Lung-Derived SOD3 Attenuates Neurovascular Injury After Transient Global Cerebral Ischemia.

abstract：:Background Short-term variability of the QT interval (STVQT) has been proposed as a novel electrophysiological marker for the prediction of imminent ventricular arrhythmias in animal models. Our aim is to study whether STVQT can predict imminent ventricular arrhythmias in patients. Methods and Results In 2331 patients...

journal_title：Journal of the American Heart Association

authors： Smoczyńska A,Loen V,Sprenkeler DJ,Tuinenburg AE,Ritsema van Eck HJ,Malik M,Schmidt G,Meine M,Vos MA

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:The structure of the aorta is considered to influence exercise systolic blood pressure (SBP) response, which, in turn, might impact upon adverse outcomes. The current study sought to investigate the relationship of aortic calcification and exercise SBP with adverse outcomes among elderly individuals. METHOD...

journal_title：Journal of the American Heart Association

authors： Cho IJ,Chang HJ,Cho I,Heo R,Lee SE,Shim CY,Hong GR,Chung N

更新日期：2016-04-22 00:00:00

abstract：:Background The majority of studies evaluating cardiorespiratory fitness ( CRF ) as a cardiovascular risk factor use cardiovascular mortality and not cardiovascular disease events as the primary end point, and generally do not include women. The aim of this study was to investigate the association of estimated CRF ( eC...

journal_title：Journal of the American Heart Association

authors： Shigdel R,Dalen H,Sui X,Lavie CJ,Wisløff U,Ernstsen L

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:Although automated external defibrillators (AEDs) have contributed to a better survival of out-of-hospital cardiac arrests, there have been reports of their malfunctioning. We investigated the diagnostic accuracy of commercially available AEDs using surface ECGs of ventricular fibrillation (VF), ventricular ...

journal_title：Journal of the American Heart Association

authors： Nishiyama T,Nishiyama A,Negishi M,Kashimura S,Katsumata Y,Kimura T,Nishiyama N,Tanimoto Y,Aizawa Y,Mitamura H,Fukuda K,Takatsuki S

更新日期：2015-12-01 00:00:00

abstract：:Background Genetic testing in pediatric primary dilated cardiomyopathy (DCM) patients has identified numerous disease-causing variants, but few studies have evaluated genetic testing outcomes in this population in the context of patient and familial clinical data or assessed the clinical implications of temporal chang...

journal_title：Journal of the American Heart Association

authors： Quiat D,Witkowski L,Zouk H,Daly KP,Roberts AE

更新日期：2020-06-02 00:00:00

abstract：BACKGROUND:Multiple studies have shown that an NO-induced activation of vascular smooth muscle BK channels contributes to the NO-evoked dilation in many blood vessels. In vivo, NO is released continuously. NO attenuates vessel constrictions and, therefore, exerts an anticontractile effect. It is unknown whether the ant...

journal_title：Journal of the American Heart Association

authors： Schmid J,Müller B,Heppeler D,Gaynullina D,Kassmann M,Gagov H,Mladenov M,Gollasch M,Schubert R

更新日期：2018-03-24 00:00:00

abstract：:Background Race influences medical decision making, but its impact on advanced heart failure therapy allocation is unknown. We sought to determine whether patient race influences allocation of advanced heart failure therapies. Methods and Results Members of a national heart failure organization were randomized to clin...

journal_title：Journal of the American Heart Association

authors： Breathett K,Yee E,Pool N,Hebdon M,Crist JD,Knapp S,Larsen A,Solola S,Luy L,Herrera-Theut K,Zabala L,Stone J,McEwen MM,Calhoun E,Sweitzer NK

更新日期：2019-11-19 00:00:00

abstract：BACKGROUND:Impaired generation and signaling of nitric oxide (NO) contribute substantially to cardiovascular (CV) risk (CVR) associated with hypertension, hyperlipidemia, and diabetes mellitus. In our rapidly aging society, advanced age is, in itself, a consistent and independent CVR factor. Many processes involved in ...

