Impact of Transport Time and Cardiac Arrest Centers on the Neurological Outcome After Out-of-Hospital Cardiac Arrest: A Retrospective Cohort Study.

abstract：:Background Catheter ablation is an effective treatment for atrial fibrillation (AF), but high levels of post-procedure inflammation predict adverse clinical events. Ascorbic acid (AA) has shown promise in reducing inflammation but is untested in this population. We sought to test the feasibility, safety, and prelimina...

journal_title：Journal of the American Heart Association

authors： Trankle CR,Puckett L,Swift-Scanlan T,DeWilde C,Priday A,Sculthorpe R,Ellenbogen KA,Fowler A,Koneru JN

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Hispanic persons represent a heterogeneous and growing population of any race with origins in Mexico, the Caribbean, Central America, South America, or other Spanish-speaking countries. Previous studies have documented variation in cardiovascular risk and outcomes among Hispanic subgroups. Few studies have i...

journal_title：Journal of the American Heart Association

authors： Rodriguez F,Hastings KG,Hu J,Lopez L,Cullen M,Harrington RA,Palaniappan LP

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:Fatty acids constitute the critical components of cell structure and function, and dysregulation of fatty acid composition may exert diverging vascular effects including proliferation, migration, and differentiation of vascular smooth muscle cells (VSMCs). However, direct evidence for this hypothesis has bee...

journal_title：Journal of the American Heart Association

authors： Sunaga H,Matsui H,Anjo S,Syamsunarno MR,Koitabashi N,Iso T,Matsuzaka T,Shimano H,Yokoyama T,Kurabayashi M

更新日期：2016-11-23 00:00:00

abstract：:Background Gait speed is a reliable measure of physical function and frailty in patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). Slow gait speed pre-TAVR predicts worse clinical outcomes post-TAVR. The consequences of improved versus worsened physical function post-TAVR are unkno...

journal_title：Journal of the American Heart Association

authors： Goel K,O'Leary JM,Barker CM,Levack M,Rajagopal V,Makkar RR,Bajwa T,Kleiman N,Linke A,Kereiakes DJ,Waksman R,Allocco DJ,Rizik DG,Reardon MJ,Lindman BR

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Stroke is a leading cause of death in the world. In >80% of strokes, the initial acute phase of ischemic injury is due to the occlusion of a blood vessel resulting in severe focal hypoperfusion, excitotoxicity, and oxidative damage. Interferon-β (IFNβ), a cytokine with immunomodulatory properties, was approv...

journal_title：Journal of the American Heart Association

authors： Kuo PC,Scofield BA,Yu IC,Chang FL,Ganea D,Yen JH

更新日期：2016-01-08 00:00:00

abstract：BACKGROUND:Greater understanding of differences between men and women with coronary heart disease is needed. METHODS AND RESULTS:In this post hoc analysis of the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial, we described psychosocial factors, treatments, and outcomes of...

journal_title：Journal of the American Heart Association

authors： Guimarães PO,Granger CB,Stebbins A,Chiswell K,Held C,Hochman JS,Krug-Gourley S,Lonn E,Lopes RD,Stewart RAH,Vinereanu D,Wallentin L,White HD,Hagström E,Danchin N

更新日期：2017-09-14 00:00:00

abstract：:Background Kidney function decreases during the lifetime, and this decline is a powerful predictor of both kidney and cardiovascular outcomes. Statins lower cardiovascular risk, which may relate to beneficial effects on kidney function. We studied whether atorvastatin influences kidney function decline and assessed th...

journal_title：Journal of the American Heart Association

authors： Vogt L,Bangalore S,Fayyad R,Melamed S,Hovingh GK,DeMicco DA,Waters DD

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging of carotid plaque can aid in stroke risk stratification in patients with carotid stenosis. However, the prevalence of complicated carotid plaque in patients with cryptogenic stroke is uncertain, especially as assessed by plaque imaging techniques routinely included in acute stroke ...

