Abstract:
BACKGROUND:Schistosomiasis is a neglected tropical disease and drug-repurposing is a useful strategy to fill its exhausted drug development pipeline. The ferrocenyl analogue of chloroquine, ferroquine, is an antimalarial in late-stage drug development. The aim of the present work was to study the antischistosomal activity of ferroquine against Schistosoma mansoni adult worms and newly transformed schistosomula (NTS) in vitro and in vivo. Hydroxyl-ferroquine and ruthenoquine were included to study the potential role of reactive oxygen species in the antischistosomal activity. Chloroquine and mefloquine, the later described for its antischistosomal properties, served as comparators. FINDINGS:All metal complexes were shown to be moderately cytotoxic on human cervix HeLa cancer cells and human fetal lung fibroblasts MRC-5. 72 hours post-incubation NTS exposed to 33.3 µM ruthenoquine had died, while ferroquine and hydroxyl-ferroquine treated worms were strongly affected. No activity was observed treating NTS with chloroquine at 33.3 µM. Incubation of adult S. mansoni with 33.3 µM of the organometallic derivatives were highly affected in viability but were still alive 72 hours post-incubation. Mefloquine showed the highest activity against NTS and adult S. mansoni. Low total worm burden reductions of 0-36% were observed following oral administration of 200-800 mg/kg of the ferroquine derivatives to S. mansoni-infected mice. CONCLUSIONS:The organometallic compounds evaluated in this study revealed moderate in vitro activity against both larval and adult stages of S. mansoni but low in vivo activity. No correlation can be drawn between the antimalarial and antischistosomal activity of chloroquine analogues and oxidative shock does not seem to play a role in the activity of these compounds against S. mansoni.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Keiser J,Vargas M,Rubbiani R,Gasser G,Biot Cdoi
10.1186/1756-3305-7-424subject
Has Abstractpub_date
2014-09-04 00:00:00pages
424issn
1756-3305pii
1756-3305-7-424journal_volume
7pub_type
杂志文章abstract:BACKGROUND:The myxosporean parasite Parvicapsula pseudobranchicola commonly infects farmed Atlantic salmon in northern Norway. Heavy infections are associated with pseudobranch lesions, runting and mortality in the salmon populations. The life-cycle of the parasite is unknown, preventing controlled challenge experiment...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2583-9
更新日期:2018-01-06 00:00:00
abstract:BACKGROUND:Improved surveillance techniques are required to accelerate efforts against major arthropod-borne diseases such as malaria, dengue, filariasis, Zika and yellow-fever. Light-emitting diodes (LEDs) are increasingly used in mosquito traps because they improve energy efficiency and battery longevity relative to ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3673-7
更新日期:2019-08-27 00:00:00
abstract:BACKGROUND:Red deer (Cervus elaphus) are a common wild definitive host for liver fluke (Fasciola hepatica) that have been the subject of limited diagnostic surveillance. This study aimed to explore the extent to which coprological diagnoses for F. hepatica in red deer in the Scottish Highlands, Scotland, are associated...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3782-3
更新日期:2019-11-12 00:00:00
abstract:BACKGROUND:Insect-specific viruses do not replicate in vertebrate cells, but persist in mosquito populations and are highly prevalent in nature. These viruses may naturally regulate the transmission of pathogenic vertebrate-infecting arboviruses in co-infected mosquitoes. Following the isolation of the first Australian...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1683-2
更新日期:2016-07-25 00:00:00
abstract:BACKGROUND:Investigating malaria transmission dynamics is essential to inform policy decision making. Whether multiplicity of infection (MOI) dynamic from individual infections could be a reliable malaria metric in high transmission settings with marked variation in seasons of malaria transmission has been poorly asses...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04302-z
更新日期:2020-08-20 00:00:00
abstract:BACKGROUND:The analysis of large mosquito samples is expensive and time-consuming, delaying the efficient timing of vector control measurements. Processing a fraction of a sample using a subsampling method can significantly reduce the processing effort. However, a comprehensive evaluation of the reliability of differen...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3606-5
更新日期:2019-07-16 00:00:00
abstract:BACKGROUND:The emergence and spread of insecticide resistance in the major African malaria vectors Anopheles gambiae (s.s.) and An. arabiensis may compromise the current vector control interventions and threatens the global malaria control and elimination efforts. METHODS:Insecticide resistance was monitored in severa...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2342-y