journal_title：Journal of the American Heart Association

authors： Sverdlov AL,Ngo DT,Chan WP,Chirkov YY,Horowitz JD

更新日期：2014-08-18 00:00:00

abstract：:Background Should all out-of-hospital cardiac arrest (OHCA) patients be directly transported to cardiac arrest centers (CACs) remains under debate. Our study evaluated the impacts of different transport time and destination hospital on the outcomes of OHCA patients. Methods and Results Data were collected from 6655 OH...

journal_title：Journal of the American Heart Association

authors： Chien CY,Tsai SL,Tsai LH,Chen CB,Seak CJ,Weng YM,Lin CC,Ng CJ,Chien WC,Huang CH,Lin CY,Chaou CH,Liu PH,Tseng HJ,Fang CT

更新日期：2020-06-02 00:00:00

abstract：:Background Postpericardiotomy syndrome ( PPS ) is a common complication after cardiac surgery. However, large-scale epidemiological studies about the effect of procedure type on the occurrence of PPS and mortality of patients with PPS have not yet been performed. Methods and Results We studied the association of PPS o...

journal_title：Journal of the American Heart Association

authors： Lehto J,Kiviniemi T,Gunn J,Airaksinen J,Rautava P,Kytö V

更新日期：2018-11-20 00:00:00

abstract：:Background Recent publications reached conflicting conclusions about the cost-effectiveness of left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, Marlborough, MA) for stroke risk reduction in nonvalvular atrial fibrillation (AF). This analysis sought to assess the cost-effectiveness of L...

journal_title：Journal of the American Heart Association

authors： Reddy VY,Akehurst RL,Gavaghan MB,Amorosi SL,Holmes DR Jr

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Obesity is closely associated with various cardiovascular diseases (CVDs). Adipose tissue inflammation and perturbation of adipokine secretion may contribute to the pathogenesis of CVD. This study aimed to evaluate whether the 2 most abundant adipokines, adipocyte-fatty acid binding protein (A-FABP) and adip...

journal_title：Journal of the American Heart Association

authors： Chow WS,Tso AW,Xu A,Yuen MM,Fong CH,Lam TH,Lo SV,Tse HF,Woo YC,Yeung CY,Cheung BM,Lam KS

更新日期：2013-01-15 00:00:00

abstract：:Background Aerobic exercise capacity is inversely associated with cardiovascular and all-cause mortality in men and women without coronary artery disease (CAD); however, a higher amount of vigorous exercise is associated with a J-shaped relationship in CAD patients. Therefore, the optimal type and amount of exercise f...

journal_title：Journal of the American Heart Association

authors： Malik A,Kanduri JS,Asbeutah AAA,Khraishah H,Shen C,Welty FK

更新日期：2020-04-07 00:00:00

abstract：:Background Characterizing associations of sleep characteristics with blood-glucose-level factors among blacks may clarify the underlying mechanisms of impaired glucose metabolism and help identify treatment targets to prevent diabetes mellitus in blacks. Methods and Results Cross-sectional analyses were conducted in 7...

journal_title：Journal of the American Heart Association

authors： Yano Y,Gao Y,Johnson DA,Carnethon M,Correa A,Mittleman MA,Sims M,Mostofsky E,Wilson JG,Redline S

更新日期：2020-05-05 00:00:00

abstract：:Background Impaired heart rate variability (HRV) is associated with increased mortality in sinus rhythm. However, HRV has not been systematically assessed in patients with atrial fibrillation (AF). We hypothesized that parameters of HRV may be predictive of cardiovascular death in patients with AF. Methods and Results...

journal_title：Journal of the American Heart Association

authors： Hämmerle P,Eick C,Blum S,Schlageter V,Bauer A,Rizas KD,Eken C,Coslovsky M,Aeschbacher S,Krisai P,Meyre P,Vesin JM,Rodondi N,Moutzouri E,Beer J,Moschovitis G,Kobza R,Di Valentino M,Corino VDA,Laureanti R,Mainardi L

更新日期：2020-08-04 00:00:00

abstract：BACKGROUND:CSL112 is a new formulation of human apolipoprotein A-I (apoA-I) being developed to reduce cardiovascular events following acute coronary syndrome. This phase 2a, randomized, double-blind, multicenter, dose-ranging trial represents the first clinical investigation to assess the safety and pharmacokinetics/ph...

