Immunolocalization of TSOL18 and TSOL45-1A, the successful protective peptides against porcine cysticercosis, in Taenia solium oncospheres.

Abstract:

:Taenia solium life cycle includes humans as definitive hosts and pigs as intermediate hosts. One of the measures to stop the life cycle of this parasite is by vaccination of pigs. In experiments performed in pigs with TSOL18 and TSOL45-1A, two recombinant T. solium proteins, 99.5% and 97.0% protection was induced, respectively. The purpose of this paper was to localize these antigens in all stages of the parasite (adult worms, oncospheres and cysticerci) by immunofluorescence, with the use of antibodies against TSOL18 and TSOL45-1A that were obtained from the pigs used in the vaccination experiment. Results show that TSOL18 and TSOL45-1A are expressed on the surface of T. solium oncospheres and not in tapeworms or cysticerci, indicating that they are stage-specific antigens. This, therefore, might explain the high level of protection these antigens induce against pig cysticercosis.

journal_name

Parasit Vectors

journal_title

Parasites & vectors

authors

Martinez-Ocaña J,Romero-Valdovinos M,de Kaminsky RG,Maravilla P,Flisser A

doi

10.1186/1756-3305-4-3

subject

Has Abstract

pub_date

2011-01-06 00:00:00

pages

3

issn

1756-3305

pii

1756-3305-4-3

journal_volume

4

pub_type

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