Tick-borne pathogen detection in midgut and salivary glands of adult Ixodes ricinus.

Abstract:

BACKGROUND:The tick midgut and salivary glands represent the primary organs for pathogen acquisition and transmission, respectively. Specifically, the midgut is the first organ to have contact with pathogens during the blood meal uptake, while salivary glands along with their secretions play a crucial role in pathogen transmission to the host. Currently there is little data about pathogen composition and prevalence in Ixodes ricinus midgut and salivary glands. The present study investigated the presence of 32 pathogen species in the midgut and salivary glands of unfed I. ricinus males and females using high-throughput microfluidic real-time PCR. Such an approach is important for enriching the knowledge about pathogen distribution in distinct tick organs which should lead to a better understanding I. ricinus-borne disease epidemiology. RESULTS:Borrelia lusitaniae, Borrelia spielmanii and Borrelia garinii, were detected in both midgut and salivary glands suggesting that the migration of these pathogens between these two organs might not be triggered by the blood meal. In contrast, Borrelia afzelii was detected only in the tick midgut. Anaplasma phagocytophilum and Rickettsia helvetica were the most frequently detected in ticks and were found in both males and females in the midgut and salivary glands. In contrast, Rickettsia felis was only detected in salivary glands. Finally, Borrelia miyamotoi and Babesia venatorum were detected only in males in both midguts and salivary glands. Among all collected ticks, between 10-21% of organs were co-infected. The most common bacterial co-infections in male and female midgut and salivary glands were Rickettsia helvetica + Anaplasma phagocytophilum and Rickettsia helvetica + Borrelia lusitaniae, respectively. CONCLUSIONS:Analysing tick-borne pathogen (TBP) presence in specific tick organs enabled us to (i) highlight contrasting results with well-established transmission mechanism postulates; (ii) venture new hypotheses concerning pathogen location and migration from midgut to salivary glands; and (iii) suggest other potential associations between pathogens not previously detected at the scale of the whole tick. This work highlights the importance of considering all tick scales (i.e. whole ticks vs organs) to study TBP ecology and represents another step towards improved understanding of TBP transmission.

journal_name

Parasit Vectors

journal_title

Parasites & vectors

authors

Lejal E,Moutailler S,Šimo L,Vayssier-Taussat M,Pollet T

doi

10.1186/s13071-019-3418-7

subject

Has Abstract

pub_date

2019-04-02 00:00:00

pages

152

issue

1

issn

1756-3305

pii

10.1186/s13071-019-3418-7

journal_volume

12

pub_type

杂志文章
  • Determinants of Plasmodium falciparum multiplicity of infection and genetic diversity in Burkina Faso.

    abstract:BACKGROUND:Investigating malaria transmission dynamics is essential to inform policy decision making. Whether multiplicity of infection (MOI) dynamic from individual infections could be a reliable malaria metric in high transmission settings with marked variation in seasons of malaria transmission has been poorly asses...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-04302-z

    authors: Sondo P,Derra K,Rouamba T,Nakanabo Diallo S,Taconet P,Kazienga A,Ilboudo H,Tahita MC,Valéa I,Sorgho H,Lefèvre T,Tinto H

    更新日期:2020-08-20 00:00:00

  • Fluralaner as a novel treatment for sarcoptic mange in the bare-nosed wombat (Vombatus ursinus): safety, pharmacokinetics, efficacy and practicable use.

    abstract:BACKGROUND:Sarcoptic mange causes significant animal welfare and occasional conservation concerns for bare-nosed wombats (Vombatus ursinus) throughout their range. To date, in situ chemotherapeutic interventions have involved macrocytic lactones, but their short duration of action and need for frequent re-administratio...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-04500-9

    authors: Wilkinson V,Tokano K,Nichols D,Martin A,Holme R,Phalen D,Mounsey K,Charleston M,Kreiss A,Pye R,Browne E,Næsborg-Nielsen C,Richards SA,Carver S

    更新日期:2021-01-06 00:00:00

  • In vitro and in vivo antischistosomal activity of ferroquine derivatives.

    abstract:BACKGROUND:Schistosomiasis is a neglected tropical disease and drug-repurposing is a useful strategy to fill its exhausted drug development pipeline. The ferrocenyl analogue of chloroquine, ferroquine, is an antimalarial in late-stage drug development. The aim of the present work was to study the antischistosomal activ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-7-424

    authors: Keiser J,Vargas M,Rubbiani R,Gasser G,Biot C

    更新日期:2014-09-04 00:00:00

  • Establishment and optimization of a liquid bead array for the simultaneous detection of ten insect-borne pathogens.

