Abstract:
BACKGROUND:Sheep scab is caused by the ectoparasitic mite Psoroptes ovis which initiates a profound cutaneous inflammatory response, leading to the development of the skin lesions which are characteristic of the disease. Existing control strategies rely upon injectable endectocides and acaricidal dips but concerns over residues, eco-toxicity and the development of acaricide resistance limit the sustainability of this approach. In order to identify alternative means of disease control, a deeper understanding of both the parasite and its interaction with the host are required. METHODS:Herein we describe the development and utilisation of an annotated P. ovis cDNA microarray containing 3,456 elements for the measurement of gene expression in this economically important ectoparasite. The array consists of 981 P. ovis EST sequences printed in triplicate along with 513 control elements. Array performance was validated through the analysis of gene expression differences between fed and starved P. ovis mites. RESULTS:Sequences represented on the array include homologues of major house dust mite allergens and tick salivary proteins, along with factors potentially involved in mite reproduction and xenobiotic metabolism. In order to validate the performance of this unique resource under biological conditions we used the array to analyse gene expression differences between fed and starved P. ovis mites. These analyses identified a number of house dust mite allergen homologues up-regulated in fed mites and P. ovis transcripts involved in stress responses, autophagy and chemosensory perception up-regulated in starved mites. CONCLUSION:The P. ovis cDNA microarray described here has been shown to be both robust and reproducible and will enable future studies to analyse gene expression in this important ectoparasite.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Burgess ST,Downing A,Watkins CA,Marr EJ,Nisbet AJ,Kenyon F,McNair C,Huntley JFdoi
10.1186/1756-3305-5-30subject
Has Abstractpub_date
2012-02-08 00:00:00pages
30issn
1756-3305pii
1756-3305-5-30journal_volume
5pub_type
杂志文章abstract:BACKGROUND:The protozoan Toxoplasma gondii is the causative agent of toxoplasmosis, with complications varying from mental disease to death. While human infection can occur via ingestion of tissue cysts from infected meat, most human infection comes from oocysts. Cats are the only definitive host, and thus shedding of ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-266
更新日期:2013-09-17 00:00:00
abstract:BACKGROUND:The myxosporean parasite Parvicapsula pseudobranchicola commonly infects farmed Atlantic salmon in northern Norway. Heavy infections are associated with pseudobranch lesions, runting and mortality in the salmon populations. The life-cycle of the parasite is unknown, preventing controlled challenge experiment...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2583-9
更新日期:2018-01-06 00:00:00
abstract:: Canine leishmaniosis is widespread in South America, where a number of Leishmania species have been isolated or molecularly characterised from dogs. Most cases of canine leishmaniosis are caused by Leishmania infantum (syn. Leishmania chagasi) and Leishmania braziliensis. The only well-established vector of Leishmani...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-2-S1-S1
更新日期:2009-03-26 00:00:00
abstract:BACKGROUND:Schistosomiasis japonica remains a major public health problem in China. Integrating molecular analyses, such as population genetic analyses, of the parasite into the on-going surveillance programs is helpful in exploring the factors causing the persistence and/or spread of Schistosoma japonicum. However, ge...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1074-0
更新日期:2015-09-08 00:00:00
abstract:BACKGROUND:The low prevalence of blood parasites in some bird species may be related to the habitats they frequent, the inexistence of the right host-parasite assemblage or the immunological capacity of the host. Here, we assess the parasite load of breeding populations of Eleonora's falcon (Falco eleonorae), a medium-...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0802-9
更新日期:2015-03-31 00:00:00
abstract:BACKGROUND:The poultry red mite Dermanyssus gallinae negatively impacts bird welfare and health, and interferes with egg production and quality, while emerging acaricide resistance limits control options. Fluralaner, a novel miticide for administration in drinking water, is approved for control of D. gallinae infestati...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2956-8
更新日期:2018-06-25 00:00:00
abstract:BACKGROUND:The mosquito Aedes aegypti, vector of dengue fever, is a target for control by entomopathogenic fungi. Recent studies by our group have shown the susceptibility of adult A. aegypti to fungal infection by Metarhizium anisopliae. This fungus is currently being tested under field conditions. However, it is unkn...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-91
