Abstract:
BACKGROUND:Rats (Rattus spp.) invaded most of the world as stowaways including some that carried the rat lungworm, Angiostrongylus cantonensis, the cause of eosinophilic meningoencephalitis in humans and other warm-blooded animals. A high genetic diversity of A. cantonensis based on short mitochondrial DNA regions is reported from Southeast Asia. However, the identity of invasive A. cantonensis is known for only a minority of countries. The affordability of next-generation sequencing for characterisation of A. cantonensis genomes should enable new insights into rat lung worm invasion and parasite identification in experimental studies. METHODS:Genomic DNA from morphologically verified A. cantonensis (two laboratory-maintained strains and two field isolates) was sequenced using low coverage whole genome sequencing. The complete mitochondrial genome was assembled and compared to published A. cantonensis and Angiostrongylus malaysiensis sequences. To determine if the commonly sequenced partial cox1 can unequivocally identify A. cantonensis genetic lineages, the diversity of cox1 was re-evaluated in the context of the publicly available cox1 sequences and the entire mitochondrial genomes. Published experimental studies available in Web of Science were systematically reviewed to reveal published identities of A. cantonensis used in experimental studies. RESULTS:New A. cantonensis mitochondrial genomes from Sydney (Australia), Hawaii (USA), Canary Islands (Spain) and Fatu Hiva (French Polynesia), were assembled from next-generation sequencing data. Comparison of A. cantonensis mitochondrial genomes from outside of Southeast Asia showed low genetic diversity (0.02-1.03%) within a single lineage of A. cantonensis. Both cox1 and cox2 were considered the preferred markers for A. cantonensis haplotype identification. Systematic review revealed that unequivocal A. cantonensis identification of strains used in experimental studies is hindered by absence of their genetic and geographical identity. CONCLUSIONS:Low coverage whole genome sequencing provides data enabling standardised identification of A. cantonensis laboratory strains and field isolates. The phenotype of invasive A. cantonensis, such as the capacity to establish in new territories, has a strong genetic component, as the A. cantonensis found outside of the original endemic area are genetically uniform. It is imperative that the genotype of A. cantonensis strains maintained in laboratories and used in experimental studies is unequivocally characterised.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Červená B,Modrý D,Fecková B,Hrazdilová K,Foronda P,Alonso AM,Lee R,Walker J,Niebuhr CN,Malik R,Šlapeta Jdoi
10.1186/s13071-019-3491-ysubject
Has Abstractpub_date
2019-05-16 00:00:00pages
241issue
1issn
1756-3305pii
10.1186/s13071-019-3491-yjournal_volume
12pub_type
杂志文章abstract:BACKGROUND:Few reports of Echinococcus spp. have been described in the USA; however, the geographical distribution of Echinococcus spp. in wild hosts is increasing consequent to human activities. In the early 2000's, 253 elk (Cervus canadensis) originating from Alberta, Canada were released into the Great Smoky Mountai...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04198-9
更新日期:2020-06-30 00:00:00
abstract:BACKGROUND:Dirofilaria repens is the causative agent of subcutaneous dirofilariosis of dogs, other animals and humans. This nematode is transmitted by mosquitoes of Aedes, Anopheles and Culex genera. In dogs, the parasite may cause subclinical infection or cutaneous signs. Recently, D. repens has emerged and spread in ...
journal_title:Parasites & vectors
pub_type: 杂志文章,随机对照试验
doi:10.1186/1756-3305-7-347
更新日期:2014-07-29 00:00:00
abstract:BACKGROUND:The aim of this study was to determine exposure to vector-borne pathogens (VBPs) in populations of dogs living on Greek islands in the Ionian and Aegean seas. METHODS:In total, 1154 dogs with different lifestyles and of varying ages and breeds were randomly sampled and examined for the presence of clinical ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04153-8
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:This laboratory study compared the efficacy of Bravecto™ (fluralaner), formulated as a chewable tablet, with the efficacy of Advocate® (imidacloprid/moxidectin), formulated for topical administration, against naturally acquired generalized demodicosis in dogs. METHODS:Sixteen dogs, all diagnosed with genera...
