Abstract:
BACKGROUND:The efficacy of fluralaner for the treatment of Otodectes cynotis infestations in dogs and cats was evaluated after oral (dogs) or topical administration (dogs and cats). Twenty-four dogs and sixteen cats were experimentally infested with O. cynotis and randomly allocated to equal sized groups (n = 8/group). Dog groups were treated once, either orally with fluralaner at a minimum dose of 25 mg/kg body weight, topically with fluralaner at a dose of 25 mg/kg body weight or topically with saline solution (control). Cat groups were treated once, either topically with fluralaner at a dose of 40 mg/kg body weight or topically with saline solution. Ears of all animals were examined otoscopically for live visible mites and the amount of debris and cerumen before, and 14 and 28 days after treatment. Twenty-eight days after treatment, animals were sedated and both ears were flushed to obtain the total number of live mites per animal. The efficacy was calculated, based on the results of the ear flushing, by comparing mean live mite counts in the fluralaner treated groups versus the saline solution treated group. RESULTS:A single topical treatment of cats with fluralaner reduced the mean mite counts by 100% (P < 0.001) at 28 days after treatment. Similarly, a single oral or topical treatment of dogs with fluralaner reduced the mean mite counts by 99.8% (P < 0.001) at 28 days after treatment. Cats treated topically with fluralaner had no mites visible during otoscopic examination at either 14 or 28 days after treatment. All dogs treated orally or topically with fluralaner had no mites visible during otoscopic examination at 28 days after treatment. At 14 days after treatment, only 1-2 mites were visible in three dogs (oral treatment: 2 dogs, topical treatment: 1 dog). All fluralaner-treated animals showed improvement in the amount of cerumen exudation compared with observations performed before treatment. No treatment related adverse events were observed in any dogs or cats enrolled in these studies. CONCLUSIONS:In this study, fluralaner administered topically to cats and orally or topically to dogs was highly effective against Otodectes cynotis mite infestations.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Taenzler J,de Vos C,Roepke RK,Frénais R,Heckeroth ARdoi
10.1186/s13071-016-1954-ysubject
Has Abstractpub_date
2017-01-16 00:00:00pages
30issue
1issn
1756-3305pii
10.1186/s13071-016-1954-yjournal_volume
10pub_type
杂志文章abstract:BACKGROUND:Many cases of cutaneous leishmaniasis (CL) have been recorded in the Jenin District based on their clinical appearance. Here, their parasites have been characterized in depth. METHODS:Leishmanial parasites isolated from 12 human cases of CL from the Jenin District were cultured as promastigotes, whose DNA w...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-121
更新日期:2012-06-18 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2228-z
更新日期:2017-06-17 00:00:00
abstract:BACKGROUND:Surveillance of outdoor resting malaria vector populations is crucial to monitor possible changes in vector resting and feeding behaviour following the widespread use of indoor-based vector control interventions. However, it is seldom included in the routine vector surveillance system in Africa due to lack o...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3535-3
更新日期:2019-05-31 00:00:00
abstract:BACKGROUND:Toxoplasmosis is one of the most common parasitic zoonoses. The seroprevalence of Toxoplasma gondii infection in humans varies widely worldwide. Detection of Toxoplasma-specific antibodies has been a gold standard method for both epidemiological investigation and clinical diagnosis. Genetic investigation ind...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-241
更新日期:2013-08-20 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0579-2
更新日期:2014-12-12 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-207
更新日期:2012-09-21 00:00:00
abstract:BACKGROUND:Dirofilaria immitis and Dirofilaria repens are transmitted by bloodsucking culicid mosquitoes belonging to Culex, Aedes, Ochlerotatus, Anopheles and Mansonia genera. The detection of filarioids in mosquitoes for assessing distribution of vectors and/or of pathogens in a given area (also known as "xenomonitor...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-76
更新日期:2012-04-20 00:00:00
abstract:BACKGROUND:Because agriculture and offshore oil extraction are significant economic activities in the southern Gulf of Mexico, high concentrations of nutrients and hydrocarbons are expected. As parasite communities are sensitive to environmental impacts, these contaminants should have an effect on metrics such as speci...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0541-3
更新日期:2014-11-27 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04134-x
更新日期:2020-05-19 00:00:00
abstract:BACKGROUND:Liver fluke (Fasciola hepatica) is a widespread parasite of ruminants which can have significant economic impact on cattle production. Fluke infection status at the animal-level is captured during meat inspection of all animals processed for human consumption within Northern Ireland. These national datasets ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1489-2
