Abstract:
:Aging is the progressive decline of physiological functions necessary for survival and reproduction. In gaining a better understanding of the inevitable aging process, the hope is to preserve, promote, or delay healthy aging through the treatment of common age-associated diseases. Although there are theories that try to explain the aging process, none of them seem to fully satisfy. Microcirculation describes blood flow through the capillaries in the circulatory system. The main functions of the microcirculation are the delivery of oxgen and nutrients and the removal of CO2, metabolic debris, and toxins. The microcirculatory impairment or dysfunction over time will result in the accumulation of toxic products and CO2 and loss of nutrition supplementation and O2 in corresponding tissue systems or internal organs, which eventually affect normal tissue and organ functions, leading to aging. Therefore, I propose a microcirculatory theory of aging: aging is the process of continuous impairment of microcirculation in the body.
journal_name
Aging Disjournal_title
Aging and diseaseauthors
Jin Kdoi
10.14336/AD.2019.0315subject
Has Abstractpub_date
2019-06-01 00:00:00pages
676-683issue
3issn
2152-5250pii
ad-10-3-676journal_volume
10pub_type
杂志文章abstract::A promising strategy for the prevention of Alzheimer's disease (AD) is the identification of age-related changes that place the brain at risk for the disease. Additionally, AD is associated with chronic dehydration, and one of the significant changes that are known to result in metabolic dysfunction is an increase in ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2016.0323
更新日期:2016-10-01 00:00:00
abstract::Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-cell populations aft...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2020.0619
更新日期:2020-07-23 00:00:00
abstract::It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial im...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500307
更新日期:2014-10-01 00:00:00
abstract::Galectin-3 (Gal-3) is highly expressed in fibrotic tissue related to diverse etiologies. endothelial-to-mesenchymal transition (EndoMT), A less well studied phenomenon serves as a critical process in pulmonary vascular remodeling associated with the development of pulmonary arterial hypertension (PAH). EndoMT is hypot...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2018.1001
更新日期:2019-08-01 00:00:00
abstract::Liver hypoxia/ischemia injury leads to acute liver injury, delayed graft dysfunction, and failure during liver transplantation. Previous studies showed that autophagy is involved in liver hypoxia/ischemia injury. Our and others' studies have found that the damage-regulated autophagy modulator (DRAM) could induce the a...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2018.0210
更新日期:2019-02-01 00:00:00
abstract::Many oncogenes are involved in the progression from low-grade squamous intraepithelial lesions (LSILs) to high-grade squamous intraepithelial lesions (HSILs); which greatly increases the risk of cervical cancer (CC). Thus, a reliable biomarker for risk classification of LSILs is urgently needed. The prolyl isomerase P...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2019.0415
更新日期:2020-02-01 00:00:00
abstract::Dopamine (DA) is one of the major neurotransmitters and participates in a number of functions such as motor coordination, emotions, memory, reward mechanism, neuroendocrine regulation etc. DA exerts its effects through five DA receptors that are subdivided in 2 families: D1-like DA receptors (D1 and D5) and the D2-lik...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2015.0330
更新日期:2015-10-01 00:00:00
abstract::DICER1 deficiency in the retinal pigment epithelium (RPE) was associated with the accumulation of Alu transcripts and implicated in geographic atrophy (GA), a form of age-related macular degeneration (AMD), an eye disease leading to blindness in millions of people. Although the exact mechanism of this association is n...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0809
更新日期:2020-07-23 00:00:00
abstract::A temporal framework linking circadian rhythms and clocks to aging rates identifies a specific window of target of rapamycin (TOR) signaling associated with growth hormone (GH) and insulin-like growth factor (IGF-1) (largely exclusive of insulin) in early sleep. IGF-1 signaling is released by growth hormone secretory ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2010-10-01 00:00:00
abstract::Aging is a common risk factor for the occurrence and development of many diseases, such as Parkinson's disease, Alzheimer's disease, diabetes, hypertension, atherosclerosis and coronary heart disease, and cancer, among others, and is a key problem threatening the health and life expectancy of the elderly. Oxidative da...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.1021
更新日期:2020-10-01 00:00:00
abstract::The expending of elderly population worldwide has resulted in a dramatic rise in the incidence of chronic diseases such as Alzheimer's disease (AD). Inadequate understanding of the mechanisms underlying AD has hampered the development of efficient tools for definitive diagnosis and curative interventions. Previous stu...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2020.0217
更新日期:2020-12-01 00:00:00
abstract::Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) can improve clinical outcome in eligible patients with acute ischemic stroke (AIS). However, its efficacy is strongly time-dependent. This study was aimed to examine whether prehospital notification by emergency medical service (EMS) ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0601
更新日期:2018-06-01 00:00:00
abstract::The immune system declines with aging, leading to an increased susceptibility to infections and higher incidence and progression of autoimmune phenomena and neoplasia. Down syndrome prematurely shows clinical manifestations that are normally seen with aging. This review provides a concise overview of abnormalities in ...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-12-01 00:00:00
abstract::Age related bone loss predisposes adults to osteoporosis. This is especially true for individuals with spinal cord injury (SCI). The effects of decreased bone loading with older age and paralysis significantly contribute to decreased bone mass and increased risk for fragility fractures. Loading bone via volitional mus...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2013-02-07 00:00:00
