Nocturnal Blood Pressure Is Reduced by a Mandibular Advancement Device for Sleep Apnea in Women: Findings From Secondary Analyses of a Randomized Trial.

abstract：:Background The role of platelets in the development of vascular inflammation and endothelial dysfunction in the pathogenesis of hypertension is well established at this time. Aspirin is known to relieve pain, decrease fever, reduce inflammation, impair platelet aggregation, and prevent clotting, yet its effect in the ...

journal_title：Journal of the American Heart Association

authors： Jiang X,Liu X,Liu X,Wu X,Jose PA,Liu M,Yang Z

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:Intestinal microbiota have been found to be linked to cardiovascular disease via conversion of the dietary compounds choline and carnitine to the atherogenic metabolite TMAO (trimethylamine-N-oxide). Specifically, a vegan diet was associated with decreased plasma TMAO levels and nearly absent TMAO production...

journal_title：Journal of the American Heart Association

authors： Smits LP,Kootte RS,Levin E,Prodan A,Fuentes S,Zoetendal EG,Wang Z,Levison BS,Cleophas MCP,Kemper EM,Dallinga-Thie GM,Groen AK,Joosten LAB,Netea MG,Stroes ESG,de Vos WM,Hazen SL,Nieuwdorp M

更新日期：2018-03-26 00:00:00

abstract：BACKGROUND:Ethnicity is an important predictor of coronary artery bypass graft surgery (CABG) outcomes. South Asians (SA), one of the largest ethnic groups with a high burden of cardiovascular disease, are hypothesized to have inferior outcomes after CABG compared to other ethnic groups. Given the paucity and controver...

journal_title：Journal of the American Heart Association

authors： Deb S,Tu JV,Austin PC,Ko DT,Rocha R,Mazer CD,Kiss A,Fremes SE

更新日期：2016-07-22 00:00:00

abstract：:Background Hyperkalemia has been associated with increased mortality in patients with myocardial infarction, but few data exist regarding hyperkalemia in cardiac intensive care unit ( CICU ) patients. We hypothesize that hyperkalemia is associated with increased mortality in unselected CICU patients. Methods and Resul...

journal_title：Journal of the American Heart Association

authors： Brueske B,Sidhu MS,Schulman-Marcus J,Kashani KB,Barsness GW,Jentzer JC

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Time to peak velocity (TPV) is an echocardiographic variable that can be easily measured and reflects a late peaking murmur, a classic physical finding suggesting severe aortic stenosis (AS). The aim of this study was to investigate the usefulness of TPV to evaluate AS severity. METHODS AND RESULTS:This stu...

journal_title：Journal of the American Heart Association

authors： Kamimura D,Hans S,Suzuki T,Fox ER,Hall ME,Musani SK,McMullan MR,Little WC

更新日期：2016-10-22 00:00:00

abstract：:Background Prior reports indicate that the effect of P2Y12 inhibitors may be different in East Asian patients ("East Asian paradox"); therefore, understanding the outcomes associated with potent P2Y12 inhibitors in different populations is clinically important. Methods and Results In this observational cohort study us...

journal_title：Journal of the American Heart Association

authors： Yun JE,Kim YJ,Park JJ,Kim S,Park K,Cho MS,Nam GB,Park DW

更新日期：2019-07-16 00:00:00

abstract：BACKGROUND:Renal denervation has no validated marker of procedural success. We hypothesized that successful renal denervation would reduce renal sympathetic nerve signaling demonstrated by attenuation of α-1-adrenoceptor-mediated autotransfusion during the Valsalva maneuver. METHODS AND RESULTS:In this substudy of the...

journal_title：Journal of the American Heart Association

authors： Saxena M,Shour T,Shah M,Wolff CB,Julu POO,Kapil V,Collier DJ,Ng FL,Gupta A,Balawon A,Pheby J,Zak A,Rull G,O'Brien B,Schmieder RE,Lobo MD

更新日期：2018-06-12 00:00:00

abstract：:Background Vascular calcification (VC) is associated with high morbidity and mortality among older adults, a population that exhibits a higher tendency for developing frailty at the same time. Whether VC serves as a risk factor for the development of frailty in this population remains unclear. Methods and Results We a...

