miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation.

abstract：:Background Soluble urokinase plasminogen activator receptor (su PAR ) is a proinflammatory biomarker associated with immune activation and fibrinolysis inhibition. Plasminogen activator inhibitor ( PAI -1) is associated with excessive fibrin accumulation, thrombus formation, and atherosclerosis. The relationship betwe...

journal_title：Journal of the American Heart Association

authors： Corban MT,Prasad A,Nesbitt L,Loeffler D,Herrmann J,Lerman LO,Lerman A

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:The time-sensitive hazard of perioperative cardiac troponin T (cTnT) elevation and whether long-term mortality differs by mechanism of myocardial injury are poorly understood. METHODS AND RESULTS:In this observational study of 12 882 patients who underwent noncardiac vascular surgery, patients were assessed...

journal_title：Journal of the American Heart Association

authors： Reed GW,Horr S,Young L,Clevenger J,Malik U,Ellis SG,Lincoff AM,Nissen SE,Menon V

更新日期：2017-06-06 00:00:00

abstract：:Background We aim to generate a line of "universal donor" human induced pluripotent stem cells (hi PSC s) that are nonimmunogenic and, therefore, can be used to derive cell products suitable for allogeneic transplantation. Methods and Results hi PSC s carrying knockout mutations for 2 key components (β2 microglobulin ...

journal_title：Journal of the American Heart Association

authors： Mattapally S,Pawlik KM,Fast VG,Zumaquero E,Lund FE,Randall TD,Townes TM,Zhang J

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Physical activity is of benefit for primary prevention of cardiovascular diseases, but it appears to increase the risk for atrial fibrillation. We aimed to study a cohort of patients following a first stroke in individuals with previous high physical activity, compare them to the general population with resp...

journal_title：Journal of the American Heart Association

authors： Hållmarker U,Åsberg S,Michaëlsson K,Ärnlöv J,Hellberg D,Lindbäck J,Wester P,James S

更新日期：2015-09-24 00:00:00

abstract：:Background Current approaches fail to separate patients at high versus low risk for ventricular arrhythmias owing to overreliance on a snapshot left ventricular ejection fraction measure. We used statistical machine learning to identify important cardiac imaging and time-varying risk predictors. Methods and Results Th...

journal_title：Journal of the American Heart Association

authors： Wu KC,Wongvibulsin S,Tao S,Ashikaga H,Stillabower M,Dickfeld TM,Marine JE,Weiss RG,Tomaselli GF,Zeger SL

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:The incidence of abdominal aortic aneurysms (AAAs) will significantly increase during the next decade. Novel biomarkers, besides diameter, are needed for a better characterization of aneurysms and the estimation of the risk of rupture. Fibrin is a key protein in the formation of focal hematoma associated wit...

journal_title：Journal of the American Heart Association

authors： Botnar RM,Brangsch J,Reimann C,Janssen CHP,Razavi R,Hamm B,Makowski MR

更新日期：2018-05-30 00:00:00

abstract：:Background In statin trials, men and women derived similar relative risk reductions in cardiovascular events per 39 mg/ dL low-density lipoprotein cholesterol ( LDL -C) reduction. We explored whether lower LDL -C levels and greater LDL -C percentage reductions than those achieved with statins are associated with reduc...

journal_title：Journal of the American Heart Association

authors： Vallejo-Vaz AJ,Ginsberg HN,Davidson MH,Eckel RH,Cannon CP,Lee LV,Bessac L,Pordy R,Letierce A,Ray KK

更新日期：2018-09-18 00:00:00

abstract：:Background This study was performed to characterize the metabolic, functional, and structural cardiac changes in a canine model of radiation-induced heart disease by serial in vivo imaging and ex vivo analyses. Methods and Results Thirty-six dogs were randomly assigned to control or irradiated groups at 3 time points ...

journal_title：Journal of the American Heart Association

authors： Yan R,Li X,Song J,Guo M,Cai H,Wu Z,Wu P,Li L,Yang M,Wang Y,Li S

更新日期：2020-09-15 00:00:00

abstract：:Background Recent publications reached conflicting conclusions about the cost-effectiveness of left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, Marlborough, MA) for stroke risk reduction in nonvalvular atrial fibrillation (AF). This analysis sought to assess the cost-effectiveness of L...

