Sex-Specific Relationship Between Serum Uric Acid and Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies.

abstract：BACKGROUND:Identifying the best markers to judge the adequacy of lipid-lowering treatment is increasingly important for coronary heart disease (CHD) prevention given that several novel, potent lipid-lowering therapies are in development. Reductions in LDL-C, non-HDL-C, or apoB can all be used but which most closely rel...

journal_title：Journal of the American Heart Association

authors： Thanassoulis G,Williams K,Ye K,Brook R,Couture P,Lawler PR,de Graaf J,Furberg CD,Sniderman A

更新日期：2014-04-14 00:00:00

abstract：:Background Apolipoprotein CIII (apo CIII ) is a crucial player in triglyceride-rich lipoprotein metabolism, but may also act pleiotropically, provoking inflammatory responses and stimulating coagulation. Elevated apo CIII plasma levels have been associated with increased activity of coagulation factors. Since these fe...

journal_title：Journal of the American Heart Association

authors： Olivieri O,Turcato G,Moruzzi S,Castagna A,Girelli D,Pizzolo F,Friso S,Sandri M,Bassi A,Martinelli N

更新日期：2019-01-22 00:00:00

abstract：BACKGROUND:Stroke is a leading cause of death in the world. In >80% of strokes, the initial acute phase of ischemic injury is due to the occlusion of a blood vessel resulting in severe focal hypoperfusion, excitotoxicity, and oxidative damage. Interferon-β (IFNβ), a cytokine with immunomodulatory properties, was approv...

journal_title：Journal of the American Heart Association

authors： Kuo PC,Scofield BA,Yu IC,Chang FL,Ganea D,Yen JH

更新日期：2016-01-08 00:00:00

abstract：BACKGROUND:Sleep disordered breathing in children is associated with increased blood flow velocity and sympathetic overactivity. Sympathetic overactivity results in peripheral vasoconstriction and reduced systemic vascular compliance, which increases blood flow velocity during systole. Augmented blood flow velocity is ...

journal_title：Journal of the American Heart Association

authors： Kontos A,Lushington K,Martin J,Schwarz Q,Green R,Wabnitz D,Xu X,M Sokoya E,Willoughby S,Baumert M,Ferrante A,La Forgia M,Kennedy D

更新日期：2017-07-17 00:00:00

abstract：:Background We aimed to determine the change in treatment strategies and times to treatment over the first 5 years of the Mission: Lifeline program. Methods and Results We assessed pre- and in-hospital care and outcomes from 2008 to 2012 for patients with ST -segment-elevation myocardial infarction at US hospitals, usi...

journal_title：Journal of the American Heart Association

authors： Granger CB,Bates ER,Jollis JG,Antman EM,Nichol G,O'Connor RE,Gregory T,Roettig ML,Peng SA,Ellrodt G,Henry TD,French WJ,Jacobs AK

更新日期：2019-01-08 00:00:00

abstract：:Background Stroke is a serious complication of hypertensive disorders of pregnancy (HDP), with potentially severe and long-term sequelae. However, the temporal trends, predictors, and outcomes of stroke in women with HDP at delivery remain unknown. Methods and Results All HDP delivery hospitalizations with or without ...

journal_title：Journal of the American Heart Association

authors： Wu P,Jordan KP,Chew-Graham CA,Coutinho T,Lundberg GP,Park KE,Chappell LC,Myint PK,Maas AHEM,Mamas MA

更新日期：2020-08-04 00:00:00

abstract：BACKGROUND:Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. METHODS AND RESULTS:We performed a...

journal_title：Journal of the American Heart Association

authors： van 't Hof FN,Ruigrok YM,Lee CH,Ripke S,Anderson G,de Andrade M,Baas AF,Blankensteijn JD,Böttinger EP,Bown MJ,Broderick J,Bijlenga P,Carrell DS,Crawford DC,Crosslin DR,Ebeling C,Eriksson JG,Fornage M,Foroud T,von Un

