Abstract:
BACKGROUND:The emergence and spread of insecticide resistance in the major African malaria vectors Anopheles gambiae (s.s.) and An. arabiensis may compromise the current vector control interventions and threatens the global malaria control and elimination efforts. METHODS:Insecticide resistance was monitored in several study sites in Ethiopia from 2013 to 2015 using papers impregnated with discriminating concentrations of DDT, deltamethrin, bendiocarb, propoxur, malathion, fenitrothion and pirimiphos-methyl, following the WHO insecticide susceptibility test procedure. Mosquitoes sampled from different localities for WHO bioassay were morphologically identified as An. gambiae (s.l.) using standard taxonomic keys. Samples were identified to species using species-specific polymerase chain reaction (PCR) and screened for the presence of target site mutations L1014F, L1014S and N1575Y in the voltage gated sodium channel (VGSC) gene and G119S in the acethylcholinesterase (AChE) gene using allele-specific PCR. Biochemical assays were performed to assess elevated levels of acetylcholinesterases, carboxylcholinesterases, glutathione-S-transferases (GSTs) and cytochrome P450s monooxygenases in wild populations of An. arabiensis, compared to the fully susceptible Sekoru An. arabiensis laboratory strain. RESULTS:Populations of An. arabiensis were resistant to DDT and deltamethrin but were susceptible to fenitrothion in all the study sites. Reduced susceptibility to malathion, pirimiphos-methyl, propoxur and bendiocarb was observed in some of the study sites. Knockdown resistance (kdr L1014F) was detected in all mosquito populations with allele frequency ranging from 42 to 91%. Elevated levels of glutathione-S-transferases (GSTs) were detected in some of the mosquito populations. However, no elevated levels of monooxygenases and esterases were detected in any of the populations assessed. CONCLUSIONS:Anopheles arabiensis populations from all surveyed sites in Ethiopia exhibited resistance against DDT and pyrethroids. Moreover, some mosquito populations exhibited resistance to propoxur and possible resistance to bendiocarb. Target site mutation kdr L1014F was detected in all mosquito populations while elevated levels of glutathione-S-transferases (GSTs) was detected in some mosquito populations. The reduced susceptibility of An. arabiensis to propoxur and bendiocarb, which are currently used for indoor residual spraying (IRS) in Ethiopia, calls for continuous resistance monitoring, in order to plan and implement evidence based insecticide resistance management.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Alemayehu E,Asale A,Eba K,Getahun K,Tushune K,Bryon A,Morou E,Vontas J,Van Leeuwen T,Duchateau L,Yewhalaw Ddoi
10.1186/s13071-017-2342-ysubject
Has Abstractpub_date
2017-09-02 00:00:00pages
407issue
1issn
1756-3305pii
10.1186/s13071-017-2342-yjournal_volume
10pub_type
杂志文章abstract:BACKGROUND:Spatial repellents that drive mosquitoes away from treated areas, and odour-baited traps, that attract and kill mosquitoes, can be combined and work synergistically in a push-pull system. Push-pull systems have been shown to reduce house entry and outdoor biting rates of malaria vectors and so have the poten...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04263-3
更新日期:2020-07-31 00:00:00
abstract:BACKGROUND:A microsporidian was previously reported to infect the crustacean parasite, Lepeophtheirus salmonis (Krøyer, 1837) (Copepoda, Caligidae), on farmed Atlantic salmon (Salmo salar L.) in Scotland. The microsporidian was shown to be a novel species with a molecular phylogenetic relationship to Nucleospora (Enter...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-2-58
更新日期:2009-11-27 00:00:00
abstract:BACKGROUND:Even though male-biased parasitism is common in mammals, little effort has been made to evaluate whether higher parasitic burden in males results in an extra biological cost, and thus a decrease in fitness. Body condition impairment and the augmentation of oxidative stress can be used as indicators of the co...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2060-5
更新日期:2017-04-21 00:00:00
abstract::Taenia solium life cycle includes humans as definitive hosts and pigs as intermediate hosts. One of the measures to stop the life cycle of this parasite is by vaccination of pigs. In experiments performed in pigs with TSOL18 and TSOL45-1A, two recombinant T. solium proteins, 99.5% and 97.0% protection was induced, res...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-3
更新日期:2011-01-06 00:00:00
abstract:BACKGROUND:This laboratory study compared the efficacy of Bravecto™ (fluralaner), formulated as a chewable tablet, with the efficacy of Advocate® (imidacloprid/moxidectin), formulated for topical administration, against naturally acquired generalized demodicosis in dogs. METHODS:Sixteen dogs, all diagnosed with genera...