更新日期:2017-09-02 00:00:00
abstract:BACKGROUND:Thelazia callipaeda is transmitted by Phortica variegata, a drosophilid that feeds on lachrymal secretions of mammals. Scientific information on human thelaziosis is still relatively limited, mainly for physicians and ophthalmologists. Indeed, the literature is full of misleading information on the transmiss...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0881-7
更新日期:2015-05-14 00:00:00
abstract:BACKGROUND:Psoroptes cuniculi can parasitise the ear canal of the rabbit, and cause the afflicted animals to cease feeding and become severely debilitated, sometimes resulting in death. In this study, we examined the oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuni...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-124
更新日期:2014-03-25 00:00:00
abstract:BACKGROUND:Human and animal fascioliasis poses serious public health problems in South America. In Venezuela, livestock infection represents an important veterinary problem whereas there appear to be few human cases reported, most of which are passively detected in health centres. However, results of recent surveys sug...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-200
更新日期:2011-10-14 00:00:00
abstract:BACKGROUND:Anaplasma ovis is a gram-negative, tick-borne obligate intraerythrocytic pathogen, which causes ovine anaplasmosis in small ruminants worldwide. VirB10 of A. ovis is an integral component of the Type IV Secretion System (T4SS). The T4SS is used by bacteria to transfer DNA and/or proteins undeviatingly into t...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-3975-9
更新日期:2020-02-27 00:00:00
abstract:BACKGROUND:Schistosomiasis is a serious global health problem that afflicts more than 230 million people in 77 countries. Long-term mass treatments with the only available drug, praziquantel, have caused growing concerns about drug resistance. PSD-95/Dlg/ZO-1 (PDZ) domain-containing proteins are recognized as potential...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-227
更新日期:2012-10-10 00:00:00
abstract:BACKGROUND:Understanding the dispersal dynamics of invasive mosquito species is fundamental to improve vector surveillance and to target control efforts. Aedes albopictus has been deemed a poor flyer as its range of active dispersal is generally assumed to be limited to a few hundred metres, while laboratory studies su...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3837-5
更新日期:2019-12-12 00:00:00
abstract:BACKGROUND:Toxoplasma gondii is a widely prevalent protozoan parasite that causes serious toxoplasmosis in humans and animals. The present study aimed to determine the genetic diversity of T. gondii isolates from pigs in Jiangxi, Sichuan, Guangdong Provinces and Chongqing Municipality in China using multilocous polymer...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-227
更新日期:2013-08-07 00:00:00
abstract:BACKGROUND:Schistosomiasis primarily affects poor and neglected communities due to their lack of safe water and sanitation facilities. In an effort to improve intervention strategies, the present study investigated the association of socio-demographic characteristics of women with their existing knowledge, perceptions ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3668-4
更新日期:2019-09-23 00:00:00
abstract:BACKGROUND:A blinded, randomized, negative controlled laboratory study was conducted to evaluate the efficacy of lotilaner (CredelioTM, Elanco) when administered orally to dogs, against experimentally induced adult flea infestations and flea egg production. METHODS:Twenty dogs were selected for the study and allocated...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3873-1
更新日期:2020-01-14 00:00:00
abstract::Companion vector-borne diseases (CVBDs) are an important threat for pet life, but may also have an impact on human health, due to their often zoonotic character. The importance and awareness of CVBDs continuously increased during the last years. However, information on their occurrence is often limited in several part...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-019-3407-x
更新日期:2019-03-28 00:00:00
abstract:BACKGROUND:Blackflies (Diptera: Simuliidae) are known as effective vectors of human and animal pathogens, worldwide. We have already indicated that some individuals in the Simulium turgaicum complex are annoying pests of humans and livestock in the Aras River Basin, Iran. However, there is no evidence of host preferenc...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04432-4
更新日期:2020-11-04 00:00:00
