Abstract:
BACKGROUND:During a Plasmodium infection, exposure of human host immune cells to both the asexual and the sexual stages of the parasite elicit immune responses. These responses may be protective and prevent the development of high parasitaemia and its associated clinical symptoms, or block the transmission of malaria to an uninfected person. This study aimed at examining the dynamics of naturally acquired immune responses against the asexual and sexual forms of Plasmodium falciparum as well as assessing differences in the multiplicity of infection (MOI) in asymptomatic Ghanaian children living in two communities with varying malaria transmission intensities. METHODS:School children aged between 6 and 12 years were recruited from Obom, a high malaria prevalence setting and Abura, a low malaria prevalence setting and enrolled in monthly multiple cross sectional surveys between February and May 2015. Filter paper blood blots (DBS) as well as thick and thin blood smears were made from finger-pricked blood at each visit. Plasmodium falciparum parasite prevalence was determined by microscopy and PCR. Serum eluted from the DBS were used to assess anti-Pfs230 (sexual stage) and anti-MSP3 (asexual stage) antibody levels using indirect ELISA and DNA extracted from the DBS used to assess MOI. RESULTS:Malaria parasite point prevalence and MOI throughout the study was higher in Obom than Abura. The trend of parasite prevalence estimated by microscopy was similar to that determined by PCR in Obom but not in Abura. The trend of MSP3 antibody seroprevalence followed that of PCR-estimated parasite prevalence in Obom, while in Abura the trend of Pfs230 antibody seroprevalence followed that of PCR-estimated parasite prevalence. CONCLUSIONS:Microscopy can more accurately predict changes in parasite prevalence in high transmission settings than low transmission settings. In high transmission settings, P. falciparum parasite prevalence can predict antibody seroprevalence to MSP3, whilst in low transmission settings, seroprevalence against Pfs230 may be a useful predictor of parasite prevalence.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Amoah LE,Acquah FK,Ayanful-Torgby R,Oppong A,Abankwa J,Obboh EK,Singh SK,Theisen Mdoi
10.1186/s13071-017-2607-5subject
Has Abstractpub_date
2018-01-05 00:00:00pages
13issue
1issn
1756-3305pii
10.1186/s13071-017-2607-5journal_volume
11pub_type
杂志文章abstract::Here we describe a case of paediatric visceral leishmaniasis recorded in an infant initially suspected for acute lymphoblastic leukaemia due to the clinical and haematological presentation. Eventually the patient was found positive for Leishmania infantum infection and successfully treated. This case emphasises how pi...
journal_title:Parasites & vectors
pub_type: 信件
doi:10.1186/1756-3305-6-123
更新日期:2013-04-29 00:00:00
abstract:BACKGROUND:Both falciparum and vivax malaria were historically prevalent in China with high incidence. With the control efforts, the annual incidence in the whole country has reduced to 0.0001% except in some areas in the southern borders after 2000. Despite this, the re-emergence or outbreak of malaria was unavoidable...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-136
更新日期:2012-07-09 00:00:00
abstract:BACKGROUND:Effective and sustainable worm control in horses would benefit from detailed information about the current regional occurrence of tapeworms. Different diagnostic methods are currently available to detect Anoplocephala spp. infections in horses. However, the format as well as the sensitivity and specificity o...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04318-5
更新日期:2020-09-10 00:00:00
abstract:BACKGROUND:The relationship between the environment and infection of cattle with trematodes was studied at Arumeru District, Arusha Region, northern Tanzania. Randomly selected villages were grouped into three cattle management strata, (i) zero-grazing (ZZ) (ii) communal grazing without irrigation (ZC) and (iii) commun...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-107
更新日期:2014-03-20 00:00:00
abstract:BACKGROUND:The Cqm1 α-glucosidase of Culex quinquefasciatus larvae acts as the midgut receptor for the binary toxin of the biolarvicide Lysinibacillus sphaericus. Mutations within the cqm1 gene can code for aberrant polypeptides that can no longer be properly expressed or bind to the toxin, leading to insect resistance...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1347-2
更新日期:2016-02-04 00:00:00
abstract:BACKGROUND:The protozoan Giardia duodenalis is a common but highly diverse human parasite that comprises a complex of seven morphologically identical genetic assemblages, further divided into sub-assemblages. There is very little information available on the diversity of Giardia sub-assemblages and multi-locus genotype...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1059-z
更新日期:2015-09-04 00:00:00