journal_title:Parasites & vectors
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13071-015-0775-8
更新日期:2015-03-28 00:00:00
abstract:BACKGROUND:Canine monocytic ehrlichiosis (CME) is a tick-borne disease with a global distribution, caused by Ehrlichia canis. The inflammatory response to E. canis infection includes changes in certain acute phase proteins (APP) and in biomarkers of the oxidative status. APP responses are considered part of the innate ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0798-1
更新日期:2015-03-23 00:00:00
abstract:BACKGROUND:With the spread of pyrethroid resistance in mosquitoes, the combination of an insecticide (carbamate or organophosphate) with a repellent (DEET) is considered as a promising alternative strategy for the treatment of mosquito nets and other relevant materials. The efficacy of these mixtures comes from the fac...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-2-17
更新日期:2009-04-16 00:00:00
abstract::Presently, 45% of the total human population of Europe, as well as their domestic and companion animals, are exposed to the risk of vector-borne helminths (VBH) causing diseases. A plethora of intrinsic biological and extrinsic factors affect the relationship among helminths, vectors and animal hosts, in a constantly ...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/1756-3305-6-16
更新日期:2013-01-16 00:00:00
abstract:BACKGROUND:Resistance to chemical insecticides plus high morbidity rates have lead to rising interest in fungi as candidates for biocontrol agents of mosquito vectors. In most studies fungal infections have been induced by exposure of mosquitoes to various surfaces treated with conidia. In the present study eight Mexic...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-24
更新日期:2011-02-26 00:00:00
abstract:BACKGROUND:The present study was conducted to investigate the serological survey of Toxoplasma antibodies in local.horses from three major regions: a neighbourhood of a city in the North (Sidi Thabet), a neighbourhood of a city on the coast (Monastir) and a neighbourhood of a city in the middle (Battan) of Tunisia (Nor...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-218
更新日期:2011-11-22 00:00:00
abstract:BACKGROUND:Chagas disease transmission risk is a function of the presence of triatomines in domestic habitats. Rhodnius ecuadoriensis is one of the main vectors implicated in transmission of Trypanosoma cruzi in Ecuador. This triatomine species is present in domestic, peridomestic and sylvatic habitats in the country. ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-17
更新日期:2012-01-13 00:00:00
abstract:BACKGROUND:The prolonged feeding process of ixodid ticks, in combination with bacterial transmission, should lead to a robust inflammatory response at the blood-feeding site. Yet, factors present in tick saliva may down-regulate such responses, which may be beneficial to spirochete transmission. The primary goal of thi...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1638-7
更新日期:2016-07-08 00:00:00
abstract:BACKGROUND:Toxoplasma gondii is an intracellular protozoan parasite that infects a wide variety of warm-blooded hosts, including humans. Limited information about T. gondii infection in bats is available in China. The objective of the present study was to determine prevalence and genetic characterization of T. gondii i...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-014-0558-7
更新日期:2014-12-03 00:00:00
abstract:BACKGROUND:Reunion Island regularly faces outbreaks of epizootic haemorrhagic disease (EHD) and bluetongue (BT), two viral diseases transmitted by haematophagous midges of the genus Culicoides (Diptera: Ceratopogonidae) to ruminants. To date, five species of Culicoides are recorded in Reunion Island in which the first ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3812-1
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:The brown dog tick Rhipicephalus sanguineus (sensu stricto) is reputed to be the most widespread tick of domestic dogs worldwide and has also been implicated in the transmission of many pathogens to dogs and humans. For more than two centuries, Rh. sanguineus (s.s.) was regarded as a single taxon, even consi...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2941-2
更新日期:2018-07-09 00:00:00
abstract:BACKGROUND:Understanding the variation in prevalence of Borrelia burgdorferi sensu lato (Lyme Borreliosis Spirochaetes, LBS) and Anaplasma phagocytophilum (causing tick-borne fever in ruminants and human granulocytic ehrlichiosis) in ticks is vital from both a human and an animal disease perspective to target the most ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-187
更新日期:2013-06-20 00:00:00
abstract:BACKGROUND:Trichinella spiralis expresses paramyosin (Ts-Pmy) not only as a structural protein but also as an immunomodulator that inhibits host complement as a survival strategy. Previous studies demonstrated that Ts-Pmy bound to complement components C8 and C9 and inhibited the polymerization of C9 during the formati...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-313
更新日期:2014-07-04 00:00:00
