Abstract：
BACKGROUND:The frequent outbreaks of human trichinellosis globally underscore the need to develop effective vaccine. We hypothesized that a novel vaccine could improve vaccine efficacy against Trichinella spiralis. METHODS:In this study, we developed virus-like particles (VLPs) containing the 53 KDa excretory/secretory (ES) protein of T. spiralis and the influenza matrix protein 1 (M1) as a core protein, and investigated the protective efficacy of the VLPs alone or with cholera toxin (CT) in a mouse model. RESULTS:Intramuscular immunization induced T. spiralis-specific IgG, IgG1 and IgG2a antibody responses before and after challenge infections in the sera. These antibody responses were significantly enhanced in mice immunized with adjuvanted VLPs. Upon challenge infection, vaccinated mice showed significantly reduced worm burden in the diaphragm. Protective immune responses and efficacy of protection were significantly improved by immunization with VLPs together with CT adjuvant. CONCLUSIONS:Our results are informative for a better understanding of the protective immunity induced by T. spiralis VLPs, and will provide insight into designing safe and effective vaccines.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Lee SH,Kim SS,Lee DH,Kim AR,Quan FSdoi
10.1186/s13071-016-1662-7subject
Has Abstractpub_date
2016-07-04 00:00:00pages
384issue
1issn
1756-3305pii
10.1186/s13071-016-1662-7journal_volume
9pub_type
杂志文章abstract：BACKGROUND:Leishmaniasis represents an important public health problem in Brazil. The continuous process of urbanization and expansion of human activities in forest areas impacts natural habitats, modifying the ecology of some species of Leishmania, as well as its vectors and reservoirs and, consequently, changes the e...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-2742-7
更新日期：2018-03-07 00:00:00
abstract：BACKGROUND:Chagas disease is caused by Trypanosoma cruzi, which is transmitted by triatomine vectors. The northeastern region of Brazil is endemic for Chagas disease and has the largest diversity of triatomine species. T. cruzi development in its triatomine vector depends on diverse factors, including the composition o...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0836-z
更新日期：2015-04-24 00:00:00
abstract：BACKGROUND:Mutation of the voltage-gated sodium channel (VGSC) gene, or knockdown resistance (kdr) gene, is an important resistance mechanism against DDT and pyrethroids for dengue vector Aedes albopictus. A phenylalanine to serine (F1534S), leucine (F1534L) and cysteine (F1534C) substitution were detected in many Ae. ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3829-5
更新日期：2019-12-26 00:00:00
abstract：BACKGROUND:Two hemoplasma species, Mycoplasma suis and M. parvum, previously known as Eperythrozoon suis and E. parvum, respectively, have been identified in pigs. Swine hemoplasmosis is a global problem, and M. suis infection results in economic losses to pig producers worldwide. This study investigated the frequency ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3638-x
更新日期：2019-07-29 00:00:00
abstract：BACKGROUND:Thelazia callipaeda is transmitted by Phortica variegata, a drosophilid that feeds on lachrymal secretions of mammals. Scientific information on human thelaziosis is still relatively limited, mainly for physicians and ophthalmologists. Indeed, the literature is full of misleading information on the transmiss...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0881-7
更新日期：2015-05-14 00:00:00
abstract：BACKGROUND:Schistosomiasis is a prevalent but neglected tropical disease caused by parasitic trematodes of the genus Schistosoma, with the primary disease-causing species being S. haematobium, S. mansoni and S. japonicum. Male-female pairing of schistosomes is necessary for sexual maturity and the production of a large...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3672-8
更新日期：2019-08-23 00:00:00
abstract：BACKGROUND:A blinded, randomized, negative controlled laboratory study was conducted to evaluate the efficacy of lotilaner (CredelioTM, Elanco) when administered orally to dogs, against experimentally induced adult flea infestations and flea egg production. METHODS:Twenty dogs were selected for the study and allocated...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3873-1
更新日期：2020-01-14 00:00:00
abstract：BACKGROUND:Ixodes ricinus is the most common tick species in Europe and the main vector for Borrelia burgdorferi (sensu lato) and tick-borne encephalitis virus (TBEV). It is involved also in the transmission of Borrelia miyamotoi, a relapsing fever spirochete that causes health disorders in humans. Little is known rega...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-3969-7
