Abstract:
BACKGROUND:Most studies on Enterocytozoon bieneusi are conducted based on the internal transcribed spacer (ITS) region of the rRNA gene, whereas some have examined E. bieneusi population structures. Currently, the population genetics of this pathogen in giant panda remains unknown. The objective of this study was to determine the E. bieneusi population in captive giant pandas in China. RESULTS:We examined 69 E. bieneusi-positive specimens from captive giant pandas in China using five loci (ITS, MS1, MS3, MS4 and MS7) to infer E. bieneusi population genetics. For multilocus genotype (MLG) analysis of E. bieneusi-positive isolates, the MS1, MS3, MS4, and MS7 microsatellite and minisatellite loci were amplified and sequenced in 48, 45, 50 and 47 specimens, respectively, generating ten, eight, nine and five types. We successfully amplified 36 specimens and sequenced all five loci, forming 24 MLGs. Multilocus sequence analysis revealed a strong and significant linkage disequilibrium (LD), indicating a clonal population. This result was further supported by measurements of pairwise intergenic LD and a standardized index of association (I SA) from allelic profile data. The analysis in STRUCTURE suggested three subpopulations in E. bieneusi, further confirmed using right's fixation index (F ST). Subpopulations 1 and 2 exhibited an epidemic structure, whereas subpopulation 3 had a clonal structure. CONCLUSIONS:Our results describe E. bieneusi population genetics in giant pandas for the first time, improving the current understanding E. bieneusi epidemiology in the studied region. These data also benefit future studies exploring potential transmission risks from pandas to other animals, including humans.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Li W,Song Y,Zhong Z,Huang X,Wang C,Li C,Yang H,Liu H,Ren Z,Lan J,Wu K,Peng Gdoi
10.1186/s13071-017-2459-zsubject
Has Abstractpub_date
2017-10-18 00:00:00pages
499issue
1issn
1756-3305pii
10.1186/s13071-017-2459-zjournal_volume
10pub_type
杂志文章abstract:BACKGROUND:The preventive effect of fluralaner spot-on solution against transmission of Babesia canis by Dermacentor reticulatus ticks was evaluated. FINDINGS:Sixteen dogs, tested negative for B. canis by polymerase chain reaction (PCR) and immunofluorescence assay test (IFAT), were allocated to two study groups. On d...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1481-x
更新日期:2016-05-31 00:00:00
abstract:BACKGROUND:Lymphatic filariasis (LF) is a mosquito-borne parasitic disease and a major cause of disability worldwide. It is one of the neglected tropical diseases identified by the World Health Organization for elimination as a public health problem by 2020. Maps displaying disease distribution are helpful tools to ide...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3097-9
更新日期:2018-09-17 00:00:00
abstract:BACKGROUND:Human schistosomiasis is a neglected tropical disease caused by parasitic worms of the genus Schistosoma that still affects some 200 million people. The mainstay of schistosomiasis control is a single drug, praziquantel. The reliance on this drug carries a risk of resistance emerging to this anthelmintic, su...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3197-6
更新日期:2018-11-27 00:00:00
abstract:BACKGROUND:Proteins from the ABC family (ATP-binding cassette) represent the largest known group of efflux pumps, responsible for transporting specific molecules across lipid membranes in both prokaryotic and eukaryotic organisms. In arthropods they have been shown to play a role in insecticide defense/resistance. The ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-349
更新日期:2014-07-29 00:00:00
abstract:BACKGROUND:Schistosoma mansoni cercariae penetrate the skin by releasing excretory/secretory (E/S) products known as 0-3hRP, which are associated with immune modulation through Toll like receptor (TLR) signalling. Furthermore, these secretions contain Sm16, which when given to cells as a recombinant protein inhibits hu...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0608-1
更新日期:2015-01-06 00:00:00
abstract:BACKGROUND:This study aimed to map the occurrence of Taenia solium taeniosis/cysticercosis at national level within Central America and the Caribbean basin, and to map the distribution of porcine cysticercosis at first-level administrative subdivision level (department level) and the porcine population at risk. This zo...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-017-2362-7
更新日期:2017-09-18 00:00:00
abstract:BACKGROUND:Schistosomiasis remains prevalent in Africa, Asia and South America with an estimated burden of 1.9 million disability-adjusted life years in 2016. Targeting snails as a key to success for schistosomiasis control has been widely approved, but the long-term quantitative effects of interventions on snail contr...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04273-1