journal_title：Journal of the American Heart Association

authors： Lee SY,Chao CT,Huang JW,Huang KC

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) is a common condition associated with cardiovascular disease. Its potential effect on progression of subclinical atherosclerosis is not well understood. We tested the hypothesis that self-reported OSA is associated with progression of coronary artery calcium (CAC). We also evalu...

journal_title：Journal of the American Heart Association

authors： Kwon Y,Duprez DA,Jacobs DR,Nagayoshi M,McClelland RL,Shahar E,Budoff M,Redline S,Shea S,Carr JJ,Lutsey PL

更新日期：2014-09-26 00:00:00

abstract：BACKGROUND:Sedentary behaviors have been directly associated with all-cause mortality. However, little is known about different types of sedentary behaviors in relation to overall mortality. Our objective was to assess the association between different sedentary behaviors and all-cause mortality. METHODS AND RESULTS:I...

journal_title：Journal of the American Heart Association

authors： Basterra-Gortari FJ,Bes-Rastrollo M,Gea A,Núñez-Córdoba JM,Toledo E,Martínez-González MÁ

更新日期：2014-06-25 00:00:00

abstract：BACKGROUND:Long chain acyl-CoA synthetases (ACSL) catalyze long-chain fatty acids (FA) conversion to acyl-CoAs. Temporal ACSL1 inactivation in mouse hearts (Acsl1(H-/-)) impaired FA oxidation and dramatically increased glucose uptake, glucose oxidation, and mTOR activation, resulting in cardiac hypertrophy. We used unb...

journal_title：Journal of the American Heart Association

authors： Schisler JC,Grevengoed TJ,Pascual F,Cooper DE,Ellis JM,Paul DS,Willis MS,Patterson C,Jia W,Coleman RA

更新日期：2015-02-24 00:00:00

abstract：:Background Coronary artery disease is the primary etiology for sudden cardiac arrest in adults, but potential differences in the incidence and utility of invasive coronary testing between resuscitated men and women have not been extensively evaluated. Our aim was to characterize angiographic similarities and differenc...

journal_title：Journal of the American Heart Association

authors： May T,Skinner K,Unger B,Mooney M,Patel N,Dupont A,McPherson J,McMullan P,Nielsen N,Seder DB,Kern KB

更新日期：2020-04-07 00:00:00

abstract：:Background Hypodense filling defects within the pulmonary veins on computed tomography described as pulmonary vein sign (PVS) have been noted in acute pulmonary embolism and shown to be associated with poor prognosis. We evaluated venous flow abnormalities in chronic thromboembolic pulmonary hypertension (CTEPH) to de...

journal_title：Journal of the American Heart Association

authors： Gopalan D,Nordgren-Rogberg A,Le EPV,Pavey H,Tarkin J,Nyrén S,Auger W,Lindholm P

更新日期：2020-11-03 00:00:00

abstract：:Background Knowledge is scarce regarding how multimorbidity is associated with therapeutic decisions regarding oral anticoagulants (OACs) in patients with atrial fibrillation. Methods and Results We conducted a cross-sectional study of hospitalized patients with atrial fibrillation using the Get With The Guidelines-At...

journal_title：Journal of the American Heart Association

authors： Dalgaard F,Xu H,Matsouaka RA,Russo AM,Curtis AB,Rasmussen PV,Ruwald MH,Fonarow GC,Lowenstern A,Hansen ML,Pallisgaard JL,Alexander KP,Alexander JH,Lopes RD,Granger CB,Lewis WR,Piccini JP,Al-Khatib SM

更新日期：2020-12-01 00:00:00

abstract：:Background Noninvasive cardiac tests, including exercise treadmill tests (ETTs), are commonly utilized in the evaluation of patients in the emergency department with suspected acute coronary syndrome. However, there are ongoing debates on their clinical utility and cost-effectiveness. It is important to be able to use...

