Abstract:
:Rickettsioses are among the oldest known infectious diseases. In spite of this, and of the extensive research carried out, many aspects of the biology and epidemiology of tick-borne rickettsiae are far from being completely understood. Their association with arthropod vectors, the importance of vertebrates as reservoirs, the rarity of clinical signs in animals, or the interactions of pathogenic species with rickettsial endosymbionts and with the host intracellular environment, are only some examples. Moreover, new rickettsiae are continuously being discovered. In this review, we focus on the 'neglected' aspects of tick-borne rickettsioses and on the gaps in knowledge, which could help to explain why these infections are still emerging and re-emerging threats worldwide.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Tomassone L,Portillo A,Nováková M,de Sousa R,Oteo JAdoi
10.1186/s13071-018-2856-ysubject
Has Abstractpub_date
2018-04-24 00:00:00pages
263issue
1issn
1756-3305pii
10.1186/s13071-018-2856-yjournal_volume
11pub_type
杂志文章,评审abstract:BACKGROUND:NOD-like receptor protein 3 (NLRP3) inflammasome was reported as expressed in schistosomiasis-induced liver fibrosis (SSLF). We used an NLRP3 inflammasome inhibitor, MCC950, to investigate whether it inhibited liver fibrosis, and explored the preliminary molecular mechanism. METHODS:BALB/c mice were infecte...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3223-8
更新日期:2019-01-11 00:00:00
abstract:BACKGROUND:Dengue has become the subject of public health programs worldwide. The lack of a vaccine and the high environmental risk of synthetic insecticides, arouse the interest in natural products against this vector. This study aimed to determine the chemical composition of the essential oil of ripe fruits and seeds...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0746-0
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The Cqm1 α-glucosidase of Culex quinquefasciatus larvae acts as the midgut receptor for the binary toxin of the biolarvicide Lysinibacillus sphaericus. Mutations within the cqm1 gene can code for aberrant polypeptides that can no longer be properly expressed or bind to the toxin, leading to insect resistance...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1347-2
更新日期:2016-02-04 00:00:00
abstract:BACKGROUND:Environmental changes caused by urbanization can cause alterations in the ecology and behavior of sandflies and in the epidemiology of leishmaniasis. Geotechnological tools allow the analysis and recognition of spatiotemporal patterns by monitoring and mapping risk areas of this vector-borne disease. This st...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-364
更新日期:2014-08-15 00:00:00
abstract:BACKGROUND:In the Eastern and Upper Midwestern regions of North America, Ixodes scapularis (L.) is the most abundant tick species encountered by humans and the primary vector of B. burgdorferi, whereas in the southeastern region Amblyomma americanum (Say) is the most abundant tick species encountered by humans but cann...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-139
更新日期:2012-07-10 00:00:00
abstract:BACKGROUND:Multiplicity and genetic diversity of Plasmodium falciparum infection might play a role in determining the clinical outcome of malaria infection and could be a fair reflection of the disease transmission rate. This study investigated the genetic diversity of P. falciparum and multiplicity of infection in rel...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1641-z
更新日期:2016-06-27 00:00:00
abstract:BACKGROUND:The transmission of malaria is heterogeneous, and varies due to altitude. The information on whether the transmission of malaria is indigenous or imported to highland areas is scarce. Therefore, this study aimed to assess the species composition and infection rates of Anopheles at different altitudinal trans...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2288-0
更新日期:2017-07-19 00:00:00
abstract::Ticks (Acari: Ixodida) are arthropod ectoparasites dependent on a bloodmeal from a vertebrate host at each developmental stage for completion of their life cycle. This tick feeding cycle impacts animal health by causing damage to hides, secondary infections, immune reactions and diseases caused by transmission of path...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1185-7
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:Widespread deforestation occurring in the tropics is hypothesized to impact the transmission of vector-borne diseases (VBD). Predicting how environmental changes will impact VBD transmission is dependent on understanding the ecology and behaviour of potential vector species outside of domestic settings. Howe...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2926-1
更新日期:2018-06-14 00:00:00
abstract:BACKGROUND:Lymphatic filariasis (LF) is a debilitating disease associated with extensive disfigurement and is one of a diverse group of diseases referred to as neglected tropical diseases (NTDs) which mainly occur among the poorest populations. In line with global recommendations to eliminate LF, Kenya launched its LF ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2044-5
更新日期:2017-02-22 00:00:00
abstract:BACKGROUND:During a Plasmodium infection, exposure of human host immune cells to both the asexual and the sexual stages of the parasite elicit immune responses. These responses may be protective and prevent the development of high parasitaemia and its associated clinical symptoms, or block the transmission of malaria t...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2607-5
更新日期:2018-01-05 00:00:00
abstract:BACKGROUND:The sibling species of the malaria mosquito, Anopheles gambiae (sensu stricto) and Anopheles coluzzii co-exist in many parts of West Africa and are thought to have recently diverged through a process of ecological speciation with gene flow. Divergent larval ecological adaptations, resulting in Genotype-by-En...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04483-7
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Preventive chemotherapy with donated anthelminthic drugs is the cornerstone for the control of helminthiases. However, reinfection can occur rapidly in the absence of clean water and sanitation coupled with unhygienic behaviour. The purpose of this study was to assess the effect of an integrated package of i...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2642-x
更新日期:2018-02-27 00:00:00
abstract::Taenia solium life cycle includes humans as definitive hosts and pigs as intermediate hosts. One of the measures to stop the life cycle of this parasite is by vaccination of pigs. In experiments performed in pigs with TSOL18 and TSOL45-1A, two recombinant T. solium proteins, 99.5% and 97.0% protection was induced, res...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-3