    abstract:BACKGROUND:Insect-borne diseases could induce severe symptoms in human and clinical signs in animals, such as febrility, erythra, arthralgia and hemorrhagic fever, and cause significant economic losses and pose public health threat all over the world. The significant advantages of Luminex xMAP technology are high-throu...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-018-2996-0

    authors: Wang HY,Wu SQ,Jiang L,Xiao RH,Li T,Mei L,Lv JZ,Liu JJ,Lin XM,Han XQ

    更新日期:2018-07-31 00:00:00

  • Molecular characterization and distribution of Schistosoma cercariae collected from naturally infected bulinid snails in northern and central Côte d'Ivoire.

    abstract:BACKGROUND:Accurate identification of schistosome species infecting intermediate host snails is important for understanding parasite transmission, schistosomiasis control and elimination. Cercariae emerging from infected snails cannot be precisely identified morphologically to the species level. We used molecular tools...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-019-3381-3

    authors: Tian-Bi YT,Webster B,Konan CK,Allan F,Diakité NR,Ouattara M,Salia D,Koné A,Kakou AK,Rabone M,Coulibaly JT,Knopp S,Meïté A,Utzinger J,N'Goran EK,Rollinson D

    更新日期:2019-03-19 00:00:00

  • Retrospective data analyses of social and environmental determinants of malaria control for elimination prospects in Eritrea.

    abstract:BACKGROUND:The present study focuses on both long- and short-term malaria transmission in Eritrea and investigates the risk factors. Annual aggregates of information on malaria cases, deaths, diagnostics and control interventions from 2001 to 2008 and monthly reported data from 2009 to 2017 were obtained from the Natio...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-3974-x

    authors: Mihreteab S,Lubinda J,Zhao B,Rodriguez-Morales AJ,Karamehic-Muratovic A,Goitom A,Shad MY,Haque U

    更新日期:2020-03-12 00:00:00

  • Susceptibility of adult female Aedes aegypti (Diptera: Culicidae) to the entomopathogenic fungus Metarhizium anisopliae is modified following blood feeding.

    abstract:BACKGROUND:The mosquito Aedes aegypti, vector of dengue fever, is a target for control by entomopathogenic fungi. Recent studies by our group have shown the susceptibility of adult A. aegypti to fungal infection by Metarhizium anisopliae. This fungus is currently being tested under field conditions. However, it is unkn...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-4-91

    authors: Paula AR,Carolino AT,Silva CP,Samuels RI

    更新日期:2011-05-26 00:00:00

  • Abiotic predictors and annual seasonal dynamics of Ixodes ricinus, the major disease vector of Central Europe.

    abstract:BACKGROUND:Abiotic conditions provide cues that drive tick questing activity. Defining these cues is critical in predicting biting risk, and in forecasting climate change impacts on tick populations. This is particularly important for Ixodes ricinus nymphs, the vector of numerous pathogens affecting humans. METHODS:A ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-015-1092-y

    authors: Daniel M,Malý M,Danielová V,Kříž B,Nuttall P

    更新日期:2015-09-18 00:00:00

  • The colonization of pyrethroid resistant strain from wild Anopheles sinensis, the major Asian malaria vector.

    abstract:BACKGROUND:Anopheles sinensis is one of the most important malaria vectors in Asian countries. The rapid spread of insecticide resistance has become a major obstacle for insecticide-based strategies for vector control. Therefore, it is necessary to prepare an insecticide-resistant strain of An. sinensis to further unde...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-014-0582-7

    authors: Zhu G,Zhou H,Li J,Tang J,Bai L,Wang W,Gu Y,Liu Y,Lu F,Cao Y,Zhang C,Xu S,Cao J,Gao Q

    更新日期:2014-12-11 00:00:00

  • Investigation of temperature conditions in Swiss urban and suburban microhabitats for the overwintering suitability of diapausing Aedes albopictus eggs.

    abstract:BACKGROUND:In Switzerland, the invasive Asian tiger mosquito, Aedes albopictus, is firmly established in the Canton of Ticino, south of the Alps. According to a large-scale distribution model developed in 2013, suitable climatic conditions for the establishment of Ae. albopictus north of the Alps are found in Basel and...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-018-2803-y

    authors: Ravasi D,Guidi V,Flacio E,Lüthy P,Perron K,Lüdin S,Tonolla M

    更新日期:2018-03-27 00:00:00

  • Integrated community-directed intervention for schistosomiasis and soil transmitted helminths in western Kenya - a pilot study.

