Genetic Etiology of Left-Sided Obstructive Heart Lesions: A Story in Development.

abstract：BACKGROUND:Women are more likely than men to develop resistant hypertension, which is associated with excess risk of major adverse outcomes; however, the impact of resistant hypertension in women with ischemia has not been explicitly studied. In this Women's Ischemia Syndrome Evaluation (WISE) analysis, we assessed lon...

journal_title：Journal of the American Heart Association

authors： Smith SM,Huo T,Delia Johnson B,Bittner V,Kelsey SF,Vido Thompson D,Noel Bairey Merz C,Pepine CJ,Cooper-Dehoff RM

更新日期：2014-02-28 00:00:00

abstract：:Background Duchenne muscular dystrophy (DMD) is a neuromuscular disorder caused by mutations within the dystrophin gene. DMD is characterized by progressive skeletal muscle degeneration and atrophy and progressive cardiomyopathy. It has been observed the severity of cardiomyopathy varies in patients with DMD. Methods ...

journal_title：Journal of the American Heart Association

authors： Jiang X,Shao Y,Araj FG,Amin AA,Greenberg BM,Drazner MH,Xing C,Mammen PPA

更新日期：2020-10-20 00:00:00

abstract：:Background Although PAR-1 (protease-activated receptor-1) exerts important functions in the pathophysiology of the cardiovascular system, the role of PAR-1 signaling in heart failure development remains largely unknown. We tested the hypothesis that PAR-1 signaling inhibition has protective effects on the progression ...

journal_title：Journal of the American Heart Association

authors： Yokono Y,Hanada K,Narita M,Tatara Y,Kawamura Y,Miura N,Kitayama K,Nakata M,Nozaka M,Kato T,Kudo N,Tsushima M,Toyama Y,Itoh K,Tomita H

更新日期：2020-06-16 00:00:00

abstract：:Background In the 2000s, adults with HIV had a higher risk for atherosclerotic cardiovascular disease (ASCVD) compared with those without HIV. There is uncertainty if this excess risk still exists in the United States given changes in antiretroviral therapies and increased statin use. Methods and Results We compared t...

journal_title：Journal of the American Heart Association

authors： Rosenson RS,Hubbard D,Monda KL,Reading SR,Chen L,Dluzniewski PJ,Burkholder GA,Muntner P,Colantonio LD

更新日期：2020-01-07 00:00:00

abstract：:Background Recent literature reports a strong thrombotic tendency in patients hospitalized for a coronavirus disease 2019 (COVID-19) infection. This characteristic is unusual and seems specific to COVID-19 infections, especially in their severe form. Viral infections can trigger acquired thrombophilia, which can then ...

journal_title：Journal of the American Heart Association

authors： Ferrari E,Sartre B,Squara F,Contenti J,Occelli C,Lemoel F,Levraut J,Doyen D,Dellamonica J,Mondain V,Chirio D,Risso K,Cua E,Orban JC,Ichai C,Labbaoui M,Mossaz B,Moceri P,Appert-Flory A,Fischer F,Toulon P

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Intramyocardial injection of mesenchymal stem cells (MSCs) in chronic ischemic cardiomyopathy is associated with reverse remodeling in experimental models and humans. Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular remodeling by producing durable and progressive scar size reduct...

journal_title：Journal of the American Heart Association

authors： Williams AR,Suncion VY,McCall F,Guerra D,Mather J,Zambrano JP,Heldman AW,Hare JM

更新日期：2013-05-17 00:00:00

abstract：BACKGROUND:This study aimed to determine the relationship of statin therapy and cardiovascular risk factors to changes in atherosclerosis in the carotid artery. METHODS AND RESULTS:Carotid magnetic resonance imaging was used to evaluate 106 hyperlipidemic participants at baseline and after 12 months of 3-hydroxy-3-met...

journal_title：Journal of the American Heart Association

authors： Sandfort V,Lai S,Ahlman MA,Mallek M,Liu S,Sibley CT,Turkbey EB,Lima JA,Bluemke DA

