Abstract：
BACKGROUND:West African Dwarf (WAD) goats serve an important role in the rural village economy of West Africa, especially among small-holder livestock owners. They have been shown to be trypanotolerant and to resist infections with Haemonchus contortus more effectively than any other known breed of goat. METHODS:In this paper we review what is known about the origins of this goat breed, explain its economic importance in rural West Africa and review the current status of our knowledge about its ability to resist parasitic infections. CONCLUSIONS:We suggest that its unique capacity to show both trypanotolerance and resistance to gastrointestinal (GI) nematode infections is immunologically based and genetically endowed, and that knowledge of the underlying genes could be exploited to improve the capacity of more productive wool and milk producing, but GI nematode susceptible, breeds of goats to resist infection, without recourse to anthelmintics. Either conventional breeding allowing introgression of resistance alleles into susceptible breeds, or transgenesis could be exploited for this purpose. Appropriate legal protection of the resistance alleles of WAD goats might provide a much needed source of revenue for the countries in West Africa where the WAD goats exist and where currently living standards among rural populations are among the lowest in the world.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Chiejina SN,Behnke JMdoi
10.1186/1756-3305-4-12subject
Has Abstractpub_date
2011-02-03 00:00:00pages
12issn
1756-3305pii
1756-3305-4-12journal_volume
4pub_type
杂志文章,评审abstract：BACKGROUND:Thymidylate synthase is a housekeeping gene, designated ancient due to its role in DNA synthesis and ubiquitous phyletic distribution. The genomic sequences were characterized coding for thymidylate synthase in two species of the genus Trichinella, an encapsulating T. spiralis and a non-encapsulating T. pseu...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-175
更新日期：2014-04-09 00:00:00
abstract：BACKGROUND:Prior work has shown that the levels of moxidectin in dogs treated with Advantage Multi® for Dogs (Bayer Animal Health) remain at a high plasma concentration for the full month after application. The objective of this study was to demonstrate the efficacy of 10% imidacloprid + 2.5% moxidectin topical solutio...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2432-x
更新日期：2017-11-09 00:00:00
abstract：BACKGROUND:The red fox (Vulpes vulpes) is host to a community of zoonotic and other helminth species. Tracking their community structure and dynamics over decades is one way to monitor the long term risk of parasitic infectious diseases relevant to public and veterinary health. METHODS:We identified 17 helminth specie...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-166
更新日期：2014-04-03 00:00:00
abstract：:Companion vector-borne diseases (CVBDs) are an important threat for pet life, but may also have an impact on human health, due to their often zoonotic character. The importance and awareness of CVBDs continuously increased during the last years. However, information on their occurrence is often limited in several part...
journal_title：Parasites & vectors
pub_type： 杂志文章,评审
doi：10.1186/s13071-019-3407-x
更新日期：2019-03-28 00:00:00
abstract：BACKGROUND:Pathogenic intestinal protozoa infections are common in school-aged children in the developing world and they are frequently associated with malabsorption syndromes and gastrointestinal morbidity. Since diagnosis of these parasites is difficult, prevalence data on intestinal protozoa is scarce. METHODS:We c...