更新日期:2020-08-05 00:00:00
abstract:BACKGROUND:Vector-borne diseases (VBD) are of growing global importance. Sand flies are potential vectors for phleboviruses (family Phenuiviridae) including Toscana virus (TOSV), Sicilian virus, Sandfly fever, Naples virus, and Leishmania parasites in Europe. To date, only two phlebotomine species have been recorded fo...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04058-6
更新日期:2020-04-21 00:00:00
abstract:BACKGROUND:Cats appear to be the primary reservoir host for Bartonella koehlerae, an alpha Proteobacteria that is most likely transmitted among cat populations by fleas (Ctenocephalides felis). Bartonella koehlerae has caused endocarditis in a dog and in one human patient from Israel, but other clinically relevant repo...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-76
更新日期:2010-08-24 00:00:00
abstract::Rickettsioses are among the oldest known infectious diseases. In spite of this, and of the extensive research carried out, many aspects of the biology and epidemiology of tick-borne rickettsiae are far from being completely understood. Their association with arthropod vectors, the importance of vertebrates as reservoi...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-018-2856-y
更新日期:2018-04-24 00:00:00
abstract:BACKGROUND:Antigen B (EgAgB) is an abundant lipoprotein released by the larva of the cestode Echinococcus granulosus into the host tissues. Its protein moiety belongs to the cestode-specific family known as hydrophobic ligand binding protein (HLBP), and is encoded by five gene subfamilies (EgAgB8/1-EgAgB8/5). The funct...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1350-7
更新日期:2016-02-04 00:00:00
abstract:BACKGROUND:Fluralaner is a novel isoxazoline eliciting both acaricidal and insecticidal activity through potent blockage of GABA- and glutamate-gated chloride channels. The aim of the study was to investigate the susceptibility of juvenile stages of common tick species exposed to fluralaner through either contact (Rhip...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0704-x
更新日期:2015-02-08 00:00:00
abstract:BACKGROUND:The Anopheles gambiae Giles complex is the most widely studied and the most important insect vector group. We explored the use of the palp ratio method as a field tool to identify A. melas and A. gambiae in Ghana. METHODS:Human landing catches were conducted to collect mosquitoes in the coastal area of West...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0913-3
更新日期:2015-05-28 00:00:00
abstract:BACKGROUND:Publications are often used as a measure of success of research work. Leishmaniasis is considered endemic in 98 countries, most of which are developing. This article describes a bibliometric review of the literature on leishmaniasis research indexed in PubMed during a 66-year period. METHODS:Medline was use...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/1756-3305-6-55
更新日期:2013-03-07 00:00:00
abstract:BACKGROUND:Toxocara canis is quite closely related to Ascaris suum but its biology is more complex, involving a phase of arrested development (diapause or hypobiosis) in tissues as well as transplacental and transmammary transmission routes. In the present study, we explored and compared dauer-like signalling pathways ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3265-y
更新日期:2019-01-14 00:00:00
abstract:BACKGROUND:Canine vector-borne diseases (CVBDs) are caused by a wide range of pathogens transmitted to dogs by arthropods including ticks and insects. Many CVBD-agents are of zoonotic concern, with dogs potentially serving as reservoirs and sentinels for human infections. The present study aimed at assessing the seropr...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-62
更新日期:2012-03-27 00:00:00
abstract:BACKGROUND:A cytogenetic analysis of the new local triploid population of the caryophyllidean tapeworm Atractolytocestus huronensis, a unique parthenogenetic species with the ability to colonise new regions, was performed to understand the inner structure of its chromosome complement. METHODS:A karyotype analysis was ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3420-0
更新日期:2019-04-11 00:00:00
abstract:BACKGROUND:Several studies were carried out in experimental hut station in areas surrounding the city of Bouaké, after the crisis in Côte d'Ivoire. They reported increasing resistance levels to insecticide for malaria transmiting mosquitoes. The present work aims to evaluate the current resistance level of An. gambiae ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2702-2
更新日期:2018-03-02 00:00:00