journal_title：Journal of the American Heart Association

authors： Tricoci P,D'Andrea DM,Gurbel PA,Yao Z,Cuchel M,Winston B,Schott R,Weiss R,Blazing MA,Cannon L,Bailey A,Angiolillo DJ,Gille A,Shear CL,Wright SD,Alexander JH

更新日期：2015-08-25 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) shares several risk factors with atrial fibrillation (AF), and persons with PAD have an increased risk of stroke. It is unclear if PAD is associated with an increased risk for AF and whether this potential association explains the increased risk of stroke observed in those w...

journal_title：Journal of the American Heart Association

authors： O'Neal WT,Efird JT,Nazarian S,Alonso A,Heckbert SR,Soliman EZ

更新日期：2014-11-17 00:00:00

abstract：BACKGROUND:The geometric organization of myocytes in the ventricular wall comprises the structural underpinnings of cardiac mechanical function. Cardiac myosin binding protein-C (MYBPC3) is a sarcomeric protein, for which phosphorylation modulates myofilament binding, sarcomere morphology, and myocyte alignment in the ...

journal_title：Journal of the American Heart Association

authors： Taylor EN,Hoffman MP,Barefield DY,Aninwene GE 2nd,Abrishamchi AD,Lynch TL 4th,Govindan S,Osinska H,Robbins J,Sadayappan S,Gilbert RJ

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Atherosclerosis is a chronic inflammatory disorder whose development is inversely correlated with high-density lipoprotein concentration. Current therapies involve pharmaceuticals that significantly elevate plasma high-density lipoprotein cholesterol concentrations. Our studies were conducted to investigate ...

journal_title：Journal of the American Heart Association

authors： Kaul S,Xu H,Zabalawi M,Maruko E,Fulp BE,Bluemn T,Brzoza-Lewis KL,Gerelus M,Weerasekera R,Kallinger R,James R,Zhang YS,Thomas MJ,Sorci-Thomas MG

更新日期：2016-11-07 00:00:00

abstract：BACKGROUND:Though left ventricular mass (LVM) predicts cardiovascular events (CVD) and mortality in African Americans, limited data exists on factors contributing to change in LVM and its prognostic significance. We hypothesized that baseline blood pressure (BP) and body mass index (BMI) and change in these variables o...

journal_title：Journal of the American Heart Association

authors： Fox ER,Musani SK,Samdarshi TE,Taylor JK,Beard WL,Sarpong DF,Xanthakis V,McClendon EE,Liebson PR,Skelton TN,Butler KR,Mosley TH,Taylor H,Vasan RS

更新日期：2015-02-05 00:00:00

abstract：BACKGROUND:Vascular smooth muscle cell proliferation, migration, and dedifferentiation are critical for vascular diseases. Recently, it was demonstrated that Notch receptors have opposing effects on intima formation after vessel injury. Therefore, it is important to investigate the specific regulatory pathways that act...

journal_title：Journal of the American Heart Association

authors： Jiang D,Zhuang J,Peng W,Lu Y,Liu H,Zhao Q,Chi C,Li X,Zhu G,Xu X,Yan C,Xu Y,Ge J,Pang J

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:Cardiac mesenchymal cell (CMC) administration improves cardiac function in animal models of heart failure. Although the precise mechanisms remain unclear, transdifferentiation and paracrine signaling are suggested to underlie their cardiac reparative effects. We have shown that histone deacetylase 1 (HDAC1) ...

journal_title：Journal of the American Heart Association

authors： Moore JB 4th,Zhao J,Fischer AG,Keith MCL,Hagan D,Wysoczynski M,Bolli R

更新日期：2017-07-05 00:00:00

abstract：:Background Quantitative flow ratio ( QFR ) has a high diagnostic accuracy in assessing functional stenoses relevance, as judged by fractional flow reserve ( FFR ). However, its diagnostic performance has not been thoroughly evaluated using instantaneous wave-free ratio ( iFR ) or coronary flow reserve as the reference...