更新日期:2016-04-14 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-271
更新日期:2013-09-19 00:00:00
abstract:BACKGROUND:Schistosomiasis studies in western Kenya have mainly focused on the intestinal form, with evidence of urinary schistosomiasis remaining anecdotal. Detailed disease mapping has been carried out predominantly along the shores of Lake Victoria, but there is a paucity of information on intestinal and urinary sch...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-125
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2864-y
更新日期:2018-05-29 00:00:00
abstract:BACKGROUND:We investigated the prevalence, risk factors, and clinical manifestations of schistosomiasis in White Nile State, Sudan, to determine the local characteristics of schistosomiasis in the White Nile River basin. METHODS:Urine and stool samples were collected from 338 students (176 boys, 162 girls) at three pr...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0478-6
更新日期:2014-10-15 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-274
更新日期:2014-06-19 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3672-8
更新日期:2019-08-23 00:00:00
abstract:BACKGROUND:In Lithuania, the first case of canine subcutaneous dirofilariosis was recorded in 2010. Since then, an increasing number of cases of canine dirofilariosis have been documented in different veterinary clinics throughout the country. Human dirofilariosis was diagnosed in Lithuania for the first time in Septem...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3406-y
更新日期:2019-04-18 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2407-y
更新日期:2017-10-24 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1366-z
更新日期:2016-02-11 00:00:00
abstract:BACKGROUND:The current study shows the results of three years of IRS entomological monitoring (2016, before intervention; 2017 and 2018, after intervention) performed in Alibori and Donga, northern Benin. METHODS:Mosquito collections were performed on a monthly basis using human landing catches and pyrethrum spray cat...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3865-1
更新日期:2019-12-30 00:00:00
abstract::The need to discover new treatments for human schistosomiasis has been an important driver for molecular research on schistosomes, a major breakthrough being the publication of the Schistosoma mansoni and Schistosoma japonicum genomes in 2009. This 'Primer' considers recent advances in the understanding of schistosome...
journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2011-10-20 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-398
更新日期:2014-08-28 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2745-4
更新日期:2018-03-06 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04483-7
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Antigen B (EgAgB) is an abundant lipoprotein released by the larva of the cestode Echinococcus granulosus into the host tissues. Its protein moiety belongs to the cestode-specific family known as hydrophobic ligand binding protein (HLBP), and is encoded by five gene subfamilies (EgAgB8/1-EgAgB8/5). The funct...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1350-7
更新日期:2016-02-04 00:00:00
abstract:BACKGROUND:Two hemoplasma species, Mycoplasma suis and M. parvum, previously known as Eperythrozoon suis and E. parvum, respectively, have been identified in pigs. Swine hemoplasmosis is a global problem, and M. suis infection results in economic losses to pig producers worldwide. This study investigated the frequency ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3638-x
更新日期:2019-07-29 00:00:00
abstract:BACKGROUND:Arthropod-borne diseases are some of the most rapidly spreading diseases. Reducing the vector population is currently the only effective way to reduce case numbers. Central metabolic pathways are potential targets to control vector populations, but have not been well explored to this aim. The information ava...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1391-y
更新日期:2016-02-25 00:00:00
abstract:BACKGROUND:The G subfamily of ABC (ATP-binding cassette) transporters of Leishmania include 6 genes (ABCG1-G6), some with relevant biological functions associated with drug resistance and phospholipid transport. Several studies have shown that Leishmania LABCG2 transporter plays a role in the exposure of phosphatidylse...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2198-1
更新日期:2017-05-30 00:00:00
abstract:BACKGROUND:Lyme borreliosis is the most common tick-borne human disease and is caused by Borrelia burgdorferi sensu lato (s.l.). Borrelia miyamotoi, a relapsing fever spirochaete, is transmitted transovarially, whereas this has not been shown for B. burgdorferi (s.l). Therefore, B. burgdorferi (s.l) is considered to cy...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1389-5
更新日期:2016-02-20 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1481-x
更新日期:2016-05-31 00:00:00