abstract:BACKGROUND:Rhipicephalus sanguineus is a ubiquitous tick responsible for transmitting Ehrlichia canis and most likely Anaplasma platys to dogs, as either single or co-infections. The objective of this study was to assess the effects of either simultaneous or sequential experimental infections with E. canis and A. platy...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-33
更新日期:2010-04-08 00:00:00
abstract:BACKGROUND:Trichinella spiralis is a major zoonotic tissue-dwelling nematode, which is a public health concern and a serious hazard to animal food safety. It is necessary to exploit an anti-Trichinella vaccine to interrupt the transmission of Trichinella infection among animals and from animals to humans. The purpose o...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3833-9
更新日期:2019-12-11 00:00:00
abstract:BACKGROUND:Gastrointestinal nematodes are parasites that commonly infect dogs, and infections can be subclinical or may cause considerable clinical disease. Some species are zoonotic and may also cause clinical disease in humans. Year-round treatment of dogs is recommended to eliminate existing infections, which also i...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-3947-0
更新日期:2020-03-01 00:00:00
abstract:: The proteasome inhibitor and anti-cancer drug bortezomib was tested for in vitro activity against bloodstream forms of Trypanosoma brucei. The concentrations of bortezomib required to reduce the growth rate by 50% and to kill all trypanosomes were 3.3 nM and 10 nM, respectively. In addition, bortezomib was 10 times m...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-2-29
更新日期:2009-07-07 00:00:00
abstract:BACKGROUND:Bluetongue virus (BTV) is transmitted by Culicoides biting midges and causes bluetongue (BT), a clinical disease observed primarily in sheep. BT has a detrimental effect on subsistence farmers in India, where hyperendemic outbreaks impact on smallholdings in the southern states of the country. In this study,...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-1992-0
更新日期:2017-01-31 00:00:00
abstract:BACKGROUND:Dengue virus (DENV) is the arbovirus with the highest incidence in New Caledonia and in the South Pacific region. In 2012-2014, a major DENV-1 outbreak occurred in New Caledonia. The only known vector of DENV in New Caledonia is Aedes aegypti but no study has yet evaluated the competence of New Caledonia Ae....
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2319-x
更新日期:2017-08-09 00:00:00
abstract:BACKGROUND:Taxonomic identification of ticks obtained during a longitudinal survey of the critically endangered marsupial, Bettongia penicillata Gray, 1837 (woylie, brush-tailed bettong) revealed a new species of Ixodes Latrielle, 1795. Here we provide morphological data for the female and nymphal life stages of this n...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-1997-8
更新日期:2017-02-07 00:00:00
abstract:BACKGROUND:A plethora of evidence shows that activated microglia play a critical role in the pathogenesis of the central nervous system (CNS). Toxoplasmic encephalitis (TE) frequently occurs in HIV/AIDS patients. However, knowledge remains limited on the contributions of activated microglia to the pathogenesis of TE. ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-372
更新日期:2014-08-15 00:00:00
abstract:BACKGROUND:Ticks are increasingly reported on cats worldwide, with Ixodes ricinus being a relevant species across Europe and in near by areas of North Africa and the Middle East. Yet there are few acaracidal products with proven efficacy approved for use in cats. The objective of this study was to compare the efficacy ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2259-5
更新日期:2017-06-29 00:00:00
abstract:BACKGROUND:Spatial repellents that drive mosquitoes away from treated areas, and odour-baited traps, that attract and kill mosquitoes, can be combined and work synergistically in a push-pull system. Push-pull systems have been shown to reduce house entry and outdoor biting rates of malaria vectors and so have the poten...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04263-3
更新日期:2020-07-31 00:00:00
abstract:BACKGROUND:Anopheles sinensis is one of the most important malaria vectors in Asian countries. The rapid spread of insecticide resistance has become a major obstacle for insecticide-based strategies for vector control. Therefore, it is necessary to prepare an insecticide-resistant strain of An. sinensis to further unde...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0582-7
更新日期:2014-12-11 00:00:00
abstract:BACKGROUND:Culex quinquefasciatus is a hematophagous insect from the Culicidae family that feeds on the blood of humans, dogs, birds and livestock. This species transmits a wide variety of pathogens between humans and animals. The midgut environment is the first location of pathogen-vector interactions for blood-feedin...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0985-0
更新日期:2015-07-16 00:00:00