Abstract:
BACKGROUND:In the final phase of China's national programme to eliminate malaria by 2020, it is vitally important to monitor the resistance of malaria vectors for developing effective vector control strategies. In 2017 Shanghai declared that it had eliminated malaria; however, the insecticide resistance status of the primary malaria vector Anopheles sinensis remains unknown. METHODS:We examined the pyrethroid and organophosphate resistance of An. sinensis via a bioassay of two populations from the Chongming District of Shanghai. The voltage-gated sodium channel (VGSC) and acetylcholinesterase 1 (ace-1) genes were partially sequenced to examine the association between resistance phenotype and target site genotype. In addition, the geographical distribution, polymorphism and genotype frequencies of insecticide resistance genes were examined using samples collected during routine mosquito surveillance in 2016 and 2017 from Chongming, Songjiang, Jiading and Qingpu Districts. RESULTS:In Chongming District, the An. sinensis population near Dongtan National Nature Reserve showed resistance to pyrethroids, sensitivity to organophosphate, no knockdown resistance (kdr) mutations in the VGSC gene, and a low frequency (1.71%) of the ace-1 119S allele. An An. sinensis population near the Chongming central area (CM-Xinhe population) showed high resistance to pyrethroids and organophosphates and high frequencies of kdr 1014F and 1014C (80.73%) and ace-1 119S (85.98%) alleles. A significant association was detected between the homozygous kdr mutation 1014F/1014F and pyrethroid resistance in the CM-Xinhe population, indicating that the kdr mutation is probably recessive. Eight kdr genotypes with 1014F and 1014C substitutions were detected in the four surveyed districts of Shanghai. TTT and GGC/AGC were the dominant kdr allele and ace-1 genotype, respectively, and were prevalent in most Shanghai An. sinensis populations. CONCLUSIONS:On the basis of our assessment of insecticide resistance gene mutations in Shanghai, we identified a kdr mutation-free population in Chongming Dongtan. However, high frequencies of target-site mutations of insecticide resistance genes were observed in most areas of Shanghai. Bioassays of An. sinensis populations in the central Chongming District indicated the high insecticide resistance status of An. sinensis populations in Shanghai. We accordingly recommend a restriction on insecticide usage and development of effective integrated pest/vector management interventions to support disease control efforts.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Fang Y,Shi WQ,Wu JT,Li YY,Xue JB,Zhang Ydoi
10.1186/s13071-019-3657-7subject
Has Abstractpub_date
2019-08-09 00:00:00pages
396issue
1issn
1756-3305pii
10.1186/s13071-019-3657-7journal_volume
12pub_type
杂志文章abstract:BACKGROUND:The tick midgut and salivary glands represent the primary organs for pathogen acquisition and transmission, respectively. Specifically, the midgut is the first organ to have contact with pathogens during the blood meal uptake, while salivary glands along with their secretions play a crucial role in pathogen ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3418-7
更新日期:2019-04-02 00:00:00
abstract:BACKGROUND:Gyrodactylus salaris Malmberg, 1957 has had a devastating impact on wild Norwegian stocks of Atlantic salmon Salmo salar L., and it is the only Office International des Epizooties (OIE) listed parasitic pathogen of fish. The UK is presently recognised as G. salaris-free, and management plans for its containm...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0576-5
更新日期:2014-12-20 00:00:00
abstract::Since the implementation of Roll Back Malaria, the widespread use of insecticide-treated nets (ITNs) and indoor residual spraying (IRS) is thought to have played a major part in the decrease in mortality and morbidity achieved in malaria-endemic regions. In the past decade, resistance to major classes of insecticides ...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-020-04170-7
更新日期:2020-06-10 00:00:00
abstract:BACKGROUND:Taxonomic identification of ticks obtained during a longitudinal survey of the critically endangered marsupial, Bettongia penicillata Gray, 1837 (woylie, brush-tailed bettong) revealed a new species of Ixodes Latrielle, 1795. Here we provide morphological data for the female and nymphal life stages of this n...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-1997-8
更新日期:2017-02-07 00:00:00
abstract:BACKGROUND:Cyclospora is a protistan parasite that causes enteritis in several species of animals including humans. The aim of this study was to investigate the presence of Cyclospora in captive non-human primates. METHODS:A total of 119 faecal samples from Pan troglodytes, Macaca sylvanus, Cercopithecus cephus, Eryth...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0872-8
更新日期:2015-05-15 00:00:00
abstract:BACKGROUND:Triatoma dimidiata (Latreille) is a key vector complex of Trypanosoma cruzi, etiologic agent of Chagas disease, as it spans North, Central, and South America. Although morphological and genetic studies clearly indicate existence of at least five clades within the species, there has been no robust or systemat...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0678-8