journal_title：Journal of the American Heart Association

authors： Hwang D,Choi KH,Lee JM,Mejía-Rentería H,Kim J,Park J,Rhee TM,Jeon KH,Lee HJ,Kim HK,Park TK,Yang JH,Song YB,Shin ES,Nam CW,Kwak JJ,Doh JH,Hahn JY,Choi JH,Choi SH,Escaned J,Koo BK,Gwon HC

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Inappropriate sinus tachycardia (IST) and postural tachycardia syndrome (POTS) are 2 disorders characterized by sinus tachycardia. It is debated whether the pathophysiology of IST and POTS results from abnormal autonomic regulation or abnormal sinus node function. We hypothesized that intrinsic heart rate (I...

journal_title：Journal of the American Heart Association

authors： Nwazue VC,Paranjape SY,Black BK,Biaggioni I,Diedrich A,Dupont WD,Robertson D,Raj SR

更新日期：2014-04-10 00:00:00

abstract：:Background Bleeding is a common, morbid, and costly complication of percutaneous coronary intervention. While bleeding avoidance strategies ( BAS ) are effective, they are used paradoxically less in patients at high risk of bleeding. Whether a patient-centered approach to specifically increase the risk-concordant use ...

journal_title：Journal of the American Heart Association

authors： Amin AP,Miller S,Rahn B,Caruso M,Pierce A,Sorensen K,Kurz H,Zajarias A,Bach R,Singh J,Lasala JM,Kulkarni H,Crimmins-Reda P

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is a pediatric vasculitis with coronary artery aneurysm (CAA) as a major complication. Controversy exists about cardiovascular risk later in life. The aim of our study was to evaluate whether KD patients are at increased risk, as assessed by carotid intima-media thickness (cIMT). METHO...

journal_title：Journal of the American Heart Association

authors： Dietz SM,Tacke CE,de Groot E,Kuipers IM,Hutten BA,Kuijpers TW,Dutch Kawasaki Study Groupten BergeMaartjeBiezeveldMaarten H.BruijnMartijnDelemarreLuçan C.DolmanKoert M.FilippiniLuc H.P.M.HendriksTomMaingay‐VisserDianne A.P.G.F.NoordzijJeroen

更新日期：2016-07-05 00:00:00

abstract：:Background Many observational studies and trials have shown that coronary artery bypass grafting improves the survival in patients with ischemic cardiomyopathy. However, these results are based on data generated from developed countries. Poor socioeconomic statuses, lack of uniformity in healthcare delivery, differenc...

journal_title：Journal of the American Heart Association

authors： Jose R,Shetty A,Krishna N,Chathoth V,Bhaskaran R,Jayant A,Varma PK

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:Cryoballoon pulmonary vein isolation (PVI) has emerged as an alternative to radiofrequency PVI for atrial fibrillation (AF). Data are lacking to define the rates and predictors of complications, particularly phrenic nerve injury (PNI). METHODS AND RESULTS:We evaluated a single-center prospective registry of...

journal_title：Journal of the American Heart Association

authors： Guhl EN,Siddoway D,Adelstein E,Bazaz R,Mendenhall GS,Nemec J,Saba S,Schwartzman D,Voigt A,Wang NC,Jain SK

更新日期：2016-07-21 00:00:00

abstract：BACKGROUND:Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in older individuals. Currently, therapeutic options are limited to surgical interventions. Although it has long been known that AAA tissue is enriched in B cells and immunoglobulins, their involvement in AAA pathogenesi...

journal_title：Journal of the American Heart Association

authors： Furusho A,Aoki H,Ohno-Urabe S,Nishihara M,Hirakata S,Nishida N,Ito S,Hayashi M,Imaizumi T,Hiromatsu S,Akashi H,Tanaka H,Fukumoto Y

更新日期：2018-03-15 00:00:00

abstract：:Background Although coffee consumption is often reported as a trigger for atrial fibrillation (AF) among patients with paroxysmal AF, prospective studies on the relation of coffee consumption with AF risk have been inconsistent. Hence, we sought to assess the association between coffee consumption and risk of AF in me...

journal_title：Journal of the American Heart Association

authors： Bodar V,Chen J,Gaziano JM,Albert C,Djoussé L

更新日期：2019-08-06 00:00:00