Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib.

Abstract:

: The proteasome inhibitor and anti-cancer drug bortezomib was tested for in vitro activity against bloodstream forms of Trypanosoma brucei. The concentrations of bortezomib required to reduce the growth rate by 50% and to kill all trypanosomes were 3.3 nM and 10 nM, respectively. In addition, bortezomib was 10 times more toxic to trypanosomes than to human HL-60 cells. Moreover, exposure of trypanosomes to 10 nM bortezomib for 16 h was enough to kill 90% of the parasites following incubation in fresh medium. However, proteasomal peptidase activities of trypanosomes exposed to bortezomib were only inhibited by 10% and 30% indicating that the proteasome is not the main target of the drug. The results suggest that bortezomib may be useful as drug for the treatment of human African trypanosomiasis.

journal_name

Parasit Vectors

journal_title

Parasites & vectors

authors

Steverding D,Wang X

doi

10.1186/1756-3305-2-29

subject

Has Abstract

pub_date

2009-07-07 00:00:00

pages

29

issue

1

issn

1756-3305

pii

1756-3305-2-29

journal_volume

2

pub_type

杂志文章
  • Efficacy of Actellic 300 CS-based indoor residual spraying on key entomological indicators of malaria transmission in Alibori and Donga, two regions of northern Benin.

    abstract:BACKGROUND:The current study shows the results of three years of IRS entomological monitoring (2016, before intervention; 2017 and 2018, after intervention) performed in Alibori and Donga, northern Benin. METHODS:Mosquito collections were performed on a monthly basis using human landing catches and pyrethrum spray cat...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-019-3865-1

    authors: Salako AS,Dagnon F,Sovi A,Padonou GG,Aïkpon R,Ahogni I,Syme T,Govoétchan R,Sagbohan H,Sominahouin AA,Akinro B,Iyikirenga L,Agossa F,Akogbeto MC

    更新日期:2019-12-30 00:00:00

  • Anopheles gambiae densovirus (AgDNV) negatively affects Mayaro virus infection in Anopheles gambiae cells and mosquitoes.

    abstract:BACKGROUND:Recent studies demonstrate that insect-specific viruses can influence the ability of their mosquito hosts to become infected with and transmit arboviruses of medical and veterinary importance. The aim of this study was to evaluate the interactions between Anopheles gambiae densovirus (AgDNV) (Parvoviridae) (...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-04072-8

    authors: Urakova N,Brustolin M,Joseph RE,Johnson RM,Pujhari S,Rasgon JL

    更新日期:2020-04-22 00:00:00

  • Correction to: The tree that hides the forest: cryptic diversity and phylogenetic relationships in the Palaearctic vector Obsoletus/Scoticus complex (Diptera: Ceratopogonidae) at the European level.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:Parasites & vectors

    pub_type: 已发布勘误

    doi:10.1186/s13071-020-04349-y

    authors: Mignotte A,Garros C,Gardès L,Balenghien T,Duhayon M,Rakotoarivony I,Tabourin L,Poujol L,Mathieu B,Ibañez-Justicia A,Deniz A,Cvetkovikj A,Purse BV,Ramilo DW,Stougiou D,Werner D,Pudar D,Petrić D,Veronesi E,Jacobs F,

    更新日期:2020-09-22 00:00:00

  • A new baseline for fascioliasis in Venezuela: lymnaeid vectors ascertained by DNA sequencing and analysis of their relationships with human and animal infection.

    abstract:BACKGROUND:Human and animal fascioliasis poses serious public health problems in South America. In Venezuela, livestock infection represents an important veterinary problem whereas there appear to be few human cases reported, most of which are passively detected in health centres. However, results of recent surveys sug...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-4-200

    authors: Bargues MD,González LC,Artigas P,Mas-Coma S

    更新日期:2011-10-14 00:00:00

  • Low prevalence of blood parasites in a long-distance migratory raptor: the importance of host habitat.

