Abstract：
BACKGROUND:Insect haemocytes mediate cellular immune responses (e.g., phagocytosis) and contribute to the synthesis of humoral immune factors. In previous work, a genome-wide molecular characterization of Anopheles gambiae circulating haemocytes was followed by functional gene characterization using cell-based RNAi screens. Assays were carried out to investigate the role of selected haemocyte-specific or enriched genes in phagocytosis of bacterial bio-particles, expression of the antimicrobial peptide cecropin1, and basal and induced expression of the mosquito complement factor LRIM1 (leucine-rich repeat immune gene I). FINDINGS:Here we studied the impact of a subset of genes (37 candidates) from the haemocyte-specific dsRNA collection on the development of Plasmodium in the mosquito by in vivo gene silencing. Our screening identifies 10 novel factors with a role in the mosquito response to Plasmodium. Analysis of in vivo screening phenotypes reveals a significant anti-correlation between the prevalence of oocysts and melanised ookinetes. CONCLUSIONS:Among novel immune genes are putative pattern recognition proteins (leucine-rich repeat, fibrinogen-domain and R-type lectins), immune modulation and signalling proteins (LPS-induced tumor necrosis factor alpha factor, LITAF and CLIP proteases), and components of extracellular matrix such as laminin and collagen. Additional identified proteins such as the storage protein hexamerin and vesicular-type ATPase (V-ATPase) are associated for the first time with the mosquito response against Plasmodium.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Lombardo F,Christophides GKdoi
10.1186/s13071-016-1359-ysubject
Has Abstractpub_date
2016-02-09 00:00:00pages
78issn
1756-3305pii
10.1186/s13071-016-1359-yjournal_volume
9pub_type
杂志文章abstract：BACKGROUND:Carboxylesterase overproduction is a frequently observed resistance mechanism of insects to organophosphate insecticides. As a major transmitter of human diseases, mosquitoes in the Culex pipiens complex have evolved 13 carboxylesterase alleles (Ester) that confer organophosphate resistance. Six alleles, Est...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-5-209
更新日期：2012-09-24 00:00:00
abstract：BACKGROUND:Rhipicephalus microplus is an efficient biological vector of Babesia bovis, a causative agent of bovine babesiosis. Babesia bovis is passed transovarially to the next generation of ticks, which then transmit the parasite to naïve animals. Due to the importance of the R. microplus ovary for tick reproduction ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-3270-1
更新日期：2019-01-05 00:00:00
abstract：BACKGROUND:Libyostrongylus douglassii, Libyostrongylus dentatus and Libyostrongylus magnus are nematodes that infect ostriches. The first species has been identified in ostriches from Africa, Europe, Americas and Oceania. Although the natural range of ostriches is Africa, L. dentatus was first described in birds from t...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-2815-7
更新日期：2018-04-13 00:00:00
abstract：BACKGROUND:Schistosomiasis japonica remains a major public health problem in China. Integrating molecular analyses, such as population genetic analyses, of the parasite into the on-going surveillance programs is helpful in exploring the factors causing the persistence and/or spread of Schistosoma japonicum. However, ge...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-1074-0
更新日期：2015-09-08 00:00:00
abstract：BACKGROUND:Bravecto™ Chewable Tablets for Dogs, containing fluralaner as active ingredient, is an innovative treatment for flea and tick infestations that provides safe, rapid and long acting efficacy after a single oral administration in dogs. Topically applied fluralaner provides similar safe, rapid and long acting e...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1564-8
更新日期：2016-05-31 00:00:00
abstract：BACKGROUND:In Lithuania, the first case of canine subcutaneous dirofilariosis was recorded in 2010. Since then, an increasing number of cases of canine dirofilariosis have been documented in different veterinary clinics throughout the country. Human dirofilariosis was diagnosed in Lithuania for the first time in Septem...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3406-y
更新日期：2019-04-18 00:00:00
abstract：BACKGROUND:Hard ticks are hematophagous ectoparasites characterized by their long-term feeding. The saliva that they secrete during their blood meal is their crucial weapon against host-defense systems including hemostasis, inflammation and immunity. The anti-hemostatic, anti-inflammatory and immune-modulatory activiti...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-2874-9
更新日期：2018-05-24 00:00:00
