Investigation of Causal Effect of Atrial Fibrillation on Alzheimer Disease: A Mendelian Randomization Study.

abstract：BACKGROUND:Data are sparse regarding the value of physical activity (PA) surveillance among older adults-particularly among those with mobility limitations. The objective of this study was to examine longitudinal associations between objectively measured daily PA and the incidence of cardiovascular events among older a...

journal_title：Journal of the American Heart Association

authors： Cochrane SK,Chen SH,Fitzgerald JD,Dodson JA,Fielding RA,King AC,McDermott MM,Manini TM,Marsh AP,Newman AB,Pahor M,Tudor-Locke C,Ambrosius WT,Buford TW,LIFE Study Research Group.

更新日期：2017-12-02 00:00:00

abstract：BACKGROUND:Previous studies have suggested that n-3 polyunsaturated fatty acids (n-3 PUFAs) have antiarrhythmic effects on atrial fibrillation (AF). We aimed to assess the effects of therapy with n-3 PUFAs on the incidence of recurrent AF and on postoperative AF. METHODS AND RESULTS:Electronic searches were conducted ...

journal_title：Journal of the American Heart Association

authors： Mariani J,Doval HC,Nul D,Varini S,Grancelli H,Ferrante D,Tognoni G,Macchia A

更新日期：2013-02-19 00:00:00

abstract：BACKGROUND:Cardiac fibrosis occurs because of disruption of the extracellular matrix network leading to myocardial dysfunction. Angiotensin II has been implicated in the development of cardiac fibrosis. Recently, microRNAs have been identified as an attractive target for therapeutic intervention in cardiac pathologies;...

journal_title：Journal of the American Heart Association

authors： Li L,Bounds KR,Chatterjee P,Gupta S

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:Transcription of the myristoylated alanine-rich C kinase substrate (MARCKS) is upregulated in animal models of intimal hyperplasia. MARCKS knockdown inhibits vascular smooth muscle cell (VSMC) migration in vitro; however, the mechanism is as yet unknown. We sought to elucidate the mechanism of MARCKS-mediate...

journal_title：Journal of the American Heart Association

authors： Yu D,Makkar G,Strickland DK,Blanpied TA,Stumpo DJ,Blackshear PJ,Sarkar R,Monahan TS

更新日期：2015-10-08 00:00:00

abstract：:Background Patients with tetralogy of Fallot ( TOF ) remain at risk for cardiovascular events despite successful repair. Some of the current risk stratification tools require advanced imaging and invasive studies, and hence are difficult to apply to routine patient care. A recent study showed that QRS fragmentation ( ...

journal_title：Journal of the American Heart Association

authors： Egbe AC,Miranda WR,Mehra N,Ammash NM,Missula VR,Madhavan M,Deshmukh AJ,Farouk Abdelsamid M,Kothapalli S,Connolly HM

更新日期：2018-12-18 00:00:00

abstract：BACKGROUND:Intramyocardial injection of mesenchymal stem cells (MSCs) in chronic ischemic cardiomyopathy is associated with reverse remodeling in experimental models and humans. Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular remodeling by producing durable and progressive scar size reduct...

journal_title：Journal of the American Heart Association

authors： Williams AR,Suncion VY,McCall F,Guerra D,Mather J,Zambrano JP,Heldman AW,Hare JM

更新日期：2013-05-17 00:00:00

abstract：:Background Impaired heart rate variability (HRV) is associated with increased mortality in sinus rhythm. However, HRV has not been systematically assessed in patients with atrial fibrillation (AF). We hypothesized that parameters of HRV may be predictive of cardiovascular death in patients with AF. Methods and Results...

journal_title：Journal of the American Heart Association

authors： Hämmerle P,Eick C,Blum S,Schlageter V,Bauer A,Rizas KD,Eken C,Coslovsky M,Aeschbacher S,Krisai P,Meyre P,Vesin JM,Rodondi N,Moutzouri E,Beer J,Moschovitis G,Kobza R,Di Valentino M,Corino VDA,Laureanti R,Mainardi L

