Abstract:
BACKGROUND:To evaluate the prognosis of Chinese patients with lacrimal gland adenoid cystic carcinoma treated with eye-sparing surgery and adjuvant multimodal therapy. METHODS:The study included 24 consecutive patients with lacrimal gland adenoid cystic carcinoma treated at the Ninth People's Hospital of Shanghai from May 2008 to September 2017. All patients underwent eye-sparing surgical tumor resection and 20 (83.3%) of the 24 patients in the cohort received postoperative RT. Eight (41.7%) patients in the cohort received chemotherapy. Each patient's medical records were reviewed. RESULTS:The study included 13 male and 11 female patients. The median follow-up time after surgery was 33.5 months. Fifteen (62.5%) patients experienced local recurrence. The 1-, 3-, and 5-year recurrence rates were 27.9, 60.0, and 80.0%, respectively. Eleven (45.8%) patients developed metastasis. The 1-, 3-, and 5-year metastasis rates were 8.7, 48.5, and 66.9%, respectively. Eight (33.3%) patients died of lacrimal gland adenoid cystic carcinoma, with a median survival duration of 34.0 months. The 1-, 3-, and 5-year tumor-related mortality was 4.5, 28.1, and 58.0%, respectively. More advanced T stage (≥ T3a) was a risk factor for local recurrence (hazard ratio [HR]: 5.374, P = 0.02), distant metastasis (HR: 8.585, P < 0.01), and tumor-related survival (HR: 9.654, P < 0.01). CONCLUSIONS:Eye-sparing tumor resection protocol followed by adjuvant therapy seems to be associated with high rates of local recurrence, metastases and death. In addition, greater attention should be paid to patients with lacrimal gland adenoid cystic carcinoma with ≥ T3a tumors.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Yang J,Zhou C,Wang Y,Fan X,Jia Rdoi
10.1186/s12886-019-1110-5subject
Has Abstractpub_date
2019-06-08 00:00:00pages
125issue
1issn
1471-2415pii
10.1186/s12886-019-1110-5journal_volume
19pub_type
杂志文章abstract:BACKGROUND:This study evaluates patients with congenital aniridia and cataract who underwent phacoemulsification, capsular tension ring placement, and foldable intraocular lens implantation. METHODS:In this prospective case series, 10 patients (17 eyes) underwent cataract surgery via a 3.2 mm clear corneal incision. A...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0503-6
更新日期:2017-07-04 00:00:00
abstract:BACKGROUND:Sclopetaria is a rare ophthalmic finding in trauma CASE PRESENTATION:This is a report of a patient who developed macular holes from sclopetaria induced by indirect trauma. A 22-year-old male, suffered a gunshot wound that passed behind his eyes, resulting in bilateral macular hole formation CONCLUSION:To o...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-10-6
更新日期:2010-03-19 00:00:00
abstract:BACKGROUND:Perfluorocarbon liquid (PFCL) is widely used as an intraoperative heavy tamponade to flatten the retina and is replaced with silicone oil (SO) at the end of the surgery. Due to the long tamponade period, the SO is known to remain attached to the retina at the time of removal, and is commonly termed "sticky o...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0745-y
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:The aim of this study was to compare superior and temporal clear corneal incisions of uneventful phacoemulsification and in-the-bag intraocular lens implantation on intraocular pressure control and the bleb morphology in eyes that have undergone previous successful trabeculectomy. METHODS:In this Prospectiv...
