Abstract:
BACKGROUND:Cats appear to be the primary reservoir host for Bartonella koehlerae, an alpha Proteobacteria that is most likely transmitted among cat populations by fleas (Ctenocephalides felis). Bartonella koehlerae has caused endocarditis in a dog and in one human patient from Israel, but other clinically relevant reports involving this bacterium are lacking. Despite publication of numerous, worldwide epidemiological studies designed to determine the prevalence of Bartonella spp. bacteremia in cats, B. koehlerae has never been isolated using conventional blood agar plates. To date, successful isolation of B. koehlerae from cats and from the one human endocarditis patient has consistently required the use of chocolate agar plates. RESULTS:In this study, Bartonella koehlerae bacteremia was documented in eight immunocompetent patients by PCR amplification and DNA sequencing, either prior to or after enrichment blood culture using Bartonella alpha Proteobacteria growth medium. Presenting symptoms most often included fatigue, insomnia, joint pain, headache, memory loss, and muscle pain. Four patients were also infected with Bartonella vinsonii subsp. berkhoffii genotype II. After molecular documentation of B. koehlerae infection in these patients, a serological test was developed and serum samples were tested retrospectively. Bartonella koehlerae antibodies were not detected (titers < 1:16) in 30 healthy human control sera, whereas five of eight patient samples had B. koehlerae antibody titers of 1:64 or greater. CONCLUSIONS:Although biased by a study population consisting of individuals with extensive arthropod and animal exposure, the results of this study suggest that B. koehlerae bacteremia is more common in immunocompetent people than has been previously suspected. Future studies should more thoroughly define modes of transmission and risk factors for acquiring infection with B. koehlerae. In addition, studies are needed to determine if B. koehlerae is a cause or cofactor in the development of arthritis, peripheral neuropathies or tachyarrhythmias in patients.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Breitschwerdt EB,Maggi RG,Robert Mozayeni B,Hegarty BC,Bradley JM,Mascarelli PEdoi
10.1186/1756-3305-3-76subject
Has Abstractpub_date
2010-08-24 00:00:00pages
76issn
1756-3305pii
1756-3305-3-76journal_volume
3pub_type
杂志文章abstract::Ticks (Acari: Ixodida) are arthropod ectoparasites dependent on a bloodmeal from a vertebrate host at each developmental stage for completion of their life cycle. This tick feeding cycle impacts animal health by causing damage to hides, secondary infections, immune reactions and diseases caused by transmission of path...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1185-7
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:The efficacy of fluralaner for the treatment of Otodectes cynotis infestations in dogs and cats was evaluated after oral (dogs) or topical administration (dogs and cats). Twenty-four dogs and sixteen cats were experimentally infested with O. cynotis and randomly allocated to equal sized groups (n = 8/group)....
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1954-y
更新日期:2017-01-16 00:00:00
abstract:BACKGROUND:Paratransgenesis is an approach to reducing arthropod vector competence using genetically modified symbionts. When applied to control of Chagas disease, the symbiont bacterium Rhodococcus rhodnii, resident in the gut lumen of the triatomine vector Rhodnius prolixus (Hemiptera: Reduviidae), is transformed to ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-77
更新日期:2011-05-14 00:00:00
abstract:BACKGROUND:Triatoma dimidiata (Latreille) is a key vector complex of Trypanosoma cruzi, etiologic agent of Chagas disease, as it spans North, Central, and South America. Although morphological and genetic studies clearly indicate existence of at least five clades within the species, there has been no robust or systemat...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0678-8
更新日期:2015-02-06 00:00:00
abstract:BACKGROUND:To date there has been no evidence of mosquito-borne virus transmission of public health concern in the UK, despite the occurrence of more than 30 species of mosquito, including putative vectors of arboviruses. The saltmarsh mosquito Ochlerotatus detritus [syn. Aedes (Ochlerotatus) detritus] is locally commo...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1739-3
更新日期:2016-08-15 00:00:00
abstract:BACKGROUND:Human babesiosis is an infectious disease that is epidemic in various regions all over the world. The predominant causative pathogen of this disease is the intra-erythrocytic parasite Babesia microti. The thioredoxin system is one of the major weapons that is used in the resistance to the reactive oxygen spe...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2619-9