更新日期：2016-07-14 00:00:00

abstract：:We, the Editors of the Journal of the American Heart Association, sincerely regret the publication of the article "Diversity, Inclusion, and Equity: Evolution of Race and Ethnicity Considerations for the Cardiology Workforce in the United States of America From 1969 to 2019".1 We are aware that the publication of this...

journal_title：Journal of the American Heart Association

authors： London B,Ahmad F,Eitzman DT,Gupta AK,Jneid H,Peterson P,Remme CA,Rice K,Schelbert EB,Simon MA,Sullivan LM,Weinberg JM

更新日期：2020-10-20 00:00:00

abstract：:Background Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decline in peripheral artery disease is unknown. Methods and Results Adults with an ankle-brachial index <0.90 were identified ...

journal_title：Journal of the American Heart Association

authors： Polonsky TS,Tian L,Zhang D,Bazzano LA,Criqui MH,Ferrucci L,Guralnik JM,Kibbe MR,Leeuwenburgh C,Sufit RL,McDermott MM

更新日期：2019-07-02 00:00:00

abstract：:Background Muscular dystrophy (MD) causes a progressive cardiomyopathy characterized by diffuse fibrosis, arrhythmia, heart failure, and early death. Activation of the thromboxane-prostanoid receptor (TPr) increases calcium transients in cardiomyocytes and is proarrhythmic and profibrotic. We hypothesized that TPr act...

journal_title：Journal of the American Heart Association

authors： West JD,Galindo CL,Kim K,Shin JJ,Atkinson JB,Macias-Perez I,Pavliv L,Knollmann BC,Soslow JH,Markham LW,Carrier EJ

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:Hemorrhagic risk assessment is a crucial issue in patients with nonvalvular atrial fibrillation (NVAF) who are receiving oral anticoagulant therapy (OAT). Our aim was to analyze the relationship between vitamin E, which possesses anticoagulant properties, and bleeding events in NVAF patients. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Pastori D,Carnevale R,Cangemi R,Saliola M,Nocella C,Bartimoccia S,Vicario T,Farcomeni A,Violi F,Pignatelli P

更新日期：2013-10-28 00:00:00

abstract：BACKGROUND:Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a key role in removing toxic aldehydes. Deficient variant ALDH2*2 genotype is prevalent in up to 40% of the East Asians and reported to be associated with acute myocardial infarction (AMI). To elucidate the mechanisms underlying the association of ALDH2*2 ...

journal_title：Journal of the American Heart Association

authors： Mizuno Y,Hokimoto S,Harada E,Kinoshita K,Nakagawa K,Yoshimura M,Ogawa H,Yasue H

更新日期：2016-05-06 00:00:00

abstract：BACKGROUND:The volume-outcome relationship associated with intensive care unit (ICU) experience with managing acute myocardial infarction (AMI) remains inadequately understood. METHODS AND RESULTS:Within a multicenter clinical ICU database, we identified patients with a primary ICU admission diagnosis of AMI between 2...

journal_title：Journal of the American Heart Association

authors： Stolker JM,Badawi O,Spertus JA,Nasir A,Kennedy KF,Harris IH,Franey CS,Hsu VD,Ripple GR,Howell GH,Lem VM,Chan PS

更新日期：2015-06-11 00:00:00

abstract：BACKGROUND:We studied (1) the rates of stroke or systemic embolism and bleeding in patients with atrial fibrillation and peripheral artery disease (PAD) and (2) the efficacy and safety of apixaban versus warfarin in patients with atrial fibrillation with and without PAD. METHODS AND RESULTS:The Apixaban for Reduction ...

journal_title：Journal of the American Heart Association

authors： Hu PT,Lopes RD,Stevens SR,Wallentin L,Thomas L,Alexander JH,Hanna M,Lewis BS,Verheugt FW,Granger CB,Jones WS