更新日期：2020-08-04 00:00:00

abstract：:Background Hyperkalemia can be harmful, but the effect of correcting hyperkalemia is sparsely studied. We used nationwide data to examine hyperkalemia follow-up in patients with hypertension. Methods and Results We identified 7620 patients with hypertension, who had the first plasma potassium measurement ≥4.7 mmol/L (...

journal_title：Journal of the American Heart Association

authors： Krogager ML,Søgaard P,Torp-Pedersen C,Bøggild H,Gislason G,Kragholm K

更新日期：2020-12-15 00:00:00

abstract：:Background Evidence suggests familial aggregation and intergenerational associations for individual cardiovascular health (CVH) metrics. Over a 53-year life course, we examined trends and association of CVH between parents and their offspring at similar mean ages. Methods and Results We conducted a series of cross-sec...

journal_title：Journal of the American Heart Association

authors： Muchira JM,Gona PN,Mogos MF,Stuart-Shor E,Leveille SG,Piano MR,Hayman LL

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:Bromocriptine-QR (a quick-release formulation of bromocriptine mesylate), a dopamine D2 receptor agonist, is a US Food and Drug Administrration-approved treatment for type 2 diabetes mellitus (T2DM). A 3070-subject randomized trial demonstrated a significant, 40% reduction in relative risk among bromocriptin...

journal_title：Journal of the American Heart Association

authors： Gaziano JM,Cincotta AH,Vinik A,Blonde L,Bohannon N,Scranton R

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Remote ischemic conditioning (RIC) is a noninvasive therapeutic strategy that uses brief cycles of blood pressure cuff inflation and deflation to protect the myocardium against ischemia-reperfusion injury. The objective of this systematic review was to determine the impact of RIC on myocardial salvage index,...

journal_title：Journal of the American Heart Association

authors： McLeod SL,Iansavichene A,Cheskes S

更新日期：2017-05-17 00:00:00

abstract：:Background Epigenome-wide association studies for cardiometabolic risk factors have discovered multiple loci associated with incident cardiovascular disease (CVD). However, few studies have sought to directly optimize a predictor of CVD risk. Furthermore, it is challenging to train multivariate models across multiple ...

journal_title：Journal of the American Heart Association

authors： Westerman K,Fernández-Sanlés A,Patil P,Sebastiani P,Jacques P,Starr JM,J Deary I,Liu Q,Liu S,Elosua R,DeMeo DL,Ordovás JM

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:Cystathionine γ-lyase, cystathionine β-synthase, and 3-mercaptopyruvate sulfurtransferase are endogenous enzymatic sources of hydrogen sulfide (H2S). Functions of H2S are mediated by several targets including ion channels and signaling proteins. Nuclear factor-erythroid 2-related factor 2 is responsible for ...

journal_title：Journal of the American Heart Association

authors： Islam KN,Polhemus DJ,Donnarumma E,Brewster LP,Lefer DJ

更新日期：2015-05-14 00:00:00

abstract：BACKGROUND:Our laboratory has previously demonstrated the importance of a cytoskeletal-based survival signaling pathway using in vitro models of ischemia/reperfusion (IR). However, the importance of this pathway in mediating stress-elicited survival signaling in vivo is unknown. METHODS AND RESULTS:The essential cytos...

journal_title：Journal of the American Heart Association

authors： Perricone AJ,Bivona BJ,Jackson FR,Vander Heide RS

更新日期：2013-09-30 00:00:00

abstract：:Background Pregnancy increases the risk of acute myocardial infarction (AMI). The purpose of this study was to examine timing and risk factors for AMI in pregnancy and poor outcome. Methods and Results National Inpatient Sample (2003-2015) was screened in pregnancy, labor and delivery, and postpartum. There were 11 29...