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND:Cutaneous leishmaniasis (CL) is caused by Leishmania (Viannia) braziliensis, which infects dermal macrophages and dendritic cells, causing an intense immune-mediated-tissue inflammation and a skin ulcer with elevated borders that can heal spontaneously or after antimonial therapy. The resolution of lesions d...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2152-2
更新日期:2017-05-03 00:00:00
abstract:BACKGROUND:This study aimed to map the occurrence of Taenia solium taeniosis/cysticercosis at national level within Central America and the Caribbean basin, and to map the distribution of porcine cysticercosis at first-level administrative subdivision level (department level) and the porcine population at risk. This zo...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-017-2362-7
更新日期:2017-09-18 00:00:00
abstract:BACKGROUND:In the past, immune responses to several Brugia malayi immunodominant antigens have been characterized in filaria-infected populations; however, little is known regarding Wolbachia proteins. We earlier cloned and characterized few B. malayi (trehalose-6-phosphate phosphatase, Bm-TPP and heavy chain myosin, B...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1963-x
更新日期:2017-01-24 00:00:00
abstract:BACKGROUND:Red deer (Cervus elaphus) are a common wild definitive host for liver fluke (Fasciola hepatica) that have been the subject of limited diagnostic surveillance. This study aimed to explore the extent to which coprological diagnoses for F. hepatica in red deer in the Scottish Highlands, Scotland, are associated...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3782-3
更新日期:2019-11-12 00:00:00
abstract:BACKGROUND:The diagnosis of cutaneous leishmaniasis (CL) might be difficult, in particular in endemic areas where different species of Leishmania can cause lesions of very similar appearance and where other skin diseases with similar clinical symptoms occur. Even today, the parasitological diagnosis of CL remains the g...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-420
更新日期:2014-09-04 00:00:00
abstract:BACKGROUND:A cytogenetic analysis of the new local triploid population of the caryophyllidean tapeworm Atractolytocestus huronensis, a unique parthenogenetic species with the ability to colonise new regions, was performed to understand the inner structure of its chromosome complement. METHODS:A karyotype analysis was ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3420-0
更新日期:2019-04-11 00:00:00
abstract:BACKGROUND:The parasitic mite Varroa destructor is considered the major pest of the European honey bee (Apis mellifera) and responsible for declines in honey bee populations worldwide. Exploiting the full potential of gene sequences becoming available for V. destructor requires adaptation of modern molecular biology ap...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-73
更新日期:2010-08-16 00:00:00
abstract:BACKGROUND:Studies of avian haemosporidians allow understanding how these parasites affect wild bird populations, and if their presence is related to factors such as habitat loss, degradation and fragmentation, and climate change. Considering the importance of the highland Plateau of Mexico as part of the North America...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1569-3
更新日期:2016-05-27 00:00:00
abstract:BACKGROUND:The lungworm Dictyocaulus viviparus, causing parasitic bronchitis in cattle, induces a temporary protective immunity that prevents clinical disease. A radiation-attenuated larvae based vaccine is commercially available in a few European countries, but has the disadvantages of a live vaccine. As a recombinant...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0733-5
更新日期:2015-02-24 00:00:00
abstract:BACKGROUND:Malaria mosquitoes spend a considerable part of their life in the aquatic stage, rendering them vulnerable to interventions directed to aquatic habitats. Recent successes of mosquito larval control have been reported using environmental and biological tools. Here, we report the effects of shading by plants a...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-130
更新日期:2011-07-06 00:00:00
abstract:BACKGROUND:African trypanosomes are extracellular protozoan parasites that are transmitted between mammalian hosts by the bite of an infected tsetse fly. Human African Trypanosomiasis (HAT) or sleeping sickness is caused by Trypanosoma brucei rhodesiense or T. brucei gambiense, while African Animal Trypanosomiasis (AAT...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-217
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Agrochemicals have been widely used in Pakistan for several years. This exposes mosquito populations, particularly those present around agricultural settings, to an intense selection pressure for insecticide resistance. The aim of the present study was to investigate the toxicity of representative agrochemic...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-146
更新日期:2011-07-22 00:00:00
