Abstract:
:Background Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decline in peripheral artery disease is unknown. Methods and Results Adults with an ankle-brachial index <0.90 were identified from Chicago-area hospitals in 2002-2004. Weight and 6-minute walk distance were measured annually. Weight change categories were weight loss or gain (≥5 pounds/year at ≥1 visit) or stable (weight change <5 pounds at each visit). Participants reported whether weight loss was "intentional" or "unintentional." Calf muscle area was measured with computed tomography every 2 years. Associations of weight change with changes in calf muscle area and 6-minute walk distance were analyzed using mixed-effects models and adjusted for age, body mass index, ankle-brachial index, physical activity, and other confounders. Among 389 participants, mean ankle-brachial index was 0.63±0.16, mean age was 74.5±7.8, and mean body mass index was 28.1±5.1 kg/m2. Over 3.23±1.37 years, muscle area declined more in adults with intentional weight loss versus stable or gain (pair-wise comparisons, P<0.001). Intentional weight loss was associated with less annual decline in 6-minute walk distance than weight gain (intentional loss, 3.7 m; stable, -14.0 m; gain, -28.5 m; unintentional loss, -20.8 m; pair-wise comparison intentional loss versus gain, P=0.003). Conclusions Despite a greater loss of calf muscle area, adults with peripheral artery disease who intentionally lost ≥5 pounds experienced less functional decline than those who gained weight. A randomized trial is needed to establish whether benefits of weight loss in peripheral artery disease outweigh potential adverse effects.
journal_name
J Am Heart Assocjournal_title
Journal of the American Heart Associationauthors
Polonsky TS,Tian L,Zhang D,Bazzano LA,Criqui MH,Ferrucci L,Guralnik JM,Kibbe MR,Leeuwenburgh C,Sufit RL,McDermott MMdoi
10.1161/JAHA.118.010890subject
Has Abstractpub_date
2019-07-02 00:00:00pages
e010890issue
13issn
2047-9980journal_volume
8pub_type
杂志文章abstract:BACKGROUND:Clinical symptoms are part of the risk stratification approaches used in the emergency department (ED) to evaluate patients with suspected acute coronary syndromes (ACS). The objective of this study was to determine the sensitivity, specificity, and predictive value of 13 symptoms for a discharge diagnosis o...
journal_title:Journal of the American Heart Association
pub_type: 杂志文章,多中心研究
doi:10.1161/JAHA.113.000586
更新日期:2014-04-02 00:00:00
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abstract::Background The Institute of Medicine has called for actions to understand and target sex-related differences in care and outcomes for out-of-hospital cardiac arrest patients. We assessed changes in bystander and first-responder interventions and outcomes for males versus females after statewide efforts to improve card...
journal_title:Journal of the American Heart Association
pub_type: 杂志文章,多中心研究
doi:10.1161/JAHA.118.009873
更新日期:2018-09-18 00:00:00
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更新日期:2018-06-22 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1161/JAHA.118.010212
更新日期:2019-01-08 00:00:00
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更新日期:2020-03-03 00:00:00
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pub_type: 杂志文章
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更新日期:2016-06-17 00:00:00
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pub_type: 评论,社论
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更新日期:2019-06-04 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
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更新日期:2020-05-18 00:00:00
abstract:BACKGROUND:CSL112 is a new formulation of human apolipoprotein A-I (apoA-I) being developed to reduce cardiovascular events following acute coronary syndrome. This phase 2a, randomized, double-blind, multicenter, dose-ranging trial represents the first clinical investigation to assess the safety and pharmacokinetics/ph...
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-08-25 00:00:00
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更新日期:2018-11-06 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.119.015616
更新日期:2020-06-16 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
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更新日期:2017-01-06 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.120.016771
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journal_title:Journal of the American Heart Association
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pub_type: 杂志文章,多中心研究
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更新日期:2016-09-14 00:00:00
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journal_title:Journal of the American Heart Association
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更新日期:2015-04-20 00:00:00
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pub_type: 杂志文章
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更新日期:2018-08-07 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
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更新日期:2020-05-18 00:00:00
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journal_title:Journal of the American Heart Association
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更新日期:2012-04-01 00:00:00
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更新日期:2012-10-01 00:00:00
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更新日期:2018-08-21 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2017-02-01 00:00:00