abstract：BACKGROUND:Parasitic flatworms (Trematoda: Digenea) represent one of the most remarkable examples of drastic morphological diversity among the stages within a life cycle. Which genes are responsible for extreme differences in anatomy, physiology, behavior, and ecology among the stages? Here we report a comparative tran...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04424-4
更新日期：2020-11-10 00:00:00
abstract：BACKGROUND:Sheep scab is caused by the ectoparasitic mite Psoroptes ovis which initiates a profound cutaneous inflammatory response, leading to the development of the skin lesions which are characteristic of the disease. Existing control strategies rely upon injectable endectocides and acaricidal dips but concerns over...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-5-30
更新日期：2012-02-08 00:00:00
abstract：BACKGROUND:Taenia solium is an important zoonotic parasite that infects humans as definitive host (taeniasis) and pigs as intermediate host (cysticercosis). Serological diagnosis of porcine cysticercosis is limited to antigen detection using ELISA, which is known to cross-react with other Taenia species, and antibody d...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-3279-5
更新日期：2019-01-24 00:00:00
abstract：BACKGROUND:Surveillance of outdoor resting malaria vector populations is crucial to monitor possible changes in vector resting and feeding behaviour following the widespread use of indoor-based vector control interventions. However, it is seldom included in the routine vector surveillance system in Africa due to lack o...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3535-3
更新日期：2019-05-31 00:00:00
abstract：BACKGROUND:Aedes albopictus, the Asian tiger mosquito, is an exotic invasive species in Europe. It has substantial public health relevance due to its potential role in transmitting several human pathogens. Out of the European countries, Spain has one of the highest risk levels of autochthonous arbovirus transmission du...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3359-1
更新日期：2019-03-29 00:00:00
abstract：BACKGROUND:Reliable maps of the geographical distribution, number of infected individuals and burden estimates of schistosomiasis are essential tools to plan, monitor and evaluate control programmes. Large-scale disease mapping and prediction efforts rely on compiled historical survey data obtained from the peer-review...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-4-142
更新日期：2011-07-20 00:00:00
abstract：BACKGROUND:The cat flea (Ctenocephalides felis) is a blood-feeding ectoparasitic insect and particular nuisance pest of companion animals worldwide. Identification of genes that are differentially expressed in response to feeding is important for understanding flea biology and discovering targets for their control. ME...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0972-5
更新日期：2015-07-14 00:00:00
abstract：: The brown dog tick (Rhipicephalus sanguineus) is the most widespread tick in the world and a well-recognized vector of many pathogens affecting dogs and occasionally humans. This tick can be found on dogs living in both urban and rural areas, being highly adapted to live within human dwellings and being active throug...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-3-26
更新日期：2010-04-08 00:00:00
abstract：BACKGROUND:In 2011, we reported occurrence of natural human infections with Brugia pahangi, a filarial worm of dogs and cats, in a surburb of Kuala Lumpur, the capital city of Malaysia. Our preliminary entomological survey at that time suggested the mosquito species Armigeres subalbatus as the vector of the zoonotic in...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-219
更新日期：2013-07-30 00:00:00
abstract：BACKGROUND:Northeastern Italy is a hotspot for several tick-borne pathogens, transmitted to animals and humans mainly by Ixodes ricinus. Here we compare the results of molecular monitoring of ticks and zoonotic TBPs over a six-year period, with the monitoring of red foxes (Vulpes vulpes) in an endemic area. RESULTS:In...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-2726-7
更新日期：2018-03-20 00:00:00
abstract：BACKGROUND:Canine filarioids are important nematodes transmitted to dogs by arthropods. Diagnosis of canine filariosis is accomplished by the microscopic identification of microfilariae, serology or PCR for filarial-DNA. The aim of this study was to evaluate a molecular assay for the detection of canine filariae in dog...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0783-8
更新日期：2015-03-23 00:00:00
abstract：BACKGROUND:Bovine besnoitiosis, caused by the apicomplexan parasite Besnoitia besnoiti, is a chronic and debilitating cattle disease that notably impairs fertility. Acutely infected bulls may develop respiratory signs and orchitis, and sterility has been reported in chronic infections. However, the pathogenesis of acut...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-3959-9