journal_title：Parasites & vectors
pub_type： 杂志文章,随机对照试验
doi：10.1186/1756-3305-6-3
更新日期：2013-01-04 00:00:00
abstract：BACKGROUND:Fluralaner is a novel isoxazoline eliciting both acaricidal and insecticidal activity through potent blockage of GABA- and glutamate-gated chloride channels. The aim of the study was to investigate the susceptibility of juvenile stages of common tick species exposed to fluralaner through either contact (Rhip...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0704-x
更新日期：2015-02-08 00:00:00
abstract：BACKGROUND:Intestinal protozoan parasites are major contributors to the global burden of gastrointestinal disease causing significant socioeconomic consequences. Children living in resource-poor settings with restricted access to water and sanitary services are particularly at risk of these infections. METHODS:A prosp...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-3054-7
更新日期：2018-08-30 00:00:00
abstract：BACKGROUND:The prolonged feeding process of ixodid ticks, in combination with bacterial transmission, should lead to a robust inflammatory response at the blood-feeding site. Yet, factors present in tick saliva may down-regulate such responses, which may be beneficial to spirochete transmission. The primary goal of thi...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1638-7
更新日期：2016-07-08 00:00:00
abstract：BACKGROUND:Human schistosomiasis is a neglected tropical disease caused by parasitic worms of the genus Schistosoma that still affects some 200 million people. The mainstay of schistosomiasis control is a single drug, praziquantel. The reliance on this drug carries a risk of resistance emerging to this anthelmintic, su...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-3197-6
更新日期：2018-11-27 00:00:00
abstract：BACKGROUND:Recent reports have demonstrated the presence of Crimean-Congo hemorrhagic fever virus (CCHFV) genomic material in Hyalomma aegyptium ticks feeding primarily on tortoises belonging to the genus Testudo. This raises the question if these ticks and their hosts play a role in the natural transmission dynamics o...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04074-6
更新日期：2020-04-19 00:00:00
abstract：BACKGROUND:The protozoan Giardia duodenalis is a common but highly diverse human parasite that comprises a complex of seven morphologically identical genetic assemblages, further divided into sub-assemblages. There is very little information available on the diversity of Giardia sub-assemblages and multi-locus genotype...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-1059-z
更新日期：2015-09-04 00:00:00
abstract：BACKGROUND:Most studies on Enterocytozoon bieneusi are conducted based on the internal transcribed spacer (ITS) region of the rRNA gene, whereas some have examined E. bieneusi population structures. Currently, the population genetics of this pathogen in giant panda remains unknown. The objective of this study was to de...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2459-z
更新日期：2017-10-18 00:00:00
abstract：BACKGROUND:The relationship between the environment and infection of cattle with trematodes was studied at Arumeru District, Arusha Region, northern Tanzania. Randomly selected villages were grouped into three cattle management strata, (i) zero-grazing (ZZ) (ii) communal grazing without irrigation (ZC) and (iii) commun...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-107
更新日期：2014-03-20 00:00:00
abstract：BACKGROUND:In Brazil, preventive chemotherapy targeting soil-transmitted helminthiasis is being scaled-up. Hence, spatially explicit estimates of infection risks providing information about the current situation are needed to guide interventions. Available high-resolution national model-based estimates either rely on a...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-440
更新日期：2014-09-18 00:00:00
abstract：BACKGROUND:Red deer (Cervus elaphus) are a common wild definitive host for liver fluke (Fasciola hepatica) that have been the subject of limited diagnostic surveillance. This study aimed to explore the extent to which coprological diagnoses for F. hepatica in red deer in the Scottish Highlands, Scotland, are associated...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3782-3
更新日期：2019-11-12 00:00:00
abstract：BACKGROUND:Insect-specific viruses do not replicate in vertebrate cells, but persist in mosquito populations and are highly prevalent in nature. These viruses may naturally regulate the transmission of pathogenic vertebrate-infecting arboviruses in co-infected mosquitoes. Following the isolation of the first Australian...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1683-2
更新日期：2016-07-25 00:00:00
abstract：BACKGROUND:With the spread of pyrethroid resistance in mosquitoes, the combination of an insecticide (carbamate or organophosphate) with a repellent (DEET) is considered as a promising alternative strategy for the treatment of mosquito nets and other relevant materials. The efficacy of these mixtures comes from the fac...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-2-17
更新日期：2009-04-16 00:00:00
abstract：BACKGROUND:Leishmania infantum infections in dogs play a crucial role in the transmission of pathogens causing visceral leishmaniasis to humans in the Gansu province, northwest China. To be able to control zoonotic transmission of the parasite to humans, a non-invasive loop-mediated isothermal amplification (LAMP) assa...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0991-2
更新日期：2015-07-15 00:00:00
abstract：BACKGROUND:Recently the role of gastrointestinal nematodes in modulating the immune responses in inflammatory and immune-mediated conditions such as allergy and autoimmune diseases has been introduced. This is mainly due to the suppressive effects of somatic and excretory secretory (ES) products of nematodes on the imm...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2159-8
更新日期：2017-05-12 00:00:00
abstract：BACKGROUND:Trichinella nematodes are globally distributed food-borne pathogens, in which Trichinella spiralis is the most common species in China. Microsatellites are a powerful tool in population genetics and phylogeographic analysis. However, only a few microsatellite markers were reported in T. spiralis. Thus, there...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-3929-2
更新日期：2020-02-11 00:00:00
abstract：:Major efforts are currently underway to develop novel, complementary methods to combat mosquito-borne diseases. Mosquito genetic control strategies (GCSs) have become an increasingly important area of research on account of their species-specificity, track record in targeting agricultural insect pests, and their envir...