更新日期：2020-02-27 00:00:00
abstract：BACKGROUND:Sheep scab is a highly contagious disease of sheep caused by the ectoparasitic mite Psoroptes ovis. The disease is endemic in the UK and has significant economic impact through its effects on performance and welfare. Diagnosis of sheep scab is achieved through observation of clinical signs e.g. itching, prur...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-5-7
更新日期：2012-01-10 00:00:00
abstract：BACKGROUND:Taenia multiceps is a harmful tapeworm and its larval form (coenurus cerebralis) is the causative agent of coenurosis, a disease affecting the health of herbivores, resulting in great economic loss to animal husbandry. Heat-shock proteins (HSPs), expressed in all prokaryotes and eukaryotes, act as molecular ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3352-8
更新日期：2019-03-12 00:00:00
abstract：:Trypanosoma rangeli is a protozoan that is non-pathogenic for humans and other mammals but causes pathology in the genus Rhodnius. T. rangeli and R. prolixus is an excellent model for studying the parasite-vector interaction, but its cycle in invertebrates remains unclear. The vector becomes infected on ingesting bloo...
journal_title：Parasites & vectors
pub_type： 杂志文章,评审
doi：10.1186/1756-3305-5-105
更新日期：2012-05-30 00:00:00
abstract：BACKGROUND:Global climate change can seriously impact on the epidemiological dynamics of vector-borne diseases. In this study we investigated how future climatic changes could affect the climatic niche of Ixodes ricinus (Acari, Ixodida), among the most important vectors of pathogens of medical and veterinary concern in...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-271
更新日期：2013-09-19 00:00:00
abstract：BACKGROUND:Cryptosporidiosis is a gastrointestinal disease affecting many people worldwide. Disease incidence is often unknown and surveillance of human cryptosporidiosis is installed in only a handful of developed countries. A genetic marker that mirrors disease incidence is potentially a powerful tool for monitoring ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0921-3
更新日期：2015-06-06 00:00:00
abstract：:Ticks (Acari: Ixodida) are arthropod ectoparasites dependent on a bloodmeal from a vertebrate host at each developmental stage for completion of their life cycle. This tick feeding cycle impacts animal health by causing damage to hides, secondary infections, immune reactions and diseases caused by transmission of path...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-1185-7
更新日期：2015-11-14 00:00:00
abstract：BACKGROUND:During a Plasmodium infection, exposure of human host immune cells to both the asexual and the sexual stages of the parasite elicit immune responses. These responses may be protective and prevent the development of high parasitaemia and its associated clinical symptoms, or block the transmission of malaria t...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2607-5
更新日期：2018-01-05 00:00:00
abstract：BACKGROUND:Angiostrongylus cantonensis (A. cantonensis) infection can result in increased risk of eosinophilic meningitis. Accumulation of eosinophils and inflammation can result in the A. cantonensis infection playing an important role in brain tissue injury during this pathological process. However, underlying mechan...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0939-6
更新日期：2015-06-14 00:00:00
abstract：BACKGROUND:Sarcoptic mange causes significant animal welfare and occasional conservation concerns for bare-nosed wombats (Vombatus ursinus) throughout their range. To date, in situ chemotherapeutic interventions have involved macrocytic lactones, but their short duration of action and need for frequent re-administratio...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04500-9
更新日期：2021-01-06 00:00:00
abstract：BACKGROUND:Elimination of lymphatic filariasis (LF) in Samoa continues to be challenging despite multiple annual mass drug campaigns aimed at stopping transmission by reducing the prevalence and density of microfilaraemia. The persistence of transmission may be partly related to the highly efficient Aedes vectors. The ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0886-2
更新日期：2015-05-28 00:00:00
