Prognostic Significance of Serum Cholinesterase Level in Patients With Acute Decompensated Heart Failure With Preserved Ejection Fraction: Insights From the PURSUIT-HFpEF Registry.

abstract：:Background Although many patients with coronary artery disease are using statins before off-pump coronary artery bypass grafting ( OPCAB ) following current guidelines, recent studies have raised concerns regarding adverse effects of preoperative statins on postoperative kidney function. We evaluated the effects of pr...

journal_title：Journal of the American Heart Association

authors： Park J,Lee JH,Kim KA,Lee SH,Lee YT,Kim WS,Min JJ

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Greater understanding of differences between men and women with coronary heart disease is needed. METHODS AND RESULTS:In this post hoc analysis of the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial, we described psychosocial factors, treatments, and outcomes of...

journal_title：Journal of the American Heart Association

authors： Guimarães PO,Granger CB,Stebbins A,Chiswell K,Held C,Hochman JS,Krug-Gourley S,Lonn E,Lopes RD,Stewart RAH,Vinereanu D,Wallentin L,White HD,Hagström E,Danchin N

更新日期：2017-09-14 00:00:00

abstract：BACKGROUND:Hospital procedures have been associated with cognitive change in older patients. This study aimed to document the prevalence of mild cognitive impairment in individuals undergoing left heart catheterization (LHC) before the procedure and the incidence of cognitive decline to 3 months afterwards. METHODS AN...

journal_title：Journal of the American Heart Association

authors： Scott DA,Evered L,Maruff P,MacIsaac A,Maher S,Silbert BS

更新日期：2018-03-10 00:00:00

abstract：:Background Normal-flow, low-gradient severe aortic stenosis (NF-LG-SAS), defined by aortic valve area <1 cm2, mean gradient <40 mm Hg, and indexed stroke volume >35 mL/m2, is the most prevalent form of low-gradient aortic stenosis (AS). However, the true severity of AS and the management of NF-LG-SAS are controversial...

journal_title：Journal of the American Heart Association

authors： Chadha G,Bohbot Y,Rusinaru D,Maréchaux S,Tribouilloy C

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The 2005 Bethesda Conference Guidelines advise patients with long QT syndrome against competitive sports. We assessed cardiac event rates during competitive and recreational sports, and daily activities among treated long QT syndrome patients. METHODS AND RESULTS:Long QT syndrome patients aged ≥4 years trea...

journal_title：Journal of the American Heart Association

authors： Chambers KD,Beausejour Ladouceur V,Alexander ME,Hylind RJ,Bevilacqua L,Mah DY,Bezzerides V,Triedman JK,Walsh EP,Abrams DJ

更新日期：2017-09-21 00:00:00

abstract：BACKGROUND:Pulse pressure (PP) is related to cardiac function, arterial stiffness, fluid status, and vascular events. This study aimed to explore the prognostic role of PP upon admission in patients with acute ischemic stroke (AIS) based on a nation-wide stroke registry. METHODS AND RESULTS:We evaluated the associatio...

journal_title：Journal of the American Heart Association

authors： Tang SC,Yin JH,Liu CH,Sun MH,Lee JT,Sun Y,Hsu CS,Sun MC,Lin CH,Chen CH,Lien LM,Muo CH,Jeng JS,Hsu CY,Taiwan Stroke Registry Investigators.

更新日期：2017-06-22 00:00:00

abstract：BACKGROUND:Sex-based differences in clinical presentation, pathophysiology, and outcomes of patients with acute chest pain are increasingly being recognized, but are not implemented in guidelines and clinical prediction tools. We evaluated the performance of the HEART score in women versus men, because sex-based differ...

journal_title：Journal of the American Heart Association

authors： Bank IEM,de Hoog VC,de Kleijn DPV,Pasterkamp G,Doevendans PA,den Ruijter HM,Dalmeijer G,Wildbergh TX,Mosterd A,Timmers L

更新日期：2017-06-21 00:00:00

abstract：BACKGROUND:Among the growing numbers of patients with heart failure, up to one half have heart failure with preserved ejection fraction (HFpEF). The lack of effective treatments for HFpEF is a substantial and escalating unmet clinical need-and the lack of HFpEF-specific animal models represents a major preclinical barr...

