Abstract:
BACKGROUND:Leishmania major and Leishmania infantum are among the main species that are responsible for cutaneous leishmaniosis (CL) and visceral leishmaniosis (VL), respectively. The leishmanioses represent the second-largest parasitic killer in the world after malaria. Recently, we succeeded in generating a plasmid DNA (pCMV-HISA70m2A) and demonstrated that immunized mice were protected against L. major challenge. The efficacy of the DNA-vaccine was further enhanced by the inclusion of KMP-11 antigen into the antibiotic-free plasmid pVAX1-asd. METHODS:Here, we describe the use of a HisAK70 DNA-vaccine encoding seven Leishmania genes (H2A, H2B, H3, H4, A2, KMP11 and HSP70) for vaccination of mice to assess the induction of a resistant phenotype against VL and CL. RESULTS:HisAK70 was successful in vaccinated mice, resulting in a high amount of efficient sterile hepatic granulomas associated with a hepatic parasite burden fully resolved in the VL model; and resulting in 100% inhibition of parasite visceralization in the CL model. CONCLUSIONS:The results suggest that immunization with the HisAK70 DNA-vaccine may provide a rapid, suitable, and efficient vaccination strategy to confer cross-protective immunity against VL and CL.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Domínguez-Bernal G,Horcajo P,Orden JA,Ruiz-Santa-Quiteria JA,De La Fuente R,Ordóñez-Gutiérrez L,Martínez-Rodrigo A,Mas A,Carrión Jdoi
10.1186/s13071-015-1246-ysubject
Has Abstractpub_date
2015-12-09 00:00:00pages
629issn
1756-3305pii
10.1186/s13071-015-1246-yjournal_volume
8pub_type
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pub_type: 杂志文章
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journal_title:Parasites & vectors
pub_type: 杂志文章,meta分析
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journal_title:Parasites & vectors
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2012-04-27 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2015-09-17 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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journal_title:Parasites & vectors
pub_type: 杂志文章,多中心研究
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更新日期:2014-11-20 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2018-03-06 00:00:00
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pub_type: 杂志文章
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更新日期:2012-09-05 00:00:00