Abstract:
BACKGROUND:National deworming programmes rely almost exclusively on mass drug administration (MDA) to children to control morbidity caused by these parasitic infections. The provision of other interventions, consisting of preventive chemotherapy at high population level coverage together with water, sanitation and hygiene (WaSH) and changes in risk behaviour, should enable sustainable control of soil-transmitted helminths (STH) and schistosomiasis and ultimately interrupt transmission. METHODS/DESIGN:Two interventions will be implemented by the project: (i) community-wide biannual albendazole and annual praziquantel treatment with a target of 80-90% treatment coverage ("expanded MDA"); and (ii) provision of WaSH with behaviour change communication (BCC), within the Wolaita zone, Ethiopia. The project has three study arms: (i) expanded community-wide MDA, WaSH and BCC; (ii) expanded community-wide MDA only; and (iii) annual school-based MDA (the current National STH/schistosomiasis Control Programme). The impact of these interventions will be evaluated through prevalence mapping at baseline and endline (after four rounds of MDA), combined with annual longitudinal parasitological surveillance in defined cohorts of people to monitor trends in prevalence and reinfection throughout the project. Treatment coverage and individual compliance to treatment will be monitored by employing fingerprint biometric technology and barcoded identification cards at treatment. WaSH utilisation will be evaluated through school and household level observations and annual WaSH assessment survey. Complementary qualitative surveys will explore practices, cultural and social drivers of risk behaviours, uptake of WaSH and treatment, and assessing the impact of the BCC. DISCUSSION:The study has the potential to define an 'End Game' for STH and schistosomiasis programmes through provision of multiple interventions. Interrupting transmission of these infections would eliminate the need for long-term repeated MDA, lead to sustained health improvements in children and adults, thereby allowing health systems to focus on other disease control priorities.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Mekete K,Ower A,Dunn J,Sime H,Tadesse G,Abate E,Nigussu N,Seife F,McNaughton E,Anderson RM,Phillips AEdoi
10.1186/s13071-019-3757-4subject
Has Abstractpub_date
2019-10-29 00:00:00pages
503issue
1issn
1756-3305pii
10.1186/s13071-019-3757-4journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Preventive chemotherapy with donated anthelminthic drugs is the cornerstone for the control of helminthiases. However, reinfection can occur rapidly in the absence of clean water and sanitation coupled with unhygienic behaviour. The purpose of this study was to assess the effect of an integrated package of i...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2642-x
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:Rickettsiae are emerging pathogens causing public health problems in many countries around the world. Rickettsia spp. are found in association with a wide range of arthropods which feed on different species of animals. However, the distribution and natural cycle of Rickettsia species and their association wi...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2947-9
更新日期:2018-06-28 00:00:00
abstract:BACKGROUND:Studies of avian haemosporidians allow understanding how these parasites affect wild bird populations, and if their presence is related to factors such as habitat loss, degradation and fragmentation, and climate change. Considering the importance of the highland Plateau of Mexico as part of the North America...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1569-3
更新日期:2016-05-27 00:00:00
abstract:BACKGROUND:Tick-borne infections are no longer confined to rural areas, they are documented with increasing frequency in urban settlements across the world. They are known to cause diseases in humans as well as in their companion animals. METHODS:During a period of 2 years, from January 2013 until December 2014, ticks...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1632-0
更新日期:2016-06-21 00:00:00
abstract:BACKGROUND:Diagnostic procedures for the diagnosis of infection with the nematode parasite Onchocerca volvulus are currently based on the microscopic detection of microfilariae in skin biopsies. Alternative approaches based on amplification of parasitic DNA in these skin biopsies are currently being explored. Mostly th...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1913-7
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Zoonotic leishmaniosis, caused by the protozoan Leishmania infantum, is a public and animal health problem in Asia, Central and South America, the Middle East and the Mediterranean Basin. Several phlebotomine sand fly species from the subgenus Larroussius are vectors of L. infantum. Data from dogs living in ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3376-0
更新日期:2019-03-26 00:00:00
abstract:BACKGROUND:Investigating malaria transmission dynamics is essential to inform policy decision making. Whether multiplicity of infection (MOI) dynamic from individual infections could be a reliable malaria metric in high transmission settings with marked variation in seasons of malaria transmission has been poorly asses...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04302-z
