Abstract:
:Taenia solium life cycle includes humans as definitive hosts and pigs as intermediate hosts. One of the measures to stop the life cycle of this parasite is by vaccination of pigs. In experiments performed in pigs with TSOL18 and TSOL45-1A, two recombinant T. solium proteins, 99.5% and 97.0% protection was induced, respectively. The purpose of this paper was to localize these antigens in all stages of the parasite (adult worms, oncospheres and cysticerci) by immunofluorescence, with the use of antibodies against TSOL18 and TSOL45-1A that were obtained from the pigs used in the vaccination experiment. Results show that TSOL18 and TSOL45-1A are expressed on the surface of T. solium oncospheres and not in tapeworms or cysticerci, indicating that they are stage-specific antigens. This, therefore, might explain the high level of protection these antigens induce against pig cysticercosis.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Martinez-Ocaña J,Romero-Valdovinos M,de Kaminsky RG,Maravilla P,Flisser Adoi
10.1186/1756-3305-4-3subject
Has Abstractpub_date
2011-01-06 00:00:00pages
3issn
1756-3305pii
1756-3305-4-3journal_volume
4pub_type
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
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