Abstract:
BACKGROUND:The aim of this study was to identify gene signatures and prognostic values of m6A methylation regulators in uveal melanoma (UM). METHODS:The RNA sequencing dataset and corresponding clinical information were downloaded from TCGA and GEO database. Based on the expression of m6A RNA methylation regulators, the patients were further clustered into different groups by applying the "ClassDiscovery" algorithm. Best survival analysis was performed to select prognostic m6A regulators and multivariate cox regression analysis was applied to constructed m6A regulators signature. The association between mutations and m6A regulators was assessed by Kruskal-Wallis tests and clinical characteristics were examined by using chi-square test. RESULTS:Totally, we identified two molecular subtypes of UM (C1/2) by applying consensus clustering to m6A RNA methylation regulators. In contrast to the C1 subtype, the C2 subtype associates with a better prognosis, has higher percentage of subtype 1 and lower percentage of Monosomy 3 which have been regarded as the well established prognostic markers for UM. The malignant hallmarks of mTORC1 signaling, oxidative phosphorylation, interferon-a response and apoptosis signaling are also significantly enriched in the C1 subtype. Moreover, a 3-m6A regulators signature was constructed by multivariate cox regression analysis method, which closely correlated with chromosome 3 status, subtype 1 of UM and can robustly predict patients' overall survival time. CONCLUSIONS:m6A RNA methylation regulators take a crucial role in the potential malignant progression and prognostic value of UM and might be regarded as a new promising biomarker for UM prognosis and treatment strategy development.
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Tang J,Wan Q,Lu Jdoi
10.1186/s12885-020-07159-8subject
Has Abstractpub_date
2020-07-18 00:00:00pages
674issue
1issn
1471-2407pii
10.1186/s12885-020-07159-8journal_volume
20pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Chromosomal and genomic aberrations are common features of human cancers. However, chromosomal numerical and structural aberrations, breakpoints and disrupted genes have yet to be identified in esophageal squamous cell carcinoma (ESCC). METHODS:Using multiplex-fluorescence in situ hybridization (M-FISH) and...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-367
更新日期:2012-08-24 00:00:00
abstract:BACKGROUND:Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 and 20q13 are recurrently amplified in breast cancers. METHODS:To assess the frequenci...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-245
更新日期:2006-10-13 00:00:00
abstract:BACKGROUND:Analysis of the clinical response of extramedullary lesions in leukemic patients treated with radiation therapy (RT) and defining the optimal dose of radiation. METHODS:Forty-two extramedullary lesions found in 24 leukemic patients treated with RT were reviewed. The radiation was delivered usually 2 Gy/day,...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-428
更新日期:2011-10-06 00:00:00
abstract:BACKGROUND:An imbalance between proliferation and apoptosis is one of the main features of carcinogenesis. TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis upon binding to the TRAIL death receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2, whereas binding to TRAIL-R3 and TRAIL-R4 might promote cell surv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-532
更新日期:2013-11-09 00:00:00
abstract:BACKGROUND:Comorbidity has a well documented detrimental effect on cancer survival. However it is difficult to disentangle the direct effects of comorbidity on survival from indirect effects via the influence of comorbidity on treatment choice. This study aimed to assess the impact of comorbidity on colon cancer patien...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-9-116
更新日期:2009-04-20 00:00:00
abstract:BACKGROUND:Cyclo-oxygenase-2 (COX-2), the key enzyme in the conversion of arachidonic acid to prostaglandins, is involved in critical steps of tumor onset and progression, and is a strong predictor of chemotherapy resistance and poor outcome in advanced ovarian cancer. To our knowledge, no data has been reported until ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-6-182
更新日期:2006-07-11 00:00:00
abstract:BACKGROUND:Tumor genotype plays a crucial role in clinical management of GIST. Whether genetic polymorphism of KIT may influence GIST patient outcome is unclear. METHODS:We investigated the biological and clinical significance of the presence of KIT exon 10 variant (c.1621 A > C), KIT (L541), in a transfected cell lin...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1817-5
更新日期:2015-10-24 00:00:00
abstract:BACKGROUND:Cancer is a major public health issue and represents a significant economic burden to health care systems worldwide. The objective of this analysis was to estimate phase-specific, 5-year and lifetime net costs for the 21 most prevalent cancer sites, and remaining tumour sites combined, in Ontario, Canada. M...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2835-7
更新日期:2016-10-18 00:00:00
abstract::Chimeric antigen receptor T (CAR-T) cells are a promising new treatment for patients with relapsed or refractory hematologic malignancies, including lymphoma. Given the success of CAR-T cells directed against CD19, new targets are being developed and tested, since not all lymphomas express CD19. CD30 is promising targ...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-019-5415-9
更新日期:2019-03-06 00:00:00
abstract:BACKGROUND:Women with BRCA1 or BRCA2 mutations have a substantially increased risk of breast and ovarian cancer compared with the general population. Therefore, prophylactic mastectomy (PM) and bilateral salpingo-oophorectomy (BSO) have been proposed as risk-reduction strategies for BRCA1/2 mutation carriers. We aimed ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-101
更新日期:2008-04-14 00:00:00
abstract:BACKGROUND:The use of combined positron emission tomography/computerised tomography (PET/CT) scanners in oncology has been shown to improve the staging of tumours and the detection of relapses. However, mis-registration errors are increasingly recognised to be a common pitfall of PET/CT studies. CASE PRESENTATION:We r...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-7-147
更新日期:2007-08-03 00:00:00
abstract:BACKGROUND:P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to the growing consensus that P38 is a tumour suppressor, and it may represent a novel target for breast cancer treatment. The aim of this study is t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4924-2
更新日期:2018-10-23 00:00:00
abstract:BACKGROUND:Obesity is associated with tumor aggressiveness and disease-specific mortality for more than 15 defined malignancies, including prostate cancer. Preclinical studies suggest that weight loss from caloric restriction and increased physical activity may suppress hormonal, energy-sensing, and inflammatory factor...