journal_title：Journal of the American Heart Association

authors： Curl CL,Danes VR,Bell JR,Raaijmakers AJA,Ip WTK,Chandramouli C,Harding TW,Porrello ER,Erickson JR,Charchar FJ,Kompa AR,Edgley AJ,Crossman DJ,Soeller C,Mellor KM,Kalman JM,Harrap SB,Delbridge LMD

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) following primary percutaneous coronary intervention (pPCI) is frequently interpreted as contrast-induced AKI but may result from other insults. We aimed to determine the causal association of contrast material exposure and the incidence of AKI following pPCI using a control group o...

journal_title：Journal of the American Heart Association

authors： Caspi O,Habib M,Cohen Y,Kerner A,Roguin A,Abergel E,Boulos M,Kapeliovich MR,Beyar R,Nikolsky E,Aronson D

更新日期：2017-06-24 00:00:00

abstract：BACKGROUND:Studies have suggested that patients with atrial fibrillation (AF) have impairment in the baroreflex. It is not clear whether these findings are the result of the associated comorbid conditions or the arrhythmia itself. We hypothesized that AF is associated with impairment in baroreflex function and that the...

journal_title：Journal of the American Heart Association

authors： Field ME,Wasmund SL,Page RL,Hamdan MH

更新日期：2016-02-23 00:00:00

abstract：BACKGROUND:All clinical and biological manifestations related to postcardiac arrest (CA) syndrome are attributed to ischemia-reperfusion injury in various organs including brain and heart. Molecular hydrogen (H(2)) has potential as a novel antioxidant. This study tested the hypothesis that inhalation of H(2) gas starti...

journal_title：Journal of the American Heart Association

authors： Hayashida K,Sano M,Kamimura N,Yokota T,Suzuki M,Maekawa Y,Kawamura A,Abe T,Ohta S,Fukuda K,Hori S

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Whether heart rate upon discharge following hospitalization for heart failure is associated with long-term adverse outcomes and whether this association differs between patients with sinus rhythm (SR) and atrial fibrillation (AF) have not been well studied. METHODS AND RESULTS:We conducted a retrospective c...

journal_title：Journal of the American Heart Association

authors： Laskey WK,Alomari I,Cox M,Schulte PJ,Zhao X,Hernandez AF,Heidenreich PA,Eapen ZJ,Yancy C,Bhatt DL,Fonarow GC,AHA Get With The Guidelines®‐Heart Failure Program.

更新日期：2015-04-22 00:00:00

abstract：BACKGROUND:Atherosclerotic cardiovascular disease (ASCVD) causes most deaths in the United States and accounts for the highest healthcare spending. The association between the modifiable risk factors (MRFs) of ASCVD and pharmaceutical expenditures are largely unknown. METHODS AND RESULTS:We examined the association be...

journal_title：Journal of the American Heart Association

authors： Salami JA,Valero-Elizondo J,Ogunmoroti O,Spatz ES,Rana JS,Virani SS,Blankstein R,Younus A,Arrieta A,Blaha MJ,Veledar E,Nasir K

更新日期：2017-06-09 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether reducing plasma homocysteine concentrations with long-term, combined treatment with folic acid, vitamin B6, and vitamin B12 alters plasma biomarkers of inflammation and endothelial dysfunction in women at increased risk of cardiovascular disease. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Christen WG,Cook NR,Van Denburgh M,Zaharris E,Albert CM,Manson JE

更新日期：2018-05-18 00:00:00

abstract：BACKGROUND:Several cross-sectional, but few prospective, studies suggest that inflammation may be involved in the development of hypertension. We examined markers of inflammation-high-sensitivity C-reactive protein, interleukin-6, and soluble intercellular adhesion molecule-1-and a marker of fibrinolysis, D-dimer, for ...