journal_title:BMC ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12886-017-0500-9
更新日期:2017-06-26 00:00:00
abstract:BACKGROUND:Endogenous endophthalmitis could lead to a devastating outcome without a prompt and appropriate management. We report a case of advanced endogenous Klebsiella pneumoniae endophthalmitis with extensive subretinal abscess that was successfully treated with a vitrectomy. CASE PRESENTATION:A systemically well 6...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0908-x
更新日期:2018-09-05 00:00:00
abstract:BACKGROUND:To investigate the expression and significance of mechanistic target of rapamycin complex 1(mTORC1) in diabetic retinopathy (DR), and to find new targets and new methods for the treatment of DR. METHODS:A DR rat model was prepared by general feeding combined with intraperitoneal injection of 10% streptozoto...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01553-3
更新日期:2020-07-20 00:00:00
abstract:BACKGROUND:Macular thickening (MT) without clinically recognized macular edema has been described in anterior uveitis (AU). Although fellow-eyes of patients have been used as controls in several studies, little is known about macular thickness in these eyes. We studied the rate and extent of MT in both AU-affected and ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-12-30
更新日期:2012-07-29 00:00:00
abstract:BACKGROUND:To evaluate the effectiveness of intravitreal bevacizumab (IVB) and intravitreal ranibizumab (IVR) in actual practice for treating patients with retinal diseases in Thailand. METHODS:A prospective, multi-centre, observational study was conducted among eight hospitals in their ophthalmology outpatient depart...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12886-019-1086-1
更新日期:2019-03-29 00:00:00
abstract:BACKGROUND:We explore and compare the advantages and disadvantages of different operating methods for a peripheral iridectomy (PI) for phakic posterior chamber implantable contact lens (ICL) implantation in patients with dark-brown irides. METHODS:Forty-six patients completed this prospective comparative study. Neodym...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0229-x
更新日期:2016-05-05 00:00:00
abstract:BACKGROUND:We report the enhanced depth imaging optical coherence tomography (EDI-OCT) characteristics and variations in a patient with subretinal fluid secondary to a carotid cavernous fistula. CASE PRESENTATION:A 59-year-old man presented with blurred vision in his right eye. Venous congestion of the epiescleral and...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0240-2
更新日期:2016-05-26 00:00:00
abstract:BACKGROUND:The performance of glaucoma diagnostic systems could be conceivably improved by the integration of functional and structural test measurements that provide relevant and complementary information for reaching a diagnosis. The purpose of this study was to investigate the performance of data fusion methods and ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-11-20
更新日期:2011-08-04 00:00:00
abstract:BACKGROUND:Graves' disease is a common autoimmune inflammatory condition of the thyroid. About one in four of affected patients also develop orbital symptoms like exophthalmos, proptosis and diplopia - called Graves' Ophthalmopathy. Not all patients respond well to the standard therapy of systemic glucocorticoid admini...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0718-1
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:Previous techniques resulted with low rates of successful fusion after the surgeries and high necessity of additional surgeries in the treatment of thyroid orbitopathy related strabismus. In this study, reviewing the results of our patients who had surgical correction with relaxed muscle positioning techniqu...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0974-0
更新日期:2018-11-23 00:00:00
abstract:BACKGROUND:To evaluate the correlation between visual acuity improvement and vision-related QOL after ranibizumab treatment in Japanese patients with AMD. METHODS:In this one-year prospective, interventional, open-label, multicenter study involving four sites, patients with neovascular AMD were enrolled and observed f...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-021-01816-7
更新日期:2021-01-23 00:00:00
abstract:BACKGROUND:The mechanism by which vitrectomy improves macular edema in patients with branch retinal vein occlusion remains unclear, although intraocular levels of vascular endothelial growth factor have been suggested to influence the visual prognosis and macular edema. METHODS:A series of 54 consecutive patients (54 ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-10-11
更新日期:2010-04-29 00:00:00
abstract:BACKGROUND:An increase in macular thickness due to fluid accumulation in the macula in patients with diabetes mellitus. Optical coherence tomography (OCT) has been shown to be highly reproducible in measuring macular thickness in normal individuals and diabetic patients. OCT can detect subtle changes of macular thickne...
