Abstract：
BACKGROUND:Pyrethroid resistance in African vector mosquitoes is a threat to malaria control. Resistant mosquitoes can survive insecticide doses that would normally be lethal. We studied effects of such doses on Plasmodium falciparum development inside kdr-resistant Anopheles gambiae s.s. in Uganda. METHODS:We collected An. gambiae s.s. homozygous for kdr-L1014S mutation, fed them on blood samples from 42 P. falciparum-infected local patients, then exposed them either to nets treated with sub-lethal doses of deltamethrin or to untreated nets. After seven days, we dissected 692 mosquitoes and examined their midguts for oocysts. Prevalence (proportion infected) and intensity of infection (number of oocysts per infected mosquito) were recorded for each group. RESULTS:Both prevalence and intensity of infection were significantly reduced in deltamethrin-exposed mosquitoes, compared to those exposed to untreated nets. With low doses (2.5-5.0 mg/m(2)), prevalence was reduced by 59% (95% CI = 22%-78%) and intensity by 41% (95% CI = 25%-54%). With high doses (10-16.7 mg/m(2)), prevalence was reduced by 80% (95% CI = 67%-88 %) and intensity by 34 % (95 % CI = 20%-46%). CONCLUSIONS:We showed that, with locally-sampled parasites and mosquitoes, doses of pyrethroids that are sub-lethal for resistant mosquitoes can interfere with parasite development inside mosquitoes. This mechanism could enable pyrethroid-treated nets to prevent malaria transmission despite increasing vector resistance.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Kristan M,Lines J,Nuwa A,Ntege C,Meek SR,Abeku TAdoi
10.1186/s13071-016-1384-xsubject
Has Abstractpub_date
2016-02-24 00:00:00pages
100issn
1756-3305pii
10.1186/s13071-016-1384-xjournal_volume
9pub_type
杂志文章abstract：:Control and eventual elimination of human parasitic diseases in the People's Republic of China (P.R. China) requires novel approaches, particularly in the areas of diagnostics, mathematical modelling, monitoring, evaluation, surveillance and public health response. A comprehensive effort, involving the collaboration o...
journal_title：Parasites & vectors
pub_type： 杂志文章,评审
doi：10.1186/1756-3305-5-221
更新日期：2012-10-04 00:00:00
abstract：BACKGROUND:Malaria remains a major public health threat in Cameroon and disease prevention is facing strong challenges due to the rapid expansion of insecticide resistance in vector populations. The present review presents an overview of published data on insecticide resistance in the main malaria vectors in Cameroon t...
journal_title：Parasites & vectors
pub_type： 杂志文章,评审
doi：10.1186/s13071-017-2417-9
更新日期：2017-10-10 00:00:00
abstract：BACKGROUND:Spatial repellents that drive mosquitoes away from treated areas, and odour-baited traps, that attract and kill mosquitoes, can be combined and work synergistically in a push-pull system. Push-pull systems have been shown to reduce house entry and outdoor biting rates of malaria vectors and so have the poten...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04263-3
更新日期：2020-07-31 00:00:00
abstract：BACKGROUND:Rhipicephalus microplus is a hard tick that has a major impact on cattle health in tropical and subtropical regions because it feeds on cattle and is implicated in the transmission of pathogens that cause diseases such as bovine anaplasmosis and babesiosis. Presently, acaricides are used to control tick infe...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2081-0
更新日期：2017-03-23 00:00:00
abstract：BACKGROUND:Aedes albopictus is widely distributed across tropical and sub-tropical regions and is associated with the transmission of several arboviruses. Although this species is increasingly relevant to public health due its ability to successfully colonize both urban and rural habitats, favoring the dispersion of vi...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-253
更新日期：2014-05-30 00:00:00
abstract：BACKGROUND:Diagnostics provide a means to measure progress toward disease elimination. Many countries in Africa are approaching elimination of onchocerciasis after successful implementation of mass drug administration programs as well as vector control. An understanding of how markers for infection such as skin snip mi...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1623-1
更新日期：2016-06-13 00:00:00
abstract：BACKGROUND:Low-density asymptomatic infections of Plasmodium spp. are common in low endemicity areas worldwide, but outside Africa, their contribution to malaria transmission is poorly understood. Community-based studies with highly sensitive molecular diagnostics are needed to quantify the asymptomatic reservoir of Pl...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2407-y
更新日期：2017-10-24 00:00:00