journal_title：Parasites & vectors
pub_type： 杂志文章,评审
doi：10.1186/s13071-018-3222-9
更新日期：2018-12-24 00:00:00
abstract：BACKGROUND:Knowledge on the capacity of Australian ticks to carry Borrelia species is currently limited or missing. To evaluate the potential of ticks to carry bacterial pathogens and their DNA, it is imperative to have a robust workflow that maximises recovery of bacterial DNA within ticks in order to enable accurate ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2579-5
更新日期：2017-12-20 00:00:00
abstract：BACKGROUND:Culex pipiens L. is the most widespread mosquito vector in temperate regions including North Africa. Cx. pipiens has two recognized forms or biotypes; pipiens and molestus are morphologically indistinguishable with distinct behavior and physiology that may influence their vectorial status. In our study, we p...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-5-83
更新日期：2012-04-27 00:00:00
abstract：BACKGROUND:Entomopathogenic fungi are potential candidates for use in integrated vector management and many isolates are compatible with synthetic and natural insecticides. Neem oil was tested separately and in combination with the entomopathogenic fungus Metarhizium anisopliae against larvae of the dengue vector Aedes...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-1280-9
更新日期：2015-12-30 00:00:00
abstract：BACKGROUND:The transformation of noninfective epimastigotes into infective metacyclic trypomastigotes (metacyclogenesis) is a fundamental step in the life cycle of Trypanosoma cruzi, comprising several morphological and biochemical changes. GP82 and GP90 are glycoproteins expressed at the surface of metacyclic trypomas...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-127
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:The G subfamily of ABC (ATP-binding cassette) transporters of Leishmania include 6 genes (ABCG1-G6), some with relevant biological functions associated with drug resistance and phospholipid transport. Several studies have shown that Leishmania LABCG2 transporter plays a role in the exposure of phosphatidylse...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2198-1
更新日期：2017-05-30 00:00:00
abstract：BACKGROUND:Cutaneous leishmaniasis (CL) is endemic in the highlands of Ethiopia, and almost always caused by Leishmania aethiopica. Hitherto, Addis Ababa (the capital city of Ethiopia) was not considered endemic for CL, mainly due to absence of epidemiological and field ecological studies. This report summarizes the pr...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-2-60
更新日期：2009-12-02 00:00:00
abstract：BACKGROUND:Understanding mosquito resting behaviour is important for the control of vector-borne diseases, but this remains a challenge because of the paucity of efficient sampling tools. We evaluated two novel sampling methods in the field: the Sticky Resting Box (SRB) and the Resting Bucket trap (RBu) to test their e...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-1066-0
更新日期：2015-09-17 00:00:00
abstract：BACKGROUND:A question of epidemiological relevance in Chagas disease studies is to understand Trypanosoma cruzi transmission cycles and trace the origins of (re)emerging cases in areas under vector or disease surveillance. Conventional parasitological methods lack sensitivity whereas molecular approaches can fill in th...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3817-9
更新日期：2019-11-29 00:00:00
abstract：BACKGROUND:Spotted Fever Group (SFG) Rickettsiae can cause febrile diseases with or without rash in humans worldwide. In Germany only limited data are available about their medical significance. Serological screening tests for antibodies against rickettsiae usually only distinguish between SFG and Typhus Group (TG) Ric...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0745-1
更新日期：2015-03-23 00:00:00
