Abstract:
BACKGROUND:The use of phytochemicals is a promising solution in biological control against salmon louse (Lepeophtheirus salmonis). Glucosinolates belong to a diverse group of compounds used as protection against herbivores by plants in the family Brassicaceae, while in vertebrates, ingested glucosinolates exert health-promoting effects due to their antioxidant and detoxifying properties as well as effects on cell proliferation and growth. The aim of this study was to investigate if Atlantic salmon fed two different doses of glucosinolate-enriched feeds would be protected against lice infection. The effects of feeding high dose of glucosinolates before the infection, and of high and low doses five weeks into the infection were studied. METHODS:Skin was screened by 15 k oligonucleotide microarray and qPCR. RESULTS:A 25 % reduction (P < 0.05) in lice counts was obtained in the low dose group and a 17 % reduction in the high dose group compared to fish fed control feed. Microarray analysis revealed induction of over 50 interferon (IFN)-related genes prior to lice infection. Genes upregulated five weeks into the infection in glucosinolate-enriched dietary groups included Type 1 pro-inflammatory factors, antimicrobial and acute phase proteins, extracellular matrix remodeling proteases and iron homeostasis regulators. In contrast, genes involved in muscle contraction, lipid and glucose metabolism were found more highly expressed in the skin of infected control fish. CONCLUSIONS:Atlantic salmon fed glucosinolates had a significantly lower number of sea lice at the end of the experimental challenge. Feeding glucosinolates coincided with increased expression of IFN-related genes, and higher expression profiles of Type 1 immune genes late into the infection. In addition, regulation of genes involved in the metabolism of iron, lipid and sugar suggested an interplay between metabolism of nutrients and mechanisms of resistance.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Jodaa Holm H,Wadsworth S,Bjelland AK,Krasnov A,Evensen Ø,Skugor Sdoi
10.1186/s13071-016-1537-ysubject
Has Abstractpub_date
2016-05-10 00:00:00pages
271issue
1issn
1756-3305pii
10.1186/s13071-016-1537-yjournal_volume
9pub_type
杂志文章abstract:BACKGROUND:Arthropod-borne diseases are some of the most rapidly spreading diseases. Reducing the vector population is currently the only effective way to reduce case numbers. Central metabolic pathways are potential targets to control vector populations, but have not been well explored to this aim. The information ava...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1391-y
更新日期:2016-02-25 00:00:00
abstract:BACKGROUND:Lymphatic filariasis (LF) due to Wuchereria bancrofti is being eliminated from Oceania under the Pacific Elimination of Lymphatic Filariasis Programme. LF was endemic in Solomon Islands but in the 2010-2020 Strategic Plan of the Global Programme to Eliminate LF, Solomon Islands was listed as non-endemic for ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-218
更新日期:2013-07-26 00:00:00
abstract:BACKGROUND:Rickettsiae are emerging pathogens causing public health problems in many countries around the world. Rickettsia spp. are found in association with a wide range of arthropods which feed on different species of animals. However, the distribution and natural cycle of Rickettsia species and their association wi...
journal_title:Parasites & vectors
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doi:10.1186/s13071-018-2947-9
更新日期:2018-06-28 00:00:00
abstract:BACKGROUND:The transmission of malaria is heterogeneous, and varies due to altitude. The information on whether the transmission of malaria is indigenous or imported to highland areas is scarce. Therefore, this study aimed to assess the species composition and infection rates of Anopheles at different altitudinal trans...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2288-0
更新日期:2017-07-19 00:00:00
abstract:BACKGROUND:Protostrongylus oryctolagi and P. pulmonalis are causative agents of pulmonary protostrongyliasis in Lagomorphs in France. These nematodes need usually one intermediate host for its life cycle, a terrestrial snail. However, some studies, mainly in experimental conditions, have identified the species of snail...
journal_title:Parasites & vectors
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更新日期:2015-02-15 00:00:00
abstract:BACKGROUND:Insect haemocytes mediate cellular immune responses (e.g., phagocytosis) and contribute to the synthesis of humoral immune factors. In previous work, a genome-wide molecular characterization of Anopheles gambiae circulating haemocytes was followed by functional gene characterization using cell-based RNAi scr...