更新日期:2015-02-06 00:00:00
abstract:BACKGROUND:Most studies on Enterocytozoon bieneusi are conducted based on the internal transcribed spacer (ITS) region of the rRNA gene, whereas some have examined E. bieneusi population structures. Currently, the population genetics of this pathogen in giant panda remains unknown. The objective of this study was to de...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2459-z
更新日期:2017-10-18 00:00:00
abstract:BACKGROUND:Rhipicephalus sanguineus sensu lato (s.l.) is the most widely distributed ixodid tick and is a vector of major canine and human pathogens. High-throughput technologies have revealed that individual ticks carry a high diversity of pathogens, including bacteria, protozoa and viruses. Currently, it is accepted ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3194-9
更新日期:2019-01-07 00:00:00
abstract:BACKGROUND:Nematodirus battus, unlike most other gastrointestinal nematodes, undergoes maturation to an infective larva within the egg. Historically, eggs were considered to require a period of chilling over winter followed by a period of temperature above 10 °C for synchronous hatching to occur (generally in spring). ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04368-9
更新日期:2020-09-29 00:00:00
abstract:BACKGROUND:Toxoplasma gondii is a widely prevalent protozoan parasite that causes serious toxoplasmosis in humans and animals. The present study aimed to determine the genetic diversity of T. gondii isolates from pigs in Jiangxi, Sichuan, Guangdong Provinces and Chongqing Municipality in China using multilocous polymer...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-227
更新日期:2013-08-07 00:00:00
abstract:BACKGROUND:The use of inland valley swamps for vegetable crop agriculture contributes to food security in urban and less urbanized settings in Africa. The impact of this agriculture on aggressive mosquitoes' diversity and malaria transmission in central Africa is poorly documented. This study is aimed at assessing the ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0906-2
更新日期:2015-05-28 00:00:00
abstract:BACKGROUND:Many cases of cutaneous leishmaniasis (CL) have been recorded in the Jenin District based on their clinical appearance. Here, their parasites have been characterized in depth. METHODS:Leishmanial parasites isolated from 12 human cases of CL from the Jenin District were cultured as promastigotes, whose DNA w...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-121
更新日期:2012-06-18 00:00:00
abstract:BACKGROUND:Trichinella spiralis is a major zoonotic tissue-dwelling nematode, which is a public health concern and a serious hazard to animal food safety. It is necessary to exploit an anti-Trichinella vaccine to interrupt the transmission of Trichinella infection among animals and from animals to humans. The purpose o...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3833-9
更新日期:2019-12-11 00:00:00
abstract:BACKGROUND:The argasid tick Ornithodoros erraticus is the vector of African swine fever virus and of several Borrelia species that cause human relapsing fever in the Iberian Peninsula. The tick midgut is part of the ectoparasite-host interface and expresses proteins that are vital for the survival of the tick. Midgut p...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1148-z
更新日期:2015-10-12 00:00:00
abstract:BACKGROUND:Schistosomiasis japonica remains a major public health problem in China. Integrating molecular analyses, such as population genetic analyses, of the parasite into the on-going surveillance programs is helpful in exploring the factors causing the persistence and/or spread of Schistosoma japonicum. However, ge...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1074-0
更新日期:2015-09-08 00:00:00
abstract:BACKGROUND:The frequent outbreaks of human trichinellosis globally underscore the need to develop effective vaccine. We hypothesized that a novel vaccine could improve vaccine efficacy against Trichinella spiralis. METHODS:In this study, we developed virus-like particles (VLPs) containing the 53 KDa excretory/secretor...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1662-7
更新日期:2016-07-04 00:00:00
abstract:BACKGROUND:Accurate diagnosis of urogenital schistosomiasis is vital for surveillance/control programs. Amplification of schistosome DNA in urine by PCR is sensitive and specific but requires infrastructure, financial resources and skilled personnel, often not available in endemic areas. Recombinase Polymerase Amplific...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1055-3
更新日期:2015-09-04 00:00:00
abstract::In the more than 100 years since its discovery, our knowledge of Toxoplasma biology has improved enormously. The evolution of molecular biology, immunology and genomics has had profound influences on our understanding of this ubiquitous bug. However, it could be argued that in science today the adage "seeing is believ...