journal_title：Journal of the American Heart Association

authors： Balgobin CA,Zhang X,Lima FV,Avila C,Parikh PB,Yang J,Stergiopoulos K

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Although automated external defibrillators (AEDs) have contributed to a better survival of out-of-hospital cardiac arrests, there have been reports of their malfunctioning. We investigated the diagnostic accuracy of commercially available AEDs using surface ECGs of ventricular fibrillation (VF), ventricular ...

journal_title：Journal of the American Heart Association

authors： Nishiyama T,Nishiyama A,Negishi M,Kashimura S,Katsumata Y,Kimura T,Nishiyama N,Tanimoto Y,Aizawa Y,Mitamura H,Fukuda K,Takatsuki S

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Acute end points of catheter ablation for ventricular tachycardia (VT) remain incompletely defined. The aim of this study is to identify causes for failure in patients with structural heart disease and to assess the relation of this acute outcome to longer-term management and outcomes. METHODS AND RESULTS:F...

journal_title：Journal of the American Heart Association

authors： Tokuda M,Kojodjojo P,Tung S,Tedrow UB,Nof E,Inada K,Koplan BA,Michaud GF,John RM,Epstein LM,Stevenson WG

更新日期：2013-05-31 00:00:00

abstract：:Background The purpose of this study was to determine whether the presence of antegrade blood flow was related to stroke subtype in patients with acute intracranial large artery occlusion. Methods and Results The prospectively collected data for consecutive patients who had occlusion of the unilateral M1 segment of th...

journal_title：Journal of the American Heart Association

authors： Zhang M,Chen Z,Xu J,Gong X,Shi F,Lou M

更新日期：2020-10-20 00:00:00

abstract：:Background Kidney function decreases during the lifetime, and this decline is a powerful predictor of both kidney and cardiovascular outcomes. Statins lower cardiovascular risk, which may relate to beneficial effects on kidney function. We studied whether atorvastatin influences kidney function decline and assessed th...

journal_title：Journal of the American Heart Association

authors： Vogt L,Bangalore S,Fayyad R,Melamed S,Hovingh GK,DeMicco DA,Waters DD

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Postural tachycardia syndrome (POTS) is a disorder of chronic orthostatic intolerance accompanied by excessive orthostatic tachycardia. Patients with POTS commonly have comorbid conditions such as attention deficit hyperactivity disorder, depression, or fibromyalgia that are treated with medications that inh...

journal_title：Journal of the American Heart Association

authors： Green EA,Raj V,Shibao CA,Biaggioni I,Black BK,Dupont WD,Robertson D,Raj SR

更新日期：2013-09-03 00:00:00

abstract：BACKGROUND:Galectin-3 (Gal-3) participates in different mechanisms involved in atherothrombosis, such as inflammation, proliferation, or macrophage chemotaxis. Thus, there have been committed intensive efforts to elucidate the function of Gal-3 in cardiovascular (CV) diseases. The role of Gal-3 as a circulating biomark...

journal_title：Journal of the American Heart Association

authors： Madrigal-Matute J,Lindholt JS,Fernandez-Garcia CE,Benito-Martin A,Burillo E,Zalba G,Beloqui O,Llamas-Granda P,Ortiz A,Egido J,Blanco-Colio LM,Martin-Ventura JL

更新日期：2014-08-05 00:00:00

abstract：BACKGROUND:Among the growing numbers of patients with heart failure, up to one half have heart failure with preserved ejection fraction (HFpEF). The lack of effective treatments for HFpEF is a substantial and escalating unmet clinical need-and the lack of HFpEF-specific animal models represents a major preclinical barr...

journal_title：Journal of the American Heart Association

authors： Curl CL,Danes VR,Bell JR,Raaijmakers AJA,Ip WTK,Chandramouli C,Harding TW,Porrello ER,Erickson JR,Charchar FJ,Kompa AR,Edgley AJ,Crossman DJ,Soeller C,Mellor KM,Kalman JM,Harrap SB,Delbridge LMD

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Atherosclerosis is an inflammatory lipid disorder and the main underlying pathology of acute ischemic events. Despite a vast amount of data from murine atherosclerosis models, evidence of B-cell involvement in human atherosclerotic disease is limited. We therefore investigated the association of circulating ...