journal_title：Journal of the American Heart Association

authors： Sesso HD,Jiménez MC,Wang L,Ridker PM,Buring JE,Gaziano JM

更新日期：2015-09-21 00:00:00

abstract：:Background Increased vagal modulation is a mechanism that may partially explain the protective effect of healthy lifestyles. However, it is unclear how healthy lifestyles relate to vagal regulation longitudinally. We prospectively examined associations between a comprehensive measure of 4 important lifestyle factors a...

journal_title：Journal of the American Heart Association

authors： Jandackova VK,Scholes S,Britton A,Steptoe A

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The time-sensitive hazard of perioperative cardiac troponin T (cTnT) elevation and whether long-term mortality differs by mechanism of myocardial injury are poorly understood. METHODS AND RESULTS:In this observational study of 12 882 patients who underwent noncardiac vascular surgery, patients were assessed...

journal_title：Journal of the American Heart Association

authors： Reed GW,Horr S,Young L,Clevenger J,Malik U,Ellis SG,Lincoff AM,Nissen SE,Menon V

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate whether the association between baseline cardiovascular health (CVH) and incident cardiovascular disease differs according to coronary heart disease (CHD) and stroke subtypes, and to assess the mediating effect of inflammatory and hemostatic blood biomarkers. METHODS...

journal_title：Journal of the American Heart Association

authors： Gaye B,Tafflet M,Arveiler D,Montaye M,Wagner A,Ruidavets JB,Kee F,Evans A,Amouyel P,Ferrieres J,Empana JP

更新日期：2017-10-17 00:00:00

abstract：BACKGROUND:We investigated whether disease location influences survival in patients with peripheral arterial disease. METHODS AND RESULTS:Patients (n = 12,731; mean age, 67.5 ± 12.7 years; 57.4% male) who underwent outpatient noninvasive lower extremity arterial evaluation were followed up for 5.9 ± 3.1 years for all-...

journal_title：Journal of the American Heart Association

authors： Chen Q,Smith CY,Bailey KR,Wennberg PW,Kullo IJ

更新日期：2013-10-21 00:00:00

abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) reduces obesity-associated comorbidities and cardiovascular mortality. RYGB improves endothelial dysfunction, reducing c-Jun N-terminal kinase (JNK) vascular phosphorylation. JNK activation links obesity with insulin resistance and endothelial dysfunction. Herein, we examined ...

journal_title：Journal of the American Heart Association

authors： Doytcheva P,Bächler T,Tarasco E,Marzolla V,Engeli M,Pellegrini G,Stivala S,Rohrer L,Tona F,Camici GG,Vanhoutte PM,Matter CM,Lutz TA,Lüscher TF,Osto E

更新日期：2017-11-14 00:00:00

abstract：:Background Previous studies have reported an association between the timing of menarche and cardiovascular disease ( CVD ). However, emerging studies have not examined the timing of menarche in relation to role of estrogen over a lifetime and major adverse cardiac events ( MACE ). Methods and Results A total of 648 wo...

journal_title：Journal of the American Heart Association

authors： Lee JJ,Cook-Wiens G,Johnson BD,Braunstein GD,Berga SL,Stanczyk FZ,Pepine CJ,Bairey Merz CN,Shufelt CL

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:Despite guideline recommendations, a significant number of patients with non-ST elevation myocardial infarction (NSTEMI) do not receive dual antiplatelet therapy (DAPT) before angiography "pretreatment." While there may be valid clinical reasons to not pretreat, such as concern for bleeding or multivessel di...

journal_title：Journal of the American Heart Association

authors： Shafiq A,Valle J,Jang JS,Qintar M,Gosch K,Cohen DJ,Singh M,Bach R,Spertus JA

更新日期：2016-06-10 00:00:00

abstract：:Background The aim of the present study was to investigate the efficacy and safety of antiplatelet (aspirin plus cilostazol) dual therapy for patients with noncardioembolic stroke within 48 hours of symptom onset. Methods and Results The ADS (Acute Aspirin Plus Cilostazol Dual Therapy for Non-Cardiogenic Stroke Patien...