journal_title：Journal of the American Heart Association

authors： Reddy VY,Akehurst RL,Gavaghan MB,Amorosi SL,Holmes DR Jr

更新日期：2019-07-02 00:00:00

abstract：:Background Patients with tetralogy of Fallot ( TOF ) remain at risk for cardiovascular events despite successful repair. Some of the current risk stratification tools require advanced imaging and invasive studies, and hence are difficult to apply to routine patient care. A recent study showed that QRS fragmentation ( ...

journal_title：Journal of the American Heart Association

authors： Egbe AC,Miranda WR,Mehra N,Ammash NM,Missula VR,Madhavan M,Deshmukh AJ,Farouk Abdelsamid M,Kothapalli S,Connolly HM

更新日期：2018-12-18 00:00:00

abstract：BACKGROUND:The volume-outcome relationship associated with intensive care unit (ICU) experience with managing acute myocardial infarction (AMI) remains inadequately understood. METHODS AND RESULTS:Within a multicenter clinical ICU database, we identified patients with a primary ICU admission diagnosis of AMI between 2...

journal_title：Journal of the American Heart Association

authors： Stolker JM,Badawi O,Spertus JA,Nasir A,Kennedy KF,Harris IH,Franey CS,Hsu VD,Ripple GR,Howell GH,Lem VM,Chan PS

更新日期：2015-06-11 00:00:00

abstract：:Background Impaired heart rate variability (HRV) is associated with increased mortality in sinus rhythm. However, HRV has not been systematically assessed in patients with atrial fibrillation (AF). We hypothesized that parameters of HRV may be predictive of cardiovascular death in patients with AF. Methods and Results...

journal_title：Journal of the American Heart Association

authors： Hämmerle P,Eick C,Blum S,Schlageter V,Bauer A,Rizas KD,Eken C,Coslovsky M,Aeschbacher S,Krisai P,Meyre P,Vesin JM,Rodondi N,Moutzouri E,Beer J,Moschovitis G,Kobza R,Di Valentino M,Corino VDA,Laureanti R,Mainardi L

更新日期：2020-08-04 00:00:00

abstract：:Background Catheter ablation is an effective treatment for atrial fibrillation (AF), but high levels of post-procedure inflammation predict adverse clinical events. Ascorbic acid (AA) has shown promise in reducing inflammation but is untested in this population. We sought to test the feasibility, safety, and prelimina...

journal_title：Journal of the American Heart Association

authors： Trankle CR,Puckett L,Swift-Scanlan T,DeWilde C,Priday A,Sculthorpe R,Ellenbogen KA,Fowler A,Koneru JN

更新日期：2020-02-04 00:00:00

abstract：:Background Cardiac hypertrophy has been recognized as an important independent risk factor for the development of heart failure and increases the risk of cardiac morbidity and mortality. A disintegrin and metalloprotease 23 (ADAM23), a member of ADAM family, is involved in cancer and neuronal differentiation. Although...

journal_title：Journal of the American Heart Association

authors： Xiang M,Luo H,Wu J,Ren L,Ding X,Wu C,Chen J,Chen S,Zhang H,Yu L,Zou Y,Xu H,Ye P,Chen M,Xia J

更新日期：2018-09-18 00:00:00

abstract：:Background Congenital heart disease is common in patients with Trisomy 13 (T13) and Trisomy 18 (T18), but offering cardiac surgery to these patients has been controversial. We describe the landscape of surgical management across the United States, perioperative risk factors, and surgical outcomes in patients with T13 ...

journal_title：Journal of the American Heart Association

authors： Cooper DS,Riggs KW,Zafar F,Jacobs JP,Hill KD,Pasquali SK,Swanson SK,Gelehrter SK,Wallace A,Jacobs ML,Morales DLS,Bryant R 3rd

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Recent literature suggests that blood pressure variability (BPV) predicts outcome beyond blood pressure level (BPL) and that antihypertensive drug classes differentially influence BPV. We compared calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockade for effect...

journal_title：Journal of the American Heart Association

authors： Asayama K,Ohkubo T,Hanazawa T,Watabe D,Hosaka M,Satoh M,Yasui D,Staessen JA,Imai Y,Hypertensive Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED‐BP) Study Investigators.