更新日期:2011-01-06 00:00:00
abstract:BACKGROUND:Invasive mosquito species (IMS) of the genus Aedes are a cause of increasing concern in Europe owing to their ability to vector important human viral diseases. Entomological surveillance to early detect alien mosquito and flavivirus circulation in Liguria, northwest Italy, has been carried out since 2011. R...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3589-2
更新日期:2019-07-05 00:00:00
abstract:BACKGROUND:The tick midgut and salivary glands represent the primary organs for pathogen acquisition and transmission, respectively. Specifically, the midgut is the first organ to have contact with pathogens during the blood meal uptake, while salivary glands along with their secretions play a crucial role in pathogen ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3418-7
更新日期:2019-04-02 00:00:00
abstract:BACKGROUND:Long-term field studies of parasite communities are rare but provide a powerful insight into the ecological processes shaping host-parasite interactions. The aim of our study was to monitor long-term trends in the haemoparasite communities of spiny mice (Acomys dimidiatus) and to identify the principal facto...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1471-z
更新日期:2016-04-08 00:00:00
abstract:BACKGROUND:The knowledge of mosquito species diversity and the level of anthropophily exhibited by each species in a region are of great importance to the integrated vector control. Culicine species are the primary vectors of Japanese encephalitis (JE) virus and filariasis in China. Anopheles sinensis plays a major rol...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-221
更新日期:2011-11-24 00:00:00
abstract:BACKGROUND:Red foxes (Vulpes vulpes) are one of the most widespread wild carnivores in the world, being recognized to harbor and transmit a wide range of vector-borne diseases. Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato are zoonotic tick-borne pathogens causing emerging diseases. Wild animals play an...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1130-9
更新日期:2015-10-08 00:00:00
abstract:BACKGROUND:Investigating malaria transmission dynamics is essential to inform policy decision making. Whether multiplicity of infection (MOI) dynamic from individual infections could be a reliable malaria metric in high transmission settings with marked variation in seasons of malaria transmission has been poorly asses...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04302-z
更新日期:2020-08-20 00:00:00
abstract:: The proteasome inhibitor and anti-cancer drug bortezomib was tested for in vitro activity against bloodstream forms of Trypanosoma brucei. The concentrations of bortezomib required to reduce the growth rate by 50% and to kill all trypanosomes were 3.3 nM and 10 nM, respectively. In addition, bortezomib was 10 times m...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-2-29
更新日期:2009-07-07 00:00:00
abstract:BACKGROUND:Neospora caninum is an obligate intracellular parasite, and its ability to survive inside host immune cells may be a key mechanism for the establishment of infection in cattle. In vitro studies carried out by our group have shown that N. caninum is able to replicate in bovine macrophages (MØs), alter their m...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04239-3
更新日期:2020-07-25 00:00:00
abstract::The Companion Vector-Borne Diseases (CVBD) World Forum is a working group of leading international experts who meet annually to evaluate current scientific findings and future trends concerning the distribution, pathogenesis, clinical presentation, diagnosis and prevention of vector-borne infections of dogs and cats. ...
journal_title:Parasites & vectors
pub_type: 信件
doi:10.1186/s13071-020-04407-5
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Equine piroplasmosis is a highly endemic protozoan disease of horses worldwide, caused by Theileria equi and Babesia caballi. While most horses in endemic areas are subclinically infected, the mechanisms leading to clinical outcome are vastly unknown. Moreover, since clinical signs of disease are not specifi...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04133-y
更新日期:2020-05-20 00:00:00
abstract:BACKGROUND:Sheep scab is a highly contagious disease of sheep caused by the ectoparasitic mite Psoroptes ovis. The disease is endemic in the UK and has significant economic impact through its effects on performance and welfare. Diagnosis of sheep scab is achieved through observation of clinical signs e.g. itching, prur...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-7
更新日期:2012-01-10 00:00:00
abstract:BACKGROUND:Haemoproteus parasites (Haemosporida, Haemoproteidae) are cosmopolitan in birds and recent molecular studies indicate enormous genetic diversity of these pathogens, which cause diseases in non-adapted avian hosts. However, life-cycles remain unknown for the majority of Haemoproteus species. Information on th...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3773-4
更新日期:2019-11-04 00:00:00
abstract:BACKGROUND:With the spread of pyrethroid resistance in mosquitoes, the combination of an insecticide (carbamate or organophosphate) with a repellent (DEET) is considered as a promising alternative strategy for the treatment of mosquito nets and other relevant materials. The efficacy of these mixtures comes from the fac...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-2-17
更新日期:2009-04-16 00:00:00
abstract:BACKGROUND:Gyrodactylus salaris Malmberg, 1957 has had a devastating impact on wild Norwegian stocks of Atlantic salmon Salmo salar L., and it is the only Office International des Epizooties (OIE) listed parasitic pathogen of fish. The UK is presently recognised as G. salaris-free, and management plans for its containm...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0576-5
更新日期:2014-12-20 00:00:00
abstract:BACKGROUND:Porcine cysticercosis is an emerging agricultural problem in sub-Saharan Africa. This has been documented primarily through cross-sectional studies, however detailed knowledge of the transmission dynamics of this disease in sub-Saharan Africa is lacking. This study aims to describe seasonal variations in ser...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0574-7
更新日期:2014-12-04 00:00:00
abstract:BACKGROUND:Over 60 % of human emerging infectious diseases are zoonotic, and there is growing evidence of the zooanthroponotic transmission of diseases from humans to livestock and wildlife species, with major implications for public health, economics, and conservation. Zooanthroponoses are of relevance to critically e...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2283-5
更新日期:2017-07-18 00:00:00