    abstract:BACKGROUND:The low prevalence of blood parasites in some bird species may be related to the habitats they frequent, the inexistence of the right host-parasite assemblage or the immunological capacity of the host. Here, we assess the parasite load of breeding populations of Eleonora's falcon (Falco eleonorae), a medium-...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-015-0802-9

    authors: Gutiérrez-López R,Gangoso L,Martínez-de la Puente J,Fric J,López-López P,Mailleux M,Muñoz J,Touati L,Samraoui B,Figuerola J

    更新日期:2015-03-31 00:00:00

  • Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, Tanzania.

    abstract:BACKGROUND:Soil-transmitted helminthiases are important neglected tropical diseases that result in a notably high number of disability-adjusted life years worldwide. Characterizing the interactions between the human intestinal microbiome and helminths is of interest in the development of alternative treatments that do ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-021-04580-1

    authors: Chen H,Mozzicafreddo M,Pierella E,Carletti V,Piersanti A,Ali SM,Ame SM,Wang C,Miceli C

    更新日期:2021-01-19 00:00:00

  • Developing and evaluating health education learning package (HELP) to control soil-transmitted helminth infections among Orang Asli children in Malaysia.

    abstract:BACKGROUND:This study was carried out to develop a health education learning package (HELP) about soil-transmitted helminth (STH) infections, and to evaluate what impact such a package could have in terms of reducing the incidence and intensity of STH infections among Orang Asli schoolchildren in Pahang, Malaysia. MET...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-7-416

    authors: Al-Delaimy AK,Al-Mekhlafi HM,Lim YA,Nasr NA,Sady H,Atroosh WM,Mahmud R

    更新日期:2014-09-02 00:00:00

  • LONGRANGE® (eprinomectin 5% w/v extended-release injection) efficacy against Hypoderma lineatum in an endemic area in southern Italy.

    abstract:BACKGROUND:Despite intensive control measures including governmental campaigns using highly-efficacious systemic insecticides, there is evidence for persisting or recurring bovine Hypoderma species populations in parts of Europe, the USA and Canada. The present study evaluated the efficacy of LONGRANGE® (eprinomectin 5...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-019-3475-y

    authors: Lia RP,Rehbein S,Giannelli A,Fankhauser B,Otranto D

    更新日期:2019-05-14 00:00:00

  • Environmental suitability for Lutzomyia (Nyssomyia) whitmani (Diptera: Psychodidae: Phlebotominae) and the occurrence of American cutaneous leishmaniasis in Brazil.

    abstract:BACKGROUND:Leishmaniasis represents an important public health problem in Brazil. The continuous process of urbanization and expansion of human activities in forest areas impacts natural habitats, modifying the ecology of some species of Leishmania, as well as its vectors and reservoirs and, consequently, changes the e...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-018-2742-7

    authors: da Costa SM,Cordeiro JLP,Rangel EF

    更新日期:2018-03-07 00:00:00

  • A comparative study of Toxoplasma gondii seroprevalence in three healthy Chinese populations detected using native and recombinant antigens.

    abstract:BACKGROUND:Toxoplasmosis is one of the most common parasitic zoonoses. The seroprevalence of Toxoplasma gondii infection in humans varies widely worldwide. Detection of Toxoplasma-specific antibodies has been a gold standard method for both epidemiological investigation and clinical diagnosis. Genetic investigation ind...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-6-241

    authors: Sun X,Lu H,Jia B,Chang Z,Peng S,Yin J,Chen Q,Jiang N

    更新日期:2013-08-20 00:00:00

  • Modelling the risk of being bitten by malaria vectors in a vector control area in southern Benin, west Africa.

    abstract:BACKGROUND:The diversity of malaria vector populations, expressing various resistance and/or behavioural patterns could explain the reduced effectiveness of vector control interventions reported in some African countries. A better understanding of the ecology and distribution of malaria vectors is essential to design m...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-6-71

    authors: Moiroux N,Bio-Bangana AS,Djènontin A,Chandre F,Corbel V,Guis H

    更新日期:2013-03-15 00:00:00

  • Genetic characterization of Toxoplasma gondii from pigs from different localities in China by PCR-RFLP.

