Abstract：
BACKGROUND:With the spread of pyrethroid resistance in mosquitoes, the combination of an insecticide (carbamate or organophosphate) with a repellent (DEET) is considered as a promising alternative strategy for the treatment of mosquito nets and other relevant materials. The efficacy of these mixtures comes from the fact that they reproduce pyrethroid features and that positive interactions occur between insecticides and repellent. To better understand the mechanisms involved and assess the impact of detoxifying enzymes (oxidases and esterases) in these interactions, bioassays were carried out in the laboratory against the main dengue vector Aedes aegypti. METHODS:Topical applications of DEET and propoxur (carbamate), used alone or as a mixture, were carried out on female mosquitoes, using inhibitors of the two main detoxification pathways in the insect. PBO, an inhibitor of multi-function oxidases, and DEF, an inhibitor of esterases, were applied one hour prior to the main treatment. RESULTS:Results showed that synergism between DEET and propoxur disappeared in the presence of PBO but not with DEF. This suggests that oxidases, contrary to esterases, play a key role in the interactions occurring between DEET and cholinesterase inhibitors in mosquitoes. CONCLUSION:These findings are of great interest for the implementation of "combination nets" in the field. They support the need to combine insecticide with repellent to overcome insecticide resistance in mosquitoes of public health importance.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Bonnet J,Pennetier C,Duchon S,Lapied B,Corbel Vdoi
10.1186/1756-3305-2-17subject
Has Abstractpub_date
2009-04-16 00:00:00pages
17issue
1issn
1756-3305pii
1756-3305-2-17journal_volume
2pub_type
杂志文章abstract：BACKGROUND:In Morocco, the main strategies of leishmaniasis vector control are based on environmental modifications. Use of local residual indoor spraying with synthetic pyrethroids is often envisaged. The need to evaluate this control method is essential. The current study was conducted to determine the efficacy of an...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-354
更新日期：2013-12-13 00:00:00
abstract：:Echinococcus transmission is known to be affected by various environmental factors, which may be modified by human influence or natural events including global warming. Considerable population growth in the last fifty years in Ningxia Hui Autonomous Region (NHAR), the People's Republic of China (PRC), has led to drama...
journal_title：Parasites & vectors
pub_type： 杂志文章,评审
doi：10.1186/1756-3305-5-146
更新日期：2012-07-24 00:00:00
abstract：BACKGROUND:Bioclimatic variables play an integral part in the life-cycle of Ctenocephalides felis, the most common flea found on companion animals. It is essential that we understand the effects of climate on C. felis distribution as fleas are a major veterinary and public health concern. This study investigated the cu...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3399-6
更新日期：2019-03-22 00:00:00
abstract：BACKGROUND:Schistosome and soil-transmitted helminth (STH) infections are recognized as major global public health problems, causing severe and subtle morbidity, including significant educational and nutritional effects in children. Although effective and safe drugs are available, ensuring access to these drugs by all ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-5-182
更新日期：2012-08-31 00:00:00
abstract：BACKGROUND:Alternative splicing (AS) of mRNA is a vital mechanism for enhancing genomic complexity in eukaryotes. Spliced isoforms of the same gene can have diverse molecular and biological functions and are often differentially expressed across various tissues, times, and conditions. Thus, AS has important implication...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-151
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:The use of phytochemicals is a promising solution in biological control against salmon louse (Lepeophtheirus salmonis). Glucosinolates belong to a diverse group of compounds used as protection against herbivores by plants in the family Brassicaceae, while in vertebrates, ingested glucosinolates exert health-...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1537-y
更新日期：2016-05-10 00:00:00
abstract：:Mosquito salivary proteins are involved in several biological processes that facilitate their blood feeding and have also been reported to elicit an IgG response in vertebrates. A growing number of studies have focused on this immunological response for its potential use as a biological marker of exposure to arthropod...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-4-33
更新日期：2011-03-08 00:00:00
abstract：BACKGROUND:Global climate change can seriously impact on the epidemiological dynamics of vector-borne diseases. In this study we investigated how future climatic changes could affect the climatic niche of Ixodes ricinus (Acari, Ixodida), among the most important vectors of pathogens of medical and veterinary concern in...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-271
更新日期：2013-09-19 00:00:00
