Abstract:
BACKGROUND:Rhipicephalus microplus is an efficient biological vector of Babesia bovis, a causative agent of bovine babesiosis. Babesia bovis is passed transovarially to the next generation of ticks, which then transmit the parasite to naïve animals. Due to the importance of the R. microplus ovary for tick reproduction and transmission of B. bovis, we investigated the hypothesis that silencing vitellogenin receptor gene expression in the ovary during tick feeding on B. bovis-infected cattle would affect parasite transmission to the next generation of ticks. RESULTS:Silencing expression of the vitellogenin receptor in the ovary by RNA interference, resulted in reduced tick fertility. We observed reduced egg production (i.e. reduced weight of eggs), a lower rate of embryonic development, and a reduction in hatching. Analysis of individual larvae by PCR confirmed that RNAi mediated downregulation of the R. microplus vitellogenin receptor and also interfered with transovarial transmission of B. bovis. None of the larvae (0/58) from the RmVgR dsRNA-injected group were PCR-positive, whereas 12% (7/58) and 17% (10/58) of larvae from the non-injected and buffer-injected control groups, respectively, were infected with B. bovis. CONCLUSIONS:The combined effects of reduced fecundity and reduced infection in surviving larvae resulting from silencing indicate that vitellogenin receptor is essential for tick reproduction and may play a vital role in B. bovis transmission.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Hussein HE,Johnson WC,Taus NS,Suarez CE,Scoles GA,Ueti MWdoi
10.1186/s13071-018-3270-1subject
Has Abstractpub_date
2019-01-05 00:00:00pages
7issue
1issn
1756-3305pii
10.1186/s13071-018-3270-1journal_volume
12pub_type
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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pub_type: 杂志文章
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更新日期:2015-02-08 00:00:00
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journal_title:Parasites & vectors
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更新日期:2018-07-09 00:00:00
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pub_type: 杂志文章
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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pub_type: 杂志文章,meta分析
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
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更新日期:2015-10-12 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2019-01-14 00:00:00
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journal_title:Parasites & vectors
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更新日期:2019-01-07 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2020-03-30 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2017-06-27 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2018-04-13 00:00:00
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pub_type: 杂志文章
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更新日期:2011-07-20 00:00:00