Abstract:
BACKGROUND:Recently the role of gastrointestinal nematodes in modulating the immune responses in inflammatory and immune-mediated conditions such as allergy and autoimmune diseases has been introduced. This is mainly due to the suppressive effects of somatic and excretory secretory (ES) products of nematodes on the immune responses. In this study, we evaluated the immunomodulatory potentials of somatic products of Marshallagia marshalli, a gastrointestinal nematodes of sheep, to suppress the immune-mediated responses in a murine model of allergic airway inflammation. BALB/c mice were intraperitoneally (IP) sensitized with ovalbumin (OVA)/Alum and then challenged with 1% OVA. Somatic products of M. marshalli were administered during each sensitization. The effects of somatic products on development of allergic airway inflammation were evaluated by analyzing inflammatory cells recruitment, histopathological changes, cytokines production (IL-4, IL-13, IL-10, TGF-β) and serum antibody titers (IgG1, IgG2a). RESULTS:Somatic products of M. marshalli were able to suppress the induction of allergic airway inflammation in mice. Modulation of Th2 type responses (IL-4, IL-13, IgG1) via upregulations of IL-10 and TGF-β production was observed after injection of somatic products of M. marshalli. In addition, inflammatory cells infiltration and pathological disorders were significantly diminished following administration of somatic products. CONCLUSIONS:Our data raised the possibility that helminths could be a potential therapeutic candidate to alleviate the inflammatory conditions in allergic asthma. According to these results, we concluded that M. marshalli may contain immune-modulatory molecules that attenuate allergic airway inflammation via induction of regulatory cytokines. Further investigations are required to identify molecules that might have potentials for development of novel therapeutic targets.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Parande Shirvan S,Ebrahimby A,Dousty A,Maleki M,Movassaghi A,Borji H,Haghparast Adoi
10.1186/s13071-017-2159-8subject
Has Abstractpub_date
2017-05-12 00:00:00pages
233issue
1issn
1756-3305pii
10.1186/s13071-017-2159-8journal_volume
10pub_type
杂志文章abstract:BACKGROUND:Lyme borreliosis is the most common tick-borne human disease and is caused by Borrelia burgdorferi sensu lato (s.l.). Borrelia miyamotoi, a relapsing fever spirochaete, is transmitted transovarially, whereas this has not been shown for B. burgdorferi (s.l). Therefore, B. burgdorferi (s.l) is considered to cy...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1389-5
更新日期:2016-02-20 00:00:00
abstract:BACKGROUND:Toxoplasma gondii is a widely prevalent protozoan parasite that causes serious toxoplasmosis in humans and animals. The present study aimed to determine the genetic diversity of T. gondii isolates from pigs in Jiangxi, Sichuan, Guangdong Provinces and Chongqing Municipality in China using multilocous polymer...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-227
更新日期:2013-08-07 00:00:00
abstract:BACKGROUND:Triatoma dimidiata (Latreille) is a key vector complex of Trypanosoma cruzi, etiologic agent of Chagas disease, as it spans North, Central, and South America. Although morphological and genetic studies clearly indicate existence of at least five clades within the species, there has been no robust or systemat...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0678-8
更新日期:2015-02-06 00:00:00
abstract:BACKGROUND:Trichinella spiralis expresses paramyosin (Ts-Pmy) not only as a structural protein but also as an immunomodulator that inhibits host complement as a survival strategy. Previous studies demonstrated that Ts-Pmy bound to complement components C8 and C9 and inhibited the polymerization of C9 during the formati...
journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2014-07-04 00:00:00
abstract:BACKGROUND:Spatial repellents that drive mosquitoes away from treated areas, and odour-baited traps, that attract and kill mosquitoes, can be combined and work synergistically in a push-pull system. Push-pull systems have been shown to reduce house entry and outdoor biting rates of malaria vectors and so have the poten...
