当前位置： SCI文献检索 > Parasites & Vectors期刊下所有文献 > Changes in the immune system in experimental acanthamoebiasis in immunocompetent and immunosuppressed hosts.

Changes in the immune system in experimental acanthamoebiasis in immunocompetent and immunosuppressed hosts.

Abstract：

BACKGROUND:Acanthamoebiasis is most often found in patients with immune deficiency, with infections facilitated by the intake of immunosuppressive drugs. The host immune response to Acanthamoeba spp. infection is poorly understood. Thus, in this study, we aimed to examine the course of Acanthamoeba spp. infection taking into account the host's immunological status, including assessment of the hematological parameters, cytokine analysis, immunophenotypic changes in spleen populations, and histological spleen changes, which could help clarify some aspects of the immune response to acanthamoebiasis. In our experimental study, we used Acanthamoeba strain AM 22 isolated from the bronchoaspirate of a patient with acute myeloid leukaemia (AML) and atypical pneumonia symptoms. RESULTS:Acanthamoeba spp. affected the hematological parameters in immunocompetent and immunosuppressed mice and induced a change in spleen weight during infection. Moreover, analysis of anti-inflammatory (IL-4 and IL-10) and pro-inflammatory (IL-17A and IFN-γ) cytokines produced by splenocytes stimulated with concanavalin A demonstrated that Acanthamoeba spp. induced a selective Th1, Th2 and Th17 response at later stages of the infection in immunocompetent hosts. In the case of hosts with low immunity, Acanthamoeba elicited robust Th1 cell-mediated immunity without the participation of Th17. We observed suppression of CD8+ and CD4+ T lymphocytes and CD3+CD4-CD8- double-negative (DN) T lymphocyte populations in the beginning, and in the case of CD3+/CD4+/CD8+ double-positive (DP) T cells in the final phase of Acanthamoeba spp. infection in hosts with low immunity. Also, CD4+T lymphocytes and CD3+/CD4+ and CD3+/CD8+ lymphocyte counts during each stage of acanthamoebiasis were shown to be upregulated. CONCLUSIONS:We demonstrated that analysis of the immune response and pathogenesis mechanisms of clinical isolates of Acanthamoeba spp. in an animal model not only has purely cognitive significance but above all, may help in the development of effective methods of pharmacological therapy especially in patients with low immunity.

journal_name

Parasit Vectors

journal_title

Parasites & vectors

authors

Łanocha-Arendarczyk N,Kolasa-Wołosiuk A,Wojciechowska-Koszko I,Kot K,Roszkowska P,Krasnodębska-Szponder B,Paczkowska E,Machaliński B,Łuczkowska K,Wiszniewska B,Kosik-Bogacka D

doi

10.1186/s13071-018-3108-x

subject

Has Abstract

pub_date

2018-09-20 00:00:00

pages

517

issue

1

issn

1756-3305

pii

10.1186/s13071-018-3108-x

journal_volume

11

pub_type

杂志文章

相关文献

Parasites & Vectors文献大全
  • Evidence of multiple insecticide resistance mechanisms in Anopheles gambiae populations in Bangui, Central African Republic.

    abstract：BACKGROUND:Knowledge of insecticide resistance status in the main malaria vectors is an essential component of effective malaria vector control. This study presents the first evaluation of the status of insecticide resistance in Anopheles gambiae populations from Bangui, the Central African Republic. METHODS:Anopheles...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-016-1965-8

    authors： Olé Sangba ML,Sidick A,Govoetchan R,Dide-Agossou C,Ossè RA,Akogbeto M,Ndiath MO

    更新日期：2017-01-13 00:00:00

  • Schistosoma haematobium hotspots in south Nyanza, western Kenya: prevalence, distribution and co-endemicity with Schistosoma mansoni and soil-transmitted helminths.

    abstract：BACKGROUND:Schistosomiasis studies in western Kenya have mainly focused on the intestinal form, with evidence of urinary schistosomiasis remaining anecdotal. Detailed disease mapping has been carried out predominantly along the shores of Lake Victoria, but there is a paucity of information on intestinal and urinary sch...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/1756-3305-7-125

    authors： Sang HC,Muchiri G,Ombok M,Odiere MR,Mwinzi PN

    更新日期：2014-03-25 00:00:00

  • Prevalence and risk factors associated with ectoparasite infestation of buffaloes in an Amazonian ecosystem.

