Energy Drinks: Another Cause of QT Prolongation?

abstract：BACKGROUND:Family history of coronary heart disease (CHD) as well as genetic predisposition to CHD assessed by a genetic risk score (GRS) are predictors of CHD risk. It is, however, uncertain to what extent these risk predictors are mediated by major metabolic pathways. METHODS AND RESULTS:Total effects of self-report...

journal_title：Journal of the American Heart Association

authors： Fritz J,Shiffman D,Melander O,Tada H,Ulmer H

更新日期：2017-03-20 00:00:00

abstract：:Background Recent publications reached conflicting conclusions about the cost-effectiveness of left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, Marlborough, MA) for stroke risk reduction in nonvalvular atrial fibrillation (AF). This analysis sought to assess the cost-effectiveness of L...

journal_title：Journal of the American Heart Association

authors： Reddy VY,Akehurst RL,Gavaghan MB,Amorosi SL,Holmes DR Jr

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Hypertension is a frequent risk factor for the development of heart failure with preserved ejection fraction (HFPEF). Progressive extracellular matrix accumulation has been presumed to be the fundamental pathophysiologic mechanism that leads to the transition to impaired diastolic reserve. However, the contr...

journal_title：Journal of the American Heart Association

authors： van Empel VP,Mariani J,Borlaug BA,Kaye DM

更新日期：2014-12-02 00:00:00

abstract：BACKGROUND:Cryoballoon pulmonary vein isolation (PVI) has emerged as an alternative to radiofrequency PVI for atrial fibrillation (AF). Data are lacking to define the rates and predictors of complications, particularly phrenic nerve injury (PNI). METHODS AND RESULTS:We evaluated a single-center prospective registry of...

journal_title：Journal of the American Heart Association

authors： Guhl EN,Siddoway D,Adelstein E,Bazaz R,Mendenhall GS,Nemec J,Saba S,Schwartzman D,Voigt A,Wang NC,Jain SK

更新日期：2016-07-21 00:00:00

abstract：:Background Use of inpatient brain magnetic resonance imaging (MRI) in patients with acute ischemic stroke is highly institution dependent and has been associated with increased length and cost of hospital stay. We examined whether inpatient brain MRI in patients with acute ischemic stroke is associated with improved c...

journal_title：Journal of the American Heart Association

authors： Lee H,Yang Y,Liu B,Castro SA,Shi T

更新日期：2020-10-20 00:00:00

abstract：:Background Although many patients with coronary artery disease are using statins before off-pump coronary artery bypass grafting ( OPCAB ) following current guidelines, recent studies have raised concerns regarding adverse effects of preoperative statins on postoperative kidney function. We evaluated the effects of pr...

journal_title：Journal of the American Heart Association

authors： Park J,Lee JH,Kim KA,Lee SH,Lee YT,Kim WS,Min JJ

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease (CAD). Functional studies suggest that ADAMTS7 may promote cellular processes in atherosclerosis. We sought to examine the association between genetic variation at ADAMTS7 and measures of atherosclerosis using hist...

journal_title：Journal of the American Heart Association

authors： Chan K,Pu X,Sandesara P,Poston RN,Simpson IA,Quyyumi AA,Ye S,Patel RS

更新日期：2017-10-31 00:00:00

abstract：BACKGROUND:Stroke is a leading cause of death in the world. In >80% of strokes, the initial acute phase of ischemic injury is due to the occlusion of a blood vessel resulting in severe focal hypoperfusion, excitotoxicity, and oxidative damage. Interferon-β (IFNβ), a cytokine with immunomodulatory properties, was approv...

journal_title：Journal of the American Heart Association

authors： Kuo PC,Scofield BA,Yu IC,Chang FL,Ganea D,Yen JH

更新日期：2016-01-08 00:00:00

abstract：BACKGROUND:Recent trends of hospitalizations and in-hospital mortality are not well defined in sarcoidosis. We examined aforementioned trends and prevalence of cardiovascular manifestations and explored rates of implantable cardioverter-defibrillator implantation in hospitalizations with sarcoidosis. METHODS AND RESUL...

journal_title：Journal of the American Heart Association

authors： Patel N,Kalra R,Doshi R,Arora H,Bajaj NS,Arora G,Arora P

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:Higher heart rate has been associated with an adverse prognosis, but most prior studies focused on individuals with known cardiovascular disease or examined a limited number of outcomes. We sought to examine the association of baseline heart rate with both fatal and nonfatal outcomes during 2 decades of foll...

journal_title：Journal of the American Heart Association

authors： Ho JE,Larson MG,Ghorbani A,Cheng S,Coglianese EE,Vasan RS,Wang TJ

更新日期：2014-05-08 00:00:00

abstract：:Background Race influences medical decision making, but its impact on advanced heart failure therapy allocation is unknown. We sought to determine whether patient race influences allocation of advanced heart failure therapies. Methods and Results Members of a national heart failure organization were randomized to clin...