journal_title：Journal of the American Heart Association

authors： Aoki J,Iguchi Y,Urabe T,Yamagami H,Todo K,Fujimoto S,Idomari K,Kaneko N,Iwanaga T,Terasaki T,Tanaka R,Yamamoto N,Tsujino A,Nomura K,Abe K,Uno M,Okada Y,Matsuoka H,Yamagata S,Yamamoto Y,Yonehara T,Inoue T,Yagit

更新日期：2019-08-06 00:00:00

abstract：:Background Type 2 diabetes mellitus (T2 DM ) is considered a cardiovascular disease ( CVD ) risk equivalent, thereby linking assessment of cardiometabolic risk with that of CVD risk over time. Our goal was to determine how commonly used CVD risk scores and metabolic syndrome (MetS) severity performed in predicting T2 ...

journal_title：Journal of the American Heart Association

authors： Gurka MJ,Filipp SL,Pearson TA,DeBoer MD

更新日期：2018-08-21 00:00:00

abstract：BACKGROUND:Respiratory muscle weakness contributes to exercise intolerance in patients with heart failure with a preserved ejection fraction (HFpEF)-a condition characterized by multiple comorbidities with few proven treatments. We aimed, therefore, to provide novel insight into the underlying diaphragmatic alterations...

journal_title：Journal of the American Heart Association

authors： Bowen TS,Brauer D,Rolim NPL,Bækkerud FH,Kricke A,Ormbostad Berre AM,Fischer T,Linke A,da Silva GJ,Wisloff U,Adams V

更新日期：2017-10-24 00:00:00

abstract：BACKGROUND:DPP4 (Dipeptidyl peptidase-4)-GLP-1 (glucagon-like peptide-1) and its receptor (GLP-1R) axis has been involved in several intracellular signaling pathways. The Adrβ3 (β3-adrenergic receptor)/CXCL12 (C-X-C motif chemokine 12) signal was required for the hematopoiesis. We investigated the novel molecular requi...

journal_title：Journal of the American Heart Association

authors： Zhu E,Hu L,Wu H,Piao L,Zhao G,Inoue A,Kim W,Yu C,Xu W,Bando YK,Li X,Lei Y,Hao CN,Takeshita K,Kim WS,Okumura K,Murohara T,Kuzuya M,Cheng XW

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:Ticagrelor is a P2Y12 receptor inhibitor used in acute coronary syndromes to reduce platelet activity and to decrease thrombus formation. Ticagrelor is associated with a reduction in mortality incremental to that observed with clopidogrel, potentially related to its non-antiplatelet effects. Evidence from an...

journal_title：Journal of the American Heart Association

authors： Pelletier-Galarneau M,Hunter CRRN,Ascah KJ,Beanlands RSB,Dwivedi G,deKemp RA,Chow BJW,Ruddy TD

更新日期：2017-05-02 00:00:00

abstract：:Background Hypertrophic cardiomyopathy is caused by pathogenic sarcomere gene variants. Individuals with a thin-filament variant present with milder hypertrophy than carriers of thick-filament variants, although prognosis is poorer. Herein, we defined if decreased energetic status of the heart is an early pathomechani...

journal_title：Journal of the American Heart Association

authors： Parbhudayal RY,Harms HJ,Michels M,van Rossum AC,Germans T,van der Velden J

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:The aim of our study was to evaluate the relationship of pulse pressure (PP), a raw index of arterial stiffness, with noninvasively determined coronary flow reserve (CFR) and its components, in patients with angiographically normal epicardial coronary arteries. METHODS AND RESULTS:The study population inclu...

journal_title：Journal of the American Heart Association

authors： Lembo M,Sicari R,Esposito R,Rigo F,Cortigiani L,Lo Iudice F,Picano E,Trimarco B,Galderisi M

更新日期：2017-06-29 00:00:00

abstract：BACKGROUND:The 4-variable risk score from University of California, Los Angeles (UCLA) demonstrated superior discrimination in advanced heart failure, compared to established risk scores. However, the model has not been externally validated, and its suitability as a selection tool for heart transplantation (HT) and lef...

journal_title：Journal of the American Heart Association

authors： Sartipy U,Goda A,Mancini DM,Lund LH

更新日期：2014-06-06 00:00:00