Central But Not General Obesity Is Positively Associated with the Risk of Hyperhomocysteinemia in Middle-Aged Women.


OBJECTIVE:Obesity and homocysteine (Hcy) are two important risk factors for cardiovascular disease (CVD). However, evidence on the association between obesity and Hcy concentration was conflicting. The aim of our study is to explore the associations of general and central obesity with hyperhomocysteinemia (HHcy) in middle-aged women. METHODS:The current analysis was based on data from 11,007 women aged 40-60 years. Height, weight, and waist circumference (WC) were measured and serum homocysteine was determined. Multiple logistic regression models were used to assess the associations of the risk of hyperhomocysteinemia (HHcy, Hcy > 15 μmol/L) with BMI and WC. RESULTS:13.71% women had HHcy. The prevalences of BMI-based general obesity and WC-based central obesity were 11.17% and 22.88%, respectively. Compared with non-obese women, the mean serum Hcy concentration was significantly higher in WC-based central obese women (p = 0.002), but not in BMI-based general obese women (p > 0.05). In the multiple logistic regression models, central obesity was positively related to the risk of HHcy (OR = 1.30, 95% CI = 1.10 to 1.52), while general obesity was inversely related to the risk of HHcy (OR = 0.82, 95% CI = 0.72 to 0.93 and OR = 0.71, 95% CI = 0.57 to 0.89). CONCLUSIONS:Central obesity was positively related to the risk of HHcy, while general obesity was negatively related. Menopause showed no effect modification on these associations.






Wang Y,Jiang Y,Wang N,Zhu M,Liu X,Wang R,Jiang F,Chen Y,Zhao Q,Zhao G




Has Abstract


2019-07-16 00:00:00










  • Maize prolamins could induce a gluten-like cellular immune response in some celiac disease patients.

    abstract::Celiac disease (CD) is an autoimmune-mediated enteropathy triggered by dietary gluten in genetically prone individuals. The current treatment for CD is a strict lifelong gluten-free diet. However, in some CD patients following a strict gluten-free diet, the symptoms do not remit. These cases may be refractory CD or du...


    pub_type: 杂志文章,评审


    authors: Ortiz-Sánchez JP,Cabrera-Chávez F,de la Barca AM

    更新日期:2013-10-21 00:00:00

  • The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial.

    abstract::Skin is a major safeguard tissue in humans. Because biological barrier function is deteriorated by several kinds of stresses including exposure to ultra-violet (UV) rays, the protection and treatment of skin conditions by dietary supplements are important. We therefore evaluated the effects of dietary supplementation ...


    pub_type: 杂志文章,随机对照试验


    authors: Ito N,Seki S,Ueda F

    更新日期:2018-06-25 00:00:00

  • Early-Life Supplementation of Bovine Milk Osteopontin Supports Neurodevelopment and Influences Exploratory Behavior.

    abstract:INTRODUCTION:Osteopontin (OPN) is a whey protein found at high concentration in human milk and is involved in processes such as bone cell proliferation and differentiation. Milk OPN has shown to be involved in various aspects of development, including the immune system and gut health. However, the influence of dietary ...


    pub_type: 杂志文章


    authors: Joung S,Fil JE,Heckmann AB,Kvistgaard AS,Dilger RN

    更新日期:2020-07-24 00:00:00

  • Higher Diet Quality is Associated with Lower Odds of Low Hand Grip Strength in the Korean Elderly Population.

    abstract::Single nutrients or food groups have been associated with physical performance. However, little is known about the association of overall diet quality with hand grip strength (HGS), a predictive parameter in the prognosis of chronic disease morbidity and mortality, or quality of life. This study examined the associati...


    pub_type: 杂志文章


    authors: Kim H,Kwon O

    更新日期:2019-06-29 00:00:00

  • A High Protein Calorie Restriction Diet Alters the Gut Microbiome in Obesity.

    abstract:BACKGROUND:High protein calorie restriction diets have shown clinical efficacy for obesity, but the mechanisms are not fully known. The intestinal microbiome is a mediator of obesity and preclinical data support an effect of high protein diet (HPD) on the gut microbiome of obesity, but there are few studies in humans. ...


    pub_type: 杂志文章


    authors: Dong TS,Luu K,Lagishetty V,Sedighian F,Woo SL,Dreskin BW,Katzka W,Chang C,Zhou Y,Arias-Jayo N,Yang J,Ahdoot A,Li Z,Pisegna JR,Jacobs JP

    更新日期:2020-10-21 00:00:00

  • Is Eating Raisins Healthy?

    abstract::Raisins are dried grapes consumed worldwide that contain beneficial components for human health. They are rich in fiber and phytochemicals such as phenolic compounds. Despite a 60% sugar content, several studies have reported health-promoting properties for raisins and this review compiles the intervention studies, as...