更新日期：2016-07-13 00:00:00

abstract：BACKGROUND:Impacts of a single radiofrequency ablation (RFA) on quality of life (QoL) were not well investigated in atrial fibrillation (AF) patients with low stroke risk. METHODS AND RESULTS:Nine hundred AF patients with low CHADS2 score (ie, CHADS2 ≤1) who completed both a baseline and 6-month Atrial Fibrillation Ef...

journal_title：Journal of the American Heart Association

authors： Bai Y,Bai R,Wu JH,Zhang T,Liu N,Shi XB,Liu XY,Liu XH,Du X,Dong JZ,Ma CS

更新日期：2015-09-16 00:00:00

abstract：BACKGROUND:The mechanisms behind the association of atrial fibrillation (AF) and dementia are unknown. We previously found a significantly increased risk of dementia in AF patients taking warfarin with a low percentage of time in therapeutic range. The purpose of this study was to determine the extent to which AF itsel...

journal_title：Journal of the American Heart Association

authors： Bunch TJ,May HT,Bair TL,Crandall BG,Cutler MJ,Day JD,Jacobs V,Mallender C,Osborn JS,Stevens SM,Weiss JP,Woller SC

更新日期：2016-07-11 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) shares several risk factors with atrial fibrillation (AF), and persons with PAD have an increased risk of stroke. It is unclear if PAD is associated with an increased risk for AF and whether this potential association explains the increased risk of stroke observed in those w...

journal_title：Journal of the American Heart Association

authors： O'Neal WT,Efird JT,Nazarian S,Alonso A,Heckbert SR,Soliman EZ

更新日期：2014-11-17 00:00:00

abstract：BACKGROUND:It is uncertain whether sex and race affect thrombogenicity in patients with coronary artery disease. We evaluated the effects of sex and race on thrombogenicity in patients with coronary artery disease treated with aspirin. METHODS AND RESULTS:Patients on aspirin therapy for 1 week or longer with known or ...

journal_title：Journal of the American Heart Association

authors： Lev EI,Bliden KP,Jeong YH,Pandya S,Kang K,Franzese C,Tantry US,Gurbel PA

更新日期：2014-10-20 00:00:00

abstract：:Background The overall goal of this longitudinal study was to determine if the Black population has decreased myocardial function, which has the potential to lead to the early development of congestive heart failure, compared with the White population. Methods and Results A total of 673 subjects were evaluated over a ...

journal_title：Journal of the American Heart Association

authors： Kapuku G,Howie M,Ghosh S,Doshi V,Bykhovsky M,Ange B,Halbert JD,Robinson V,Bagi Z,Harshfield G,George V

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:Cardiovascular clinical trials depend on patient enrollment. Enrollment rates appear inadequate, but little is known about how frequently patients accept or decline offers of enrollment. The objective of this study was to assess trends and predictors of patient acceptance of offers to enroll in clinical tria...

journal_title：Journal of the American Heart Association

authors： Kerkhoff LA,Butler J,Kelkar AA,Shore S,Speight CD,Wall LK,Dickert NW

更新日期：2016-06-17 00:00:00

abstract：:Background Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide-ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results TTS patients from the International Takotsubo Registry we...

journal_title：Journal of the American Heart Association

authors： Jurisic S,Gili S,Cammann VL,Kato K,Szawan KA,D'Ascenzo F,Jaguszewski M,Bossone E,Citro R,Sarcon A,Napp LC,Franke J,Noutsias M,Knorr M,Heiner S,Burgdorf C,Koenig W,Pott A,Kherad B,Rajan L,Michels G,Pfister R,Cu

更新日期：2019-11-05 00:00:00

abstract：:Background Previous studies have reported an association between the timing of menarche and cardiovascular disease ( CVD ). However, emerging studies have not examined the timing of menarche in relation to role of estrogen over a lifetime and major adverse cardiac events ( MACE ). Methods and Results A total of 648 wo...