    abstract:BACKGROUND:Schistosome and soil-transmitted helminth (STH) infections are recognized as major global public health problems, causing severe and subtle morbidity, including significant educational and nutritional effects in children. Although effective and safe drugs are available, ensuring access to these drugs by all ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-5-182

    authors: Mwinzi PN,Montgomery SP,Owaga CO,Mwanje M,Muok EM,Ayisi JG,Laserson KF,Muchiri EM,Secor WE,Karanja DM

    更新日期:2012-08-31 00:00:00

  • Response of Anopheles gambiae s.l. (Diptera: Culicidae) to larval habitat age in western Kenya highlands.

    abstract:BACKGROUND:Larval control is of paramount importance in the reduction of vector populations. Previous observations have suggested that, larvae of Anopheles gambiae s.l occur more often in small temporary habitats while other studies showed that long-lasting stable habitats are more productive than unstable habitats. In...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-6-13

    authors: Munga S,Vulule J,Kweka EJ

    更新日期:2013-01-16 00:00:00

  • Integration of schistosomiasis control activities within the primary health care system: a critical review.

    abstract:BACKGROUND:Schistosomiasis is a chronic disease linked to poverty and is widely endemic, particularly in sub-Saharan Africa. For decades, the World Health Organization has called for a larger role of the primary health care system in schistosomiasis control, and its integration within the routine activities of primary ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章,评审

    doi:10.1186/s13071-019-3652-z

    authors: Bizimana P,Ortu G,Van Geertruyden JP,Nsabiyumva F,Nkeshimana A,Muhimpundu E,Polman K

    更新日期:2019-08-07 00:00:00

  • Susceptibility to insecticides and resistance mechanisms in three populations of Aedes aegypti from Peru.

    abstract:BACKGROUND:Epidemics of dengue, chikungunya and Zika are a growing threat to areas where Aedes aegypti are present. The efficacy of chemical control of Ae. aegypti is threatened by the increasing frequency of insecticide resistance. The objective of this study was to determine the susceptibility status as well as the b...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-019-3739-6

    authors: Pinto J,Palomino M,Mendoza-Uribe L,Sinti C,Liebman KA,Lenhart A

    更新日期:2019-10-22 00:00:00

  • Impact of anthropogenic and natural environmental changes on Echinococcus transmission in Ningxia Hui Autonomous Region, the People's Republic of China.

    abstract::Echinococcus transmission is known to be affected by various environmental factors, which may be modified by human influence or natural events including global warming. Considerable population growth in the last fifty years in Ningxia Hui Autonomous Region (NHAR), the People's Republic of China (PRC), has led to drama...

    journal_title:Parasites & vectors

    pub_type: 杂志文章,评审

    doi:10.1186/1756-3305-5-146

    authors: Yang YR,Clements AC,Gray DJ,Atkinson JA,Williams GM,Barnes TS,McManus DP

    更新日期:2012-07-24 00:00:00

  • Effects of global changes on the climatic niche of the tick Ixodes ricinus inferred by species distribution modelling.

    abstract:BACKGROUND:Global climate change can seriously impact on the epidemiological dynamics of vector-borne diseases. In this study we investigated how future climatic changes could affect the climatic niche of Ixodes ricinus (Acari, Ixodida), among the most important vectors of pathogens of medical and veterinary concern in...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-6-271

    authors: Porretta D,Mastrantonio V,Amendolia S,Gaiarsa S,Epis S,Genchi C,Bandi C,Otranto D,Urbanelli S

    更新日期:2013-09-19 00:00:00

  • Occurrence and identification of risk areas of Ixodes ricinus-borne pathogens: a cost-effectiveness analysis in north-eastern Italy.

    abstract:BACKGROUND:Ixodes ricinus, a competent vector of several pathogens, is the tick species most frequently reported to bite humans in Europe. The majority of human cases of Lyme borreliosis (LB) and tick-borne encephalitis (TBE) occur in the north-eastern region of Italy. The aims of this study were to detect the occurren...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-5-61

    authors: Capelli G,Ravagnan S,Montarsi F,Ciocchetta S,Cazzin S,Porcellato E,Babiker AM,Cassini R,Salviato A,Cattoli G,Otranto D