abstract:BACKGROUND:As resistance to insecticides increases in disease vectors, it has become exceedingly important to monitor populations for susceptibility. Most studies of field populations of Aedes aegypti have largely characterized resistance patterns at the spatial scale of the city or country, which may not be completely...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3275-9
更新日期:2019-01-09 00:00:00
abstract:BACKGROUND:In Switzerland, the invasive Asian tiger mosquito, Aedes albopictus, is firmly established in the Canton of Ticino, south of the Alps. According to a large-scale distribution model developed in 2013, suitable climatic conditions for the establishment of Ae. albopictus north of the Alps are found in Basel and...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2803-y
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:Even though male-biased parasitism is common in mammals, little effort has been made to evaluate whether higher parasitic burden in males results in an extra biological cost, and thus a decrease in fitness. Body condition impairment and the augmentation of oxidative stress can be used as indicators of the co...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2060-5
更新日期:2017-04-21 00:00:00
abstract:BACKGROUND:Natural compounds from plants are known to provide a source of anthelmintic molecules. In previous studies, we have shown that plant extracts from the plant Picria fel-terrae Lour. and particular fractions thereof have activity against the free-living nematode Caenorhabditis elegans, causing quite pronounced...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3429-4
更新日期:2019-04-25 00:00:00
abstract:BACKGROUND:Paratransgenesis is an approach to reducing arthropod vector competence using genetically modified symbionts. When applied to control of Chagas disease, the symbiont bacterium Rhodococcus rhodnii, resident in the gut lumen of the triatomine vector Rhodnius prolixus (Hemiptera: Reduviidae), is transformed to ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-77
更新日期:2011-05-14 00:00:00
abstract::In the more than 100 years since its discovery, our knowledge of Toxoplasma biology has improved enormously. The evolution of molecular biology, immunology and genomics has had profound influences on our understanding of this ubiquitous bug. However, it could be argued that in science today the adage "seeing is believ...
journal_title:Parasites & vectors
pub_type: 历史文章,杂志文章,评审
doi:10.1186/1756-3305-6-334
更新日期:2013-11-22 00:00:00
abstract:BACKGROUND:The application of the sterile insect technique (SIT) requires mass-production of sterile males of good biological quality. The size of the project area will in most cases determine whether it is more cost effective to produce the sterile flies locally (and invest in a mass-rearing facility) or import the st...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0869-3
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The current study shows the results of three years of IRS entomological monitoring (2016, before intervention; 2017 and 2018, after intervention) performed in Alibori and Donga, northern Benin. METHODS:Mosquito collections were performed on a monthly basis using human landing catches and pyrethrum spray cat...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3865-1
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:The two most abundant sand fly species on the Honduran Pacific coast are Lutzomyia (Lutzomyia) longipalpis and Pintomyia (Pifanomyia) evansi. Both species are known vectors of Leishmania (Leishmania) infantum, the etiological agent of visceral leishmaniasis (VL) in the Americas. Although VL and non-ulcerativ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04462-y
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Accurate diagnosis of urogenital schistosomiasis is vital for surveillance/control programs. Amplification of schistosome DNA in urine by PCR is sensitive and specific but requires infrastructure, financial resources and skilled personnel, often not available in endemic areas. Recombinase Polymerase Amplific...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1055-3
更新日期:2015-09-04 00:00:00
abstract:BACKGROUND:The transmission of malaria is heterogeneous, and varies due to altitude. The information on whether the transmission of malaria is indigenous or imported to highland areas is scarce. Therefore, this study aimed to assess the species composition and infection rates of Anopheles at different altitudinal trans...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2288-0
更新日期:2017-07-19 00:00:00
abstract:BACKGROUND:Aedes albopictus (Skuse) is an invasive mosquito that has become an important vector of chikungunya, dengue and Zika viruses. In the absence of specific antiviral therapy or a vaccine, vector management is the sole method available for reducing Aedes-induced disease morbidity. Determining the resistance stat...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2581-y
更新日期:2018-01-03 00:00:00