journal_title：Journal of the American Heart Association

authors： Gupta A,Gialdini G,Lerario MP,Baradaran H,Giambrone A,Navi BB,Marshall RS,Iadecola C,Kamel H

更新日期：2015-06-15 00:00:00

abstract：BACKGROUND:Carotid atherosclerosis (CA) is a reflector of generalized atherosclerosis that is associated with systemic vascular disease. Data are limited on the epidemiology of carotid lesions in a large, nationally representative population sample. We aimed to evaluate the prevalence of CA detected by carotid ultrason...

journal_title：Journal of the American Heart Association

authors： Wang X,Li W,Song F,Wang L,Fu Q,Cao S,Gan Y,Zhang W,Yue W,Yan F,Shi W,Wang X,Zhang H,Zhang H,Wang Z,Lu Z

更新日期：2018-04-05 00:00:00

abstract：:Background The 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines lowered the threshold of blood pressure (BP) for hypertension to 130/80 mm Hg. However, the clinical significance of isolated diastolic hypertension (IDH) according to the cutoff value of the 2017 ACC/AHA guidelines wa...

journal_title：Journal of the American Heart Association

authors： Kaneko H,Itoh H,Yotsumoto H,Kiriyama H,Kamon T,Fujiu K,Morita K,Michihata N,Jo T,Takeda N,Morita H,Yasunaga H,Komuro I

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Although several risk factors for acute kidney injury (AKI) have been identified, early detection of AKI in acute decompensated heart failure patients remains a challenge. The aim of this study was to develop and validate a risk score for early prediction of AKI in acute decompensated heart failure patients....

journal_title：Journal of the American Heart Association

authors： Zhou LZ,Yang XB,Guan Y,Xu X,Tan MT,Hou FF,Chen PY

更新日期：2016-11-16 00:00:00

abstract：BACKGROUND:In 2009, the Get With The Guidelines-Stroke (GWTG-Stroke) program offered additional recognition if hospitals performed well on certain stroke quality measures. We sought to determine whether quality of care for all hospitals participating in GWTG-Stroke improved with this expanded recognition program. METH...

journal_title：Journal of the American Heart Association

authors： Heidenreich PA,Zhao X,Hernandez AF,Schwamm LH,Smith E,Reeves M,Peterson ED,Fonarow GC

更新日期：2017-01-21 00:00:00

abstract：:Background Tetrahydrobiopterin is a cofactor of endothelial NO synthase ( eNOS ), which is critical to embryonic heart development. We aimed to study the effects of sapropterin (Kuvan), an orally active synthetic form of tetrahydrobiopterin on eNOS uncoupling and congenital heart defects ( CHD s) induced by pregestati...

journal_title：Journal of the American Heart Association

authors： Engineer A,Saiyin T,Lu X,Kucey AS,Urquhart BL,Drysdale TA,Norozi K,Feng Q

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Elevated serum phosphorus might aggravate the effect of hypertension on mortality. The objective of this study was to examine the joint effect of hypertension and serum phosphorus on the risk of mortality. METHODS AND RESULTS:A large prospective (n=15 833), population-based cohort of participants from the N...

journal_title：Journal of the American Heart Association

authors： Vart P,Nigatu YT,Jaglan A,van Zon SK,Shafique K

更新日期：2015-05-20 00:00:00

abstract：:Background Hypodense filling defects within the pulmonary veins on computed tomography described as pulmonary vein sign (PVS) have been noted in acute pulmonary embolism and shown to be associated with poor prognosis. We evaluated venous flow abnormalities in chronic thromboembolic pulmonary hypertension (CTEPH) to de...

journal_title：Journal of the American Heart Association

authors： Gopalan D,Nordgren-Rogberg A,Le EPV,Pavey H,Tarkin J,Nyrén S,Auger W,Lindholm P