abstract::Since the implementation of Roll Back Malaria, the widespread use of insecticide-treated nets (ITNs) and indoor residual spraying (IRS) is thought to have played a major part in the decrease in mortality and morbidity achieved in malaria-endemic regions. In the past decade, resistance to major classes of insecticides ...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-020-04170-7
更新日期:2020-06-10 00:00:00
abstract:BACKGROUND:Chagas disease transmission risk is a function of the presence of triatomines in domestic habitats. Rhodnius ecuadoriensis is one of the main vectors implicated in transmission of Trypanosoma cruzi in Ecuador. This triatomine species is present in domestic, peridomestic and sylvatic habitats in the country. ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-17
更新日期:2012-01-13 00:00:00
abstract:BACKGROUND:Cutaneous leishmaniasis (CL) is endemic in the highlands of Ethiopia, and almost always caused by Leishmania aethiopica. Hitherto, Addis Ababa (the capital city of Ethiopia) was not considered endemic for CL, mainly due to absence of epidemiological and field ecological studies. This report summarizes the pr...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-2-60
更新日期:2009-12-02 00:00:00
abstract::Acaricidal (tick) and insecticidal (flea) efficacy of systemically and cutaneously distributed ectoparasiticide products for dogs are compared based on permethrin and fluralaner as representative molecules. Results of efficacy studies against fleas and ticks are reviewed that show generally good to excellent results. ...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-016-1719-7
更新日期:2016-08-08 00:00:00
abstract:BACKGROUND:Blackflies (Diptera: Simuliidae) are known as effective vectors of human and animal pathogens, worldwide. We have already indicated that some individuals in the Simulium turgaicum complex are annoying pests of humans and livestock in the Aras River Basin, Iran. However, there is no evidence of host preferenc...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04432-4
更新日期:2020-11-04 00:00:00
abstract:BACKGROUND:Novel transgenic mosquito control methods require progressively more realistic evaluation. The goal of this study was to determine the effect of a transgene that causes a male-bias sex ratio on Anopheles gambiae target populations in large insectary cages. METHODS:Life history characteristics of Anopheles g...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3289-y
更新日期:2019-02-06 00:00:00
abstract:BACKGROUND:Zoonotic onchocerciasis is a vector-borne disease, which involves many animal species, including large ungulates, boars, dogs, and sporadically, humans. So far, 39 cases of zoonotic onchocerciasis have been reported worldwide, 30 of which have been found in the last 20 years. Onchocerca nematodes are transmi...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-3925-6
更新日期:2020-02-12 00:00:00
abstract:BACKGROUND:Leishmania infantum infections in dogs play a crucial role in the transmission of pathogens causing visceral leishmaniasis to humans in the Gansu province, northwest China. To be able to control zoonotic transmission of the parasite to humans, a non-invasive loop-mediated isothermal amplification (LAMP) assa...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0991-2
更新日期:2015-07-15 00:00:00
abstract:BACKGROUND:Lymphatic filariasis (LF) due to Wuchereria bancrofti is being eliminated from Oceania under the Pacific Elimination of Lymphatic Filariasis Programme. LF was endemic in Solomon Islands but in the 2010-2020 Strategic Plan of the Global Programme to Eliminate LF, Solomon Islands was listed as non-endemic for ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-218
更新日期:2013-07-26 00:00:00
abstract:BACKGROUND:The molecular structure of Fasciola gigantica 14-3-3 protein has been characterized. However, the involvement of this protein in parasite pathogenesis remains elusive and its effect on the functions of innate immune cells is unknown. We report on the cloning and expression of a recombinant F. gigantica 14-3-...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2745-4
更新日期:2018-03-06 00:00:00
abstract:BACKGROUND:To date there has been no evidence of mosquito-borne virus transmission of public health concern in the UK, despite the occurrence of more than 30 species of mosquito, including putative vectors of arboviruses. The saltmarsh mosquito Ochlerotatus detritus [syn. Aedes (Ochlerotatus) detritus] is locally commo...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1739-3
更新日期:2016-08-15 00:00:00
abstract:BACKGROUND:Bovine besnoitiosis, caused by the apicomplexan parasite Besnoitia besnoiti, is a chronic and debilitating cattle disease that notably impairs fertility. Acutely infected bulls may develop respiratory signs and orchitis, and sterility has been reported in chronic infections. However, the pathogenesis of acut...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-3959-9
更新日期:2020-03-02 00:00:00