journal_title:Parasites & vectors
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13071-015-0775-8
更新日期:2015-03-28 00:00:00
abstract:BACKGROUND:Domestic cats play a key role in the epidemiology of the parasite Toxoplasma gondii by excreting environmentally-resistant oocysts that may infect humans and other warm-blooded animals. The dynamics of Toxoplasma gondii seroconversion, used as a proxy for primo-infection dynamics, was investigated in five ca...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2834-4
更新日期:2018-06-08 00:00:00
abstract:BACKGROUND:Multiplicity and genetic diversity of Plasmodium falciparum infection might play a role in determining the clinical outcome of malaria infection and could be a fair reflection of the disease transmission rate. This study investigated the genetic diversity of P. falciparum and multiplicity of infection in rel...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1641-z
更新日期:2016-06-27 00:00:00
abstract:BACKGROUND:Malaria transmission in Cameroon is mediated by a plethora of vectors that are heterogeneously distributed across the country depending on the biotope. To effectively guide malaria control operations, regular update on the role of local Anopheles species is essential. Therefore, an entomological survey was c...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-262
更新日期:2014-06-05 00:00:00
abstract:BACKGROUND:Chhattisgarh state in central India is highly endemic for malaria and contributes about 13% of annually reported malaria cases in the country with predominance of P. falciparum. Entomological investigations were carried out in a tribal forested area of district Bastar located in the southern part of Chhattis...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-215
更新日期:2012-09-28 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3782-3
更新日期:2019-11-12 00:00:00
abstract:BACKGROUND:Antillean manatees (Trichechus manatus manatus) are large herbivorous aquatic mammals living in limited areas of South, Central and North America. As with other aquatic mammals, Antillean manatees can be infected by a variety of protozoan and metazoan parasites, some of them with zoonotic potential, which af...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-019-3448-1
更新日期:2019-04-27 00:00:00
abstract:BACKGROUND:The poultry red mite Dermanyssus gallinae negatively impacts bird welfare and health, and interferes with egg production and quality, while emerging acaricide resistance limits control options. Fluralaner, a novel miticide for administration in drinking water, is approved for control of D. gallinae infestati...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2956-8
更新日期:2018-06-25 00:00:00
abstract:BACKGROUND:With field releases starting in Brazil, particular interest must be given to understanding how the endosymbiotic bacterium Wolbachia pipientis affects Aedes aegypti mosquitoes with a Brazilian genetic background. Currently, there is limited information on how the bacterium affects phenotypic traits such as l...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1559-5
更新日期:2016-05-16 00:00:00
abstract:BACKGROUND:Triatomines are blood-sucking vectors of Trypanosoma cruzi, the causative agent of Chagas disease. During feeding, triatomines surpass the skin host response through biomolecules present in their saliva. Dendritic cells (DCs) play a crucial role in the induction of the protection to aggressive agents, includ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1890-x
更新日期:2016-12-09 00:00:00
abstract:BACKGROUND:Sheep scab is caused by the ectoparasitic mite Psoroptes ovis which initiates a profound cutaneous inflammatory response, leading to the development of the skin lesions which are characteristic of the disease. Existing control strategies rely upon injectable endectocides and acaricidal dips but concerns over...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-30
更新日期:2012-02-08 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-5-207
更新日期:2012-09-21 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-020-04031-3
更新日期:2020-03-30 00:00:00
abstract:BACKGROUND:Giardia duodenalis is a flagellated parasite that causes diarrhea in humans and other animals. Although G. duodenalis is found in companion animals worldwide, information regarding the prevalence and genetic characteristics of G. duodenalis in pet chipmunks in China is limited. The present study therefore ai...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2790-z
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:The G subfamily of ABC (ATP-binding cassette) transporters of Leishmania include 6 genes (ABCG1-G6), some with relevant biological functions associated with drug resistance and phospholipid transport. Several studies have shown that Leishmania LABCG2 transporter plays a role in the exposure of phosphatidylse...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-017-2198-1
更新日期:2017-05-30 00:00:00
abstract::Since 2004 there has been an increased recognition of the importance of Neglected Tropical Diseases (NTDs) as impediments to development. These diseases are caused by a variety of infectious agents - viruses, bacteria and parasites - which cause a diversity of clinical conditions throughout the tropics. The World Heal...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/1756-3305-4-234
更新日期:2011-12-13 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-015-0991-2
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-3-26
更新日期:2010-04-08 00:00:00
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journal_title:Parasites & vectors
pub_type: 临床试验,杂志文章
doi:10.1186/s13071-018-3224-7
更新日期:2018-12-20 00:00:00
abstract:BACKGROUND:The genus Bartonella is comprised of a rapidly increasing number of pathogenic species that induce a seemingly diverse spectrum of neurological symptoms. During the 12 year period that followed the initial onset of neurological and gastrointestinal symptoms, an 11 year-old girl experienced a spectrum of neur...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1547-9
更新日期:2016-05-10 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-016-1569-3
更新日期:2016-05-27 00:00:00
abstract:BACKGROUND:The African malaria vector, Anopheles gambiae s.s., is known to feed selectively on certain plants for sugar sources. However, the adaptive significance of this behaviour especially on how the extracts of such plants impact on the fitness of this vector has not been explored. This study determined the toxici...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-312
更新日期:2014-07-04 00:00:00
abstract:BACKGROUND:Publications are often used as a measure of success of research work. Leishmaniasis is considered endemic in 98 countries, most of which are developing. This article describes a bibliometric review of the literature on leishmaniasis research indexed in PubMed during a 66-year period. METHODS:Medline was use...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/1756-3305-6-55
更新日期:2013-03-07 00:00:00
abstract::Control and eventual elimination of human parasitic diseases in the People's Republic of China (P.R. China) requires novel approaches, particularly in the areas of diagnostics, mathematical modelling, monitoring, evaluation, surveillance and public health response. A comprehensive effort, involving the collaboration o...
journal_title:Parasites & vectors
pub_type: 杂志文章,评审
doi:10.1186/1756-3305-5-221
更新日期:2012-10-04 00:00:00
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journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-7-398
更新日期:2014-08-28 00:00:00
abstract:BACKGROUND:Malaria mosquitoes spend a considerable part of their life in the aquatic stage, rendering them vulnerable to interventions directed to aquatic habitats. Recent successes of mosquito larval control have been reported using environmental and biological tools. Here, we report the effects of shading by plants a...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/1756-3305-4-130
更新日期:2011-07-06 00:00:00
abstract:BACKGROUND:Several studies were carried out in experimental hut station in areas surrounding the city of Bouaké, after the crisis in Côte d'Ivoire. They reported increasing resistance levels to insecticide for malaria transmiting mosquitoes. The present work aims to evaluate the current resistance level of An. gambiae ...
journal_title:Parasites & vectors
pub_type: 杂志文章
doi:10.1186/s13071-018-2702-2
更新日期:2018-03-02 00:00:00