Abstract:
BACKGROUND:Novel transgenic mosquito control methods require progressively more realistic evaluation. The goal of this study was to determine the effect of a transgene that causes a male-bias sex ratio on Anopheles gambiae target populations in large insectary cages. METHODS:Life history characteristics of Anopheles gambiae wild type and Ag(PMB)1 (aka gfp124L-2) transgenic mosquitoes, whose progeny are 95% male, were measured in order to parameterize predictive population models. Ag(PMB)1 males were then introduced at two ratios into large insectary cages containing target wild type populations with stable age distributions and densities. The predicted proportion of females and those observed in the large cages were compared. A related model was then used to predict effects of male releases on wild mosquitoes in a west African village. RESULTS:The frequency of transgenic mosquitoes in target populations reached an average of 0.44 ± 0.02 and 0.56 ± 0.02 after 6 weeks in the 1:1 and in the 3:1 release ratio treatments (transgenic male:wild male) respectively. Transgenic males caused sex-ratio distortion of 73% and 80% males in the 1:1 and 3:1 treatments, respectively. The number of eggs laid in the transgenic treatments declined as the experiment progressed, with a steeper decline in the 3:1 than in the 1:1 releases. The results of the experiment are partially consistent with predictions of the model; effect size and variability did not conform to the model in two out of three trials, effect size was over-estimated by the model and variability was greater than anticipated, possibly because of sampling effects in restocking. The model estimating the effects of hypothetical releases on the mosquito population of a West African village demonstrated that releases could significantly reduce the number of females in the wild population. The interval of releases is not expected to have a strong effect. CONCLUSIONS:The biological data produced to parameterize the model, the model itself, and the results of the experiments are components of a system to evaluate and predict the performance of transgenic mosquitoes. Together these suggest that the Ag(PMB)1 strain has the potential to be useful for reversible population suppression while this novel field develops.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Facchinelli L,North AR,Collins CM,Menichelli M,Persampieri T,Bucci A,Spaccapelo R,Crisanti A,Benedict MQdoi
10.1186/s13071-019-3289-ysubject
Has Abstractpub_date
2019-02-06 00:00:00pages
70issue
1issn
1756-3305pii
10.1186/s13071-019-3289-yjournal_volume
12pub_type
杂志文章abstract:BACKGROUND:Culex pipiens L. is the most widespread mosquito vector in temperate regions including North Africa. Cx. pipiens has two recognized forms or biotypes; pipiens and molestus are morphologically indistinguishable with distinct behavior and physiology that may influence their vectorial status. In our study, we p...
journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章
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abstract:BACKGROUND:Culicoides biting midges are biological vectors of arboviruses including bluetongue virus (BTV), Schmallenberg virus (SBV) and African horse sickness virus (AHSV). Zoos are home to a wide range of 'at risk' exotic and native species of animals. These animals have a high value both in monetary terms, conserva...
journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
pub_type: 信件
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2019-08-09 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2015-09-17 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2013-04-26 00:00:00