journal_title：Journal of the American Heart Association

authors： Zheng C,Sun BC,Wu YL,Lee MS,Shen E,Redberg RF,Ferencik M,Natsui S,Kawatkar AA,Musigdilok VV,Sharp AL

更新日期：2020-03-03 00:00:00

abstract：BACKGROUND:Insulin resistance, characterized by hyperinsulinemia and normal or elevated serum glucose, is an established precursor to diabetes and cardiovascular disease. Despite fasting serum C-peptide levels being an accurate and stable marker of endogenous insulin production used in patients with diabetes, it is unk...

journal_title：Journal of the American Heart Association

authors： Patel N,Taveira TH,Choudhary G,Whitlatch H,Wu WC

更新日期：2012-12-01 00:00:00

abstract：:Background Public health policies reflect concerns that certain fruit sources may not have the intended benefits and that vegetables should be preferred to fruit. We assessed the relation of fruit and vegetable sources with cardiovascular outcomes using a systematic review and meta-analysis of prospective cohort studi...

journal_title：Journal of the American Heart Association

authors： Zurbau A,Au-Yeung F,Blanco Mejia S,Khan TA,Vuksan V,Jovanovski E,Leiter LA,Kendall CWC,Jenkins DJA,Sievenpiper JL

更新日期：2020-10-20 00:00:00

abstract：:Background Aging is associated with a modest decline in ankle-brachial index (ABI); however, the underpinnings of this decline are not fully understood. The greater systolic ankle than brachial blood pressure, a normal ABI implies, is partially attributed to lower central than peripheral arterial stiffness. Hence, we ...

journal_title：Journal of the American Heart Association

authors： Oberdier MT,Morrell CH,Lakatta EG,Ferrucci L,AlGhatrif M

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Black race has been shown to be a risk factor for amputation in peripheral artery disease (PAD); however, race has been argued to be a marker for socioeconomic status (SES) rather than true disparity. The aim of this study is to study the impact of race and SES on amputation risk in PAD patients. METHODS AN...

journal_title：Journal of the American Heart Association

authors： Arya S,Binney Z,Khakharia A,Brewster LP,Goodney P,Patzer R,Hockenberry J,Wilson PWF

更新日期：2018-01-12 00:00:00

abstract：:Background Antazoline mesylate represents an antihistamine capable of rapid and safe cardioversion of atrial fibrillation, yet evidence concerning its efficacy in comparison to other medications is insufficient. The study aimed to evaluate the success rate and safety of pharmacological cardioversion of atrial fibrilla...

journal_title：Journal of the American Heart Association

authors： Wybraniec MT,Wróbel W,Wilkosz K,Wrona K,Bula K,Mizia-Stec K

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:The renin-angiotensin system has a pivotal role in the pathophysiology of visceral obesity. Angiotensin II type 1 receptor (AT1R) is a major player in the signal transduction of the renin-angiotensin system, and the overactivation of this signaling contributes to the progression of visceral obesity. We have ...

journal_title：Journal of the American Heart Association

authors： Azushima K,Ohki K,Wakui H,Uneda K,Haku S,Kobayashi R,Haruhara K,Kinguchi S,Matsuda M,Maeda A,Toya Y,Yamashita A,Umemura S,Tamura K

更新日期：2017-03-06 00:00:00

abstract：:Congenital heart disease is the most common congenital defect observed in newborns. Within the spectrum of congenital heart disease are left-sided obstructive lesions (LSOLs), which include hypoplastic left heart syndrome, aortic stenosis, bicuspid aortic valve, coarctation of the aorta, and interrupted aortic arch. T...

journal_title：Journal of the American Heart Association

authors： Parker LE,Landstrom AP

更新日期：2021-01-19 00:00:00

abstract：:Background Epigenome-wide association studies for cardiometabolic risk factors have discovered multiple loci associated with incident cardiovascular disease (CVD). However, few studies have sought to directly optimize a predictor of CVD risk. Furthermore, it is challenging to train multivariate models across multiple ...

journal_title：Journal of the American Heart Association

authors： Westerman K,Fernández-Sanlés A,Patil P,Sebastiani P,Jacques P,Starr JM,J Deary I,Liu Q,Liu S,Elosua R,DeMeo DL,Ordovás JM