abstract:BACKGROUND:The pork tapeworm, Taenia solium, is a serious public health problem in rural low-resource areas of Latin America, Africa and Asia, where the associated conditions of nuerocysticercosis (NCC) and porcine cysticercosis cause substantial health and economic harms. An accurate and validated transmission model f...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04226-8
更新日期:2020-07-24 00:00:00
abstract:BACKGROUND:Thelazia callipaeda is transmitted by Phortica variegata, a drosophilid that feeds on lachrymal secretions of mammals. Scientific information on human thelaziosis is still relatively limited, mainly for physicians and ophthalmologists. Indeed, the literature is full of misleading information on the transmiss...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0881-7
更新日期:2015-05-14 00:00:00
abstract:BACKGROUND:Ticks are increasingly reported on cats worldwide, with Ixodes ricinus being a relevant species across Europe and in near by areas of North Africa and the Middle East. Yet there are few acaracidal products with proven efficacy approved for use in cats. The objective of this study was to compare the efficacy ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2259-5
更新日期:2017-06-29 00:00:00
abstract:BACKGROUND:Spatial repellents that drive mosquitoes away from treated areas, and odour-baited traps, that attract and kill mosquitoes, can be combined and work synergistically in a push-pull system. Push-pull systems have been shown to reduce house entry and outdoor biting rates of malaria vectors and so have the poten...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04263-3
更新日期:2020-07-31 00:00:00
abstract:BACKGROUND:Prevalence of lymphatic filariasis (LF) antigen in American Samoa was 16.5% in 1999. Seven rounds of mass drug administration (MDA) programmes between 2000 and 2006 reduced antigen prevalence to 2.3%. The most efficient methods of surveillance after MDA are not clear, but testing specific at-risk groups such...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-3996-4
更新日期:2020-03-12 00:00:00
abstract:BACKGROUND:Henneguya Thélohan, 1892 (Myxobolidae) is one of the most species-rich genera of myxosporean parasites infecting fish. Although common in nature, there are few reports of these parasites causing important disease in aquaculture. In this paper, we describe a new species of Henneguya infecting Pagrus major (Te...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-3888-7
更新日期:2020-01-14 00:00:00
abstract:BACKGROUND:A question of epidemiological relevance in Chagas disease studies is to understand Trypanosoma cruzi transmission cycles and trace the origins of (re)emerging cases in areas under vector or disease surveillance. Conventional parasitological methods lack sensitivity whereas molecular approaches can fill in th...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3817-9
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:In the Eastern and Upper Midwestern regions of North America, Ixodes scapularis (L.) is the most abundant tick species encountered by humans and the primary vector of B. burgdorferi, whereas in the southeastern region Amblyomma americanum (Say) is the most abundant tick species encountered by humans but cann...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-139
更新日期:2012-07-10 00:00:00
abstract:BACKGROUND:West Nile virus (WNV) is a Flavivirus transmitted to vertebrate hosts by mosquitoes, maintained in nature through an enzootic bird-mosquito cycle. In Europe the virus became of major public health and veterinary concern in the 1990s. In Italy, WNV re-emerged in 2008, ten years after the previous outbreak and...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1031-y
更新日期:2015-08-13 00:00:00
abstract:BACKGROUND:Blastocystis sp. is one of the most prevalent parasites found in human stool and has been recently considered an opportunistic emerging pathogen in immunocompromised individuals. However, cases of invasive intestinal infections and skin rashes have been attributed to infection by Blastocystis sp in immunocom...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-207
更新日期:2014-04-29 00:00:00
abstract:BACKGROUND:The studies reported here were conducted to ascertain the efficacy of imidacloprid/flumethrin incorporated in a slow-release matrix collar, against infestations of dogs by fleas, ticks, mites and lice. Efficacy was evaluated against the flea Ctenocephalides felis felis, the ticks Rhipicephalus sanguineus, Ix...
journal_title:Parasites & vectors
pub_type: 杂志文章,随机对照试验
doi:10.1186/1756-3305-5-102
更新日期:2012-05-30 00:00:00
abstract:BACKGROUND:Mosquitoes of the Culex pipiens complex, competent vectors for West Nile virus (WNV) and Rift Valley fever virus (RVFV) are widely targeted by insecticide treatments. The intensive application of chemical insecticides led to the development of resistance in many insects including Culex pipiens mosquitoes. Th...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1931-5
更新日期:2016-12-16 00:00:00