journal_title：Journal of the American Heart Association

authors： Lee JJ,Cook-Wiens G,Johnson BD,Braunstein GD,Berga SL,Stanczyk FZ,Pepine CJ,Bairey Merz CN,Shufelt CL

更新日期：2019-06-18 00:00:00

abstract：:Background To assess differences in platelet inhibition during ticagrelor monotherapy (TIC) or dual therapy with ticagrelor and aspirin (TIC+ASP) in patients after percutaneous coronary intervention using a comprehensive panel of functional tests. Methods and Results In a single-center parallel group, open label, rand...

journal_title：Journal of the American Heart Association

authors： Johnson TW,Baos S,Collett L,Hutchinson JL,Nkau M,Molina M,Aungraheeta R,Reilly-Stitt C,Bowles R,Reeves BC,Rogers CA,Mundell SJ,Baumbach A,Mumford AD

更新日期：2020-12-15 00:00:00

abstract：:Background Noninvasive cardiac tests, including exercise treadmill tests (ETTs), are commonly utilized in the evaluation of patients in the emergency department with suspected acute coronary syndrome. However, there are ongoing debates on their clinical utility and cost-effectiveness. It is important to be able to use...

journal_title：Journal of the American Heart Association

authors： Zheng C,Sun BC,Wu YL,Lee MS,Shen E,Redberg RF,Ferencik M,Natsui S,Kawatkar AA,Musigdilok VV,Sharp AL

更新日期：2020-03-03 00:00:00

abstract：:Background In this nationwide study, we used the unique Danish registries to estimate the risk of suicide and deliberate self-harm in patients with congenital heart disease (CHD). Methods and Results We identified all Danish citizens receiving a diagnosis of CHD between 1977 and 2007. As a reference cohort, we randoml...

journal_title：Journal of the American Heart Association

authors： Udholm S,Nyboe C,Lundbye-Christensen S,Nordentoft M,Hjortdal VE

更新日期：2020-05-18 00:00:00

abstract：BACKGROUND:Despite variations in the prevalence of cardiovascular disease and related risk factors among US Hispanic/Latino adults of diverse backgrounds, there is little information on whether disparities exist in the use of medications for the primary and secondary prevention of cardiovascular disease. We examined th...

journal_title：Journal of the American Heart Association

authors： Qato DM,Lee TA,Durazo-Arvizu R,Wu D,Wilder J,Reina SA,Cai J,Gonzalez F 2nd,Talavera GA,Ostfeld RJ,Daviglus ML

更新日期：2016-03-30 00:00:00

abstract：BACKGROUND:Chest pain is a common reason for referral to pediatric cardiologists. Although pediatric chest pain is rarely attributable to serious cardiac pathology, extensive and costly evaluation is often performed. We have implemented a standardized approach to pediatric chest pain in our pediatric cardiology clinics...

journal_title：Journal of the American Heart Association

authors： Verghese GR,Friedman KG,Rathod RH,Meiri A,Saleeb SF,Graham DA,Geggel RL,Fulton DR

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Currently, acute ischemic stroke is still a leading cause of mortality and morbidity. Approximately 2 years ago, mechanical thrombectomy was proven beneficial as a revolutionary new therapy for stroke in the MR-CLEAN trial (A Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic ...

journal_title：Journal of the American Heart Association

authors： Autar ASA,Hund HM,Ramlal SA,Hansen D,Lycklama À Nijeholt GJ,Emmer BJ,de Maat MPM,Dippel DWJ,van der Lugt A,van Es ACGM,van Beusekom HMM,MR CLEAN Registry Investigators.

更新日期：2018-06-22 00:00:00

abstract：:Background Several lipid-lowering therapies reduce CRP (C-reactive protein) independently of LDL-C (low-density lipoprotein cholesterol) reduction, but the association between CRP parameters and benefits from more-intensive LDL-C lowering is inconclusive. We aimed to determine whether the benefits of more- versus less...

journal_title：Journal of the American Heart Association

authors： Zhang XL,Lan RF,Zhang XW,Xu W,Wang L,Kang LN,Xu B

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. METHODS AND RESULTS:Over 0.5 million adults aged 30 to 79 years were followed fr...

journal_title：Journal of the American Heart Association

authors： Liu N,Pan XF,Yu C,Lv J,Guo Y,Bian Z,Yang L,Chen Y,Wu T,Chen Z,Pan A,Li L,China Kadoorie Biobank Collaborative Group.