更新日期：2020-04-21 00:00:00

abstract：:Background The incidence of conduction abnormalities requiring permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement (TAVR) with early and later generation prostheses remains debated. Methods and Results Based on the administrative hospital-discharge database, we collected information for...

journal_title：Journal of the American Heart Association

authors： Bisson A,Bodin A,Herbert J,Lacour T,Saint Etienne C,Pierre B,Clementy N,Deharo P,Babuty D,Fauchier L

更新日期：2020-05-05 00:00:00

abstract：:Background Coronary artery disease remains a major cause of death despite better outcomes of ST-segment-elevation myocardial infarction (STEMI). We aimed to analyze data from the Ruti-STEMI registry of in-hospital, 28-day, and 1-year events in patients with STEMI over the past 3 decades in Catalonia, Spain, to assess ...

journal_title：Journal of the American Heart Association

authors： García-García C,Oliveras T,Serra J,Vila J,Rueda F,Cediel G,Labata C,Ferrer M,Carrillo X,Dégano IR,De Diego O,El Ouaddi N,Montero S,Mauri J,Elosua R,Lupón J,Bayes-Genis A,Ruti‐STEMI Investigators †.

更新日期：2020-10-20 00:00:00

abstract：:Background Recent studies suggest that mavacamten (Myk461), a small myosin-binding molecule, decreases hypercontractility in myocardium expressing hypertrophic cardiomyopathy-causing missense mutations in myosin heavy chain. However, the predominant feature of most mutations in cardiac myosin binding protein-C ( cMyBP...

journal_title：Journal of the American Heart Association

authors： Mamidi R,Li J,Doh CY,Verma S,Stelzer JE

更新日期：2018-09-04 00:00:00

abstract：BACKGROUND:Low high-density lipoprotein (HDL) levels are major predictors of cardiovascular (CV) events, even in patients on statin treatment with low-density lipoprotein (LDL) at target. In animal models HDLs protect LDL from oxidation and blunt platelet activation. Our study aimed to examine whether HDL levels are re...

journal_title：Journal of the American Heart Association

authors： Vazzana N,Ganci A,Cefalù AB,Lattanzio S,Noto D,Santoro N,Saggini R,Puccetti L,Averna M,Davì G

更新日期：2013-04-04 00:00:00

abstract：BACKGROUND:Inappropriate sinus tachycardia (IST) and postural tachycardia syndrome (POTS) are 2 disorders characterized by sinus tachycardia. It is debated whether the pathophysiology of IST and POTS results from abnormal autonomic regulation or abnormal sinus node function. We hypothesized that intrinsic heart rate (I...

journal_title：Journal of the American Heart Association

authors： Nwazue VC,Paranjape SY,Black BK,Biaggioni I,Diedrich A,Dupont WD,Robertson D,Raj SR

更新日期：2014-04-10 00:00:00

abstract：BACKGROUND:Epinephrine administered during cardiopulmonary resuscitation (CPR) is associated with severe post-resuscitation myocardial dysfunction. We previously demonstrated that therapeutic hypothermia reduced the severity of post-resuscitation myocardial dysfunction caused by epinephrine; however, the relationship b...

journal_title：Journal of the American Heart Association

authors： Wang W,Hua T,Li H,Wu X,Bradley J,Peberdy MA,Ornato JP,Tang W

更新日期：2018-03-23 00:00:00

abstract：:Background Congenital heart disease is common in patients with Trisomy 13 (T13) and Trisomy 18 (T18), but offering cardiac surgery to these patients has been controversial. We describe the landscape of surgical management across the United States, perioperative risk factors, and surgical outcomes in patients with T13 ...

journal_title：Journal of the American Heart Association

authors： Cooper DS,Riggs KW,Zafar F,Jacobs JP,Hill KD,Pasquali SK,Swanson SK,Gelehrter SK,Wallace A,Jacobs ML,Morales DLS,Bryant R 3rd

更新日期：2019-07-02 00:00:00