更新日期:2011-05-26 00:00:00
abstract:BACKGROUND:In Switzerland, the invasive Asian tiger mosquito, Aedes albopictus, is firmly established in the Canton of Ticino, south of the Alps. According to a large-scale distribution model developed in 2013, suitable climatic conditions for the establishment of Ae. albopictus north of the Alps are found in Basel and...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2803-y
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:The molecular structure of Fasciola gigantica 14-3-3 protein has been characterized. However, the involvement of this protein in parasite pathogenesis remains elusive and its effect on the functions of innate immune cells is unknown. We report on the cloning and expression of a recombinant F. gigantica 14-3-...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2745-4
更新日期:2018-03-06 00:00:00
abstract:BACKGROUND:The Asian tiger mosquito Aedes albopictus is an extremely invasive, globally distributed and medically important vector of various human and veterinary pathogens. In Germany, where this species was recently introduced, its establishment may become modulated by interspecific competition from autochthonous mos...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2665-3
更新日期:2018-02-02 00:00:00
abstract::Major efforts are currently underway to develop novel, complementary methods to combat mosquito-borne diseases. Mosquito genetic control strategies (GCSs) have become an increasingly important area of research on account of their species-specificity, track record in targeting agricultural insect pests, and their envir...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-018-3222-9
更新日期:2018-12-24 00:00:00
abstract:BACKGROUND:Rhipicephalus microplus is a hard tick that has a major impact on cattle health in tropical and subtropical regions because it feeds on cattle and is implicated in the transmission of pathogens that cause diseases such as bovine anaplasmosis and babesiosis. Presently, acaricides are used to control tick infe...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2081-0
更新日期:2017-03-23 00:00:00
abstract:BACKGROUND:Cats appear to be the primary reservoir host for Bartonella koehlerae, an alpha Proteobacteria that is most likely transmitted among cat populations by fleas (Ctenocephalides felis). Bartonella koehlerae has caused endocarditis in a dog and in one human patient from Israel, but other clinically relevant repo...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-76
更新日期:2010-08-24 00:00:00
abstract:BACKGROUND:Transmission-blocking vaccines (TBVs) have been considered an important strategy for disrupting the malaria transmission cycle, especially for Plasmodium vivax malaria, which undergoes gametocytogenesis earlier during infection. Pvs25 and Pvs28 are transmission-blocking vaccine candidates for P. vivax malari...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-224
更新日期:2011-11-28 00:00:00
abstract:BACKGROUND:Adult fleas are haematophagous ectoparasites of warm-blooded vertebrates, particularly mammals. Among them, the cat flea (Ctenocephalides felis) and the human flea (Pulex irritans) have high veterinary-medical significance, owing to their cosmopolitan distribution and role in the transmission of important ve...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2798-4
更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:Bravecto™ Chewable Tablets for Dogs, containing fluralaner as active ingredient, is an innovative treatment for flea and tick infestations that provides safe, rapid and long acting efficacy after a single oral administration in dogs. Topically applied fluralaner provides similar safe, rapid and long acting e...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1564-8
更新日期:2016-05-31 00:00:00
abstract:BACKGROUND:Trichinella spiralis expresses paramyosin (Ts-Pmy) not only as a structural protein but also as an immunomodulator that inhibits host complement as a survival strategy. Previous studies demonstrated that Ts-Pmy bound to complement components C8 and C9 and inhibited the polymerization of C9 during the formati...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-313
更新日期:2014-07-04 00:00:00
abstract:BACKGROUND:Alternative insecticides for the control of malaria and filarial vectors are of paramount need as resistance is increasing among classes of insecticides currently in use in the public health sector. In this study, mosquitocidal activity of Schinus terebinthifolia essential oil against Anopheles gambiae s.s.,...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-129
更新日期:2011-07-05 00:00:00