更新日期：2020-11-03 00:00:00

abstract：:Background Platelets play a role in promoting inflammatory responses under several disease conditions. Platelets are activated in hypertensive patients. However, the mechanisms responsible for platelet-mediating vascular inflammation are unknown. The present study investigated the role of platelets in promoting vascul...

journal_title：Journal of the American Heart Association

authors： An X,Jiang G,Cheng C,Lv Z,Liu Y,Wang F

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Currently, acute ischemic stroke is still a leading cause of mortality and morbidity. Approximately 2 years ago, mechanical thrombectomy was proven beneficial as a revolutionary new therapy for stroke in the MR-CLEAN trial (A Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic ...

journal_title：Journal of the American Heart Association

authors： Autar ASA,Hund HM,Ramlal SA,Hansen D,Lycklama À Nijeholt GJ,Emmer BJ,de Maat MPM,Dippel DWJ,van der Lugt A,van Es ACGM,van Beusekom HMM,MR CLEAN Registry Investigators.

更新日期：2018-06-22 00:00:00

abstract：:Background Aging is associated with a modest decline in ankle-brachial index (ABI); however, the underpinnings of this decline are not fully understood. The greater systolic ankle than brachial blood pressure, a normal ABI implies, is partially attributed to lower central than peripheral arterial stiffness. Hence, we ...

journal_title：Journal of the American Heart Association

authors： Oberdier MT,Morrell CH,Lakatta EG,Ferrucci L,AlGhatrif M

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:We investigated whether disease location influences survival in patients with peripheral arterial disease. METHODS AND RESULTS:Patients (n = 12,731; mean age, 67.5 ± 12.7 years; 57.4% male) who underwent outpatient noninvasive lower extremity arterial evaluation were followed up for 5.9 ± 3.1 years for all-...

journal_title：Journal of the American Heart Association

authors： Chen Q,Smith CY,Bailey KR,Wennberg PW,Kullo IJ

更新日期：2013-10-21 00:00:00

abstract：BACKGROUND:There is increasing evidence implicating atrial mitochondrial dysfunction in the pathogenesis of atrial fibrillation. In this study, we explored whether alogliptin, a dipeptidyl peptidase-4 inhibitor, can prevent mitochondrial dysfunction and atrial remodeling in a diabetic rabbit model. METHODS AND RESULTS...

journal_title：Journal of the American Heart Association

authors： Zhang X,Zhang Z,Zhao Y,Jiang N,Qiu J,Yang Y,Li J,Liang X,Wang X,Tse G,Li G,Liu T

更新日期：2017-05-15 00:00:00

abstract：:Background Cardiovascular disease is the leading cause of morbidity and mortality in patients with end-stage renal disease. Heart rhythm complexity analysis has been shown to be useful in predicting outcomes in various diseases; however, data on patients with end-stage renal disease are limited. In this study, we anal...

journal_title：Journal of the American Heart Association

authors： Tsai CH,Huang JW,Lin C,Ma HP,Lo MT,Liu LD,Lin LY,Lin CT,Hung CS,Peng CK,Lin YH

更新日期：2020-01-21 00:00:00

abstract：:Background Type 2 diabetes mellitus (T2 DM ) is considered a cardiovascular disease ( CVD ) risk equivalent, thereby linking assessment of cardiometabolic risk with that of CVD risk over time. Our goal was to determine how commonly used CVD risk scores and metabolic syndrome (MetS) severity performed in predicting T2 ...

journal_title：Journal of the American Heart Association

authors： Gurka MJ,Filipp SL,Pearson TA,DeBoer MD

更新日期：2018-08-21 00:00:00

abstract：BACKGROUND:Atherosclerosis is a chronic inflammatory disorder whose development is inversely correlated with high-density lipoprotein concentration. Current therapies involve pharmaceuticals that significantly elevate plasma high-density lipoprotein cholesterol concentrations. Our studies were conducted to investigate ...

