Detection of Leishmania infantum DNA in Pintomyia evansi and Lutzomyia longipalpis in Honduras.

Abstract:

BACKGROUND:The two most abundant sand fly species on the Honduran Pacific coast are Lutzomyia (Lutzomyia) longipalpis and Pintomyia (Pifanomyia) evansi. Both species are known vectors of Leishmania (Leishmania) infantum, the etiological agent of visceral leishmaniasis (VL) in the Americas. Although VL and non-ulcerative cutaneous leishmaniasis (NUCL) are endemic on the Pacific versant of the Central American Pacific, the latter is the most frequent manifestation of leishmaniasis there. We evaluated the circulation of Leishmania spp. in the sand fly species on El Tigre Island, an endemic area of NUCL. RESULTS:We collected 222 specimens of six sand fly species. Lu. longipalpis (180 specimens; 81%) and Pif. (Pi.) evansi (35 specimens; 16%) were the most abundant species. L. (L.) infantum DNA was detected in nine of the 96 specimens analyzed; seven of these specimens were identified as Lu. longipalpis, and the remaining two were Pi. evansi, with an infection rate of 9.4% and 2.7%, respectively. CONCLUSION:We present the first record of L. (L.) infantum DNA in Pi. evansi from a NUCL endemic region of Central America. Our results suggest that Pi. evansi could be a secondary vector of L. (L.) infantum in the transmission cycle of leishmaniasis. The detection of natural infections of L. (L.) infantum in sand flies in this region contributes to an understanding of the epidemiology of leishmaniasis in Honduras.

journal_name

Parasit Vectors

journal_title

Parasites & vectors

authors

Sosa-Ochoa W,Varela Amador J,Lozano-Sardaneta Y,Rodriguez Segura G,Zúniga Valeriano C,Araujo GV,Sandoval Pacheco CM,Laurenti MD,Galvis-Ovallos F

doi

10.1186/s13071-020-04462-y

subject

Has Abstract

pub_date

2020-11-23 00:00:00

pages

593

issue

1

issn

1756-3305

pii

10.1186/s13071-020-04462-y

journal_volume

13

pub_type

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