abstract:BACKGROUND:Schistosomiasis japonica is an infectious disease caused by Schistosoma japonicum that seriously endangers human health. Domestic animals have important roles in disease transmission and goats are considered a primary reservoir host and source of infection. The prevalence and intensity of schistosomiasis inf...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04420-8
更新日期:2020-10-27 00:00:00
abstract:BACKGROUND:Merozoite proteins of the malaria parasites involved in the invasion of red blood cells are selected by host immunity and their diversity is greatly influenced by changes in malaria epidemiology. In the Greater Mekong Subregion (GMS), malaria transmission is concentrated along the international borders and t...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3803-2
更新日期:2019-11-20 00:00:00
abstract:BACKGROUND:The cat flea (Ctenocephalides felis) is a blood-feeding ectoparasitic insect and particular nuisance pest of companion animals worldwide. Identification of genes that are differentially expressed in response to feeding is important for understanding flea biology and discovering targets for their control. ME...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0972-5
更新日期:2015-07-14 00:00:00
abstract:BACKGROUND:The current study shows the results of three years of IRS entomological monitoring (2016, before intervention; 2017 and 2018, after intervention) performed in Alibori and Donga, northern Benin. METHODS:Mosquito collections were performed on a monthly basis using human landing catches and pyrethrum spray cat...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3865-1
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:Anaplasma phagocytophilum is an emerging tick-borne zoonotic pathogen of increased interest worldwide which has been detected in northern Africa. Anaplasma platys is also present in this region and could possibly have a zoonotic potential. However, only one recent article reports on the human esposure to A. ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2148-y
更新日期:2017-04-24 00:00:00
abstract:BACKGROUND:Knowledge of insecticide resistance status in the main malaria vectors is an essential component of effective malaria vector control. This study presents the first evaluation of the status of insecticide resistance in Anopheles gambiae populations from Bangui, the Central African Republic. METHODS:Anopheles...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1965-8
更新日期:2017-01-13 00:00:00
abstract:BACKGROUND:Aedes aegypti is a potential vector of West Nile, Japanese encephalitis, chikungunya, dengue and Zika viruses. Alternative control measurements of the vector are needed to overcome the problems of environmental contamination and chemical resistance. Xenorhabdus and Photorhabdus are symbionts in the intestine...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2383-2
更新日期:2017-09-21 00:00:00
abstract:BACKGROUND:Glutathione S-transferases (GSTs) facilitate detoxification of drugs by catalysing the conjugation of the reduced glutathione (GSH) to electrophilic xenobiotic substrates and therefore have a function in multi-drug resistance. As a result, knowledge of GSTs can inform both drug resistance in, and novel inter...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0960-9
更新日期:2015-06-26 00:00:00
abstract:BACKGROUND:Canine vector-borne diseases (CVBDs) are caused by a wide range of pathogens transmitted to dogs by arthropods including ticks and insects. Many CVBD-agents are of zoonotic concern, with dogs potentially serving as reservoirs and sentinels for human infections. The present study aimed at assessing the seropr...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-62
更新日期:2012-03-27 00:00:00
abstract::Arboviruses infecting people primarily exist in urban transmission cycles involving urban mosquitoes in densely populated tropical regions. For dengue, chikungunya, Zika and yellow fever viruses, sylvatic (forest) transmission cycles also exist in some regions and involve non-human primates and forest-dwelling mosquit...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/s13071-019-3732-0
更新日期:2019-10-02 00:00:00
abstract:BACKGROUND:Proteins from the ABC family (ATP-binding cassette) represent the largest known group of efflux pumps, responsible for transporting specific molecules across lipid membranes in both prokaryotic and eukaryotic organisms. In arthropods they have been shown to play a role in insecticide defense/resistance. The ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-349
更新日期:2014-07-29 00:00:00
abstract:BACKGROUND:Blood-feeding is a common strategy among parasitizing arthropods, including the ectoparasitic salmon louse (Lepeophtheirus salmonis), feeding off its salmon host's skin and blood. Blood is rich in nutrients, among these iron and heme. These are essential molecules for the louse, yet their oxidative propertie...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04096-0
更新日期:2020-05-06 00:00:00