    pub_type: 杂志文章,评审


    authors: Olmo-Cunillera A,Escobar-Avello D,Pérez AJ,Marhuenda-Muñoz M,Lamuela-Raventós RM,Vallverdú-Queralt A

    更新日期:2019-12-24 00:00:00

  • Antioxidant Properties of Probiotic Bacteria.

    abstract::Oxidative stress defines a condition in which the prooxidant-antioxidant balance in the cell is disturbed, resulting in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells' viability. Probiotics have been known for many beneficial health effects, and the consumptio...


    pub_type: 杂志文章,评审


    authors: Wang Y,Wu Y,Wang Y,Xu H,Mei X,Yu D,Wang Y,Li W

    更新日期:2017-05-19 00:00:00

  • Does Incorporating Gender Differences into Quantifying a Food Frequency Questionnaire Influence the Association of Total Energy Intake with All-Cause and Cause-Specific Mortality?

    abstract::This study aims to evaluate whether incorporating gender differences in portion sizes as part of quantifying a food frequency questionnaire influences the association of total energy intake with mortality. The analysis included 156,434 participants (70,142 men and 86,292 women) in the Multiethnic Cohort Study, aged 45...


    pub_type: 杂志文章


    authors: Kang M,Park SY,Boushey CJ,Wilkens LR,Le Marchand L,Hankin JH,Paik HY

    更新日期:2020-09-23 00:00:00

  • Effects of Maternal Grape Juice Intake on Unfolded Protein Response in the Mammary Glands of Offspring of High Fat Diet Fed Rat Dams.

    abstract::Maternal high fat diet (HFD) and obesity during pregnancy increase female offspring's mammary cancer risk in animal studies. We aimed to observe whether the consumption of grape juice during pregnancy can reverse this risk. During pregnancy and lactation, female Wistar rats were fed either a control or HFD and also re...


    pub_type: 杂志文章


    authors: Dani C,Gonçalves LK,Proença IT,Andrade FO,Hilakivi-Clarke L

    更新日期:2020-07-28 00:00:00

  • Effect of Caloric Restriction on BMI, Gut Microbiota, and Blood Amino Acid Levels in Non-Obese Adults.

    abstract::Adequate calorie restriction (CR) as a healthy lifestyle is recommended not only for people with metabolic disorders but also for healthy adults. Previous studies have mainly focused on the beneficial metabolic effects of CR on obese subjects, while its effects on non-obese subjects are still scarce. Here, we conducte...


    pub_type: 临床试验,杂志文章


    authors: Zou H,Wang D,Ren H,Cai K,Chen P,Fang C,Shi Z,Zhang P,Wang J,Yang H,Zhong H

    更新日期:2020-02-27 00:00:00

  • Dietary Fiber, Atherosclerosis, and Cardiovascular Disease.

    abstract::Observational studies have shown that dietary fiber intake is associated with decreased risk of cardiovascular disease. Dietary fiber is a non-digestible form of carbohydrates, due to the lack of the digestive enzyme in humans required to digest fiber. Dietary fibers and lignin are intrinsic to plants and are classifi...


    pub_type: 杂志文章,评审


    authors: Soliman GA

    更新日期:2019-05-23 00:00:00

  • Maternal Obesity During Pregnancy and Lactation Influences Offspring Obesogenic Adipogenesis but Not Developmental Adipogenesis in Mice.

    abstract::Obesity is an escalating health crisis of pandemic proportions and by all accounts it has yet to reach its peak. Growing evidence suggests that obesity may have its origins in utero. Recent studies have shown that maternal obesity during pregnancy may promote adipogenesis in offspring. However, these studies were larg...


    pub_type: 杂志文章


    authors: Sellayah D,Thomas H,Lanham SA,Cagampang FR

    更新日期:2019-02-27 00:00:00

  • A Traditional Diet Is Associated with a Reduced Risk of Eczema and Wheeze in Colombian Children.

    abstract:BACKGROUND:Diet might influence the risk of allergic diseases. Evidence from developing countries with high prevalence of childhood asthma is scant. METHODS:Information on wheeze, rhinitis, and eczema was collected from 3209 children aged 6-7 years in 2005, who were taking part in the International Study on Asthma and...


    pub_type: 杂志文章


    authors: Cepeda AM,Del Giacco SR,Villalba S,Tapias E,Jaller R,Segura AM,Reyes G,Potts J,Garcia-Larsen V

    更新日期:2015-06-25 00:00:00

  • Feeding the Outer Bran Fraction of Rice Alters Hepatic Carbohydrate Metabolism in Rats.

    abstract::Dietary intake of fiber-rich food has been reported to contribute to multiple health benefits. The aim of the current study is to investigate the effects of a diet containing the outer bran fraction of rice (OBFR), which is rich in insoluble fiber, on the intestinal environment and metabolite profiles of rats. Fourtee...