    abstract：BACKGROUND:The water buffalo (Bubalus bubalis) is well adapted in some regions of the Amazon. Of all Brazilian states, Pará contains the largest number of this species, with 510,000 animals, approximately 38% of the Brazilian buffaloes. Despite the socioeconomic importance of bubaline farming in the northern region, li...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-018-2917-2

    authors： Batista HR,Sarturi C,Stelmachtchuk FN,Oliveira DR,Morini AC,Gennari SM,Marcili A,Bastos FAN,Barata LES,Minervino AHH

    更新日期：2018-06-04 00:00:00

  • Insecticide resistance and target site mutations (G119S ace-1 and L1014F kdr) of Culex pipiens in Morocco.

    abstract：BACKGROUND:Control of the mosquito vector Culex pipiens with insecticides is the main way to control arboviruses that the species can transmit such as West Nile virus (WNV) and Rift Valley fever virus (RVFV). However, its efficiency has been hampered by the emergence of insecticide resistance. Little is known about the...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-018-2625-y

    authors： Tmimi FZ,Faraj C,Bkhache M,Mounaji K,Failloux AB,Sarih M

    更新日期：2018-01-22 00:00:00

  • Blastocystis sp. in splenic cysts: causative agent or accidental association? A unique case report.

    abstract：BACKGROUND:Blastocystis sp. is one of the most prevalent parasites found in human stool and has been recently considered an opportunistic emerging pathogen in immunocompromised individuals. However, cases of invasive intestinal infections and skin rashes have been attributed to infection by Blastocystis sp in immunocom...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/1756-3305-7-207

    authors： Santos HL,Sodré FC,de Macedo HW

    更新日期：2014-04-29 00:00:00

  • Malaria surveillance from both ends: concurrent detection of Plasmodium falciparum in saliva and excreta harvested from Anopheles mosquitoes.

    abstract：BACKGROUND:Malaria is the most important vector-borne disease in the world. Epidemiological and ecological studies of malaria traditionally utilize detection of Plasmodium sporozoites in whole mosquitoes or salivary glands by microscopy or serological or molecular assays. However, these methods are labor-intensive, and...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-019-3610-9

    authors： Ramírez AL,van den Hurk AF,Mackay IM,Yang ASP,Hewitson GR,McMahon JL,Boddey JA,Ritchie SA,Erickson SM

    更新日期：2019-07-18 00:00:00

  • Frontiers of parasitology research in the People's Republic of China: infection, diagnosis, protection and surveillance.

    abstract：:Control and eventual elimination of human parasitic diseases in the People's Republic of China (P.R. China) requires novel approaches, particularly in the areas of diagnostics, mathematical modelling, monitoring, evaluation, surveillance and public health response. A comprehensive effort, involving the collaboration o...

    journal_title：Parasites & vectors

    pub_type： 杂志文章,评审

    doi：10.1186/1756-3305-5-221

    authors： Chen JH,Wang H,Chen JX,Bergquist R,Tanner M,Utzinger J,Zhou XN

    更新日期：2012-10-04 00:00:00

  • First report outside Eastern Europe of West Nile virus lineage 2 related to the Volgograd 2007 strain, northeastern Italy, 2014.

    abstract：BACKGROUND:West Nile virus (WNV) is a Flavivirus transmitted to vertebrate hosts by mosquitoes, maintained in nature through an enzootic bird-mosquito cycle. In Europe the virus became of major public health and veterinary concern in the 1990s. In Italy, WNV re-emerged in 2008, ten years after the previous outbreak and...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-015-1031-y

    authors： Ravagnan S,Montarsi F,Cazzin S,Porcellato E,Russo F,Palei M,Monne I,Savini G,Marangon S,Barzon L,Capelli G

    更新日期：2015-08-13 00:00:00

  • How to become a successful invasive tapeworm: a case study of abandoned sexuality and exceptional chromosome diversification in the triploid carp parasite Atractolytocestus huronensis Anthony, 1958 (Caryophyllidea: Lytocestidae).

    abstract：BACKGROUND:A cytogenetic analysis of the new local triploid population of the caryophyllidean tapeworm Atractolytocestus huronensis, a unique parthenogenetic species with the ability to colonise new regions, was performed to understand the inner structure of its chromosome complement. METHODS:A karyotype analysis was ...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-019-3420-0

    authors： Špakulová M,Bombarová M,Miklisová D,Nechybová S,Langrová I

    更新日期：2019-04-11 00:00:00

  • Efficacy of lotilaner (Credelio™) against the adult cat flea, Ctenocephalides felis and flea eggs following oral administration to dogs.