    abstract:BACKGROUND:Toxoplasma gondii is a widely prevalent protozoan parasite that causes serious toxoplasmosis in humans and animals. The present study aimed to determine the genetic diversity of T. gondii isolates from pigs in Jiangxi, Sichuan, Guangdong Provinces and Chongqing Municipality in China using multilocous polymer...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-6-227

    authors: Jiang HH,Huang SY,Zhou DH,Zhang XX,Su C,Deng SZ,Zhu XQ

    更新日期:2013-08-07 00:00:00

  • Effect of an integrated control strategy for schistosomiasis japonica in the lower reaches of the Yangtze River, China: an evaluation from 2005 to 2008.

    abstract:BACKGROUND:Schistosomiasis japonica remains a major public health concern in China. There are many interventions implemented to control the transmission of the disease. The purpose of the present study was to investigate the effects of an integrated control strategy for schistosomiasis control. METHODS:An integrated c...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-4-243

    authors: Sun LP,Wang W,Liang YS,Tian ZX,Hong QB,Yang K,Yang GJ,Dai JR,Gao Y

    更新日期:2011-12-30 00:00:00

  • African schistosomiasis in mainland China: risk of transmission and countermeasures to tackle the risk.

    abstract::Schistosomiasis is a major disease of public health importance in humans occurring in 76 countries of the tropics and sub-tropics. In China, schistosomiasis japonica is one of the highest priorities in communicable disease control defined by the central government. Since 1970s, the habitats of Biomphalaria straminea, ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章,评审

    doi:10.1186/1756-3305-6-249

    authors: Wang W,Liang YS,Hong QB,Dai JR

    更新日期:2013-08-28 00:00:00

  • Can the pyruvate: ferredoxin oxidoreductase (PFOR) gene be used as an additional marker to discriminate among Blastocystis strains or subtypes?

    abstract:BACKGROUND:Blastocystis spp. are the most prevalent intestinal eukaryotes identified in humans, with at least 17 genetic subtypes (ST) based on genes coding for the small-subunit ribosomal RNA (18S). It has been argued that the 18S gene should not be the marker of choice to discriminate between STs of these strains bec...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-018-3141-9

    authors: Alarcon-Valdes P,Villalobos G,Martinez-Flores WA,Lopez-Escamilla E,Gonzalez-Arenas NR,Romero-Valdovinos M,Martinez-Hernandez F,Santillan-Benitez JG,Maravilla P

    更新日期:2018-10-29 00:00:00

  • Comparative efficacy of a new spot-on combination product containing selamectin and sarolaner (Stronghold®Plus) versus fluralaner (Bravecto®) against induced infestations with Ixodes ricinus ticks on cats.

    abstract:BACKGROUND:Ticks are increasingly reported on cats worldwide, with Ixodes ricinus being a relevant species across Europe and in near by areas of North Africa and the Middle East. Yet there are few acaracidal products with proven efficacy approved for use in cats. The objective of this study was to compare the efficacy ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-017-2259-5

    authors: Geurden T,Borowski S,Wozniakiewicz M,King V,Fourie J,Liebenberg J

    更新日期:2017-06-29 00:00:00

  • Dirofilaria repens transmission in southeastern Finland.

    abstract:BACKGROUND:The spread of vector-borne diseases to new regions has become a global threat due to climate change, increasing traffic, and movement of people and animals. Dirofilaria repens, the canine subcutaneous filarioid nematode, has expanded its distribution range northward during the last decades. The northernmost ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-017-2499-4

    authors: Pietikäinen R,Nordling S,Jokiranta S,Saari S,Heikkinen P,Gardiner C,Kerttula AM,Kantanen T,Nikanorova A,Laaksonen S,Lavikainen A,Oksanen A

    更新日期:2017-11-10 00:00:00

  • The physiological cost of male-biased parasitism in a nearly monomorphic mammal.