journal_title：Journal of the American Heart Association

authors： Kaul S,Xu H,Zabalawi M,Maruko E,Fulp BE,Bluemn T,Brzoza-Lewis KL,Gerelus M,Weerasekera R,Kallinger R,James R,Zhang YS,Thomas MJ,Sorci-Thomas MG

更新日期：2016-11-07 00:00:00

abstract：:Background This study was performed to characterize the metabolic, functional, and structural cardiac changes in a canine model of radiation-induced heart disease by serial in vivo imaging and ex vivo analyses. Methods and Results Thirty-six dogs were randomly assigned to control or irradiated groups at 3 time points ...

journal_title：Journal of the American Heart Association

authors： Yan R,Li X,Song J,Guo M,Cai H,Wu Z,Wu P,Li L,Yang M,Wang Y,Li S

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:In-stent hyperplasia (ISH) may develop in regions of low endothelial shear stress (ESS), but the relationship between the magnitude of low ESS, the extent of ISH, and subsequent clinical events has not been investigated. METHODS AND RESULTS:We assessed the association of poststent ESS with neointimal ISH an...

journal_title：Journal of the American Heart Association

authors： Shishido K,Antoniadis AP,Takahashi S,Tsuda M,Mizuno S,Andreou I,Papafaklis MI,Coskun AU,O'Brien C,Feldman CL,Saito S,Edelman ER,Stone PH

更新日期：2016-09-14 00:00:00

abstract：BACKGROUND:Bypass grafting remains the standard of care for coronary artery disease and severe lower extremity ischemia. Efficacy is limited by poor long-term venous graft patency secondary to intimal hyperplasia (IH) caused by venous injury upon exposure to arterial pressure. We investigate whether photochemical tissu...

journal_title：Journal of the American Heart Association

authors： Goldstone RN,McCormack MC,Khan SI,Salinas HM,Meppelink A,Randolph MA,Watkins MT,Redmond RW,Austen WG Jr

更新日期：2016-07-27 00:00:00

abstract：:Background In this nationwide study, we used the unique Danish registries to estimate the risk of suicide and deliberate self-harm in patients with congenital heart disease (CHD). Methods and Results We identified all Danish citizens receiving a diagnosis of CHD between 1977 and 2007. As a reference cohort, we randoml...

journal_title：Journal of the American Heart Association

authors： Udholm S,Nyboe C,Lundbye-Christensen S,Nordentoft M,Hjortdal VE

更新日期：2020-05-18 00:00:00

abstract：:Background We aim to generate a line of "universal donor" human induced pluripotent stem cells (hi PSC s) that are nonimmunogenic and, therefore, can be used to derive cell products suitable for allogeneic transplantation. Methods and Results hi PSC s carrying knockout mutations for 2 key components (β2 microglobulin ...

journal_title：Journal of the American Heart Association

authors： Mattapally S,Pawlik KM,Fast VG,Zumaquero E,Lund FE,Randall TD,Townes TM,Zhang J

更新日期：2018-12-04 00:00:00

abstract：:Background Action potential alternans can induce ventricular tachyarrhythmias and manifest on the surface ECG as T-wave alternans (TWA) and QRS alternans (QRSA). We sought to evaluate microvolt QRSA in cardiomyopathy patients in relation to TWA and ventricular tachyarrhythmia outcomes. Methods and Results Prospectivel...

journal_title：Journal of the American Heart Association

authors： Suszko A,Nayyar S,Labos C,Nanthakumar K,Pinter A,Crystal E,Chauhan VS

更新日期：2020-09-01 00:00:00

abstract：:Background For individuals with an out-of-hospital cardiac arrest (OHCA), survival may be influenced by the neighborhood in which the arrest occurs. Methods and Results Within the national CARES (Cardiac Arrest Registry to Enhance Survival) registry, we identified 169 502 patients with OHCA from 2013 to 2017. On the b...

journal_title：Journal of the American Heart Association

authors： Chan PS,McNally B,Vellano K,Tang Y,Spertus JA

更新日期：2020-02-18 00:00:00