journal_title:BMC ophthalmology
pub_type: 杂志文章,收录出版
doi:10.1186/1471-2415-13-11
更新日期:2013-04-09 00:00:00
abstract:BACKGROUND:Raised intraocular pressure (IOP) is the only causal risk factor for glaucoma that can be therapeutically manipulated to change the course of the disease process. Though Goldman applanation tonometry (GAT) is the "gold standard" for IOP measurement, readings of IOP with GAT are affected by central corneal th...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2415-12-58
更新日期:2012-11-27 00:00:00
abstract:BACKGROUND:To assess visual outcomes over 24 months in patients with neovascular age-related macular degeneration (nAMD) who initiated intravitreal aflibercept therapy under a treat-and-extend (TE) regimen in real-world settings. METHODS:In this retrospective, observational, multicentre study in Slovenia, medical reco...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12886-018-1005-x
更新日期:2018-12-20 00:00:00
abstract:BACKGROUND:Patients with primary angle closure/glaucoma (PAC/PACG) with extensive peripheral anterior synechiae (PAS), and coexisting cataract, increasingly have been treated with phacoemulsification combined with goniosynechialysis (Phaco-GSL). Since the mechanisms of acute and chronic PAC/PACG may differ, the treatme...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1070-9
更新日期:2019-03-04 00:00:00
abstract:BACKGROUND:To assess the socio-demographic and health-related risk factors associated with cataract subtypes in Korea. METHODS:A total of 11,591 participants (aged ≥40 years) were selected from the Korean National Health and Nutrition Examination Survey between 2008 and 2010. The Korean Ophthalmologic Society conducte...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-4
更新日期:2014-01-10 00:00:00
abstract:BACKGROUND:This is a case of spontaneous toric implantable collamer lens (TICL) rotation that occurred twice in the left eye of a patient. CASE PRESENTATION:A 24-year-old gentleman received TICL implantation for treatment of myopic astigmatism encountered with spontaneous rotation of approximately 90° from its origina...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01597-5
更新日期:2020-08-28 00:00:00
abstract:BACKGROUND:Patients' feedback is of great importance in health care policy decisions. The Consumer Quality Index Cataract Questionnaire (CQI Cataract) was used to measure patients' experiences with quality of care after a cataract operation. This study aims to evaluate the reliability and the dimensional structure of t...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-7-14
更新日期:2007-09-19 00:00:00
abstract:BACKGROUND:To evaluate the structural changes associated with visual acuity (VA) in patients with idiopathic macular telangiectasia (MT) type 1 using multimodal imaging modalities. METHODS:A retrospective study of 14 patients with MT type 1 and of 10 eyes from 10 healthy individuals as age-matched controls was conduct...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0737-y
更新日期:2018-03-05 00:00:00
abstract:BACKGROUND:Despite growing number of intraocular lens power calculation formulas, there is no evidence that these formulas have good predictive accuracy in pediatric, whose eyes are still undergoing rapid growth and refractive changes. This study is intended to compare the prediction error and the accuracy of predictab...
journal_title:BMC ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2415-10-20
更新日期:2010-08-25 00:00:00
abstract:PURPOSE:To investigate the dynamic changes of hyperreflective foci (HF) in diabetic macular edema (DME) patients during the intravitreal Conbercept treatment in China. METHODS:DME Patients receiving intravitreal Conbercept (IVC) injections during the year 2016-2017 were retrospectively investigated. Thirteen patients ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1168-0
更新日期:2019-07-23 00:00:00
abstract:BACKGROUND:The eMERGE (electronic MEdical Records and Genomics) network, funded by the National Human Genome Research Institute, is a national consortium formed to develop, disseminate, and apply approaches to research that combine DNA biorepositories with electronic health record (EHR) systems for large-scale, high-th...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-11-32
更新日期:2011-11-11 00:00:00
abstract:BACKGROUND:Immune responses play a key role in the pathogenesis and progression of polypoidal choroidal vasculopath (PCV) and age-related macular degeneration (AMD). In this study, we determined the Th cell-associated immune responses by measuring the cytokine expression of peripheral blood mononuclear cells (PBMC) in ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0251-z
更新日期:2016-06-07 00:00:00
abstract::Although the mechanism of dry eye disease is not clearly understood, it is certain that inflammation and the immune response play a major role in determining the health of the ocular surface in dry eye patients. Accurate ocular surface characterization during the early stages of dry eye disease is critical for success...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0133-9
更新日期:2015-12-17 00:00:00
abstract:BACKGROUND:The current study compared optical quality before and after implantation of a posterior chamber phakic intraocular lens with a central hole [V4c implantable collamer lens (ICL)] under bright and dark lighting conditions by means of the Optical Quality Analysis System™ (OQAS; Visiometrics, Terrassa, Spain). ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01340-0
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:To screen for visual impairment in Malaysian preschool children. METHODS:Visual screening was conducted in 400 preschool children aged 4 to 6 years. The screening involved two basic procedures; the distant visual acuity test using the Sheridan Gardiner chart and the depth perception test using the Langs ste...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-13-16
更新日期:2013-04-19 00:00:00