    pub_type: 杂志文章


    authors: Kawaguchi M,Nishikoba N,Shimamoto S,Tomonaga S,Kohrogi R,Yamauchi Y,Fujita Y,Ohtsuka A,Ijiri D

    更新日期:2020-02-07 00:00:00

  • Does Drinking Coffee and Tea Affect Bone Metabolism in Patients with Inflammatory Bowel Diseases?

    abstract::Patients suffering from Crohn's disease and ulcerative colitis are at higher risk of osteoporosis due to lower bone mineral density. Risk factors of osteoporosis are divided into unmodifiable, namely, age, gender, genetic factors, as well as modifiable, including diet, level of physical activity, and the use of stimul...


    pub_type: 杂志文章,评审


    authors: Ratajczak AE,Szymczak-Tomczak A,Zawada A,Rychter AM,Dobrowolska A,Krela-Kaźmierczak I

    更新日期:2021-01-13 00:00:00

  • What Makes a Front-of-Pack Nutritional Labelling System Effective: The Impact of Key Design Components on Food Purchases.

    abstract::The relative impacts on food purchases of many alternative front-of-pack nutritional labelling systems were tested, with various methods-from opinion pool to nationwide experiments. Clearly, some systems induce better purchasing responses, having better nutritional impacts on food baskets. Nonetheless, we still ignore...


    pub_type: 杂志文章


    authors: Muller L,Ruffieux B

    更新日期:2020-09-19 00:00:00

  • Impact of Coffee, Wine, and Chocolate Consumption on Cognitive Outcome and MRI Parameters in Old Age.

    abstract::Coffee, wine and chocolate are three frequently consumed substances with a significant impact on cognition. In order to define the structural and cerebral blood flow correlates of self-reported consumption of coffee, wine and chocolate in old age, we assessed cognition and brain MRI measures in 145 community-based eld...


    pub_type: 杂志文章


    authors: Haller S,Montandon ML,Rodriguez C,Herrmann FR,Giannakopoulos P

    更新日期:2018-10-01 00:00:00

  • Trace Element Provision in Parenteral Nutrition in Children: One Size Does Not Fit All.

    abstract::Routine administration of trace elements is recognised as a standard of care in children requiring parenteral nutrition. However, there is a lack of global consensus regarding trace elements provision and dosing in pediatric parenteral nutrition. This review provides an overview of available evidence regarding trace e...


    pub_type: 杂志文章,评审


    authors: Zemrani B,McCallum Z,Bines JE

    更新日期:2018-11-21 00:00:00

  • Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice.

    abstract::Background: Two different species of sage, Salvia officinalis and Salvia lavandulaefolia, have demonstrated activities in cognitive function during preclinical and clinical studies related to impaired health situations or single administration. Different memory processes have been described to be significantly and pos...


    pub_type: 杂志文章


    authors: Dinel AL,Lucas C,Guillemet D,Layé S,Pallet V,Joffre C

    更新日期:2020-06-15 00:00:00

  • Providing Comprehensive Dietary Fatty Acid Profiling from Saturates to Polyunsaturates with the Malaysia Lipid Study-Food Frequency Questionnaire: Validation Using the Triads Approach.

    abstract::To address limited food frequency questionnaire (FFQ) capacity in public health monitoring in Malaysia, we aimed to develop a semi-quantitative FFQ for an adult multiethnic population for comprehensive fatty acid (FA) profiling inclusive of saturated (SFA), monounsaturated (MUFA), polyunsaturated fatty acids (PUFA), P...


    pub_type: 杂志文章


    authors: Yeak ZW,Chuah KA,Tan CH,Ezhumalai M,Chinna K,Sundram K,Karupaiah T

    更新日期:2020-12-31 00:00:00

  • Vitamin A-not for your eyes only: requirement for heart formation begins early in embryogenesis.

    abstract::Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the e...


    pub_type: 杂志文章,评审


    authors: Zile MH

    更新日期:2010-05-01 00:00:00

  • The Dark Side of Healthy Eating: Links between Orthorexic Eating and Mental Health.

    abstract::Orthorexia nervosa (OrNe) describes a behavior where eating overly healthy develops into an obsession leading to significant impairment and stress. Initial studies support a bi-dimensional structure of orthorexic eating with one dimension healthy orthorexia (HeOr, interest in healthy eating), which can be distinguishe...


    pub_type: 杂志文章


    authors: Strahler J

    更新日期:2020-11-28 00:00:00

  • Uric Acid and Plant-Based Nutrition.