journal_title:Parasites & vectors
pub_type: 杂志文章
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更新日期:2020-07-31 00:00:00
abstract:BACKGROUND:Knowledge on the capacity of Australian ticks to carry Borrelia species is currently limited or missing. To evaluate the potential of ticks to carry bacterial pathogens and their DNA, it is imperative to have a robust workflow that maximises recovery of bacterial DNA within ticks in order to enable accurate ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2579-5
更新日期:2017-12-20 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章,评审
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更新日期:2020-01-30 00:00:00
abstract:BACKGROUND:Tick-borne diseases pose a major threat in public health. The epidemiological dynamics of these diseases depends on the tick vector species and their hosts, as well as the geographical distribution and ecology of both. Among many possible hosts for ticks, small mammals have a major role in the development of...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2791-y
更新日期:2018-03-20 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-243
更新日期:2011-12-30 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3223-8
更新日期:2019-01-11 00:00:00
abstract:BACKGROUND:Since 2008, the National Malaria Control Program (NMCP) has been engaged in the implementation of indoor residual spraying (IRS) in Benin. The first and second round was a success with a drastic decrease of malaria transmission in areas under IRS. We present here the results of the third round. The purpose o...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-163
更新日期:2012-08-08 00:00:00
abstract:BACKGROUND:The aim of this study was to determine exposure to vector-borne pathogens (VBPs) in populations of dogs living on Greek islands in the Ionian and Aegean seas. METHODS:In total, 1154 dogs with different lifestyles and of varying ages and breeds were randomly sampled and examined for the presence of clinical ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04153-8
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Cyclospora is a protistan parasite that causes enteritis in several species of animals including humans. The aim of this study was to investigate the presence of Cyclospora in captive non-human primates. METHODS:A total of 119 faecal samples from Pan troglodytes, Macaca sylvanus, Cercopithecus cephus, Eryth...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0872-8
更新日期:2015-05-15 00:00:00
abstract:BACKGROUND:Fleas (Siphonaptera) are the most clinically important ectoparasites of dogs and cats worldwide. Rising levels of pet ownership, climate change and globalisation are increasing the importance of a detailed understanding of the endemicity and prevalence of flea-borne pathogens. This requires continued surveil...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3326-x
更新日期:2019-02-06 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-3200-2
更新日期:2018-12-04 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3401-3
更新日期:2019-03-25 00:00:00
abstract:BACKGROUND:Sheep scab is caused by the ectoparasitic mite Psoroptes ovis which initiates a profound cutaneous inflammatory response, leading to the development of the skin lesions which are characteristic of the disease. Existing control strategies rely upon injectable endectocides and acaricidal dips but concerns over...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-30
更新日期:2012-02-08 00:00:00
abstract:BACKGROUND:The African malaria vector, Anopheles gambiae s.s., is known to feed selectively on certain plants for sugar sources. However, the adaptive significance of this behaviour especially on how the extracts of such plants impact on the fitness of this vector has not been explored. This study determined the toxici...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-312
更新日期:2014-07-04 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章,评审
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更新日期:2017-09-18 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04134-x
更新日期:2020-05-19 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-91
更新日期:2011-05-26 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-6-351
更新日期:2013-12-12 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1962-y
更新日期:2017-02-17 00:00:00
abstract:BACKGROUND:Many cases of cutaneous leishmaniasis (CL) have been recorded in the Jenin District based on their clinical appearance. Here, their parasites have been characterized in depth. METHODS:Leishmanial parasites isolated from 12 human cases of CL from the Jenin District were cultured as promastigotes, whose DNA w...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-121
更新日期:2012-06-18 00:00:00
abstract:BACKGROUND:Culex pipiens pipiens plays an important role in the transmission of several vector-borne pathogens such as West Nile virus (WNV) in North America. Laboratory and field studies suggest that this species is ornithophilic but because of genetic hybridization with sibling species during the active mosquito seas...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-1012-1
更新日期:2015-07-24 00:00:00
abstract:BACKGROUND:In 2012, the World Health Organization set goals for the elimination of onchocerciasis transmission by 2020 in selected African countries. Epidemiological data and mathematical modelling have indicated that elimination may not be achieved with annual ivermectin distribution in all endemic foci. Complementary...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2864-y
更新日期:2018-05-29 00:00:00
abstract:BACKGROUND:Cathepsin cysteine proteases play multiple roles in the life cycle of parasites such as food uptake, immune invasion and pathogenesis, making them valuable targets for diagnostic assays, vaccines and drugs. The purpose of this study was to identify a cathepsin B of Clonorchis sinensis (CsCB) and to investiga...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-149
更新日期:2011-07-27 00:00:00
abstract:BACKGROUND:The parasitic mite Varroa destructor is considered the major pest of the European honey bee (Apis mellifera) and responsible for declines in honey bee populations worldwide. Exploiting the full potential of gene sequences becoming available for V. destructor requires adaptation of modern molecular biology ap...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-73
更新日期:2010-08-16 00:00:00
abstract:BACKGROUND:Persistent covert infections of the myxozoan, Tetracapsuloides bryosalmonae, in primary invertebrate hosts (the freshwater bryozoan, Fredericella sultana) have been proposed to represent a reservoir for proliferative kidney disease in secondary fish hosts. However, we have limited understanding of how covert...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2495-8
更新日期:2017-11-02 00:00:00
abstract:BACKGROUND:Pyrethroid resistance has been slower to emerge in Anopheles arabiensis than in An. gambiae s.s and An. funestus and, consequently, studies are only just beginning to unravel the genes involved. Permethrin resistance in An. arabiensis in Lower Moshi, Tanzania has been linked to elevated levels of both P450 m...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-274
更新日期:2014-06-19 00:00:00