journal_title:BMC cancer
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12885-016-2075-x
更新日期:2016-02-05 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or l...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-90
更新日期:2012-03-19 00:00:00
abstract:BACKGROUND:The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown. The diminished capability of the immune system to control and resolve HPV infection is one of several hyp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-618
更新日期:2012-12-24 00:00:00
abstract:CORRECTION:After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-017-3767-6
更新日期:2018-01-11 00:00:00
abstract:BACKGROUND:To determine the effect of surgery on the survival status of patients with locally advanced cervical cancer after radiotherapy/chemoradiotherapy. METHODS:PubMed, Web of Science, ProQuest and Medline were searched using the key words "cervical cancer", "locally advanced disease", "radiotherapy" and "surgery ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-4232-x
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:Kv10.1, a voltage-gated potassium channel only detected in the healthy brain, was found to be aberrantly expressed in extracerebral cancers. Investigations of Kv10.1 in brain metastasis and glioblastoma multiforme (GBM) are lacking. METHODS:We analyzed the expression of Kv10.1 by immunohistochemistry in the...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1848-y
更新日期:2015-11-03 00:00:00
abstract:BACKGROUND:Triple-negative breast cancer (TNBC) comprises a heterogeneous group of diseases which are generally associated with poor prognosis. Up to now, no targeted treatment beyond anti-VEGF therapy has been approved for TNBC and cytotoxic agents remain the mainstay of treatment. Ixazomib is a selective and reversib...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4979-0
更新日期:2018-11-06 00:00:00
abstract:BACKGROUND:The objectives of this study were to build a normal tissue complication probability (NTCP) model of radiation-induced hypothyroidism (RHT) for nasopharyngeal carcinoma (NPC) patients and to compare it with other four published NTCP models to evaluate its efficacy. METHODS:Medical notes of 174 NPC patients a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4348-z
更新日期:2018-05-18 00:00:00
abstract:BACKGROUND:SLIT-ROBO families of proteins mediate axon pathfinding and their expression is not solely confined to nervous system. Aberrant expression of SLIT-ROBO genes was repeatedly shown in a wide variety of cancers, yet data about their collective behavior in hepatocellular carcinoma (HCC) is missing. Hence, we qua...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-392
更新日期:2008-12-29 00:00:00
abstract:BACKGROUND:We sought to examine the detection rate of cancer cells in peripheral blood (PBL) and in bone marrow (BM) using an established 7-gene marker panel and evaluated whether there were any definable associations of any individual gene with traditional predictors of prognosis. METHODS:Patients with T1-T3 primary ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-55
更新日期:2008-02-20 00:00:00
abstract:BACKGROUND:Increasing evidence suggests that alterations in mitochondrial DNA (mtDNA) content may be implicated in the tumorigenesis of several malignancies. However, the association between mtDNA content in peripheral blood lymphocytes (PBLs) and glioma risk has not been investigated. METHODS:Real-time PCR was used t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-680
更新日期:2014-09-19 00:00:00
abstract:BACKGROUND:The glycosylphosphatidylinositol-anchored extracellular membrane serine protease prostasin is expressed in normal bladder urothelial cells. Bladder inflammation reduces prostasin expression and a loss of prostasin expression is associated with epithelial-mesenchymal transition (EMT) in human bladder transiti...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-2039-6
更新日期:2015-12-29 00:00:00
abstract:BACKGROUND:KIAA1199 is a recently identified novel gene that is up-regulated in human cancer with poor survival. Our proteomic study on signaling polarity in chemotactic cells revealed KIAA1199 as a novel protein target that may be involved in cellular chemotaxis and motility. In the present study, we examined the func...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-14-194
更新日期:2014-03-15 00:00:00
abstract:BACKGROUND:Papillary renal cell carcinoma (pRCC) is the 2nd most frequent histological type of kidney cancer and accounts for approximately 15% of all renal cell carcinoma. It has a poorer prognosis than clear cell RCC (ccRCC) with a lack of standard treatments. CASE PRESENTATION:We report the case of a 51 year old ma...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-018-5049-3
更新日期:2018-11-22 00:00:00
abstract:BACKGROUND:In Chile, more than 500 women die every year from cervical cancer, and a majority of Chilean women are not up-to-date with their Papanicolau (Pap) test. Mobile health has great potential in many health areas, particularly in health promotion and prevention. There are no randomized controlled trials in Latin ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3870-8
更新日期:2017-12-13 00:00:00
abstract:BACKGROUND:Castleman's disease is a rare form of localized lymph node hyperplasia of uncertain etiology. Although the mediastinum is the most common site of involvement, rare cases occurring in lymph node bearing tissue of other localization have been reported, including only a few intramuscular cases. Unicentric and m...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-352
更新日期:2011-08-12 00:00:00
abstract:BACKGROUND:MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aimed to investigate the mechanism of miR-200c targets fucosyltransferase 4 (FUT4) on the proliferation...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07670-y
更新日期:2021-01-04 00:00:00
abstract:BACKGROUND:Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ spe...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-662
更新日期:2010-12-02 00:00:00