    更新日期:2012-03-27 00:00:00

  • Correction to: The tree that hides the forest: cryptic diversity and phylogenetic relationships in the Palaearctic vector Obsoletus/Scoticus complex (Diptera: Ceratopogonidae) at the European level.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:Parasites & vectors

    pub_type: 已发布勘误

    doi:10.1186/s13071-020-04349-y

    authors: Mignotte A,Garros C,Gardès L,Balenghien T,Duhayon M,Rakotoarivony I,Tabourin L,Poujol L,Mathieu B,Ibañez-Justicia A,Deniz A,Cvetkovikj A,Purse BV,Ramilo DW,Stougiou D,Werner D,Pudar D,Petrić D,Veronesi E,Jacobs F,

    更新日期:2020-09-22 00:00:00

  • Knowledge, perceptions and practices regarding schistosomiasis among women living in a highly endemic rural district in Zimbabwe: implications on infections among preschool-aged children.

    abstract:BACKGROUND:Schistosomiasis primarily affects poor and neglected communities due to their lack of safe water and sanitation facilities. In an effort to improve intervention strategies, the present study investigated the association of socio-demographic characteristics of women with their existing knowledge, perceptions ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-019-3668-4

    authors: Mutsaka-Makuvaza MJ,Matsena-Zingoni Z,Tshuma C,Katsidzira A,Webster B,Zhou XN,Midzi N

    更新日期:2019-09-23 00:00:00

  • Resequencing and assembly of seven complex loci to improve the Leishmania major (Friedlin strain) reference genome.

    abstract:BACKGROUND:Leishmania parasites cause severe human diseases known as leishmaniasis. These eukaryotic microorganisms possess an atypical chromosomal architecture and the regulation of gene expression occurs almost exclusively at post-transcriptional levels. Accordingly, sequencing of the genome of Leishmania major, and ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-016-1329-4

    authors: Alonso G,Rastrojo A,López-Pérez S,Requena JM,Aguado B

    更新日期:2016-02-08 00:00:00

  • Assessment of vector/host contact: comparison of animal-baited traps and UV-light/suction trap for collecting Culicoides biting midges (Diptera: Ceratopogonidae), vectors of Orbiviruses.

    abstract:BACKGROUND:The emergence and massive spread of bluetongue in Western Europe during 2006-2008 had disastrous consequences for sheep and cattle production and confirmed the ability of Palaearctic Culicoides (Diptera: Ceratopogonidae) to transmit the virus. Some aspects of Culicoides ecology, especially host-seeking and f...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-4-119

    authors: Viennet E,Garros C,Lancelot R,Allène X,Gardès L,Rakotoarivony I,Crochet D,Delécolle JC,Moulia C,Baldet T,Balenghien T

    更新日期:2011-06-27 00:00:00

  • A novel modified-indirect ELISA based on spherical body protein 4 for detecting antibody during acute and long-term infections with diverse Babesia bovis strains.

    abstract:BACKGROUND:Cattle persistently infected with Babesia bovis are reservoirs for intra- and inter-herd transmission. Since B. bovis is considered a persistent infection, developing a reliable, high-throughput assay that detects antibody during all stages of the infection could be pivotal for establishing better control pr...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-017-2016-9

    authors: Chung CJ,Suarez CE,Bandaranayaka-Mudiyanselage CL,Bandaranayaka-Mudiyanselage CB,Rzepka J,Heiniger TJ,Chung G,Lee SS,Adams E,Yun G,Waldron SJ

    更新日期:2017-02-13 00:00:00

  • Field clinical study evaluating the efficacy and safety of an oral formulation containing milbemycin oxime/praziquantel (Milbemax®, Novartis Animal Health) in the chemoprevention of the zoonotic canine infection by Dirofilaria repens.

    abstract:BACKGROUND:Dirofilaria repens is the causative agent of subcutaneous dirofilariosis of dogs, other animals and humans. This nematode is transmitted by mosquitoes of Aedes, Anopheles and Culex genera. In dogs, the parasite may cause subclinical infection or cutaneous signs. Recently, D. repens has emerged and spread in ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1756-3305-7-347

    authors: Di Cesare A,Braun G,Di Giulio E,Paoletti B,Aquilino V,Bartolini R,La Torre F,Meloni S,Drake J,Pandolfi F,Avolio S,Traversa D

    更新日期:2014-07-29 00:00:00

  • Sleeping habits affect access to host by Chagas disease vector Triatoma dimidiata.