journal_title：Journal of the American Heart Association

authors： Meeuwsen JAL,van Duijvenvoorde A,Gohar A,Kozma MO,van de Weg SM,Gijsberts CM,Haitjema S,Björkbacka H,Fredrikson GN,de Borst GJ,den Ruijter HM,Pasterkamp G,Binder CJ,Hoefer IE,de Jager SCA

更新日期：2017-09-07 00:00:00

abstract：:Background Whether physical activity is a determinant of peripheral artery disease (PAD) remains unclear. We therefore assessed the association of physical activity (amount and intensity) with subsequent risk of hospitalization with PAD and its severe form, critical limb ischemia, in the ARIC (Atherosclerosis Risk in ...

journal_title：Journal of the American Heart Association

authors： Lu Y,Ballew SH,Kwak L,Selvin E,Kalbaugh CA,Schrack JA,Matsushita K,Szklo M

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:Hypertension is a frequent risk factor for the development of heart failure with preserved ejection fraction (HFPEF). Progressive extracellular matrix accumulation has been presumed to be the fundamental pathophysiologic mechanism that leads to the transition to impaired diastolic reserve. However, the contr...

journal_title：Journal of the American Heart Association

authors： van Empel VP,Mariani J,Borlaug BA,Kaye DM

更新日期：2014-12-02 00:00:00

abstract：:Background We aimed to determine if there is an association between hospital quality and the likelihood of a given hospital being a preferred transfer destination for stroke patients. Methods and Results Data from Medicare claims identified acute ischemic stroke transferred between 394 northeast US hospitals from 2007...

journal_title：Journal of the American Heart Association

authors： Zachrison KS,Onnela JP,Reeves MJ,Hernandez A,Camargo CA Jr,Zhao X,Matsouaka RA,Goldstein JN,Metlay JP,Schwamm LH

更新日期：2020-01-07 00:00:00

abstract：:Background Data on race- and ethnicity-based disparities in the utilization and outcomes of structural heart disease interventions in the United States are scarce. Methods and Results We used the National Inpatient Sample (2011-2016) to examine racial and ethnic differences in the utilization, in-hospital outcomes, an...

journal_title：Journal of the American Heart Association

authors： Alkhouli M,Alqahtani F,Holmes DR,Berzingi C

更新日期：2019-08-06 00:00:00

abstract：:Background Hospitals in the United States vary in their use of intensive care units (ICUs) for hemodynamically stable patients with non-ST-segment-elevation myocardial infarction (NSTEMI). The association between ICU use and long-term outcomes after NSTEMI is unknown. Methods and Results Using data from the National C...

journal_title：Journal of the American Heart Association

authors： Fanaroff AC,Chen AY,van Diepen S,Peterson ED,Wang TY

更新日期：2020-03-17 00:00:00

abstract：:Background The regulation of sodium excretion is important in the pathogenesis of hypertension and salt sensitivity is predictive of cardiovascular events and mortality. C57Bl/6 and BALB/c mice have different blood pressure sensitivities to salt intake. High salt intake increases blood pressure in some C57Bl/6J mouse ...

journal_title：Journal of the American Heart Association

authors： Cuevas S,Asico LD,Jose PA,Konkalmatt P

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:Although clinical trials have proved that statin can be used prophylactically against cardiovascular events, the direct effects of statin on plaque development are not well understood. We generated low-density lipoprotein receptor knockout (LDLR(-/-)) pigs to study the effects of early statin administration ...

journal_title：Journal of the American Heart Association

authors： Li Y,Fuchimoto D,Sudo M,Haruta H,Lin QF,Takayama T,Morita S,Nochi T,Suzuki S,Sembon S,Nakai M,Kojima M,Iwamoto M,Hashimoto M,Yoda S,Kunimoto S,Hiro T,Matsumoto T,Mitsumata M,Sugitani M,Saito S,Hirayama A,Onish

更新日期：2016-04-18 00:00:00