abstract:BACKGROUND:An active immune surveillance and a range of barriers to infection allow the host to effectively eliminate microbial pathogens. However, pathogens may use diverse strategies to subdue such host defences. For instance, one such mechanism is the use of leucine-rich repeat (LRR) proteins by pathogens (microbial...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1842-5
更新日期:2016-10-21 00:00:00
abstract:BACKGROUND:Arthropod-borne diseases are some of the most rapidly spreading diseases. Reducing the vector population is currently the only effective way to reduce case numbers. Central metabolic pathways are potential targets to control vector populations, but have not been well explored to this aim. The information ava...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1391-y
更新日期:2016-02-25 00:00:00
abstract:BACKGROUND:Epidemics of dengue, chikungunya and Zika are a growing threat to areas where Aedes aegypti are present. The efficacy of chemical control of Ae. aegypti is threatened by the increasing frequency of insecticide resistance. The objective of this study was to determine the susceptibility status as well as the b...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3739-6
更新日期:2019-10-22 00:00:00
abstract::Since 2004 there has been an increased recognition of the importance of Neglected Tropical Diseases (NTDs) as impediments to development. These diseases are caused by a variety of infectious agents - viruses, bacteria and parasites - which cause a diversity of clinical conditions throughout the tropics. The World Heal...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/1756-3305-4-234
更新日期:2011-12-13 00:00:00
abstract:BACKGROUND:Arboviruses are a growing public health concern in Europe, with both endemic and exotic arboviruses expected to spread further into novel areas in the next decades. Predicting where future outbreaks will occur is a major challenge, particularly for regions where these arboviruses are not endemic. Spatial mod...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04339-0
更新日期:2020-09-10 00:00:00
abstract:BACKGROUND:During recent periods, the islands of the Republic of Seychelles experienced many diseases such as dengue, chikungunya, Bancroft's filaria and malaria. Mosquitoes transmit the agents that cause these diseases. Published information on mosquitoes in the Seychelles is notably dispersed in the literature. The m...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-207
更新日期:2012-09-21 00:00:00
abstract:BACKGROUND:Recent global changes have led to an increase in distribution of ticks towards higher elevation and latitude in Europe and livestock are at increasing risk of contracting tick-borne diseases, but psychological aspects of how this affects human well-being are rarely assessed. Departing from the theory on emot...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04162-7
更新日期:2020-06-30 00:00:00
abstract::Major efforts are currently underway to develop novel, complementary methods to combat mosquito-borne diseases. Mosquito genetic control strategies (GCSs) have become an increasingly important area of research on account of their species-specificity, track record in targeting agricultural insect pests, and their envir...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-018-3222-9
更新日期:2018-12-24 00:00:00
abstract:BACKGROUND:Understanding the dispersal dynamics of invasive mosquito species is fundamental to improve vector surveillance and to target control efforts. Aedes albopictus has been deemed a poor flyer as its range of active dispersal is generally assumed to be limited to a few hundred metres, while laboratory studies su...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3837-5
更新日期:2019-12-12 00:00:00
abstract:BACKGROUND:Northeastern Italy is a hotspot for several tick-borne pathogens, transmitted to animals and humans mainly by Ixodes ricinus. Here we compare the results of molecular monitoring of ticks and zoonotic TBPs over a six-year period, with the monitoring of red foxes (Vulpes vulpes) in an endemic area. RESULTS:In...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2726-7
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:Blood-feeding is a common strategy among parasitizing arthropods, including the ectoparasitic salmon louse (Lepeophtheirus salmonis), feeding off its salmon host's skin and blood. Blood is rich in nutrients, among these iron and heme. These are essential molecules for the louse, yet their oxidative propertie...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04096-0
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:Rhipicephalus microplus is a hard tick that has a major impact on cattle health in tropical and subtropical regions because it feeds on cattle and is implicated in the transmission of pathogens that cause diseases such as bovine anaplasmosis and babesiosis. Presently, acaricides are used to control tick infe...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2081-0
更新日期:2017-03-23 00:00:00
abstract:BACKGROUND:The control of Aedes aegypti is usually based on chemical insecticides, but the overuse of these compounds has led to increased resistance. The binary toxin produced by Lysinibacillus sphaericus in the final stages of sporulation is used for mosquito control due to its specificity against the culicid larvae;...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2171-z
更新日期:2017-05-10 00:00:00