当前位置： SCI文献检索 > Journal of the American Heart Association期刊下所有文献 > Clinical correlates and prognostic significance of change in standardized left ventricular mass in a community-based cohort of African Americans.

Clinical correlates and prognostic significance of change in standardized left ventricular mass in a community-based cohort of African Americans.

Abstract：

BACKGROUND:Though left ventricular mass (LVM) predicts cardiovascular events (CVD) and mortality in African Americans, limited data exists on factors contributing to change in LVM and its prognostic significance. We hypothesized that baseline blood pressure (BP) and body mass index (BMI) and change in these variables over time are associated with longitudinal increases in LVM and that such increase is associated with greater incidence of CVD. METHODS AND RESULTS:We investigated the clinical correlates of change in standardized logarithmically transformed-LVM indexed to height2.7 (log-LVMI) and its association with incident CVD in 606 African Americans (mean age 58±6 years, 66% women) who attended serial examinations 8 years apart. Log-LVMI and clinical covariates were standardized within sex to obtain z scores for both visits. Standardized log-LVMI was modeled using linear regression (correlates of change in standardized log-LVMI) and Cox proportional hazards regression (incidence of CVD [defined as coronary heart disease, stroke, heart failure and intermittent claudication]). Baseline clinical correlates (standardized log-LVM, BMI, systolic BP) and change in systolic BP over time were significantly associated with 8-year change in standardized log-LVMI. In prospective analysis, change in standardized LVM was significantly (P=0.0011) associated with incident CVD (hazards ratio per unit standard deviation change log-LVMI 1.51, 95% CI 1.18 to 1.93). CONCLUSIONS:In our community-based sample of African Americans, baseline BMI and BP, and change in BP on follow-up were key determinants of increase in standardized log-LVMI, which in turn carried an adverse prognosis, underscoring the need for greater control of BP and weight in this group.

journal_name

J Am Heart Assoc

journal_title

Journal of the American Heart Association

authors

Fox ER,Musani SK,Samdarshi TE,Taylor JK,Beard WL,Sarpong DF,Xanthakis V,McClendon EE,Liebson PR,Skelton TN,Butler KR,Mosley TH,Taylor H,Vasan RS

doi

10.1161/JAHA.114.001224

subject

Has Abstract

pub_date

2015-02-05 00:00:00

issue

issn

2047-9980

pii

jah3829

journal_volume

pub_type

杂志文章

在线工具

Clinical correlates and prognostic significance of change in standardized left ventricular mass in a community-based cohort of African Americans.