Abstract:
BACKGROUND:Intestinal protozoan parasites are major contributors to the global burden of gastrointestinal disease causing significant socioeconomic consequences. Children living in resource-poor settings with restricted access to water and sanitary services are particularly at risk of these infections. METHODS:A prospective, community-based, cross-sectional survey was conducted in Paraná (southern Brazil) between May 2015 and May 2016. A total of 766 stool samples were individually collected from volunteers (male/female ratio: 0.99; age range: 0-76 years) and used for investigating the presence of intestinal helminth and protozoan species by routine microscopic procedures including the Kato-Katz and modified Ritchie concentration methods and the Ziehl-Neelsen stain technique. Quantitative real-time PCR confirmed microscopy-positive samples for Giardia duodenalis and the assemblages and sub-assemblages determined by multilocus sequence-based genotyping of the glutamate dehydrogenase (gdh) and β-giardin (bg) genes of the parasite. Identification of Blastocystis subtypes was carried out by amplification and sequencing of a partial fragment of the small-subunit ribosomal RNA gene (SSU rDNA) of this heterokont microorganism. RESULTS:Overall, 46.1% (353/766) of the participants were infected/colonised by at least one intestinal parasite/commensal species. Protozoan and helminth species were detected in 42.7% and 10.1% of the surveyed population, respectively. Blastocystis sp. (28.2%), Endolimax nana (14.9%), and Giardia duodenalis (11.0%) were the most prevalent species found among protozoans and Ascaris lumbricoides (5.0%), Trichuris trichiura (4.6%) and hookworms (1.0%) among helminths. A total of 38 G. duodenalis-positive samples were genotyped at gdh and bg markers, revealing the presence of the sub-assemblages AII (47.4%), AII/AIII (2.6%), BIII (5.3%), BIV (26.3%) and BIII/BIV (13.1%). Two samples (5.3%) were only identified as assemblage B. AII was predominantly found in females aged 5-9 years and was associated with a higher likelihood of reporting gastrointestinal symptoms. A total of 102 Blastocystis-positive samples were successfully subtyped at the SSU rRNA gene revealing the presence of ST1 (36.3%), ST2 (15.7%), ST3 (41.2%), ST4 (2.9%), ST6 (1.0%) and ST8 (2.9%). CONCLUSIONS:Data presented here indicate that enteric parasites still represent a pressing health concern in Paraná, Brazil, probably due to sub-optimal water, sanitation and hygiene conditions. A mostly anthroponotic origin is suspected for G. duodenalis and Blastocystis sp. infections.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Seguí R,Muñoz-Antoli C,Klisiowicz DR,Oishi CY,Köster PC,de Lucio A,Hernández-de-Mingo M,Puente P,Toledo R,Esteban JG,Carmena Ddoi
10.1186/s13071-018-3054-7subject
Has Abstractpub_date
2018-08-30 00:00:00pages
490issue
1issn
1756-3305pii
10.1186/s13071-018-3054-7journal_volume
11pub_type
杂志文章abstract:BACKGROUND:Toxoplasma gondii is prevalent in most areas of the world and may cause abortions or neonatal complications in humans. As the only definitive host, cats play an important role in the epidemiology of the disease. Infection rates in cats, especially stray or free-living cats, are considered to be the best sent...
journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
pub_type: 杂志文章,meta分析,评审
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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abstract:BACKGROUND:Aedes albopictus, the Asian tiger mosquito, is an exotic invasive species in Europe. It has substantial public health relevance due to its potential role in transmitting several human pathogens. Out of the European countries, Spain has one of the highest risk levels of autochthonous arbovirus transmission du...
journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章,评审
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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