abstract：BACKGROUND:The relationship between climatic factors and mosquito abundance is very important to determine parasite activity levels and, therefore, disease risk. Therefore, this study was conducted to investigate the seasonal abundance of anophelines and their association with meteorological variables and disease trans...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-442
更新日期：2014-09-18 00:00:00
abstract：BACKGROUND:Leishmania (Vianna) braziliensis, Leishmania (Leishmania) amazonensis and Leishmania (Leishmania) chagasi are important parasites in the scenario of leishmaniasis in Brazil. During the life cycle of these parasites, the promastigote forms adhere to the midgut epithelial microvillii of phlebotomine insects to...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-4-216
更新日期：2011-11-14 00:00:00
abstract：BACKGROUND:The population dynamics of vector-borne pathogens inside the arthropod vector can have important consequences for vector-to-host transmission. Tick-borne spirochete bacteria of the Borrelia burgdorferi (sensu lato) species complex cause Lyme borreliosis in humans and spend long periods of time (>12 months) i...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2187-4
更新日期：2017-05-25 00:00:00
abstract：BACKGROUND:Schistosomiasis is a serious global health problem that afflicts more than 230 million people in 77 countries. Long-term mass treatments with the only available drug, praziquantel, have caused growing concerns about drug resistance. PSD-95/Dlg/ZO-1 (PDZ) domain-containing proteins are recognized as potential...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-5-227
更新日期：2012-10-10 00:00:00
abstract：BACKGROUND:Fluralaner is a novel isoxazoline eliciting both acaricidal and insecticidal activity through potent blockage of GABA- and glutamate-gated chloride channels. The aim of the study was to investigate the susceptibility of juvenile stages of common tick species exposed to fluralaner through either contact (Rhip...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0704-x
更新日期：2015-02-08 00:00:00
abstract：BACKGROUND:Sand flies are responsible for the transmission of several disease pathogens including Leishmania. Sand flies breed in habitats with high levels of humidity and organic matter. They are nocturnal in nature and peak activity ranges from dusk to dawn. The scientific evidence on breeding ecology and diurnal res...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04154-7
更新日期：2020-06-05 00:00:00
abstract：BACKGROUND:Malaria remains a major public health concern. Vector control measures based solely on insecticide treated nets (ITNs) and indoor residual spraying (IRS) have demonstrated not to be feasible for malaria elimination. It has been shown that ivermectin affects several aspects of Anopheles species biology. Along...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2563-0
更新日期：2017-12-28 00:00:00
abstract：BACKGROUND:Intestinal parasite infections (IPIs) are among the most significant causes of illness and disease of socially and economically disadvantaged populations in developing countries, including rural areas of the People's Republic of China. With the spread of the human immunodeficiency virus (HIV) among rural Chi...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-5-36
更新日期：2012-02-13 00:00:00
abstract：BACKGROUND:Cysteine peptidases of clan CA, family C1 account for a major part of proteolytic activity in the haematophagous monogenean Eudiplozoon nipponicum. The full spectrum of cysteine cathepsins is, however, unknown and their particular biochemical properties, tissue localisation, and involvement in parasite-host ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-2666-2
更新日期：2018-03-06 00:00:00
abstract：BACKGROUND:Improved surveillance techniques are required to accelerate efforts against major arthropod-borne diseases such as malaria, dengue, filariasis, Zika and yellow-fever. Light-emitting diodes (LEDs) are increasingly used in mosquito traps because they improve energy efficiency and battery longevity relative to ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3673-7
更新日期：2019-08-27 00:00:00
abstract：BACKGROUND:In Egypt, liver flukes, Fasciola spp. (Digenea: Fasciolidae), have a serious impact on the farming industry and public health. Both Fasciola hepatica and Fasciola gigantica are known to occur in cattle, providing the opportunity for genetic recombination. Little is known on the identity and genetic variabili...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1898-2
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Filariasis and leishmaniasis are two neglected tropical diseases in Mali. Due to distribution and associated clinical features, both diseases are of concern to public health. The goal of this study was to determine the prevalence of co-infection with filarial (Wuchereria bancrofti and Mansonella perstans) an...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2531-8
更新日期：2018-01-08 00:00:00
abstract：BACKGROUND:West African Dwarf (WAD) goats serve an important role in the rural village economy of West Africa, especially among small-holder livestock owners. They have been shown to be trypanotolerant and to resist infections with Haemonchus contortus more effectively than any other known breed of goat. METHODS:In th...
