Abstract:
BACKGROUND:Elevated serum phosphorus might aggravate the effect of hypertension on mortality. The objective of this study was to examine the joint effect of hypertension and serum phosphorus on the risk of mortality. METHODS AND RESULTS:A large prospective (n=15 833), population-based cohort of participants from the National Health and Nutritional Examination Survey III was examined to test potential synergism between hypertension, elevated serum phosphorus, and the risk of mortality. Interaction on additive scale and multiplicative scale was estimated. After a median follow-up of 14.3 years, 1691 cases of cardiovascular mortality and 3875 cases of all-cause mortality were identified. Interaction was observed between hypertension and elevated serum phosphorus on the additive scale for cardiovascular mortality (relative excess risk due to interaction, 0.99, 95% CI: 0.06; 1.92, adjusted for age, gender, race, and estimated glomerular filtration rate). No statistically significant interaction was found between hypertension and serum phosphorus for all-cause mortality on the additive scale. No significant interaction was detected on the multiplicative scale. In sensitivity analysis, excluding participants who died in first 2 years and adjustment for additional confounders resulted in essentially similar findings. CONCLUSIONS:The joint effect of hypertension and elevated serum phosphorus was larger than the sum of the independent effects on cardiovascular mortality but not on all-cause mortality. Future studies should investigate whether controlling elevated serum phosphorus in hypertensive individuals helps in prevention of extra risk of cardiovascular mortality.
journal_name
J Am Heart Assocjournal_title
Journal of the American Heart Associationauthors
Vart P,Nigatu YT,Jaglan A,van Zon SK,Shafique Kdoi
10.1161/JAHA.114.001706subject
Has Abstractpub_date
2015-05-20 00:00:00issue
5issn
2047-9980pii
JAHA.114.001706journal_volume
4pub_type
杂志文章abstract:BACKGROUND:Depression is known to increase the risk of coronary artery disease, but few studies have evaluated the association between depression and peripheral artery disease (PAD). We examined the association of depression with PAD and evaluated potential mediators of this association. METHODS AND RESULTS:We used da...
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pub_type: 杂志文章,随机对照试验
doi:10.1161/JAHA.118.011028
更新日期:2019-01-08 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2015-10-26 00:00:00
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更新日期:2014-11-17 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2017-06-09 00:00:00
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journal_title:Journal of the American Heart Association
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更新日期:2014-03-13 00:00:00
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更新日期:2020-03-03 00:00:00
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pub_type: 杂志文章
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更新日期:2014-10-23 00:00:00
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更新日期:2020-01-21 00:00:00
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
doi:10.1161/JAHA.117.005958
更新日期:2017-10-20 00:00:00
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更新日期:2021-01-19 00:00:00
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更新日期:2019-05-07 00:00:00
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更新日期:2017-04-24 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-06-19 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Journal of the American Heart Association
pub_type: 杂志文章
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更新日期:2015-06-15 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-06-11 00:00:00