更新日期：2020-03-02 00:00:00
abstract：:Taenia solium life cycle includes humans as definitive hosts and pigs as intermediate hosts. One of the measures to stop the life cycle of this parasite is by vaccination of pigs. In experiments performed in pigs with TSOL18 and TSOL45-1A, two recombinant T. solium proteins, 99.5% and 97.0% protection was induced, res...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-4-3
更新日期：2011-01-06 00:00:00
abstract：BACKGROUND:Improved surveillance techniques are required to accelerate efforts against major arthropod-borne diseases such as malaria, dengue, filariasis, Zika and yellow-fever. Light-emitting diodes (LEDs) are increasingly used in mosquito traps because they improve energy efficiency and battery longevity relative to ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3673-7
更新日期：2019-08-27 00:00:00
abstract：BACKGROUND:Intestinal protozoan parasites are major contributors to the global burden of gastrointestinal disease causing significant socioeconomic consequences. Children living in resource-poor settings with restricted access to water and sanitary services are particularly at risk of these infections. METHODS:A prosp...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-3054-7
更新日期：2018-08-30 00:00:00
abstract：BACKGROUND:Certain municipalities in the Belo Horizonte Metropolitan Area (BHMA), Minas Gerais, Brazil, have the highest human visceral leishmaniasis (VL) mortality rates in the country and also demonstrate high canine seropositivity. In Brazil, the etiologic agent of VL is Leishmania (Leishmania) infantum. The aim of ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0837-y
更新日期：2015-04-15 00:00:00
abstract：BACKGROUND:Lyme borreliosis is the most common tick-borne human disease and is caused by Borrelia burgdorferi sensu lato (s.l.). Borrelia miyamotoi, a relapsing fever spirochaete, is transmitted transovarially, whereas this has not been shown for B. burgdorferi (s.l). Therefore, B. burgdorferi (s.l) is considered to cy...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1389-5
更新日期：2016-02-20 00:00:00
abstract：:Here we describe a case of paediatric visceral leishmaniasis recorded in an infant initially suspected for acute lymphoblastic leukaemia due to the clinical and haematological presentation. Eventually the patient was found positive for Leishmania infantum infection and successfully treated. This case emphasises how pi...
journal_title：Parasites & vectors
pub_type： 信件
doi：10.1186/1756-3305-6-123
更新日期：2013-04-29 00:00:00
abstract：:The control of insects of medical importance, such as Aedes aegypti and Aedes albopictus are still the only effective way to prevent the transmission of diseases, such as dengue, chikungunya and Zika. Their control is performed mainly using chemical products; however, they often have low specificity to non-target orga...
journal_title：Parasites & vectors
pub_type： 杂志文章,评审
doi：10.1186/s13071-020-04236-6
更新日期：2020-07-29 00:00:00
abstract：BACKGROUND:This study focused on the distribution and abundance of the eggs of Aedes aegypti and Aedes albopictus. METHODS:Eighty ovitraps were exposed for four days of each month in peri- and intradomiciliary environments of 40 urban residences on 20 street blocks that were drawn monthly in Sebastião, SP, between Feb...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-321
更新日期：2013-11-06 00:00:00
abstract：BACKGROUND:Red deer (Cervus elaphus) are a common wild definitive host for liver fluke (Fasciola hepatica) that have been the subject of limited diagnostic surveillance. This study aimed to explore the extent to which coprological diagnoses for F. hepatica in red deer in the Scottish Highlands, Scotland, are associated...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3782-3
更新日期：2019-11-12 00:00:00
abstract：BACKGROUND:Canine vector-borne diseases (CVBD) have become a major concern for canine and human public health. The aim of the study described here is to add epidemiological data regarding four pathogens responsible for CVBD, namely anaplasmosis, borreliosis, dirofilariosis and ehrlichiosis in a national survey conducte...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1686-z
更新日期：2016-07-29 00:00:00
abstract：BACKGROUND:In the last decades, the enormous influx of immigrants to industrialized countries has led to outbreaks of parasitic diseases, with enteric infections being amongst the most frequently encountered. In its strategy to control such infection, Qatar has established the Pre-Employment Certificate (PEC) program w...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1906-6
更新日期：2016-12-01 00:00:00