journal_title：Journal of the American Heart Association

authors： Breathett K,Yee E,Pool N,Hebdon M,Crist JD,Knapp S,Larsen A,Solola S,Luy L,Herrera-Theut K,Zabala L,Stone J,McEwen MM,Calhoun E,Sweitzer NK

更新日期：2019-11-19 00:00:00

abstract：BACKGROUND:The associations between high-sensitivity troponin I (hsTnI) levels and coronary artery disease (CAD) severity and progression remain unclear. We investigated whether there is an association between hsTnI and angiographic severity and progression of CAD and whether the predictive value of hsTnI level for inc...

journal_title：Journal of the American Heart Association

authors： Samman Tahhan A,Sandesara P,Hayek SS,Hammadah M,Alkhoder A,Kelli HM,Topel M,O'Neal WT,Ghasemzadeh N,Ko YA,Gafeer MM,Abdelhadi N,Choudhary F,Patel K,Beshiri A,Murtagh G,Kim J,Wilson P,Shaw L,Vaccarino V,Epstein SE

更新日期：2018-02-21 00:00:00

abstract：BACKGROUND:Platelet-derived growth factor BB, a potent mitogen of pulmonary artery smooth muscle cells (PASMCs), has been implicated in pulmonary arterial remodeling, which is a key pathogenic feature of pulmonary arterial hypertension. Previous microRNA profiling in platelet-derived growth factor BB-treated PASMCs fou...

journal_title：Journal of the American Heart Association

authors： Li Y,Li L,Qian Z,Lin B,Chen J,Luo Y,Qu J,Raj JU,Gou D

更新日期：2018-03-07 00:00:00

abstract：BACKGROUND:The 4-variable risk score from University of California, Los Angeles (UCLA) demonstrated superior discrimination in advanced heart failure, compared to established risk scores. However, the model has not been externally validated, and its suitability as a selection tool for heart transplantation (HT) and lef...

journal_title：Journal of the American Heart Association

authors： Sartipy U,Goda A,Mancini DM,Lund LH

更新日期：2014-06-06 00:00:00

abstract：:Background Hyperhomocysteinemia is a risk factor for ischemic stroke; however, a targeted treatment strategy is lacking partly because of limited understanding of the causal role of homocysteine in cerebrovascular pathogenesis. Methods and Results In a genetic model of cystathionine beta synthase (CBS) deficiency, we ...

journal_title：Journal of the American Heart Association

authors： Gu SX,Sonkar VK,Katare PB,Kumar R,Kruger WD,Arning E,Bottiglieri T,Lentz SR,Dayal S

更新日期：2020-02-18 00:00:00

abstract：:Background Duchenne muscular dystrophy (DMD) is a neuromuscular disorder caused by mutations within the dystrophin gene. DMD is characterized by progressive skeletal muscle degeneration and atrophy and progressive cardiomyopathy. It has been observed the severity of cardiomyopathy varies in patients with DMD. Methods ...

journal_title：Journal of the American Heart Association

authors： Jiang X,Shao Y,Araj FG,Amin AA,Greenberg BM,Drazner MH,Xing C,Mammen PPA

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Insulin resistance, characterized by hyperinsulinemia and normal or elevated serum glucose, is an established precursor to diabetes and cardiovascular disease. Despite fasting serum C-peptide levels being an accurate and stable marker of endogenous insulin production used in patients with diabetes, it is unk...

journal_title：Journal of the American Heart Association

authors： Patel N,Taveira TH,Choudhary G,Whitlatch H,Wu WC

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Transcatheter pulmonary valve implantation is approved for the treatment of dysfunctional right ventricle to pulmonary artery conduits. However, the literature is limited because of a small patient population, and it does not reflect changing procedural practice patterns over the last decade. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Chatterjee A,Bajaj NS,McMahon WS,Cribbs MG,White JS,Mukherjee A,Law MA

更新日期：2017-08-04 00:00:00

abstract：:Background Neurocognitive impairment is a common complication of congenital heart disease (CHD) as well as acquired cardiovascular disease. Data are limited on neurocognitive function in adults with CHD (ACHD). Methods and Results A total of 1020 individuals with mild-to-moderate ACHD and 497 987 individuals without A...

journal_title：Journal of the American Heart Association

authors： Perrotta ML,Saha P,Zawadzki R,Beidelman M,Ingelsson E,Lui GK,Priest JR

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:The natural history of coronary artery aneurysms (CAA) after intravenous immunoglobulin (IVIG) treatment in the United States is not well described. We describe the natural history of CAA in US Kawasaki disease (KD) patients and identify factors associated with major adverse cardiac events (MACE) and CAA reg...

journal_title：Journal of the American Heart Association

authors： Friedman KG,Gauvreau K,Hamaoka-Okamoto A,Tang A,Berry E,Tremoulet AH,Mahavadi VS,Baker A,deFerranti SD,Fulton DR,Burns JC,Newburger JW

更新日期：2016-09-15 00:00:00

abstract：:Background Sex differences in the management of cardiovascular disease have been reported in secondary care. We conducted a systematic review with meta-analysis of systematically investigated sex differences in cardiovascular medication prescription among patients at high risk or with established cardiovascular diseas...