更新日期:2020-08-20 00:00:00
abstract:BACKGROUND:Ticks are increasingly reported on cats worldwide, with Ixodes ricinus being a relevant species across Europe and in near by areas of North Africa and the Middle East. Yet there are few acaracidal products with proven efficacy approved for use in cats. The objective of this study was to compare the efficacy ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2259-5
更新日期:2017-06-29 00:00:00
abstract:BACKGROUND:With field releases starting in Brazil, particular interest must be given to understanding how the endosymbiotic bacterium Wolbachia pipientis affects Aedes aegypti mosquitoes with a Brazilian genetic background. Currently, there is limited information on how the bacterium affects phenotypic traits such as l...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1559-5
更新日期:2016-05-16 00:00:00
abstract:BACKGROUND:Tick infestation is the major problem for animal health that causes substantial economic losses, particularly in tropical and subtropical countries. To better understand the spatial distribution of tick species and risk factors associated with tick prevalence in livestock in Pakistan, ticks were counted and ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2138-0
更新日期:2017-04-19 00:00:00
abstract:BACKGROUND:Resistance to chemical insecticides plus high morbidity rates have lead to rising interest in fungi as candidates for biocontrol agents of mosquito vectors. In most studies fungal infections have been induced by exposure of mosquitoes to various surfaces treated with conidia. In the present study eight Mexic...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-24
更新日期:2011-02-26 00:00:00
abstract:BACKGROUND:Natural compounds from plants are known to provide a source of anthelmintic molecules. In previous studies, we have shown that plant extracts from the plant Picria fel-terrae Lour. and particular fractions thereof have activity against the free-living nematode Caenorhabditis elegans, causing quite pronounced...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3429-4
更新日期:2019-04-25 00:00:00
abstract:BACKGROUND:The transmission of malaria is heterogeneous, and varies due to altitude. The information on whether the transmission of malaria is indigenous or imported to highland areas is scarce. Therefore, this study aimed to assess the species composition and infection rates of Anopheles at different altitudinal trans...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2288-0
更新日期:2017-07-19 00:00:00
abstract:BACKGROUND:Blastocystis spp. are the most prevalent intestinal eukaryotes identified in humans, with at least 17 genetic subtypes (ST) based on genes coding for the small-subunit ribosomal RNA (18S). It has been argued that the 18S gene should not be the marker of choice to discriminate between STs of these strains bec...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3141-9
更新日期:2018-10-29 00:00:00
abstract:BACKGROUND:Mosquito-borne arboviruses, like dengue virus, continue to cause significant global morbidity and mortality, particularly in Southeast Asia. When the infectious mosquitoes probe into human skin for a blood meal, they deposit saliva containing a myriad of pharmacologically active compounds, some of which alte...
journal_title:Parasites & vectors
pub_type: 临床试验,杂志文章
doi:10.1186/s13071-018-3224-7
更新日期:2018-12-20 00:00:00
abstract:BACKGROUND:This study was carried out to develop a health education learning package (HELP) about soil-transmitted helminth (STH) infections, and to evaluate what impact such a package could have in terms of reducing the incidence and intensity of STH infections among Orang Asli schoolchildren in Pahang, Malaysia. MET...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-416
更新日期:2014-09-02 00:00:00
abstract:BACKGROUND:Sheep scab is a highly contagious disease of sheep caused by the ectoparasitic mite Psoroptes ovis. The disease is endemic in the UK and has significant economic impact through its effects on performance and welfare. Diagnosis of sheep scab is achieved through observation of clinical signs e.g. itching, prur...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-7
更新日期:2012-01-10 00:00:00
abstract::Mosquito salivary proteins are involved in several biological processes that facilitate their blood feeding and have also been reported to elicit an IgG response in vertebrates. A growing number of studies have focused on this immunological response for its potential use as a biological marker of exposure to arthropod...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-33
更新日期:2011-03-08 00:00:00
abstract:BACKGROUND:Tick-borne relapsing fevers of humans are caused by spirochetes that must adapt to both warm-blooded vertebrates and cold-blooded ticks. In western North America, most human cases of relapsing fever are caused by Borrelia hermsii, which cycles in nature between its tick vector Ornithodoros hermsi and small m...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1170-1
更新日期:2015-10-21 00:00:00
abstract:BACKGROUND:Quantification of malaria heterogeneity is very challenging, partly because of the underlying characteristics of mosquitoes and also because malaria is an environmentally driven disease. Furthermore, in order to assess the spatial and seasonal variability in malaria transmission, vector data need to be colle...
