Alteration of Metabolic Profile and Potential Biomarkers in the Plasma of Alzheimer's Disease.

abstract：:Cataract is a major cause of blindness worldwide, its complicated and unclear etiopathogenesis limit effective therapy. Here, we found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in lens epithelial cells and Yap conditional knockout (cKO) in the lens leads to cataract. Histologicall...

journal_title：Aging and disease

authors： He Q,Gao Y,Wang T,Zhou L,Zhou W,Yuan Z

更新日期：2019-04-01 00:00:00

abstract：:Oxidative stress and iron accumulation are tightly associated with neurodegenerative diseases. Mitochondrial ferritin (FtMt) is identified as an iron-storage protein located in the mitochondria, and its role in regulation of iron hemeostasis in neurodegenerative diseases has been reported. However, the role of FtMt in...

journal_title：Aging and disease

authors： Gao G,Zhang N,Wang YQ,Wu Q,Yu P,Shi ZH,Duan XL,Zhao BL,Wu WS,Chang YZ

更新日期：2017-07-21 00:00:00

abstract：:Aging intersects with reproductive senescence in women by promoting a systemic low-grade chronic inflammation that predisposes women to several diseases including ovarian cancer (OC). OC risk at menopause is significantly modified by parity records during prior fertile life. To date, the combined effects of age and pa...

journal_title：Aging and disease

authors： Urzua U,Chacon C,Lizama L,Sarmiento S,Villalobos P,Kroxato B,Marcelain K,Gonzalez MJ

更新日期：2017-10-01 00:00:00

abstract：:Melatonin is a pleiotropically acting regulator molecule, which influences numerous physiological functions. Its secretion by the pineal gland progressively declines by age. Strong reductions of circulating melatonin are also observed in numerous disorders and diseases, including Alzheimer's disease, various other neu...

journal_title：Aging and disease

authors： Hardeland R

更新日期：2012-04-01 00:00:00

abstract：:Aging is a common risk factor for the occurrence and development of many diseases, such as Parkinson's disease, Alzheimer's disease, diabetes, hypertension, atherosclerosis and coronary heart disease, and cancer, among others, and is a key problem threatening the health and life expectancy of the elderly. Oxidative da...

journal_title：Aging and disease

authors： Zhang X,Li L

更新日期：2020-10-01 00:00:00

abstract：:Myocardial fibrosis is observed in various cardiovascular diseases and plays a key role in the impairment of cardiac function. Endomyocardial biopsy, as the gold standard for the diagnosis of myocardial fibrosis, has limitations in terms of clinical application. Therefore, biomarkers have been recommended for noninvas...

journal_title：Aging and disease

authors： Ding Y,Wang Y,Zhang W,Jia Q,Wang X,Li Y,Lv S,Zhang J

更新日期：2020-10-01 00:00:00

abstract：:Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease. Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin and its aglycon baicalein are flavonoids extracted from Scutellaria baicalensis, an important traditional Chinese herb. In recent yea...

journal_title：Aging and disease

authors： Liang W,Huang X,Chen W

更新日期：2017-12-01 00:00:00

abstract：:Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) can improve clinical outcome in eligible patients with acute ischemic stroke (AIS). However, its efficacy is strongly time-dependent. This study was aimed to examine whether prehospital notification by emergency medical service (EMS) ...

journal_title：Aging and disease

authors： Zhang S,Zhang J,Zhang M,Zhong G,Chen Z,Lin L,Lou M

更新日期：2018-06-01 00:00:00

abstract：:Cortical atrophy, neuronal loss, beta-amyloid deposition, neuritic plaques, and neurofibrillary tangles are neuropathological key features in the Alzheimer's disease (AD). Antibodies against beta-amyloid, neurotransmitters, microvascular endothelium components and microglial cells have been detected in AD serum sugges...

journal_title：Aging and disease

authors： Giulia P,Michele L,Andrea F,Grazia D,Filomena C,Francesco P,Leandro C,Maria U,Carolina G,Massimiliano C,Antonio G

更新日期：2015-11-24 00:00:00

abstract：:Emerging evidence indicates that the intestinal microbiota could interact with the central nervous system and modulate multiple pathophysiological changes, including the integrity of intestinal barrier and blood-brain barrier, as well as neuroinflammatory response. In the present study, we investigated the potential r...