    abstract：BACKGROUND:A blinded, randomized, negative controlled laboratory study was conducted to evaluate the efficacy of lotilaner (CredelioTM, Elanco) when administered orally to dogs, against experimentally induced adult flea infestations and flea egg production. METHODS:Twenty dogs were selected for the study and allocated...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-019-3873-1

    authors： Young L,Karadzovska D,Wiseman S,Helbig R

    更新日期：2020-01-14 00:00:00

  • Correction to: The tree that hides the forest: cryptic diversity and phylogenetic relationships in the Palaearctic vector Obsoletus/Scoticus complex (Diptera: Ceratopogonidae) at the European level.

    abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title：Parasites & vectors

    pub_type： 已发布勘误

    doi：10.1186/s13071-020-04349-y

    authors： Mignotte A,Garros C,Gardès L,Balenghien T,Duhayon M,Rakotoarivony I,Tabourin L,Poujol L,Mathieu B,Ibañez-Justicia A,Deniz A,Cvetkovikj A,Purse BV,Ramilo DW,Stougiou D,Werner D,Pudar D,Petrić D,Veronesi E,Jacobs F,

    更新日期：2020-09-22 00:00:00

  • Chikungunya virus transmission between Aedes albopictus and laboratory mice.

    abstract：BACKGROUND:Chikungunya virus (CHIKV) is a mosquito-borne alphavirus associated with epidemics of acute and chronic arthritic disease in humans. Aedes albopictus has emerged as an important new natural vector for CHIKV transmission; however, mouse models for studying transmission have not been developed. METHODS:Aedes ...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-016-1838-1

    authors： Hugo LE,Prow NA,Tang B,Devine G,Suhrbier A

    更新日期：2016-10-19 00:00:00

  • Effectiveness of a field trap barrier system for controlling Aedes albopictus: a "removal trapping" strategy.

    abstract：BACKGROUND:Aedes aegypti and Aedes albopictus are the main vectors for the transmission of several viral pathogens, in particular, dengue, Zika and chikungunya. In the absence of vaccines and treatment, control of Aedes mosquitoes is the only means of keeping these diseases in check. Aedes control is difficult, and it ...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-018-2691-1

    authors： Akhoundi M,Jourdain F,Chandre F,Delaunay P,Roiz D

    更新日期：2018-02-20 00:00:00

  • Efficacy of common laboratory disinfectants and heat on killing trypanosomatid parasites.

    abstract：: The disinfectants TriGene, bleach, ethanol and liquid hand soap, and water and temperature were tested for their ability to kill bloodstream forms of Trypanosoma brucei, epimastigotes of Trypanosoma rangeli and promastigotes of Leishmania major. A 5-min exposure to 0.2% TriGene, 0.1% liquid hand soap and 0.05% bleach...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/1756-3305-1-35

    authors： Wang X,Jobe M,Tyler KM,Steverding D

    更新日期：2008-09-22 00:00:00

  • Lipophosphoglycan polymorphisms do not affect Leishmania amazonensis development in the permissive vectors Lutzomyia migonei and Lutzomyia longipalpis.

    abstract：BACKGROUND:Lipophosphoglycan (LPG) is a dominant surface molecule of Leishmania promastigotes. Its species-specific polymorphisms are found mainly in the sugars that branch off the conserved Gal(β1,4)Man(α1)-PO4 backbone of repeat units. Leishmania amazonensis is one of the most important species causing human cutaneou...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-017-2568-8

    authors： Nogueira PM,Guimarães AC,Assis RR,Sadlova J,Myskova J,Pruzinova K,Hlavackova J,Turco SJ,Torrecilhas AC,Volf P,Soares RP

    更新日期：2017-12-16 00:00:00

  • IL-33/ST2 axis is involved in disease progression in the spleen during Leishmania donovani infection.

    abstract：BACKGROUND:During infection with Leishmania donovani, parasite control is linked to the systemic Th1 immune response, but in infected organs (liver, spleen and bone marrow), the response differs according to the micro-environment. The pleiomorphic cytokine interleukin-33 (IL-33) exerts various roles during infection, e...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-020-04190-3

    authors： Lamberet A,Rostan O,Dion S,Jan A,Guegan H,Manuel C,Samson M,Gangneux JP,Robert-Gangneux F

    更新日期：2020-06-22 00:00:00

  • Parasite-mediated interactions within the insect vector: Trypanosoma rangeli strategies.