更新日期：2016-03-23 00:00:00

abstract：:Background There are limited data about cardiac resynchronization therapy (CRT) in adult congenital heart disease. We aimed to assess early and late outcomes of CRT among patients with adult congenital heart disease. Methods and Results We retrospectively studied 54 patients with adult congenital heart disease (median...

journal_title：Journal of the American Heart Association

authors： Yin Y,Dimopoulos K,Shimada E,Lascelles K,Griffiths S,Wong T,Gatzoulis MA,Babu-Narayan SV,Li W

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:Pediatric syncope is common. Cardiac causes are rarely found. We describe and assess a pragmatic approach to these patients first seen by a pediatric cardiologist in the New England region, using Standardized Clinical Assessment and Management Plans (SCAMPs). METHODS AND RESULTS:Ambulatory patients aged 7 t...

journal_title：Journal of the American Heart Association

authors： Paris Y,Toro-Salazar OH,Gauthier NS,Rotondo KM,Arnold L,Hamershock R,Saudek DE,Fulton DR,Renaud A,Alexander ME,New England Congenital Cardiology Association (NECCA).

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Sleep disordered breathing in children is associated with increased blood flow velocity and sympathetic overactivity. Sympathetic overactivity results in peripheral vasoconstriction and reduced systemic vascular compliance, which increases blood flow velocity during systole. Augmented blood flow velocity is ...

journal_title：Journal of the American Heart Association

authors： Kontos A,Lushington K,Martin J,Schwarz Q,Green R,Wabnitz D,Xu X,M Sokoya E,Willoughby S,Baumert M,Ferrante A,La Forgia M,Kennedy D

更新日期：2017-07-17 00:00:00

abstract：BACKGROUND:No data are available on the long-term performance of ultrathin strut biodegradable polymer sirolimus-eluting stents (BP-SES). We reported 2-year clinical outcomes of the BIOSCIENCE (Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Stent Versus Durable Polymer Everolimus-Eluting Stent for Percutaneous...

journal_title：Journal of the American Heart Association

authors： Zbinden R,Piccolo R,Heg D,Roffi M,Kurz DJ,Muller O,Vuilliomenet A,Cook S,Weilenmann D,Kaiser C,Jamshidi P,Franzone A,Eberli F,Jüni P,Windecker S,Pilgrim T

更新日期：2016-03-15 00:00:00

abstract：:Background Short-term variability of the QT interval (STVQT) has been proposed as a novel electrophysiological marker for the prediction of imminent ventricular arrhythmias in animal models. Our aim is to study whether STVQT can predict imminent ventricular arrhythmias in patients. Methods and Results In 2331 patients...

journal_title：Journal of the American Heart Association

authors： Smoczyńska A,Loen V,Sprenkeler DJ,Tuinenburg AE,Ritsema van Eck HJ,Malik M,Schmidt G,Meine M,Vos MA

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Patients with normalized mean pulmonary artery pressure (mPAP) after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) do not always regain normal exercise capacity. We evaluated right ventricular function, its interaction with both pulsatile and resistive afterload, an...

journal_title：Journal of the American Heart Association

authors： Claessen G,La Gerche A,Dymarkowski S,Claus P,Delcroix M,Heidbuchel H

更新日期：2015-03-23 00:00:00

abstract：BACKGROUND:Early reperfusion in the setting of an ST-elevation myocardial infarction (STEMI) is of utmost importance. However, the effects of early versus late reperfusion in this patient group undergoing primary percutaneous coronary intervention (PCI) have so far been inconsistent in previous studies. The purpose of ...

journal_title：Journal of the American Heart Association

authors： Koul S,Andell P,Martinsson A,Gustav Smith J,van der Pals J,Scherstén F,Jernberg T,Lagerqvist B,Erlinge D