更新日期：2016-12-21 00:00:00

abstract：:Background Angiotensin II type 1 receptor ( AT 1R) autoantibody ( AT 1- AA ) was first identified as a causative factor in preeclampsia. Unlike physiological ligand angiotensin II (Ang II ), AT 1- AA can induce vasoconstriction in a sustained manner, causing a series of adverse effects, such as vascular injury and poo...

journal_title：Journal of the American Heart Association

authors： Bian J,Lei J,Yin X,Wang P,Wu Y,Yang X,Wang L,Zhang S,Liu H,Fu MLX

更新日期：2019-03-19 00:00:00

abstract：:Background Kidney function decreases during the lifetime, and this decline is a powerful predictor of both kidney and cardiovascular outcomes. Statins lower cardiovascular risk, which may relate to beneficial effects on kidney function. We studied whether atorvastatin influences kidney function decline and assessed th...

journal_title：Journal of the American Heart Association

authors： Vogt L,Bangalore S,Fayyad R,Melamed S,Hovingh GK,DeMicco DA,Waters DD

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:A prior randomized controlled trial of social media exposure at Circulation determined that social media did not increase 30-day page views. Whether insufficient social media intensity contributed to these results is uncertain. METHODS AND RESULTS:Original article manuscripts were randomized to social media...

journal_title：Journal of the American Heart Association

authors： Fox CS,Gurary EB,Ryan J,Bonaca M,Barry K,Loscalzo J,Massaro J

更新日期：2016-04-27 00:00:00

abstract：:Background Soluble urokinase plasminogen activator receptor (su PAR ) is a proinflammatory biomarker associated with immune activation and fibrinolysis inhibition. Plasminogen activator inhibitor ( PAI -1) is associated with excessive fibrin accumulation, thrombus formation, and atherosclerosis. The relationship betwe...

journal_title：Journal of the American Heart Association

authors： Corban MT,Prasad A,Nesbitt L,Loeffler D,Herrmann J,Lerman LO,Lerman A

更新日期：2018-08-07 00:00:00

abstract：:Background Left ventricular (LV) hemodynamic assessment has been sparsely performed in patients supported on continuous-flow LV assist devices (cf LVADs ). Insight into dynamic changes of left heart parameters during ramp studies may improve LV assist device optimization and evaluate pathology. Methods and Results To ...

journal_title：Journal of the American Heart Association

authors： Rosenbaum AN,Frantz RP,Kushwaha SS,Stulak JM,Maltais S,Behfar A

更新日期：2019-02-19 00:00:00

abstract：BACKGROUND:Postural tachycardia syndrome (POTS) is a disorder of chronic orthostatic intolerance accompanied by excessive orthostatic tachycardia. Patients with POTS commonly have comorbid conditions such as attention deficit hyperactivity disorder, depression, or fibromyalgia that are treated with medications that inh...

journal_title：Journal of the American Heart Association

authors： Green EA,Raj V,Shibao CA,Biaggioni I,Black BK,Dupont WD,Robertson D,Raj SR

更新日期：2013-09-03 00:00:00

abstract：BACKGROUND:Increased platelet aggregation during antiplatelet therapy may predict cardiovascular events in patients with coronary artery disease. The majority of these patients receive aspirin monotherapy. We aimed to investigate whether high platelet-aggregation levels predict cardiovascular events in stable coronary ...

journal_title：Journal of the American Heart Association

authors： Larsen SB,Grove EL,Neergaard-Petersen S,Würtz M,Hvas AM,Kristensen SD

更新日期：2017-08-05 00:00:00