journal_title：Aging and disease

authors： Han D,Li Z,Liu T,Yang N,Li Y,He J,Qian M,Kuang Z,Zhang W,Ni C,Guo X

更新日期：2020-10-01 00:00:00

abstract：:Age related bone loss predisposes adults to osteoporosis. This is especially true for individuals with spinal cord injury (SCI). The effects of decreased bone loading with older age and paralysis significantly contribute to decreased bone mass and increased risk for fragility fractures. Loading bone via volitional mus...

journal_title：Aging and disease

authors： Dolbow JD,Dolbow DR,Gorgey AS,Adler RA,Gater DR

更新日期：2013-02-07 00:00:00

abstract：:Better understanding of survival factors in amyotrophic lateral sclerosis (ALS) could help physicians and patients schedule therapeutic interventions. We conducted a study to evaluate the predictive factors associated with longer survival and construct prognostic nomogram in ALS patients. A total of 553 ALS patients w...

journal_title：Aging and disease

authors： Wei QQ,Chen Y,Chen X,Cao B,Ou R,Zhang L,Hou Y,Shang H

更新日期：2018-12-04 00:00:00

abstract：:Healthcare-associated pneumonia (HCAP) is a new concept of pneumonia proposed by the American Thoracic Society/Infectious Diseases Society of America in 2005. This category is located between community-acquired pneumonia and hospital-acquired pneumonia with respect to the characteristics of the causative pathogens and...

journal_title：Aging and disease

authors： Komiya K,Ishii H,Kadota J

更新日期：2014-02-08 00:00:00

abstract：:Silence information regulator 1 (SIRT1), a member of the sirtuin family, targets histones and many non-histone proteins and participates in various physiological functions. The enzymatic activity of SIRT1 is decreased in patients with Parkinson's disease (PD), which may reduce their ability to resist neuronal damage c...

journal_title：Aging and disease

authors： Li X,Feng Y,Wang XX,Truong D,Wu YC

更新日期：2020-12-01 00:00:00

abstract：:Healthy aged individuals are more likely to suffer profound memory impairments following a challenging life event such as a severe bacterial infection, surgery, or an intense psychological stressor, than are younger adults. These peripheral challenges are capable of producing a neuroinflammatory response, (e.g., incre...

journal_title：Aging and disease

authors： Barrientos RM,Frank MG,Watkins LR,Maier SF

更新日期：2010-01-01 00:00:00

abstract：:Aging is associated with myriad changes in behavioral performance and brain structure and function. Given this complex interplay of brain and behavior, two streams of findings are reviewed here that show that aging is generally associated with dedifferentiated neural processes, and also changes in functional connectiv...

journal_title：Aging and disease

authors： Goh JO

更新日期：2011-01-01 00:00:00

abstract：:The population undergoing dialysis is aging worldwide, particularly in Japan. The clinical condition of frailty is the most problematic expression in the elderly population. Potential pathophysiological factors of frailty present in patients with CKD and are accentuated in patients with ESRD. The aim of this study was...

journal_title：Aging and disease

authors： Takeuchi H,Uchida HA,Kakio Y,Okuyama Y,Okuyama M,Umebayashi R,Wada K,Sugiyama H,Sugimoto K,Rakugi H,Wada J

更新日期：2018-04-01 00:00:00

abstract：:Longstanding immunological dogma holds that flexible immune recognition, which forms the mechanistic basis of adaptive immunity, is strictly confined to the lymphocyte lineage. In higher vertebrates, flexible immune recognition is represented by recombinatorial antigen receptors of enormous diversity known as immunogl...

journal_title：Aging and disease

authors： Kaminski WE,Beham AW,Puellmann K

更新日期：2012-10-01 00:00:00

abstract：:The immune system declines with aging, leading to an increased susceptibility to infections and higher incidence and progression of autoimmune phenomena and neoplasia. Down syndrome prematurely shows clinical manifestations that are normally seen with aging. This review provides a concise overview of abnormalities in ...

journal_title：Aging and disease

authors： Kusters MA,Verstegen RH,de Vries E

更新日期：2011-12-01 00:00:00

abstract：:Aging is the progressive decline of physiological functions necessary for survival and reproduction. In gaining a better understanding of the inevitable aging process, the hope is to preserve, promote, or delay healthy aging through the treatment of common age-associated diseases. Although there are theories that try ...