journal_title:Parasites & vectors
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doi:10.1186/s13071-016-1359-y
更新日期:2016-02-09 00:00:00
abstract:BACKGROUND:Prior work has shown that the levels of moxidectin in dogs treated with Advantage Multi® for Dogs (Bayer Animal Health) remain at a high plasma concentration for the full month after application. The objective of this study was to demonstrate the efficacy of 10% imidacloprid + 2.5% moxidectin topical solutio...
journal_title:Parasites & vectors
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更新日期:2017-11-09 00:00:00
abstract:BACKGROUND:Sheep scab is caused by the ectoparasitic mite Psoroptes ovis which initiates a profound cutaneous inflammatory response, leading to the development of the skin lesions which are characteristic of the disease. Existing control strategies rely upon injectable endectocides and acaricidal dips but concerns over...
journal_title:Parasites & vectors
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更新日期:2012-02-08 00:00:00
abstract:BACKGROUND:Hepatic fibrosis caused by chronic infection with Schistosoma japonica remains a serious public health problem in the world. Symptoms include inflammation, liver granuloma and fibrosis, whilst treatment options are still limited. This study aims to investigate whether and how traditional Chinese medicine Xia...
journal_title:Parasites & vectors
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更新日期:2020-05-14 00:00:00
abstract:BACKGROUND:Bartonella alsatica has been formerly isolated from the blood of wild European rabbit (Oryctolagus cuniculus) and identified as causative agent of human endocarditis and lymphadenitis. Fleas are known biological vectors for Bartonella sp. This report details the specific detection of B. alsatica in three fle...
journal_title:Parasites & vectors
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doi:10.1186/s13071-015-0664-1
更新日期:2015-01-27 00:00:00
abstract:BACKGROUND:Mosquito-borne arboviruses, like dengue virus, continue to cause significant global morbidity and mortality, particularly in Southeast Asia. When the infectious mosquitoes probe into human skin for a blood meal, they deposit saliva containing a myriad of pharmacologically active compounds, some of which alte...
journal_title:Parasites & vectors
pub_type: 临床试验,杂志文章
doi:10.1186/s13071-018-3224-7
更新日期:2018-12-20 00:00:00
abstract:BACKGROUND:The protistan pathogens Cryptosporidium and Giardia can cause significant intestinal diseases in animals and humans. Cattle, particularly calves, carrying these protists can be significant reservoirs for human infections and disease. However, little is known about the genetic make-up of Cryptosporidium and G...
journal_title:Parasites & vectors
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doi:10.1186/s13071-017-2463-3
更新日期:2017-10-25 00:00:00
abstract:BACKGROUND:Despite intensive control measures including governmental campaigns using highly-efficacious systemic insecticides, there is evidence for persisting or recurring bovine Hypoderma species populations in parts of Europe, the USA and Canada. The present study evaluated the efficacy of LONGRANGE® (eprinomectin 5...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3475-y
更新日期:2019-05-14 00:00:00
abstract:BACKGROUND:This study evaluated the exposure of dogs to three different Ehrlichia spp. in the south and central regions of the United States where vector-borne disease prevalence has been previously difficult to ascertain, particularly beyond the metropolitan areas. METHODS:Dog blood samples (n = 8,662) were submitted...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-29
更新日期:2012-02-08 00:00:00
abstract:BACKGROUND:Many tick species have great morphological similarity and are thus grouped into species complexes. Molecular methods are therefore useful in the classification and identification of ticks. However, little is known about the genetic diversity of hard ticks in China, especially at the subspecies level. Tengcho...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3048-5
更新日期:2018-08-14 00:00:00
abstract:BACKGROUND:In Morocco, the main strategies of leishmaniasis vector control are based on environmental modifications. Use of local residual indoor spraying with synthetic pyrethroids is often envisaged. The need to evaluate this control method is essential. The current study was conducted to determine the efficacy of an...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-354
更新日期:2013-12-13 00:00:00
abstract:: The proteasome inhibitor and anti-cancer drug bortezomib was tested for in vitro activity against bloodstream forms of Trypanosoma brucei. The concentrations of bortezomib required to reduce the growth rate by 50% and to kill all trypanosomes were 3.3 nM and 10 nM, respectively. In addition, bortezomib was 10 times m...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-2-29
更新日期:2009-07-07 00:00:00