abstract：BACKGROUND:Domestic cats play a key role in the epidemiology of the parasite Toxoplasma gondii by excreting environmentally-resistant oocysts that may infect humans and other warm-blooded animals. The dynamics of Toxoplasma gondii seroconversion, used as a proxy for primo-infection dynamics, was investigated in five ca...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-2834-4
更新日期：2018-06-08 00:00:00
abstract：BACKGROUND:Parasitic flatworms (Trematoda: Digenea) represent one of the most remarkable examples of drastic morphological diversity among the stages within a life cycle. Which genes are responsible for extreme differences in anatomy, physiology, behavior, and ecology among the stages? Here we report a comparative tran...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04424-4
更新日期：2020-11-10 00:00:00
abstract：BACKGROUND:In 2012, the World Health Organization set goals for the elimination of onchocerciasis transmission by 2020 in selected African countries. Epidemiological data and mathematical modelling have indicated that elimination may not be achieved with annual ivermectin distribution in all endemic foci. Complementary...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-2864-y
更新日期：2018-05-29 00:00:00
abstract：BACKGROUND:The prevalence of bovine babesiosis caused by Babesia divergens has been declining during the past decades in northeastern Hungary, and no cases have been observed since 2008. Infections of cattle with B. major and Theileria buffeli were hitherto reported in southern and western Europe. In other parts of the...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-434
更新日期：2014-09-11 00:00:00
abstract：BACKGROUND:Abundance and species composition of sympatric malaria vector species are the important factors governing transmission intensity. A widespread insecticidal bed net coverage may replace endophagic species with exophagic species. However, unique local environments also influence a vector population. This study...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-63
更新日期：2014-02-11 00:00:00
abstract：BACKGROUND:Malaria mosquitoes spend a considerable part of their life in the aquatic stage, rendering them vulnerable to interventions directed to aquatic habitats. Recent successes of mosquito larval control have been reported using environmental and biological tools. Here, we report the effects of shading by plants a...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-4-130
更新日期：2011-07-06 00:00:00
abstract：BACKGROUND:The Brazilian Semiarid is the home of the largest herd of donkeys in South America and of outbreaks of Trypanosoma vivax infection of high mortality in dairy cattle and sheep. For a comprehensive understanding of the underlying mechanisms of these outbreaks and epidemiological role of donkeys, we surveyed fo...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-1169-7
更新日期：2015-10-28 00:00:00
abstract：BACKGROUND:In Morocco, the main strategies of leishmaniasis vector control are based on environmental modifications. Use of local residual indoor spraying with synthetic pyrethroids is often envisaged. The need to evaluate this control method is essential. The current study was conducted to determine the efficacy of an...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-354
更新日期：2013-12-13 00:00:00
abstract：BACKGROUND:The current study shows the results of three years of IRS entomological monitoring (2016, before intervention; 2017 and 2018, after intervention) performed in Alibori and Donga, northern Benin. METHODS:Mosquito collections were performed on a monthly basis using human landing catches and pyrethrum spray cat...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3865-1
更新日期：2019-12-30 00:00:00
abstract：BACKGROUND:Toxoplasmosis is an important zoonosis, being a cause of congenital disease and abortion in animals and humans. DNA vaccination as a promising vaccine remains a challenge for an improved delivery system. METHODS:In this study, attenuated Salmonella typhimurium BRD509 was used to deliver a DNA vaccine encodi...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-145
更新日期：2014-03-31 00:00:00
abstract：BACKGROUND:Henneguya Thélohan, 1892 (Myxobolidae) is one of the most species-rich genera of myxosporean parasites infecting fish. Although common in nature, there are few reports of these parasites causing important disease in aquaculture. In this paper, we describe a new species of Henneguya infecting Pagrus major (Te...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-3888-7
更新日期：2020-01-14 00:00:00
abstract：BACKGROUND:Blastocystis sp. is one of the most prevalent parasites found in human stool and has been recently considered an opportunistic emerging pathogen in immunocompromised individuals. However, cases of invasive intestinal infections and skin rashes have been attributed to infection by Blastocystis sp in immunocom...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-207
