assessment of insulin resistance was associated with hypertension regardless of the presence and the degree of impaired glucose metabolism. Furthermore, fasting plasma glucose and serum immunoreactive insulin levels and areas under the curve for plasma glucose and immunoreactive insulin during oral glucose tolerance tests were associated with hypertension in normal fasting glucose/normal glucose tolerance and isolated IFG, but such a relationship was diminished in other types of prediabetes and diabetes mellitus. Conclusions The prevalence of hypertension increases with worsening stages of impaired glucose metabolism; however, hyperglycemia and hyperinsulinemia are significant contributors to the presence of hypertension only in the early stages of impaired insulin metabolism.
journal_name
J Am Heart Assocjournal_title
Journal of the American Heart Associationauthors
Sasaki N,Ozono R,Higashi Y,Maeda R,Kihara Ydoi
10.1161/JAHA.119.015546subject
Has Abstractpub_date
2020-04-07 00:00:00pages
e015546issue
7issn
2047-9980journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Although statins reduce cardiovascular events, residual risk remains. Therefore, additional modalities are needed to reduce risk. We evaluated the effect of eicosapentaenoic acid and docosahexaenoic acid in pharmacologic doses added to statin treatment on coronary artery plaque volume. METHODS AND RESULTS:A...
journal_title:Journal of the American Heart Association
pub_type: 杂志文章,随机对照试验
doi:10.1161/JAHA.117.006981
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journal_title:Journal of the American Heart Association
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2013-07-01 00:00:00
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doi:10.1161/JAHA.119.013592
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pub_type: 杂志文章
doi:10.1161/JAHA.119.015379
更新日期:2020-10-20 00:00:00
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更新日期:2015-01-28 00:00:00
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更新日期:2019-02-05 00:00:00
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pub_type: 杂志文章,随机对照试验
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abstract::Background Left ventricular assist devices (LVADs) generate electromagnetic interference that causes high-frequency noise artifacts on 12-lead ECGs. We describe the causes of this interference and potential solutions to aid ECG interpretation in patients with LVAD. Methods and Results Waveform data from ECGs performed...
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pub_type: 杂志文章
doi:10.1161/JAHA.120.017563
更新日期:2020-08-18 00:00:00
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pub_type: 杂志文章
doi:10.1161/JAHA.113.000230
更新日期:2013-05-23 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1161/JAHA.117.006071
更新日期:2017-08-22 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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更新日期:2020-01-21 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.115.002706
更新日期:2016-01-11 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章,多中心研究
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更新日期:2019-10-15 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.116.003621
更新日期:2016-07-13 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.115.002323
更新日期:2015-12-16 00:00:00
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doi:10.1161/JAHA.119.013165
更新日期:2019-09-03 00:00:00
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更新日期:2019-05-07 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
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更新日期:2016-12-22 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
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更新日期:2016-04-22 00:00:00