abstract:BACKGROUND:Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis. Secreted extracellular vesicles (EVs) play a key role in pathogen-host interfaces. Previous studies have shown that S. japonicum adult worms can release microRNA (miRNA)-containing EVs, which can transfer their cargo to mammalia...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1845-2
更新日期:2016-11-08 00:00:00
abstract::In Italy, dogs and cats are at risk of becoming infected by different vector-borne pathogens, including protozoa, bacteria, and helminths. Ticks, fleas, phlebotomine sand flies, and mosquitoes are recognized vectors of pathogens affecting cats and dogs, some of which (e.g., Anaplasma phagocytophilum, Borrelia burgdorf...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-2
更新日期:2010-01-11 00:00:00
abstract:BACKGROUND:Chagas disease is a major public health concern in Latin America and it is transmitted by insects of the subfamily Triatominae, including Rhodnius spp. Since palm trees are ubiquitous in Colombia and a habitat for Rhodnius spp., the presence of palms near villages could increase contact rates between vectors...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1884-8
更新日期:2016-11-18 00:00:00
abstract::Trypanosoma rangeli is a protozoan that is non-pathogenic for humans and other mammals but causes pathology in the genus Rhodnius. T. rangeli and R. prolixus is an excellent model for studying the parasite-vector interaction, but its cycle in invertebrates remains unclear. The vector becomes infected on ingesting bloo...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/1756-3305-5-105
更新日期:2012-05-30 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-4004-8
更新日期:2020-03-19 00:00:00
abstract:BACKGROUND:The parasitic mite Varroa destructor is considered the major pest of the European honey bee (Apis mellifera) and responsible for declines in honey bee populations worldwide. Exploiting the full potential of gene sequences becoming available for V. destructor requires adaptation of modern molecular biology ap...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-73
更新日期:2010-08-16 00:00:00
abstract:BACKGROUND:Canine dirofilariasis due to Dirofilaria immitis is known to be endemic in continental Portugal. However, information about the transmitting mosquito species is still scarce, with only Culex theileri identified to date, albeit with L1-2, through dissection. This study was carried out to investigate the poten...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0760-2
更新日期:2015-03-03 00:00:00
abstract:BACKGROUND:Trichinella spiralis expresses paramyosin (Ts-Pmy) not only as a structural protein but also as an immunomodulator that inhibits host complement as a survival strategy. Previous studies demonstrated that Ts-Pmy bound to complement components C8 and C9 and inhibited the polymerization of C9 during the formati...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-313
更新日期:2014-07-04 00:00:00
abstract:BACKGROUND:Intestinal schistosomiasis due to Schistosoma mansoni was mapped in Cameroon in the 1990s and preventive chemotherapy launched since 2005. A situation analysis conducted in 2011 revealed an increase in schistosomiasis transmission, especially in the equatorial part of the country, despite the fact that Biomp...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2763-2
更新日期:2018-03-13 00:00:00
abstract:BACKGROUND:This laboratory study compared the efficacy of Bravecto™ (fluralaner), formulated as a chewable tablet, with the efficacy of Advocate® (imidacloprid/moxidectin), formulated for topical administration, against naturally acquired generalized demodicosis in dogs. METHODS:Sixteen dogs, all diagnosed with genera...
journal_title:Parasites & vectors
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13071-015-0775-8
更新日期:2015-03-28 00:00:00
abstract:BACKGROUND:The prolonged feeding process of ixodid ticks, in combination with bacterial transmission, should lead to a robust inflammatory response at the blood-feeding site. Yet, factors present in tick saliva may down-regulate such responses, which may be beneficial to spirochete transmission. The primary goal of thi...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1638-7
更新日期:2016-07-08 00:00:00
abstract:BACKGROUND:There is a continuing need for novel approaches to tick control in dogs. One such approach lies in the ability of lotilaner (Credelio™), an isoxazoline with a rapid onset of action, to provide sustained efficacy against ticks. Two studies were undertaken to confirm lotilaner's efficacy, at the minimum dose r...
journal_title:Parasites & vectors
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13071-017-2477-x
更新日期:2017-11-01 00:00:00
abstract::Altogether 2004 Ixodes ricinus ticks, from 37 places in Hungary, were analysed in pools with a recently developed multiplex real-time PCR for the presence of Candidatus Neoehrlichia mikurensis and for other representatives of the genus. Ca. Neoehrlichia mikurensis was identified in nine sampling sites, indicating thre...
journal_title:Parasites & vectors
pub_type: 信件
doi:10.1186/1756-3305-6-267
更新日期:2013-09-17 00:00:00