    abstract::Plant-based diets (PBDs) are associated with decreased risk of morbidity and mortality associated with important noncommunicable chronic diseases. Similar to animal-based food sources (e.g., meat, fish, and animal visceral organs), some plant-based food sources (e.g., certain soy legume products, sea vegetables, and b...


    pub_type: 杂志文章,评审


    authors: Jakše B,Jakše B,Pajek M,Pajek J

    更新日期:2019-07-26 00:00:00

  • Randomized controlled trial examining the effects of fish oil and multivitamin supplementation on the incorporation of n-3 and n-6 fatty acids into red blood cells.

    abstract::The present randomized, placebo-controlled, double-blind, parallel-groups clinical trial examined the effects of fish oil and multivitamin supplementation on the incorporation of n-3 and n-6 fatty acids into red blood cells. Healthy adult humans (n = 160) were randomized to receive 6 g of fish oil, 6 g of fish oil plu...


    pub_type: 杂志文章,随机对照试验


    authors: Pipingas A,Cockerell R,Grima N,Sinclair A,Stough C,Scholey A,Myers S,Croft K,Sali A,Pase MP

    更新日期:2014-05-14 00:00:00

  • Cardiovascular Biomarkers in Association with Dietary Intake in a Longitudinal Study of Youth with Type 1 Diabetes.

    abstract::Despite cardioprotective effects of a healthy diet in the general population, few studies have investigated this relationship in individuals with type 1 diabetes, who are at elevated risks of cardiovascular disease (CVD) due to hyperglycemia. The objective of this study was to examine the association of CVD biomarkers...


    pub_type: 杂志文章


    authors: Sanjeevi N,Lipsky LM,Nansel TR

    更新日期:2018-10-19 00:00:00

  • Nativity and serum concentrations of antioxidants in Mexican American children: a cross-sectional study.

    abstract::There is limited research on the effect of immigration on biological markers of nutrition among children of Mexican origin in the United States. The purpose of this cross-sectional study was to examine data from the Third National Health and Nutrition Examination Survey (NHANES III) (1988-1994), on a national and repr...


    pub_type: 杂志文章


    authors: Eldeirawi K,Koenig MD,Persky V,Chavez N

    更新日期:2014-04-16 00:00:00

  • Effect of Micronutrient Powder (MNP) with a Low-Dose of Iron on Hemoglobin and Iron Biomarkers, and Its Effect on Morbidities in Rural Bangladeshi Children Drinking Groundwater with a High-Level of Iron: A Randomized Controlled Trial.

    abstract::Micronutrient Powder (MNP) is beneficial to control anemia, but some iron-related side-effects are common. A high level of iron in the groundwater used for drinking may exacerbate the side-effects among MNP users. We conducted a randomized controlled trial examining the effect of a low-dose iron MNP compared with the ...


    pub_type: 杂志文章,随机对照试验


    authors: Rahman S,Lee P,Raqib R,Roy AK,Khan MR,Ahmed F

    更新日期:2019-11-13 00:00:00

  • Evaluating the Impact of Different Hypercaloric Diets on Weight Gain, Insulin Resistance, Glucose Intolerance, and its Comorbidities in Rats.

    abstract::Animal experimentation has a long history in the study of metabolic syndrome-related disorders. However, no consensus exists on the best models to study these syndromes. Knowing that different diets can precipitate different metabolic disease phenotypes, herein we characterized several hypercaloric rat models of obesi...


    pub_type: 杂志文章


    authors: Melo BF,Sacramento JF,Ribeiro MJ,Prego CS,Correia MC,Coelho JC,Cunha-Guimaraes JP,Rodrigues T,Martins IB,Guarino MP,Seiça RM,Matafome P,Conde SV

    更新日期:2019-05-28 00:00:00

  • Older Adults' Awareness and Knowledge of Beans in Relation to Their Nutrient Content and Role in Chronic Disease Risk.

    abstract::Awareness and knowledge of nutrient-dense foods are important for older adults to help them make dietary choices that support a food-first approach to healthy aging. This is especially important since age is a major risk factor for chronic disease and the proportion of older adults in North America is increasing. Bean...


    pub_type: 杂志文章


    authors: Doma KM,Farrell EL,Leith-Bailey ER,Soucier VD,Duncan AM

    更新日期:2019-11-05 00:00:00

  • Chronic Zinc Deficiency Alters Chick Gut Microbiota Composition and Function.

    abstract::Zinc (Zn) deficiency is a prevalent micronutrient insufficiency. Although the gut is a vital organ for Zn utilization, and Zn deficiency is associated with impaired intestinal permeability and a global decrease in gastrointestinal health, alterations in the gut microbial ecology of the host under conditions of Zn defi...


    pub_type: 杂志文章,随机对照试验


    authors: Reed S,Neuman H,Moscovich S,Glahn RP,Koren O,Tako E

    更新日期:2015-11-27 00:00:00