    abstract:BACKGROUND:Even though male-biased parasitism is common in mammals, little effort has been made to evaluate whether higher parasitic burden in males results in an extra biological cost, and thus a decrease in fitness. Body condition impairment and the augmentation of oxidative stress can be used as indicators of the co...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-017-2060-5

    authors: Oliver-Guimerá A,Martínez-Carrasco C,Tvarijonaviciute A,Ruiz de Ybáñez MR,Martínez-Guijosa J,López-Olvera JR,Fernández-Aguilar X,Colom-Cadena A,Mentaberre G,Velarde R,Gassó D,Garel M,Rossi L,Lavín S,Serrano E

    更新日期:2017-04-21 00:00:00

  • Blastocystis sp. in splenic cysts: causative agent or accidental association? A unique case report.

    abstract:BACKGROUND:Blastocystis sp. is one of the most prevalent parasites found in human stool and has been recently considered an opportunistic emerging pathogen in immunocompromised individuals. However, cases of invasive intestinal infections and skin rashes have been attributed to infection by Blastocystis sp in immunocom...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-7-207

    authors: Santos HL,Sodré FC,de Macedo HW

    更新日期:2014-04-29 00:00:00

  • Mapping occurrence of Taenia solium taeniosis/cysticercosis and areas at risk of porcine cysticercosis in Central America and the Caribbean basin.

    abstract:BACKGROUND:This study aimed to map the occurrence of Taenia solium taeniosis/cysticercosis at national level within Central America and the Caribbean basin, and to map the distribution of porcine cysticercosis at first-level administrative subdivision level (department level) and the porcine population at risk. This zo...

    journal_title:Parasites & vectors

    pub_type: 杂志文章,评审

    doi:10.1186/s13071-017-2362-7

    authors: Braae UC,Devleesschauwer B,Sithole F,Wang Z,Willingham AL

    更新日期:2017-09-18 00:00:00

  • Trypanosome infections in naturally infected horses and donkeys of three active sleeping sickness foci in the south of Chad.

    abstract:BACKGROUND:Equine trypanosomiases are complex infectious diseases with overlapping clinical signs defined by their mode of transmission. Despite their economic impacts, these diseases have been neglected by the scientific community, the veterinary authorities and regulatory organizations. To fill the observed knowledge...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-04192-1

    authors: Vourchakbé J,Tiofack AAZ,Mbida M,Simo G

    更新日期:2020-06-23 00:00:00

  • Laboratory and microcosm experiments reveal contrasted adaptive responses to ammonia and water mineralisation in aquatic stages of the sibling species Anopheles gambiae (sensu stricto) and Anopheles coluzzii.

    abstract:BACKGROUND:The sibling species of the malaria mosquito, Anopheles gambiae (sensu stricto) and Anopheles coluzzii co-exist in many parts of West Africa and are thought to have recently diverged through a process of ecological speciation with gene flow. Divergent larval ecological adaptations, resulting in Genotype-by-En...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-04483-7

    authors: Akpodiete NO,Tripet F

    更新日期:2021-01-06 00:00:00

  • Stable and fluctuating temperature effects on the development rate and survival of two malaria vectors, Anopheles arabiensis and Anopheles funestus.

    abstract:BACKGROUND:Understanding the biology of malaria vector mosquitoes is crucial to understanding many aspects of the disease, including control and future outcomes. The development rates and survival of two Afrotropical malaria vectors, Anopheles arabiensis and Anopheles funestus, are investigated here under conditions of...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-6-104

    authors: Lyons CL,Coetzee M,Chown SL

    更新日期:2013-04-16 00:00:00

  • A new allele conferring resistance to Lysinibacillus sphaericus is detected in low frequency in Culex quinquefasciatus field populations.

    abstract:BACKGROUND:The Cqm1 α-glucosidase of Culex quinquefasciatus larvae acts as the midgut receptor for the binary toxin of the biolarvicide Lysinibacillus sphaericus. Mutations within the cqm1 gene can code for aberrant polypeptides that can no longer be properly expressed or bind to the toxin, leading to insect resistance...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-016-1347-2

    authors: Menezes HS,Chalegre KD,Romão TP,Oliveira CM,de-Melo-Neto OP,Silva-Filha MH