    abstract：:Trypanosoma rangeli is a protozoan that is non-pathogenic for humans and other mammals but causes pathology in the genus Rhodnius. T. rangeli and R. prolixus is an excellent model for studying the parasite-vector interaction, but its cycle in invertebrates remains unclear. The vector becomes infected on ingesting bloo...

    journal_title：Parasites & vectors

    pub_type： 杂志文章,评审

    doi：10.1186/1756-3305-5-105

    authors： Garcia ES,Castro DP,Figueiredo MB,Azambuja P

    更新日期：2012-05-30 00:00:00

  • Use of Multiple Displacement Amplification as Pre-polymerase Chain Reaction (Pre-PCR) to amplify genomic DNA of siphonapterids preserved for long periods in scientific collections.

    abstract：: The recently developed Multiple Displacement Amplification technique (MDA) allows for the production of a large quantity of high quality genomic DNA from low amounts of the original DNA. The goal of this study was to evaluate the performance of the MDA technique to amplify genomic DNA of siphonapterids that have been...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/1756-3305-3-86

    authors： Avelar DM,Linardi PM

    更新日期：2010-09-15 00:00:00

  • Detection of selected pathogens in ticks collected from cats and dogs in the Wrocław Agglomeration, South-West Poland.

    abstract：BACKGROUND:Tick-borne infections are no longer confined to rural areas, they are documented with increasing frequency in urban settlements across the world. They are known to cause diseases in humans as well as in their companion animals. METHODS:During a period of 2 years, from January 2013 until December 2014, ticks...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-016-1632-0

    authors： Król N,Obiegala A,Pfeffer M,Lonc E,Kiewra D

    更新日期：2016-06-21 00:00:00

  • Long-term spatiotemporal stability and dynamic changes in the haemoparasite community of spiny mice (Acomys dimidiatus) in four montane wadis in the St. Katherine Protectorate, Sinai, Egypt.

    abstract：BACKGROUND:Long-term field studies of parasite communities are rare but provide a powerful insight into the ecological processes shaping host-parasite interactions. The aim of our study was to monitor long-term trends in the haemoparasite communities of spiny mice (Acomys dimidiatus) and to identify the principal facto...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-016-1471-z

    authors： Alsarraf M,Bednarska M,Mohallal EM,Mierzejewska EJ,Behnke-Borowczyk J,Zalat S,Gilbert F,Welc-Falęciak R,Kloch A,Behnke JM,Bajer A

    更新日期：2016-04-08 00:00:00

  • Nitric oxide and cytokine production by glial cells exposed in vitro to neuropathogenic schistosome Trichobilharzia regenti.

    abstract：BACKGROUND:Helminth neuroinfections represent a serious health problem, but host immune mechanisms in the nervous tissue often remain undiscovered. This study aims at in vitro characterization of the response of murine astrocytes and microglia exposed to Trichobilharzia regenti which is a neuropathogenic schistosome mi...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-016-1869-7

    authors： Macháček T,Panská L,Dvořáková H,Horák P

    更新日期：2016-11-14 00:00:00

  • The metazoan parasite communities of the shoal flounder (Syacium gunteri) as bioindicators of chemical contamination in the southern Gulf of Mexico.

    abstract：BACKGROUND:Because agriculture and offshore oil extraction are significant economic activities in the southern Gulf of Mexico, high concentrations of nutrients and hydrocarbons are expected. As parasite communities are sensitive to environmental impacts, these contaminants should have an effect on metrics such as speci...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-014-0541-3

    authors： Vidal-Martínez VM,Centeno-Chalé OA,Torres-Irineo E,Sánchez-Ávila J,Gold-Bouchot G,Aguirre-Macedo ML

    更新日期：2014-11-27 00:00:00

  • Efficacy of an imidacloprid/flumethrin collar against fleas, ticks, mites and lice on dogs.

    abstract：BACKGROUND:The studies reported here were conducted to ascertain the efficacy of imidacloprid/flumethrin incorporated in a slow-release matrix collar, against infestations of dogs by fleas, ticks, mites and lice. Efficacy was evaluated against the flea Ctenocephalides felis felis, the ticks Rhipicephalus sanguineus, Ix...

    journal_title：Parasites & vectors

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1756-3305-5-102

    authors： Stanneck D,Kruedewagen EM,Fourie JJ,Horak IG,Davis W,Krieger KJ

    更新日期：2012-05-30 00:00:00

  • Humans from Wuchereria bancrofti endemic area elicit substantial immune response to proteins of the filarial parasite Brugia malayi and its endosymbiont Wolbachia.

