Abstract:
BACKGROUND:Fluralaner is a novel isoxazoline eliciting both acaricidal and insecticidal activity through potent blockage of GABA- and glutamate-gated chloride channels. The aim of the study was to investigate the susceptibility of juvenile stages of common tick species exposed to fluralaner through either contact (Rhipicephalus sanguineus) or contact and feeding routes (Ornithodoros moubata). METHODS:Fluralaner acaricidal activity through both contact and feeding exposure was measured in vitro using two separate testing protocols. Acaricidal contact activity against Rhipicephalus sanguineus life stages was assessed using three minute immersion in fluralaner concentrations between 50 and 0.05 μg/mL (larvae) or between 1000 and 0.2 μg/mL (nymphs and adults). Contact and feeding activity against Ornithodoros moubata nymphs was assessed using fluralaner concentrations between 1000 to 10(-4) μg/mL (contact test) and 0.1 to 10(-10) μg/mL (feeding test). Activity was assessed 48 hours after exposure and all tests included vehicle and untreated negative control groups. RESULTS:Fluralaner lethal concentrations (LC₅₀, LC₉₀/₉₅) were defined as concentrations with either 50%, 90% or 95% killing effect in the tested sample population. After contact exposure of R. sanguineus life stages lethal concentrations were (μg/mL): larvae - LC₅₀ 0.7, LC₉₀ 2.4; nymphs - LC₅₀ 1.4, LC₉₀ 2.6; and adults - LC₅₀ 278, LC₉₀ 1973. After exposure of O. moubata nymphs to fluralaner lethal concentrations were (μg/mL): contact exposure - LC₅₀ 720, LC₉₅ 1133; and feeding exposure- LC₅₀ 0.00007, LC₉₅ 0.09. CONCLUSIONS:Fluralaner demonstrates potent in vitro acaricidal activity against all life stages of the brown dog tick, R.sanguineus. The testing of fluralaner contact and feeding routes using O. moubata nymphs demonstrates a high acaricidal activity in both exposure routes.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Williams H,Zoller H,Roepke RK,Zschiesche E,Heckeroth ARdoi
10.1186/s13071-015-0704-xsubject
Has Abstractpub_date
2015-02-08 00:00:00pages
90issn
1756-3305pii
10.1186/s13071-015-0704-xjournal_volume
8pub_type
杂志文章abstract:BACKGROUND:Alveolar echinococcosis (AE) is a lethal zoonosis caused by the fox-tapeworm Echinococcus multilocularis. The disease is difficult to treat and an effective therapeutic drug is urgently needed. Reliable models are essential for drug development. In this study, we developed both in vitro and in vivo models of...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1687-y
更新日期:2016-07-25 00:00:00
abstract:BACKGROUND:Equine trypanosomiases are complex infectious diseases with overlapping clinical signs defined by their mode of transmission. Despite their economic impacts, these diseases have been neglected by the scientific community, the veterinary authorities and regulatory organizations. To fill the observed knowledge...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04192-1
更新日期:2020-06-23 00:00:00
abstract:BACKGROUND:Chagas disease is caused by Trypanosoma cruzi, which is transmitted by triatomine vectors. The northeastern region of Brazil is endemic for Chagas disease and has the largest diversity of triatomine species. T. cruzi development in its triatomine vector depends on diverse factors, including the composition o...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0836-z
更新日期:2015-04-24 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04134-x
更新日期:2020-05-19 00:00:00
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pub_type: 杂志文章
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更新日期:2020-04-21 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-62
更新日期:2012-03-27 00:00:00
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pub_type: 杂志文章
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更新日期:2019-01-11 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2499-4
更新日期:2017-11-10 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3197-6
更新日期:2018-11-27 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2011-10-20 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2017-05-30 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3553-1
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0478-6
更新日期:2014-10-15 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2265-7
更新日期:2017-07-10 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3672-8
更新日期:2019-08-23 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-125
更新日期:2014-03-25 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0906-2
更新日期:2015-05-28 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2607-5
更新日期:2018-01-05 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1508-3
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journal_title:Parasites & vectors
pub_type: 杂志文章,随机对照试验
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2020-12-22 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2013-12-11 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2018-05-10 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-33
更新日期:2010-04-08 00:00:00
abstract:BACKGROUND:Susceptibility of Ae. aegypti mosquito to dengue virus (DENV) varies geographically and can be influenced by climatic factors such as temperature, which affect the incidence, seasonality and distribution of vector-borne diseases. The first outbreak of dengue fever (DF) in Kenya occured in 1982 in the coastal...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-435
更新日期:2014-09-15 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3817-9
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:Bravecto™ Chewable Tablets for Dogs, containing fluralaner as active ingredient, is an innovative treatment for flea and tick infestations that provides safe, rapid and long acting efficacy after a single oral administration in dogs. Topically applied fluralaner provides similar safe, rapid and long acting e...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1564-8
更新日期:2016-05-31 00:00:00
abstract:BACKGROUND:Melophagus ovinus (Diptera: Hippoboscidae), a hematophagous ectoparasite, is mainly found in Europe, Northwestern Africa, and Asia. This wingless fly infests sheep, rabbits, and red foxes, and causes inflammation, wool loss and skin damage. Furthermore, this parasite has been shown to transmit diseases, and ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1885-7
更新日期:2016-11-25 00:00:00
abstract:BACKGROUND:To date there has been no evidence of mosquito-borne virus transmission of public health concern in the UK, despite the occurrence of more than 30 species of mosquito, including putative vectors of arboviruses. The saltmarsh mosquito Ochlerotatus detritus [syn. Aedes (Ochlerotatus) detritus] is locally commo...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1739-3
更新日期:2016-08-15 00:00:00
abstract:BACKGROUND:The myxosporean parasite Parvicapsula pseudobranchicola commonly infects farmed Atlantic salmon in northern Norway. Heavy infections are associated with pseudobranch lesions, runting and mortality in the salmon populations. The life-cycle of the parasite is unknown, preventing controlled challenge experiment...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2583-9
更新日期:2018-01-06 00:00:00