    更新日期:2016-02-04 00:00:00

  • Vector competence of Aedes aegypti populations from Kilifi and Nairobi for dengue 2 virus and the influence of temperature.

    abstract:BACKGROUND:Susceptibility of Ae. aegypti mosquito to dengue virus (DENV) varies geographically and can be influenced by climatic factors such as temperature, which affect the incidence, seasonality and distribution of vector-borne diseases. The first outbreak of dengue fever (DF) in Kenya occured in 1982 in the coastal...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-7-435

    authors: Chepkorir E,Lutomiah J,Mutisya J,Mulwa F,Limbaso K,Orindi B,Ng'ang'a Z,Sang R

    更新日期:2014-09-15 00:00:00

  • Age structure of bed bug (Heteroptera: Cimicidae) aggregations affects the nymphal feeding success.

    abstract:BACKGROUND:Bed bugs (Heteroptera: Cimicidae) are a group of blood-feeding ectoparasites. They mainly specialize on bats and birds, but a few species are important human pests. They exhibit several unique adaptations for their parasitic lifestyle. Among those, bed bug aggregations represent a striking example of a sub-s...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-019-3659-5

    authors: Balvín O,Chajma P,Naylor R

    更新日期:2019-08-13 00:00:00

  • Evaluation of a real-time PCR assay for diagnosis of schistosomiasis japonica in the domestic goat.

    abstract:BACKGROUND:Schistosomiasis japonica is an infectious disease caused by Schistosoma japonicum that seriously endangers human health. Domestic animals have important roles in disease transmission and goats are considered a primary reservoir host and source of infection. The prevalence and intensity of schistosomiasis inf...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-04420-8

    authors: Guo Q,Chen C,Zhou K,Li Y,Tong L,Yue Y,Zhou K,Liu J,Fu Z,Lin J,Zhao J,Sun P,Hong Y

    更新日期:2020-10-27 00:00:00

  • The evolution of TNF signaling in platyhelminths suggests the cooptation of TNF receptor in the host-parasite interplay.

    abstract:BACKGROUND:The TNF signaling pathway is involved in the regulation of many cellular processes (such as apoptosis and cell proliferation). Previous reports indicated the effect of human TNF-α on metabolism, physiology, gene expression and protein phosphorylation of the human parasite Schistosoma mansoni and suggested th...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-04370-1

    authors: Bertevello CR,Russo BRA,Tahira AC,Lopes-Junior EH,DeMarco R,Oliveira KC

    更新日期:2020-09-25 00:00:00

  • First report of Anaplasma platys infection in red foxes (Vulpes vulpes) and molecular detection of Ehrlichia canis and Leishmania infantum in foxes from Portugal.

    abstract:BACKGROUND:The bacteria Anaplasma platys and Ehrlichia canis and the protozoan Leishmania infantum are vector-borne agents that cause canine vector-borne diseases, some of which are zoonotic. The present survey investigated the prevalence of Anaplasma, Ehrlichia and Leishmania in red foxes (Vulpes vulpes) from Portugal...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-015-0756-y

    authors: Cardoso L,Gilad M,Cortes HC,Nachum-Biala Y,Lopes AP,Vila-Viçosa MJ,Simões M,Rodrigues PA,Baneth G

    更新日期:2015-03-23 00:00:00

  • Assessing the acoustic behaviour of Anopheles gambiae (s.l.) dsxF mutants: implications for vector control.

    abstract:BACKGROUND:Release of gene-drive mutants to suppress Anopheles mosquito reproduction is a promising method of malaria control. However, many scientific, regulatory and ethical questions remain before transgenic mosquitoes can be utilised in the field. At a behavioural level, gene-drive carrying mutants should be at lea...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-04382-x

    authors: Su MP,Georgiades M,Bagi J,Kyrou K,Crisanti A,Albert JT

    更新日期:2020-10-07 00:00:00