journal_title:Parasites & vectors
pub_type: 历史文章,杂志文章,评审
doi:10.1186/1756-3305-6-334
更新日期:2013-11-22 00:00:00
abstract::Taenia solium life cycle includes humans as definitive hosts and pigs as intermediate hosts. One of the measures to stop the life cycle of this parasite is by vaccination of pigs. In experiments performed in pigs with TSOL18 and TSOL45-1A, two recombinant T. solium proteins, 99.5% and 97.0% protection was induced, res...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-3
更新日期:2011-01-06 00:00:00
abstract:BACKGROUND:Schistosomiasis, caused by schistosomes, is one of the most prevalent and serious parasitic diseases in tropical and subtropical countries. This pathogen has a complex life cycle and harbors a unique repertoire of genes expressed at different life-stages. Understanding the gene regulation of schistosomes wil...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1203-9
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:Sand flies (Diptera: Psychodidae) are the vectors of Leishmania parasites, the causative agents of leishmaniasis. Cutaneous leishmaniasis is an increasing public health problem in the Republic of Suriname and is mainly caused by Leishmania (Vianna) guyanensis, but L. (V.) braziliensis, L. (L.) amazonensis, a...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-318
更新日期:2013-11-04 00:00:00
abstract:BACKGROUND:Canine vector-borne diseases (CVBD) have become a major concern for canine and human public health. The aim of the study described here is to add epidemiological data regarding four pathogens responsible for CVBD, namely anaplasmosis, borreliosis, dirofilariosis and ehrlichiosis in a national survey conducte...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1686-z
更新日期:2016-07-29 00:00:00
abstract:BACKGROUND:In the Kingdom of Saudi Arabia (KSA), Leishmania major and L. tropica are the main causative agents of Old World cutaneous leishmaniasis (CL). The national CL treatment regimen consists of topical 1% clotrimazole/2% fusidic acid cream followed by 1-2 courses of intralesional sodium stibogluconate (SSG); howe...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3453-4
更新日期:2019-05-02 00:00:00
abstract:BACKGROUND:The genus Marshallagia (Family Haemonchidae, subfamily Ostertagiinae) contains multiple species of nematodes parasitising the abomasum (or duodenum) of ruminants, in particular of Caprinae. Male specimens have been described to be polymorphic with the frequent/major morphotype initially described in the genu...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04265-1
更新日期:2020-08-12 00:00:00
abstract:BACKGROUND:Schistosomiasis is a serious global health problem that afflicts more than 230 million people in 77 countries. Long-term mass treatments with the only available drug, praziquantel, have caused growing concerns about drug resistance. PSD-95/Dlg/ZO-1 (PDZ) domain-containing proteins are recognized as potential...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-227
更新日期:2012-10-10 00:00:00
abstract:BACKGROUND:The rapid growth of Qatar in the last two decades has been associated with an enormous expansion of building programs in its cities and in the provision of new service industries. This in turn has attracted a large influx of immigrant workers seeking employment in jobs associated with food handling, domestic...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-211
更新日期:2011-11-04 00:00:00
abstract:BACKGROUND:Human and animal fascioliasis poses serious public health problems in South America. In Venezuela, livestock infection represents an important veterinary problem whereas there appear to be few human cases reported, most of which are passively detected in health centres. However, results of recent surveys sug...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-200
更新日期:2011-10-14 00:00:00
abstract:BACKGROUND:Dengue is a serious public health problem worldwide, including in Selangor, Malaysia. Being an important vector of dengue virus, Aedes aegypti are subjected to control measures which rely heavily on the usage of insecticides. Evidently, insecticide resistance in Ae. aegypti, which arise from several differen...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3472-1
更新日期:2019-05-16 00:00:00
abstract:BACKGROUND:Chagas disease transmission risk is a function of the presence of triatomines in domestic habitats. Rhodnius ecuadoriensis is one of the main vectors implicated in transmission of Trypanosoma cruzi in Ecuador. This triatomine species is present in domestic, peridomestic and sylvatic habitats in the country. ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-17
更新日期:2012-01-13 00:00:00
abstract:BACKGROUND:Estimating the abundance of Culicoides using light traps is influenced by a large variation in abundance in time and place. This study investigates the optimal trapping strategy to estimate the abundance or presence/absence of Culicoides on a field with grazing animals. We used 45 light traps to sample speci...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-151
更新日期:2013-05-24 00:00:00