Abstract:
BACKGROUND:There is a continuing need for novel approaches to tick control in dogs. One such approach lies in the ability of lotilaner (Credelio™), an isoxazoline with a rapid onset of action, to provide sustained efficacy against ticks. Two studies were undertaken to confirm lotilaner's efficacy, at the minimum dose rate of 20 mg/kg, against the three most common tick species in Europe. METHODS:In each of two studies, 16 Beagle dogs, at least 6 months old, were ranked and blocked by tick counts from infestations placed approximately 1 week before treatment. Within blocks, dogs were randomized to receive either lotilaner flavoured chewable tablets at as close as possible to, but not less than the minimum dose rate of 20 mg/kg, or to be sham-treated controls. Study 1 assessed lotilaner efficacy against concurrent infestations with 50 (± 6) Rhipicephalus sanguineus and 70 (± 6) Ixodes ricinus; Study 2 infestations were with 50 (± 2) Dermacentor reticulatus. Infestations were performed on Day -2 with counts on Day 2, 48 (± 2) hours post-treatment. Post-treatment infestations were performed on Days 7, 14, 21, 28 and 35, and ticks were counted 48 (±2) hours post-infestations. Efficacy was determined by the percent reduction in mean live tick counts. RESULTS:Control group infestations for each tick species were adequate for assessing lotilaner efficacy at all assessment times. On Day 2 no live ticks were found on any lotilaner-treated dog. For subsequent counts, in Study 1 lotilaner was 100% effective in eliminating live I. ricinus and R. sanguineus on all but two occasions for each tick; on each of those occasions efficacy was sustained at greater than 98.0%. In Study 2, except for a single unattached live tick found on Day 16, efficacy against D. reticulatus was 100% at every post-treatment assessment. CONCLUSION:The high and sustained efficacy against the three common species of ticks in Europe, R. sanguineus, I. ricinus and D. reticulatus, demonstrates that lotilaner can be a valuable tool in the treatment of canine tick infestations. Lotilaner flavoured chewable tablets were well tolerated and effectiveness was sustained through at least 35 days.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Cavalleri D,Murphy M,Gorbea RL,Seewald W,Drake J,Nanchen Sdoi
10.1186/s13071-017-2477-xsubject
Has Abstractpub_date
2017-11-01 00:00:00pages
527issue
1issn
1756-3305pii
10.1186/s13071-017-2477-xjournal_volume
10pub_type
杂志文章,随机对照试验abstract:BACKGROUND:The abundance, richness and diversity of mosquitoes and aquatic insects associated with their oviposition sites were surveyed along eight states of the Pacific coast of Mexico. Diversity was estimated using the Shannon index (H'), similarity measures and cluster analysis. METHODS:Oviposition sites were samp...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-41
更新日期:2014-01-22 00:00:00
abstract:BACKGROUND:Toxoplasma gondii is an intracellular protozoan parasite that infects a wide variety of warm-blooded hosts, including humans. Limited information about T. gondii infection in bats is available in China. The objective of the present study was to determine prevalence and genetic characterization of T. gondii i...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0558-7
更新日期:2014-12-03 00:00:00
abstract:BACKGROUND:The Culex pipiens complex (Diptera: Culicidae) includes the most widespread mosquito species in the world. Members of this complex are the primary enzootic and epidemic vectors of the West Nile virus (genus Flavivirus) in several countries. The two recognized forms of Cx. pipiens (Linnaeus, 1758) - pipiens a...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2265-7
更新日期:2017-07-10 00:00:00
abstract:BACKGROUND:Leishmania infantum and Toxoplasma gondii are protozoa with zoonotic and economic importance. Prevalences of antibodies to these agents were assessed in 173 horses from the north of Portugal. FINDINGS:Antibodies to L. infantum were detected by the direct agglutination test (DAT); seven (4.0%) horses were se...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-178
更新日期:2013-06-17 00:00:00
abstract:BACKGROUND:Antigen B (EgAgB) is an abundant lipoprotein released by the larva of the cestode Echinococcus granulosus into the host tissues. Its protein moiety belongs to the cestode-specific family known as hydrophobic ligand binding protein (HLBP), and is encoded by five gene subfamilies (EgAgB8/1-EgAgB8/5). The funct...
journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2016-02-04 00:00:00
abstract:BACKGROUND:Understanding local Anopheles species compositions and bionomic traits are vital for an effective malaria vector intervention strategy. Though eight malaria vectors, including species complexes, have been documented across the island of Sulawesi, Indonesia, a comprehensive survey linking morphological and mo...
journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2017-07-19 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2010-08-16 00:00:00
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2012-09-04 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2565-y
更新日期:2017-12-19 00:00:00
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2016-07-25 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2019-08-27 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1012-1
更新日期:2015-07-24 00:00:00
abstract::The Companion Vector-Borne Diseases (CVBD) World Forum is a working group of leading international experts who meet annually to evaluate current scientific findings and future trends concerning the distribution, pathogenesis, clinical presentation, diagnosis and prevention of vector-borne infections of dogs and cats. ...
journal_title:Parasites & vectors
pub_type: 信件
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更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Release of gene-drive mutants to suppress Anopheles mosquito reproduction is a promising method of malaria control. However, many scientific, regulatory and ethical questions remain before transgenic mosquitoes can be utilised in the field. At a behavioural level, gene-drive carrying mutants should be at lea...
journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2020-10-07 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章,随机对照试验
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更新日期:2012-05-30 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2017-02-17 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2011-11-28 00:00:00