更新日期：2014-03-04 00:00:00

abstract：:Background Although PAR-1 (protease-activated receptor-1) exerts important functions in the pathophysiology of the cardiovascular system, the role of PAR-1 signaling in heart failure development remains largely unknown. We tested the hypothesis that PAR-1 signaling inhibition has protective effects on the progression ...

journal_title：Journal of the American Heart Association

authors： Yokono Y,Hanada K,Narita M,Tatara Y,Kawamura Y,Miura N,Kitayama K,Nakata M,Nozaka M,Kato T,Kudo N,Tsushima M,Toyama Y,Itoh K,Tomita H

更新日期：2020-06-16 00:00:00

abstract：:Background Young women with coronary artery disease ( CAD ), a group with high psychosocial burden, were previously shown to have higher levels of interleukin-6 ( IL -6) compared with men of similar age. We sought to examine IL -6 response to acute stress in CAD patients across sex and age, and contrast results to hea...

journal_title：Journal of the American Heart Association

authors： Sullivan S,Hammadah M,Wilmot K,Ramadan R,Pearce BD,Shah A,Kaseer B,Gafeer MM,Lima BB,Kim JH,Ward L,Ko YA,Lewis TT,Hankus A,Elon L,Li L,Bremner JD,Raggi P,Quyyumi A,Vaccarino V

更新日期：2018-12-04 00:00:00

abstract：:Background After the coronavirus disease 2019 outbreak, social isolation measures were introduced to contain infection. Although there is currently a slowing down of the infection, a reduction of hospitalizations, especially for myocardial infarction, was observed. The aim of our study is to evaluate the impact of the...

journal_title：Journal of the American Heart Association

authors： Cammalleri V,Muscoli S,Benedetto D,Stifano G,Macrini M,Di Landro A,Di Luozzo M,Marchei M,Mariano EG,Cota L,Sergi D,Bezzeccheri A,Bonanni M,Baluci M,De Vico P,Romeo F

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Little is known about causality and pathological mechanism underlying association of postinfarct fever with myocardial injury in patients with ST-segment elevation myocardial infarction. METHODS AND RESULTS:In 276 patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocar...

journal_title：Journal of the American Heart Association

authors： Jang WJ,Yang JH,Song YB,Chun WJ,Oh JH,Park YH,Lee MR,Hwang JK,Hwang JW,Hahn JY,Choi SH,Lee SC,Choe YH,Gwon HC

更新日期：2017-04-24 00:00:00

abstract：:Background We examined the prevalence of high burdens and barriers to care among adults with heart disease treatment. Methods and Results The participants were aged 18 to 64 years from the Medical Expenditure Panel Survey-Household Component (MEPS-HC) for 2010-2015. High burden is out-of-pocket spending on care and in...

journal_title：Journal of the American Heart Association

authors： Bernard D,Fang Z

更新日期：2019-12-17 00:00:00

abstract：:Background The aim of the present study was to investigate the efficacy and safety of antiplatelet (aspirin plus cilostazol) dual therapy for patients with noncardioembolic stroke within 48 hours of symptom onset. Methods and Results The ADS (Acute Aspirin Plus Cilostazol Dual Therapy for Non-Cardiogenic Stroke Patien...

journal_title：Journal of the American Heart Association

authors： Aoki J,Iguchi Y,Urabe T,Yamagami H,Todo K,Fujimoto S,Idomari K,Kaneko N,Iwanaga T,Terasaki T,Tanaka R,Yamamoto N,Tsujino A,Nomura K,Abe K,Uno M,Okada Y,Matsuoka H,Yamagata S,Yamamoto Y,Yonehara T,Inoue T,Yagit

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Cardiac mesenchymal cell (CMC) administration improves cardiac function in animal models of heart failure. Although the precise mechanisms remain unclear, transdifferentiation and paracrine signaling are suggested to underlie their cardiac reparative effects. We have shown that histone deacetylase 1 (HDAC1) ...

journal_title：Journal of the American Heart Association

authors： Moore JB 4th,Zhao J,Fischer AG,Keith MCL,Hagan D,Wysoczynski M,Bolli R

更新日期：2017-07-05 00:00:00