    abstract:BACKGROUND:Chagas disease, caused by the parasite Trypanosoma cruzi, is mainly transmitted by blood-sucking bugs called triatomines. In the Yucatán Peninsula, Mexico, the main vector of T. cruzi is Triatoma dimidiata. While this species may colonize houses in other regions, it is mostly intrusive in Yucatán: it general...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-016-1852-3

    authors: Waleckx E,Pasos-Alquicira R,Ramírez-Sierra MJ,Dumonteil E

    更新日期:2016-11-03 00:00:00

  • Isolation and identification of Xenorhabdus and Photorhabdus bacteria associated with entomopathogenic nematodes and their larvicidal activity against Aedes aegypti.

    abstract:BACKGROUND:Aedes aegypti is a potential vector of West Nile, Japanese encephalitis, chikungunya, dengue and Zika viruses. Alternative control measurements of the vector are needed to overcome the problems of environmental contamination and chemical resistance. Xenorhabdus and Photorhabdus are symbionts in the intestine...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-017-2383-2

    authors: Fukruksa C,Yimthin T,Suwannaroj M,Muangpat P,Tandhavanant S,Thanwisai A,Vitta A

    更新日期:2017-09-21 00:00:00

  • Multi-function oxidases are responsible for the synergistic interactions occurring between repellents and insecticides in mosquitoes.

    abstract:BACKGROUND:With the spread of pyrethroid resistance in mosquitoes, the combination of an insecticide (carbamate or organophosphate) with a repellent (DEET) is considered as a promising alternative strategy for the treatment of mosquito nets and other relevant materials. The efficacy of these mixtures comes from the fac...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-2-17

    authors: Bonnet J,Pennetier C,Duchon S,Lapied B,Corbel V

    更新日期:2009-04-16 00:00:00

  • Spatiotemporal analysis of sandfly fauna (Diptera: Psychodidae) in an endemic area of visceral leishmaniasis at Pantanal, central South America.

    abstract:BACKGROUND:Environmental changes caused by urbanization can cause alterations in the ecology and behavior of sandflies and in the epidemiology of leishmaniasis. Geotechnological tools allow the analysis and recognition of spatiotemporal patterns by monitoring and mapping risk areas of this vector-borne disease. This st...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/1756-3305-7-364

    authors: Casaril AE,Monaco NZ,de Oliveira EF,Eguchi GU,Paranhos Filho AC,Pereira LE,Oshiro ET,Galati EA,Mateus NL,de Oliveira AG

    更新日期:2014-08-15 00:00:00

  • Anopheles gambiae densovirus (AgDNV) negatively affects Mayaro virus infection in Anopheles gambiae cells and mosquitoes.

    abstract:BACKGROUND:Recent studies demonstrate that insect-specific viruses can influence the ability of their mosquito hosts to become infected with and transmit arboviruses of medical and veterinary importance. The aim of this study was to evaluate the interactions between Anopheles gambiae densovirus (AgDNV) (Parvoviridae) (...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-04072-8

    authors: Urakova N,Brustolin M,Joseph RE,Johnson RM,Pujhari S,Rasgon JL

    更新日期:2020-04-22 00:00:00

  • Variation in hatching responses of Nematodirus battus eggs to temperature experiences.

    abstract:BACKGROUND:Nematodirus battus, unlike most other gastrointestinal nematodes, undergoes maturation to an infective larva within the egg. Historically, eggs were considered to require a period of chilling over winter followed by a period of temperature above 10 °C for synchronous hatching to occur (generally in spring). ...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-020-04368-9

    authors: Melville LA,Van Dijk J,Mitchell S,Innocent G,Bartley DJ

    更新日期:2020-09-29 00:00:00

  • Dynamics of Th9 cells and their potential role in immunopathogenesis of murine schistosomiasis.

    abstract:BACKGROUND:Th1, Th2, Th17, Treg and Tfh cells play important roles in schistosomiasis. Th9 cells secrete IL-9 as a signature cytokine and contribute to several classes of inflammatory disease. However, the effects of Th9 cells in schistosomiasis are unknown. We aimed to explore the dynamic changes and potential roles o...

    journal_title:Parasites & vectors

    pub_type: 杂志文章

    doi:10.1186/s13071-017-2242-1

    authors: Zhan T,Zhang T,Wang Y,Wang X,Lin C,Ma H,Duan Z,Li C,Xu J,Xia C

    更新日期:2017-06-24 00:00:00