journal_title：Parasites & vectors
pub_type： 杂志文章,评审
doi：10.1186/1756-3305-4-12
更新日期：2011-02-03 00:00:00
abstract：BACKGROUND:Human and animal fascioliasis poses serious public health problems in South America. In Venezuela, livestock infection represents an important veterinary problem whereas there appear to be few human cases reported, most of which are passively detected in health centres. However, results of recent surveys sug...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-4-200
更新日期：2011-10-14 00:00:00
abstract：BACKGROUND:Antillean manatees (Trichechus manatus manatus) are large herbivorous aquatic mammals living in limited areas of South, Central and North America. As with other aquatic mammals, Antillean manatees can be infected by a variety of protozoan and metazoan parasites, some of them with zoonotic potential, which af...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3448-1
更新日期：2019-04-27 00:00:00
abstract：BACKGROUND:Understanding the variation in prevalence of Borrelia burgdorferi sensu lato (Lyme Borreliosis Spirochaetes, LBS) and Anaplasma phagocytophilum (causing tick-borne fever in ruminants and human granulocytic ehrlichiosis) in ticks is vital from both a human and an animal disease perspective to target the most ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-187
更新日期：2013-06-20 00:00:00
abstract：BACKGROUND:Leishmaniasis is a major parasitic disease worldwide, except in Australia and Antarctica, and it poses a significant public health problem. Due to the absence of safe and effective vaccines and drugs, researchers have begun an extensive search for new drugs. The aim of the current study was to investigate th...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04543-y
更新日期：2021-01-11 00:00:00
abstract：BACKGROUND:Nosema bombycis is a unicellular eukaryotic pathogen of the silkworm, Bombyx mori, and is an economic and occupational hazard in the silkworm industry. Because of its long incubation period and horizontal and vertical transmission, it is subject to quarantine measures in sericulture production. The microspor...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-021-04595-8
更新日期：2021-01-25 00:00:00
abstract：:Rickettsioses are among the oldest known infectious diseases. In spite of this, and of the extensive research carried out, many aspects of the biology and epidemiology of tick-borne rickettsiae are far from being completely understood. Their association with arthropod vectors, the importance of vertebrates as reservoi...
journal_title：Parasites & vectors
pub_type： 杂志文章,评审
doi：10.1186/s13071-018-2856-y
更新日期：2018-04-24 00:00:00
abstract：BACKGROUND:Zoonotic Cutaneous Leishmaniasis (ZCL) due to Leishmania major (L. major) is still a serious public health problem in Tunisia. This study aimed to compare the prevalence and risk factors associated with L. major infection in old and new foci using leishmanin skin test (LST) in central Tunisia. METHODS:A cro...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-386
更新日期：2014-08-20 00:00:00
abstract：BACKGROUND:Cryptosporidiosis is a gastrointestinal disease affecting many people worldwide. Disease incidence is often unknown and surveillance of human cryptosporidiosis is installed in only a handful of developed countries. A genetic marker that mirrors disease incidence is potentially a powerful tool for monitoring ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0921-3
更新日期：2015-06-06 00:00:00
abstract：BACKGROUND:Diagnostics provide a means to measure progress toward disease elimination. Many countries in Africa are approaching elimination of onchocerciasis after successful implementation of mass drug administration programs as well as vector control. An understanding of how markers for infection such as skin snip mi...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1623-1
更新日期：2016-06-13 00:00:00