更新日期：2014-04-29 00:00:00
abstract：: Canine leishmaniosis is widespread in South America, where a number of Leishmania species have been isolated or molecularly characterised from dogs. Most cases of canine leishmaniosis are caused by Leishmania infantum (syn. Leishmania chagasi) and Leishmania braziliensis. The only well-established vector of Leishmani...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-2-S1-S1
更新日期：2009-03-26 00:00:00
abstract：BACKGROUND:Culex quinquefasciatus is a hematophagous insect from the Culicidae family that feeds on the blood of humans, dogs, birds and livestock. This species transmits a wide variety of pathogens between humans and animals. The midgut environment is the first location of pathogen-vector interactions for blood-feedin...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0985-0
更新日期：2015-07-16 00:00:00
abstract：BACKGROUND:The protozoan parasite Trichomonas vaginalis is the most common non-viral, sexually transmitted pathogen. Although T. vaginalis is highly prevalent among women in Kenya, there is lack of data regarding genetic diversity of isolates currently in circulation in Kenya. METHODS:Typing was performed on 22 clinic...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2496-7
更新日期：2017-10-30 00:00:00
abstract：BACKGROUND:Zoonotic onchocerciasis is a vector-borne disease, which involves many animal species, including large ungulates, boars, dogs, and sporadically, humans. So far, 39 cases of zoonotic onchocerciasis have been reported worldwide, 30 of which have been found in the last 20 years. Onchocerca nematodes are transmi...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-3925-6
更新日期：2020-02-12 00:00:00
abstract：BACKGROUND:Leishmania infantum is a vector-borne pathogen endemic in countries in the Mediterranean basin, including Italy. Dogs act as the primary reservoir for this parasite, but other animal species may also be infected. Low-to-moderate seroprevalence levels of infection have been reported in apparent healthy equine...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04385-8
更新日期：2020-10-22 00:00:00
abstract：:Rickettsioses are among the oldest known infectious diseases. In spite of this, and of the extensive research carried out, many aspects of the biology and epidemiology of tick-borne rickettsiae are far from being completely understood. Their association with arthropod vectors, the importance of vertebrates as reservoi...
journal_title：Parasites & vectors
pub_type： 杂志文章,评审
doi：10.1186/s13071-018-2856-y
更新日期：2018-04-24 00:00:00
abstract：BACKGROUND:The TNF signaling pathway is involved in the regulation of many cellular processes (such as apoptosis and cell proliferation). Previous reports indicated the effect of human TNF-α on metabolism, physiology, gene expression and protein phosphorylation of the human parasite Schistosoma mansoni and suggested th...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04370-1
更新日期：2020-09-25 00:00:00
abstract：BACKGROUND:Ticks are increasingly reported on cats worldwide, with Ixodes ricinus being a relevant species across Europe and in near by areas of North Africa and the Middle East. Yet there are few acaracidal products with proven efficacy approved for use in cats. The objective of this study was to compare the efficacy ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2259-5
更新日期：2017-06-29 00:00:00
abstract：BACKGROUND:The East Route Project (ERP) of the South-to-North Water Diversion Project (SNWDP) stretches across schistosomiasis endemic and non-endemic areas in China, which may lead to the dispersal of Oncomelania hupensis, the intermediate host of Schistosoma japonicum, from permissive areas along the Yangtze River Ba...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-4004-8
更新日期：2020-03-19 00:00:00
abstract：BACKGROUND:Novel transgenic mosquito control methods require progressively more realistic evaluation. The goal of this study was to determine the effect of a transgene that causes a male-bias sex ratio on Anopheles gambiae target populations in large insectary cages. METHODS:Life history characteristics of Anopheles g...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3289-y
更新日期：2019-02-06 00:00:00
abstract：BACKGROUND:Red deer (Cervus elaphus) are a common wild definitive host for liver fluke (Fasciola hepatica) that have been the subject of limited diagnostic surveillance. This study aimed to explore the extent to which coprological diagnoses for F. hepatica in red deer in the Scottish Highlands, Scotland, are associated...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3782-3
更新日期：2019-11-12 00:00:00