abstract:BACKGROUND:A good understanding of mosquito ecology is imperative for integrated vector control of malaria. In breeding sites, Anopheles larvae are concurrently exposed to predators and parasites. However, to our knowledge, there is no study on combined effects of predators and parasites on development and survival of ...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-020-3915-8
更新日期:2020-01-30 00:00:00
abstract:BACKGROUND:The ability of blood-feeding arthropods to successfully acquire and transmit pathogens of medical and veterinary importance has been shown to be interfered with, or enhanced by, the arthropod's native microbiome. Mosquitoes transmit viruses, protozoan and filarial nematodes, the majority of which contribute ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04218-8
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:Dicistroviridae is a new family of small, non-enveloped, +ssRNA viruses pathogenic to both beneficial arthropods and insect pests. Little is known about the dicistrovirus replication mechanism or gene function, and any knowledge on these subjects comes mainly from comparisons with mammalian viruses from the ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-66
更新日期:2013-03-15 00:00:00
abstract:BACKGROUND:Thelazia callipaeda is a zoonotic nematode that affects the eyes of domestic and wild animals, including dogs, cats and red foxes. This parasitic eye worm is transmitted by Phortica variegata, which is a zoophilic fruit fly spread in Europe. Two wild European rabbits (Oryctolagus cuniculus) found dead in nor...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1526-1
更新日期:2016-05-10 00:00:00
abstract:BACKGROUND:The application of the sterile insect technique (SIT) requires mass-production of sterile males of good biological quality. The size of the project area will in most cases determine whether it is more cost effective to produce the sterile flies locally (and invest in a mass-rearing facility) or import the st...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0869-3
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The disease scabies, caused by the ectoparasitic mite, Sarcoptes scabiei, causes significant morbidity in humans and other mammals worldwide. However, there is limited data available regarding the molecular basis of host specificity and host-parasite interactions. Therefore, we sought to produce a draft geno...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1198-2
更新日期:2015-11-10 00:00:00
abstract:BACKGROUND:Spatial modelling studies of schistosomiasis (SCH) are now commonplace. Covariate values are commonly extracted at survey locations, where infection does not always take place, resulting in an unknown positional exposure mismatch. The present research aims to: (i) describe the nature of the positional exposu...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3039-6
更新日期:2018-08-13 00:00:00
abstract:BACKGROUND:Ecto-Nucleoside Triphosphate Diphosphohydrolases (Ecto-NTPDases) are enzymes that hydrolyze tri- and/or di-phosphate nucleotides. Evidences point to their participation in Trypanosoma cruzi virulence and infectivity. In this work, we evaluate TcNTPDase-1 gene expression in comparison with ecto-NTPDase activi...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0463-0
更新日期:2014-10-05 00:00:00
abstract:BACKGROUND:Vector-borne diseases (VBD) are of growing global importance. Sand flies are potential vectors for phleboviruses (family Phenuiviridae) including Toscana virus (TOSV), Sicilian virus, Sandfly fever, Naples virus, and Leishmania parasites in Europe. To date, only two phlebotomine species have been recorded fo...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04058-6
更新日期:2020-04-21 00:00:00
abstract:BACKGROUND:Diagnostics provide a means to measure progress toward disease elimination. Many countries in Africa are approaching elimination of onchocerciasis after successful implementation of mass drug administration programs as well as vector control. An understanding of how markers for infection such as skin snip mi...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1623-1
更新日期:2016-06-13 00:00:00
abstract::This review explores some of the reasons why food webs seem to contain relatively few parasite species when compared to the full diversity of free living species in the system. At present, there are few coherent food web theories to guide scientific studies on parasites, and this review posits that the methods, direct...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/1756-3305-5-239
更新日期:2012-10-23 00:00:00
abstract:BACKGROUND:Helminth neuroinfections represent a serious health problem, but host immune mechanisms in the nervous tissue often remain undiscovered. This study aims at in vitro characterization of the response of murine astrocytes and microglia exposed to Trichobilharzia regenti which is a neuropathogenic schistosome mi...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1869-7
更新日期:2016-11-14 00:00:00