更新日期：2017-01-17 00:00:00

abstract：:Background Informed consent for acute myocardial infarction and stroke research is challenging. Time for enrollment decisions is limited, patients and family are usually stressed, and being asked to participate in research is often unexpected. Despite these barriers, patients and surrogates have reported a preference ...

journal_title：Journal of the American Heart Association

authors： Scicluna VM,Goldkind SF,Mitchell AR,Pentz RD,Speight CD,Silbergleit R,Dickert NW

更新日期：2019-11-19 00:00:00

abstract：:Background The blood-brain barrier (BBB) is critical for cerebrovascular health. Although aging impairs the integrity of the BBB, the mechanisms behind this phenomenon are not clear. As mitochondrial components activate inflammation as mitochondria become dysfunctional, we examined how aging impacts cerebrovascular mi...

journal_title：Journal of the American Heart Association

authors： Tyrrell DJ,Blin MG,Song J,Wood SC,Goldstein DR

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Adults with repaired coarctation of the aorta (CoA) have reduced long-term survival compared with the general population. This study aimed to determine whether CoA is independently associated with premature ischemic and hemorrhagic stroke in the contemporary era. METHODS AND RESULTS:This was a cross-section...

journal_title：Journal of the American Heart Association

authors： Pickard SS,Gauvreau K,Gurvitz M,Gagne JJ,Opotowsky AR,Jenkins KJ,Prakash A

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Patients with heart failure with preserved ejection fraction (HFpEF) exhibit a range of cardiovascular phenotypic profiles modified by several common comorbidities. In particular, patients with HFpEF tend to be older; however, it is unclear whether the effects of cardiovascular aging per se modify the expres...

journal_title：Journal of the American Heart Association

authors： Nanayakkara S,Haykowsky M,Mariani J,Van Empel V,Maeder MT,Vizi D,Kaye DM

更新日期：2017-09-22 00:00:00

abstract：:Background Angiotensin II type 1 receptor ( AT 1R) autoantibody ( AT 1- AA ) was first identified as a causative factor in preeclampsia. Unlike physiological ligand angiotensin II (Ang II ), AT 1- AA can induce vasoconstriction in a sustained manner, causing a series of adverse effects, such as vascular injury and poo...

journal_title：Journal of the American Heart Association

authors： Bian J,Lei J,Yin X,Wang P,Wu Y,Yang X,Wang L,Zhang S,Liu H,Fu MLX

更新日期：2019-03-19 00:00:00

abstract：:Background This study examined the association between ideal cardiovascular health ( CVH ) and the retinal microvasculature in midadulthood. Methods and Results The Cardiovascular Risk in Young Finns Study included children from 5 Finnish University cities, who were chosen randomly from the national population registe...

journal_title：Journal of the American Heart Association

authors： Campbell MD,Laitinen TT,Hughes A,Pahkala K,Juonala M,Kähönen M,Wong TY,Lehtimäki T,Hutri-Kähönen N,Raitakari OT,Tapp RJ

更新日期：2018-10-16 00:00:00

abstract：:See Editorial by Cenko et al. ...

journal_title：Journal of the American Heart Association

authors： Pande AN,Jacobs AK

更新日期：2019-02-19 00:00:00

abstract：BACKGROUND:Recent trends of hospitalizations and in-hospital mortality are not well defined in sarcoidosis. We examined aforementioned trends and prevalence of cardiovascular manifestations and explored rates of implantable cardioverter-defibrillator implantation in hospitalizations with sarcoidosis. METHODS AND RESUL...

journal_title：Journal of the American Heart Association

authors： Patel N,Kalra R,Doshi R,Arora H,Bajaj NS,Arora G,Arora P

更新日期：2018-01-22 00:00:00

abstract：:Background This study was performed to characterize the metabolic, functional, and structural cardiac changes in a canine model of radiation-induced heart disease by serial in vivo imaging and ex vivo analyses. Methods and Results Thirty-six dogs were randomly assigned to control or irradiated groups at 3 time points ...