journal_title：Journal of the American Heart Association

authors： Zhao M,Woodward M,Vaartjes I,Millett ERC,Klipstein-Grobusch K,Hyun K,Carcel C,Peters SAE

更新日期：2020-06-02 00:00:00

abstract：BACKGROUND:Ticagrelor is a P2Y12 receptor inhibitor used in acute coronary syndromes to reduce platelet activity and to decrease thrombus formation. Ticagrelor is associated with a reduction in mortality incremental to that observed with clopidogrel, potentially related to its non-antiplatelet effects. Evidence from an...

journal_title：Journal of the American Heart Association

authors： Pelletier-Galarneau M,Hunter CRRN,Ascah KJ,Beanlands RSB,Dwivedi G,deKemp RA,Chow BJW,Ruddy TD

更新日期：2017-05-02 00:00:00

abstract：:Background Platelets play a role in promoting inflammatory responses under several disease conditions. Platelets are activated in hypertensive patients. However, the mechanisms responsible for platelet-mediating vascular inflammation are unknown. The present study investigated the role of platelets in promoting vascul...

journal_title：Journal of the American Heart Association

authors： An X,Jiang G,Cheng C,Lv Z,Liu Y,Wang F

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:The structure of the aorta is considered to influence exercise systolic blood pressure (SBP) response, which, in turn, might impact upon adverse outcomes. The current study sought to investigate the relationship of aortic calcification and exercise SBP with adverse outcomes among elderly individuals. METHOD...

journal_title：Journal of the American Heart Association

authors： Cho IJ,Chang HJ,Cho I,Heo R,Lee SE,Shim CY,Hong GR,Chung N

更新日期：2016-04-22 00:00:00

abstract：:Background Past reports suggested that total-body irradiation at 0.5 to 1.0 Gy could be responsible for atherosclerosis. Peripheral artery disease ( PAD ) is a manifestation of systematic atherosclerosis. Whether the consequences of a low-to-moderate dose of radiation include increased risk of PAD remains to be determ...

journal_title：Journal of the American Heart Association

authors： Takahashi I,Cologne J,Haruta D,Yamada M,Takahashi T,Misumi M,Fujiwara S,Matsumoto M,Kihara Y,Hida A,Ohishi W

更新日期：2018-12-04 00:00:00

abstract：:Background Aerobic exercise capacity is inversely associated with cardiovascular and all-cause mortality in men and women without coronary artery disease (CAD); however, a higher amount of vigorous exercise is associated with a J-shaped relationship in CAD patients. Therefore, the optimal type and amount of exercise f...

journal_title：Journal of the American Heart Association

authors： Malik A,Kanduri JS,Asbeutah AAA,Khraishah H,Shen C,Welty FK

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Recent studies using stress-rest perfusion cardiovascular magnetic resonance (CMR) demonstrated a close correlation between myocardial ischemia and reduced fractional flow reserve (FFR). However, its diagnostic concordance may be reduced in patients with multivessel disease. We sought to evaluate the concord...

journal_title：Journal of the American Heart Association

authors： Nakamori S,Sakuma H,Dohi K,Ishida M,Tanigawa T,Yamada A,Takase S,Nakajima H,Sawai T,Masuda J,Nagata M,Ichikawa Y,Kitagawa K,Fujii E,Yamada N,Ito M

更新日期：2018-01-26 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) is a major risk factor for cardiovascular events. We aimed to investigate the coronary plaque phenotype of diabetic patients who presented with acute coronary syndromes by optical coherence tomography. METHODS AND RESULTS:A total of 322 patients with acute coronary syndromes who under...

journal_title：Journal of the American Heart Association

authors： Sugiyama T,Yamamoto E,Bryniarski K,Xing L,Fracassi F,Lee H,Jang IK

更新日期：2018-07-13 00:00:00

abstract：BACKGROUND:History of gestational diabetes mellitus (GDM) increases lifetime risk of type 2 diabetes (DM) and the metabolic syndrome (MetS), which increase risk of cardiovascular disease. It is unclear, however, whether GDM increases risk of early atherosclerosis independent of pre-pregnancy obesity and subsequent meta...

journal_title：Journal of the American Heart Association

authors： Gunderson EP,Chiang V,Pletcher MJ,Jacobs DR,Quesenberry CP,Sidney S,Lewis CE

更新日期：2014-03-12 00:00:00

abstract：BACKGROUND:Despite guideline recommendations, a significant number of patients with non-ST elevation myocardial infarction (NSTEMI) do not receive dual antiplatelet therapy (DAPT) before angiography "pretreatment." While there may be valid clinical reasons to not pretreat, such as concern for bleeding or multivessel di...

journal_title：Journal of the American Heart Association

authors： Shafiq A,Valle J,Jang JS,Qintar M,Gosch K,Cohen DJ,Singh M,Bach R,Spertus JA

更新日期：2016-06-10 00:00:00