abstract：BACKGROUND:The relationship between the environment and infection of cattle with trematodes was studied at Arumeru District, Arusha Region, northern Tanzania. Randomly selected villages were grouped into three cattle management strata, (i) zero-grazing (ZZ) (ii) communal grazing without irrigation (ZC) and (iii) commun...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-107
更新日期：2014-03-20 00:00:00
abstract：BACKGROUND:Practical, field-ready age-grading tools for mosquito vectors of disease are urgently needed because of the impact that daily survival has on vectorial capacity. Previous studies have shown that near-infrared spectroscopy (NIRS), in combination with chemometrics and predictive modeling, can forecast the age ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04031-3
更新日期：2020-03-30 00:00:00
abstract：BACKGROUND:Whipworms (Nematoda: Trichuridae), among the most common soil-transmitted helminths (STHs), can cause the socioeconomically important disease trichuriasis in various mammalian hosts including humans and non-human primates. For many years, Trichuris from non-human primates has been assigned to the same specie...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-3100-5
更新日期：2018-09-20 00:00:00
abstract：BACKGROUND:Few reports of Echinococcus spp. have been described in the USA; however, the geographical distribution of Echinococcus spp. in wild hosts is increasing consequent to human activities. In the early 2000's, 253 elk (Cervus canadensis) originating from Alberta, Canada were released into the Great Smoky Mountai...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04198-9
更新日期：2020-06-30 00:00:00
abstract：BACKGROUND:In Europe, hard ticks of the subgenus Pholeoixodes (Ixodidae: Ixodes) are usually associated with burrow-dwelling mammals and terrestrial birds. Reports of Pholeoixodes spp. from carnivores are frequently contradictory, and their identification is not based on key diagnostic characters. Therefore, the aims o...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2424-x
更新日期：2017-11-03 00:00:00
abstract：BACKGROUND:The prevalence of bovine babesiosis caused by Babesia divergens has been declining during the past decades in northeastern Hungary, and no cases have been observed since 2008. Infections of cattle with B. major and Theileria buffeli were hitherto reported in southern and western Europe. In other parts of the...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-7-434
更新日期：2014-09-11 00:00:00
abstract：BACKGROUND:The diversity of malaria vector populations, expressing various resistance and/or behavioural patterns could explain the reduced effectiveness of vector control interventions reported in some African countries. A better understanding of the ecology and distribution of malaria vectors is essential to design m...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-71
更新日期：2013-03-15 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via the original article. ...
journal_title：Parasites & vectors
pub_type： 已发布勘误
doi：10.1186/s13071-020-04349-y
更新日期：2020-09-22 00:00:00
abstract：BACKGROUND:Fleas are obligate blood-feeding ectoparasites and vectors of several bacterial zoonotic pathogens as well as trypanosomes that parasitize rodents and other small mammals. During investigations of tick- and rodent-borne diseases in Mali, West Africa, we included fleas and rodent-borne trypanosomes, both of w...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1818-5
更新日期：2016-10-11 00:00:00
abstract：BACKGROUND:Bed bugs (Heteroptera: Cimicidae) are a group of blood-feeding ectoparasites. They mainly specialize on bats and birds, but a few species are important human pests. They exhibit several unique adaptations for their parasitic lifestyle. Among those, bed bug aggregations represent a striking example of a sub-s...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3659-5
更新日期：2019-08-13 00:00:00
abstract：BACKGROUND:Anopheles culicifacies s.l. is one of the primary vectors of malaria in India responsible for the highest number of malaria cases. This vector is resistant to DDT in most parts of the country with indication of emerging resistance to pyrethroids. Since knockdown resistance (kdr) is known to confer cross-resi...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0946-7
更新日期：2015-06-18 00:00:00
abstract：BACKGROUND:In 2011, we reported occurrence of natural human infections with Brugia pahangi, a filarial worm of dogs and cats, in a surburb of Kuala Lumpur, the capital city of Malaysia. Our preliminary entomological survey at that time suggested the mosquito species Armigeres subalbatus as the vector of the zoonotic in...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-219
更新日期：2013-07-30 00:00:00