journal_title：Journal of the American Heart Association

authors： Yan R,Li X,Song J,Guo M,Cai H,Wu Z,Wu P,Li L,Yang M,Wang Y,Li S

更新日期：2020-09-15 00:00:00

abstract：:Background Neutrophil gelatinase-associated lipocalin ( NGAL ) or lipocalin 2 may promote atherosclerosis and plaque instability leading to increased risk of cardiac events. We investigated the relationships between plasma NGAL , cardiovascular disease biomarkers, and long-term cardiac events. Methods and Results The ...

journal_title：Journal of the American Heart Association

authors： Chong JJH,Prince RL,Thompson PL,Thavapalachandran S,Ooi E,Devine A,Lim EEM,Byrnes E,Wong G,Lim WH,Lewis JR

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Remote ischemic conditioning (RIC) is a noninvasive therapeutic strategy that uses brief cycles of blood pressure cuff inflation and deflation to protect the myocardium against ischemia-reperfusion injury. The objective of this systematic review was to determine the impact of RIC on myocardial salvage index,...

journal_title：Journal of the American Heart Association

authors： McLeod SL,Iansavichene A,Cheskes S

更新日期：2017-05-17 00:00:00

abstract：:Background The aim of the present study was to investigate the efficacy and safety of antiplatelet (aspirin plus cilostazol) dual therapy for patients with noncardioembolic stroke within 48 hours of symptom onset. Methods and Results The ADS (Acute Aspirin Plus Cilostazol Dual Therapy for Non-Cardiogenic Stroke Patien...

journal_title：Journal of the American Heart Association

authors： Aoki J,Iguchi Y,Urabe T,Yamagami H,Todo K,Fujimoto S,Idomari K,Kaneko N,Iwanaga T,Terasaki T,Tanaka R,Yamamoto N,Tsujino A,Nomura K,Abe K,Uno M,Okada Y,Matsuoka H,Yamagata S,Yamamoto Y,Yonehara T,Inoue T,Yagit

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in older individuals. Currently, therapeutic options are limited to surgical interventions. Although it has long been known that AAA tissue is enriched in B cells and immunoglobulins, their involvement in AAA pathogenesi...

journal_title：Journal of the American Heart Association

authors： Furusho A,Aoki H,Ohno-Urabe S,Nishihara M,Hirakata S,Nishida N,Ito S,Hayashi M,Imaizumi T,Hiromatsu S,Akashi H,Tanaka H,Fukumoto Y

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:We investigated whether disease location influences survival in patients with peripheral arterial disease. METHODS AND RESULTS:Patients (n = 12,731; mean age, 67.5 ± 12.7 years; 57.4% male) who underwent outpatient noninvasive lower extremity arterial evaluation were followed up for 5.9 ± 3.1 years for all-...

journal_title：Journal of the American Heart Association

authors： Chen Q,Smith CY,Bailey KR,Wennberg PW,Kullo IJ

更新日期：2013-10-21 00:00:00

abstract：BACKGROUND:Decreased arterial elasticity is a risk factor for several cardiovascular outcomes. Longitudinal data on the effect of physical activity in youth on adult arterial elasticity are limited. The aim of this study was to determine the long-term effects of physical activity in children and young adults on carotid...

journal_title：Journal of the American Heart Association

authors： Pälve KS,Pahkala K,Magnussen CG,Koivistoinen T,Juonala M,Kähönen M,Lehtimäki T,Rönnemaa T,Viikari JS,Raitakari OT

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:Microvascular injury (MVI) after primary percutaneous coronary intervention for ST-elevation myocardial infarction (STEMI) is a major determinant of adverse clinical outcome. Experimental data indicate an impact of hypercholesterolemia on MVI; however, there is a lack of clinical studies confirming this rela...

journal_title：Journal of the American Heart Association

authors： Reindl M,Reinstadler SJ,Feistritzer HJ,Theurl M,Basic D,Eigler C,Holzknecht M,Mair J,Mayr A,Klug G,Metzler B

更新日期：2017-10-10 00:00:00