journal_title:Parasites & vectors
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doi:10.1186/s13071-015-0679-7
更新日期:2015-02-22 00:00:00
abstract:BACKGROUND:Leishmaniasis represents an important public health problem in Brazil. The continuous process of urbanization and expansion of human activities in forest areas impacts natural habitats, modifying the ecology of some species of Leishmania, as well as its vectors and reservoirs and, consequently, changes the e...
journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2018-03-07 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3108-x
更新日期:2018-09-20 00:00:00
abstract::Onchocerciasis (river blindness) is a blinding parasitic disease that threatens the health of approximately 120 million people worldwide. While 99% of the population at-risk for infection from onchocerciasis live in Africa, some 500,000 people in the Americas are also threatened by infection. A relatively recent arriv...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/1756-3305-4-205
更新日期:2011-10-25 00:00:00
abstract:BACKGROUND:Understanding the variation in prevalence of Borrelia burgdorferi sensu lato (Lyme Borreliosis Spirochaetes, LBS) and Anaplasma phagocytophilum (causing tick-borne fever in ruminants and human granulocytic ehrlichiosis) in ticks is vital from both a human and an animal disease perspective to target the most ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-187
更新日期:2013-06-20 00:00:00
abstract:BACKGROUND:Malaria transmission in Cameroon is mediated by a plethora of vectors that are heterogeneously distributed across the country depending on the biotope. To effectively guide malaria control operations, regular update on the role of local Anopheles species is essential. Therefore, an entomological survey was c...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-262
更新日期:2014-06-05 00:00:00
abstract:BACKGROUND:The present study was conducted to investigate the serological survey of Toxoplasma antibodies in local.horses from three major regions: a neighbourhood of a city in the North (Sidi Thabet), a neighbourhood of a city on the coast (Monastir) and a neighbourhood of a city in the middle (Battan) of Tunisia (Nor...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-218
更新日期:2011-11-22 00:00:00
abstract:BACKGROUND:Schistosoma mansoni cercariae penetrate the skin by releasing excretory/secretory (E/S) products known as 0-3hRP, which are associated with immune modulation through Toll like receptor (TLR) signalling. Furthermore, these secretions contain Sm16, which when given to cells as a recombinant protein inhibits hu...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0608-1
更新日期:2015-01-06 00:00:00
abstract:BACKGROUND:Bovine besnoitiosis, caused by the protozoan Besnoitia besnoiti, reduces productivity and fertility of affected herds. Besnoitiosis continues to expand in Europe and no effective control tools are currently available. Experimental models are urgently needed. Herein, we describe for the first time the kinetic...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1405-9
更新日期:2016-02-29 00:00:00
abstract:BACKGROUND:Canine vector-borne diseases (CVBDs) are caused by a wide range of pathogens transmitted to dogs by arthropods including ticks and insects. Many CVBD-agents are of zoonotic concern, with dogs potentially serving as reservoirs and sentinels for human infections. The present study aimed at assessing the seropr...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-62
更新日期:2012-03-27 00:00:00
abstract:BACKGROUND:The two most abundant sand fly species on the Honduran Pacific coast are Lutzomyia (Lutzomyia) longipalpis and Pintomyia (Pifanomyia) evansi. Both species are known vectors of Leishmania (Leishmania) infantum, the etiological agent of visceral leishmaniasis (VL) in the Americas. Although VL and non-ulcerativ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04462-y
更新日期:2020-11-23 00:00:00