journal_title：Aging and disease

authors： Jin K

更新日期：2019-06-01 00:00:00

abstract：:The relationship between CYP17A1 genetic polymorphisms and essential hypertension (EH) remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with EH in Han and Uighur populations in China. A Han population including 558 people (270 EH patients and 288 controls) and ...

journal_title：Aging and disease

authors： Dai CF,Xie X,Ma YT,Yang YN,Li XM,Fu ZY,Liu F,Chen BD,Gai MT

更新日期：2015-11-17 00:00:00

abstract：:Sleep duration and quality have been associated with poor physical function, but both the temporality of the association and the independence of sleep duration and quality are unclear. We examined the prospective association of sleep duration and quality with physical function impairment and disability in older adults...

journal_title：Aging and disease

authors： Campanini MZ,Mesas AE,Carnicero-Carreño JA,Rodríguez-Artalejo F,Lopez-Garcia E

更新日期：2019-06-01 00:00:00

abstract：:Our study aimed to analyse the olfactory dysfunction (OD) evaluations between self-report, the Hyposmia Rating Scale (HRS) and the Sniffin' Sticks test, and the relationship between OD and clinical features of AD. Sixty patients with AD dementia, 37 patients with mild cognitive impairment (MCI) due to AD and 30 health...

journal_title：Aging and disease

authors： Yu Q,Guo P,Li D,Zuo L,Lian T,Yu S,Hu Y,Liu L,Jin Z,Wang R,Piao Y,Li L,Wang X,Zhang W

更新日期：2018-12-04 00:00:00

abstract：:Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-cell populations aft...

journal_title：Aging and disease

authors： Schwartz MD,Emerson SG,Punt J,Goff WD

更新日期：2020-07-23 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive pathology, where dementia symptoms gradually worsen over a number of years. The hallmarks of AD, such as amyloid β-peptide (Aβ) in senile plaque and neurofibrillary tangles, are strongly intertwined with oxidative stress, which is considered one of the common effectors of the ...

journal_title：Aging and disease

authors： Morroni F,Sita G,Graziosi A,Turrini E,Fimognari C,Tarozzi A,Hrelia P

更新日期：2018-08-01 00:00:00

abstract：:The molecular processes of aging are very heterogenic and not fully understood. Studies on rare progeria syndromes, which display an accelerated progression of physiological aging, can help to get a better understanding. Pseudoxanthoma elasticum (PXE) caused by mutations in the ATP-binding cassette sub-family C member...

journal_title：Aging and disease

authors： Tiemann J,Wagner T,Vanakker OM,van Gils M,Cabrera JB,Ibold B,Faust I,Knabbe C,Hendig D

更新日期：2020-05-09 00:00:00

abstract：:Galectin-3 (Gal-3) is highly expressed in fibrotic tissue related to diverse etiologies. endothelial-to-mesenchymal transition (EndoMT), A less well studied phenomenon serves as a critical process in pulmonary vascular remodeling associated with the development of pulmonary arterial hypertension (PAH). EndoMT is hypot...

journal_title：Aging and disease

authors： Li T,Zha L,Luo H,Li S,Zhao L,He J,Li X,Qi Q,Liu Y,Yu Z

更新日期：2019-08-01 00:00:00

abstract：:Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysa...

journal_title：Aging and disease

authors： Carrera-Bastos P,Picazo Ó,Fontes-Villalba M,Pareja-Galeano H,Lindeberg S,Martínez-Selles M,Lucia A,Emanuele E

更新日期：2018-04-01 00:00:00

abstract：:Evidence indicated that inflammatory response and some pattern-recognition receptors play important roles in the occurrence and progression of osteoarthritis. This study is conducted to evaluate the role of RIG-I and its adaptor protein MAVS in the pathogenesis of osteoarthritis. Four SNPs in RIG-I gene and four in MA...

journal_title：Aging and disease

authors： Liu J,Tang LY,Wang YG,Lu SY,Zhang EN,Wang ZG,Zhang HX

更新日期：2018-02-01 00:00:00

abstract：:A promising strategy for the prevention of Alzheimer's disease (AD) is the identification of age-related changes that place the brain at risk for the disease. Additionally, AD is associated with chronic dehydration, and one of the significant changes that are known to result in metabolic dysfunction is an increase in ...

journal_title：Aging and disease

authors： Li T,Su T,He Y,Lu J,Mo W,Wei Y,He R

更新日期：2016-10-01 00:00:00