    abstract：BACKGROUND:In the past, immune responses to several Brugia malayi immunodominant antigens have been characterized in filaria-infected populations; however, little is known regarding Wolbachia proteins. We earlier cloned and characterized few B. malayi (trehalose-6-phosphate phosphatase, Bm-TPP and heavy chain myosin, B...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-016-1963-x

    authors： Jha R,Gangwar M,Chahar D,Setty Balakrishnan A,Negi MP,Misra-Bhattacharya S

    更新日期：2017-01-24 00:00:00

  • Genetic, serological and biochemical characterization of Leishmania tropica from foci in northern Palestine and discovery of zymodeme MON-307.

    abstract：BACKGROUND:Many cases of cutaneous leishmaniasis (CL) have been recorded in the Jenin District based on their clinical appearance. Here, their parasites have been characterized in depth. METHODS:Leishmanial parasites isolated from 12 human cases of CL from the Jenin District were cultured as promastigotes, whose DNA w...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/1756-3305-5-121

    authors： Azmi K,Schnur L,Schonian G,Nasereddin A,Pratlong F,El Baidouri F,Ravel C,Dedet JP,Ereqat S,Abdeen Z

    更新日期：2012-06-18 00:00:00

  • Molecular investigation of Cryptosporidium and Giardia in pre- and post-weaned calves in Hubei Province, China.

    abstract：BACKGROUND:The protistan pathogens Cryptosporidium and Giardia can cause significant intestinal diseases in animals and humans. Cattle, particularly calves, carrying these protists can be significant reservoirs for human infections and disease. However, little is known about the genetic make-up of Cryptosporidium and G...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-017-2463-3

    authors： Fan Y,Wang T,Koehler AV,Hu M,Gasser RB

    更新日期：2017-10-25 00:00:00

  • Fluralaner activity against life stages of ticks using Rhipicephalus sanguineus and Ornithodoros moubata IN in vitro contact and feeding assays.

    abstract：BACKGROUND:Fluralaner is a novel isoxazoline eliciting both acaricidal and insecticidal activity through potent blockage of GABA- and glutamate-gated chloride channels. The aim of the study was to investigate the susceptibility of juvenile stages of common tick species exposed to fluralaner through either contact (Rhip...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-015-0704-x

    authors： Williams H,Zoller H,Roepke RK,Zschiesche E,Heckeroth AR

    更新日期：2015-02-08 00:00:00

  • Nucleoside triphosphate diphosphohydrolase1 (TcNTPDase-1) gene expression is increased due to heat shock and in infective forms of Trypanosoma cruzi.

    abstract：BACKGROUND:Ecto-Nucleoside Triphosphate Diphosphohydrolases (Ecto-NTPDases) are enzymes that hydrolyze tri- and/or di-phosphate nucleotides. Evidences point to their participation in Trypanosoma cruzi virulence and infectivity. In this work, we evaluate TcNTPDase-1 gene expression in comparison with ecto-NTPDase activi...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-014-0463-0

    authors： Silva-Gomes NL,Ennes-Vidal V,Carolo JC,Batista MM,Soeiro MN,Menna-Barreto R,Moreira OC

    更新日期：2014-10-05 00:00:00

  • LONGRANGE® (eprinomectin 5% w/v extended-release injection) efficacy against Hypoderma lineatum in an endemic area in southern Italy.

    abstract：BACKGROUND:Despite intensive control measures including governmental campaigns using highly-efficacious systemic insecticides, there is evidence for persisting or recurring bovine Hypoderma species populations in parts of Europe, the USA and Canada. The present study evaluated the efficacy of LONGRANGE® (eprinomectin 5...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/s13071-019-3475-y

    authors： Lia RP,Rehbein S,Giannelli A,Fankhauser B,Otranto D

    更新日期：2019-05-14 00:00:00

  • Transmission of Beauveria bassiana from male to female Aedes aegypti mosquitoes.

    abstract：BACKGROUND:Resistance to chemical insecticides plus high morbidity rates have lead to rising interest in fungi as candidates for biocontrol agents of mosquito vectors. In most studies fungal infections have been induced by exposure of mosquitoes to various surfaces treated with conidia. In the present study eight Mexic...

    journal_title：Parasites & vectors

    pub_type： 杂志文章

    doi：10.1186/1756-3305-4-24

    authors： García-Munguía AM,Garza-Hernández JA,Rebollar-Tellez EA,Rodríguez-Pérez MA,Reyes-Villanueva F

    更新日期：2011-02-26 00:00:00