abstract::Myocardial fibrosis is observed in various cardiovascular diseases and plays a key role in the impairment of cardiac function. Endomyocardial biopsy, as the gold standard for the diagnosis of myocardial fibrosis, has limitations in terms of clinical application. Therefore, biomarkers have been recommended for noninvas...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2020.0604
更新日期:2020-10-01 00:00:00
abstract::Alzheimer's disease (AD) and vascular dementia (VAD) are the major forms of dementia affecting elderly people, in which the levels of many metabolites are altered in cerebrospinal fluid (CSF) and serum. These metabolites could be risk factors or potential biomarkers, but the significance of some of these are not clear...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2013-03-07 00:00:00
abstract::Evidence indicated that inflammatory response and some pattern-recognition receptors play important roles in the occurrence and progression of osteoarthritis. This study is conducted to evaluate the role of RIG-I and its adaptor protein MAVS in the pathogenesis of osteoarthritis. Four SNPs in RIG-I gene and four in MA...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0308
更新日期:2018-02-01 00:00:00
abstract::Metabolic syndrome is an increasing health problem, whose pathogenesis may be associated with genetic factors. The main purpose of our study was to assess relationships between MetS and the presence of the FTO rs9939609, the MC4R rs17782313, and the PPAR-γ rs1801282 polymorphisms in 45-60-year-old women. The study inc...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.1027
更新日期:2018-10-01 00:00:00
abstract::Emerging evidence indicates that the intestinal microbiota could interact with the central nervous system and modulate multiple pathophysiological changes, including the integrity of intestinal barrier and blood-brain barrier, as well as neuroinflammatory response. In the present study, we investigated the potential r...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2020.0106
更新日期:2020-10-01 00:00:00
abstract::Healthcare-associated pneumonia (HCAP) is a new concept of pneumonia proposed by the American Thoracic Society/Infectious Diseases Society of America in 2005. This category is located between community-acquired pneumonia and hospital-acquired pneumonia with respect to the characteristics of the causative pathogens and...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0127
更新日期:2014-02-08 00:00:00
abstract::Studies comparing chronologically "young" versus "old" humans document age-related decline of classical immunological functions. However, older adults aged ≥65 years have very heterogeneous health phenotypes. A significant number of them are functionally independent and are surviving well into their 8(th)-11(th) decad...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-02-01 00:00:00
abstract::Alzheimer disease (AD) is the most common dementing illness. Metabolic defects in the brain with aging contribute to the pathogenesis of AD. These changes can be found systematically and thus can be used as potential biomarkers. Erythrocytes (RBCs) are passive "reporter cells" that are not well studied in AD. In the p...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2013.0400244
更新日期:2013-10-01 00:00:00
abstract::As one of the leading causes of death around the world, suicide is a global public health threat. In the Chinese population, suicides constitute one-fifth of all recorded suicides in the world. Despite the factual data on suicide rates, the understanding of various causal factors behind suicide, including risk and pro...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0223
更新日期:2015-03-10 00:00:00
abstract::Our study aimed to analyse the olfactory dysfunction (OD) evaluations between self-report, the Hyposmia Rating Scale (HRS) and the Sniffin' Sticks test, and the relationship between OD and clinical features of AD. Sixty patients with AD dementia, 37 patients with mild cognitive impairment (MCI) due to AD and 30 health...
journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2018.0819
更新日期:2018-12-04 00:00:00
abstract::Hypoxia is an environmental stress at high altitude and underground conditions but it is also present in many chronic age-related diseases, where blood flow into tissues is impaired. The oxygen-sensing system stimulates gene expression protecting tissues against hypoxic insults. Hypoxia stabilizes the expression of hy...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2015.0929
更新日期:2016-03-15 00:00:00
abstract::Silence information regulator 1 (SIRT1), a member of the sirtuin family, targets histones and many non-histone proteins and participates in various physiological functions. The enzymatic activity of SIRT1 is decreased in patients with Parkinson's disease (PD), which may reduce their ability to resist neuronal damage c...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2020.0216
更新日期:2020-12-01 00:00:00
abstract::Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induc...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500394
更新日期:2013-12-17 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarkers for AD diagnosis, particularly in the early stage. Recently, emerging number ...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2018.1105
更新日期:2019-12-01 00:00:00
abstract::In 2011, Hansen discovered the natural antisense transcript (NAT) of the cerebellar degeneration-related protein 1 gene (CDR1), and further described CDR1 NAT as a circular RNA (CircRNA). CDR1 antisense RNA (CDR1as), which is the official name of CDR1 NAT, is conserved and extensively expressed in most eutherian mamma...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0920
更新日期:2020-07-23 00:00:00
abstract::Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease. Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin and its aglycon baicalein are flavonoids extracted from Scutellaria baicalensis, an important traditional Chinese herb. In recent yea...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2017.0829
更新日期:2017-12-01 00:00:00