Abstract:
:Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysaccharide) and zonulin (a biomarker of intestinal permeability) levels and the risk of coronary heart disease, and thus healthy aging. Serum levels of zonulin, lipopolysaccharide and soluble CD14 (a protein that binds lipopolysaccharide) were measured in disease-free centenarians, young healthy controls and patients with precocious acute myocardial infarction. Disease-free centenarians had significantly lower levels of serum zonulin (P<0.01) and lipopolysaccharide (P<0.001) than young patients with acute myocardial infarction, and had significantly lower concentrations of serum lipopolysaccharide than young healthy controls (P<0.05). No significant differences were found for soluble CD14 between groups. Our findings may stimulate further research into the role played by intestinal permeability and endotoxemia not only in coronary heart disease but also in lifespan modulation.
journal_name
Aging Disjournal_title
Aging and diseaseauthors
Carrera-Bastos P,Picazo Ó,Fontes-Villalba M,Pareja-Galeano H,Lindeberg S,Martínez-Selles M,Lucia A,Emanuele Edoi
10.14336/AD.2017.0630subject
Has Abstractpub_date
2018-04-01 00:00:00pages
317-321issue
2issn
2152-5250pii
ad-9-2-317journal_volume
9pub_type
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journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2017.0315
更新日期:2018-02-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.0601
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journal_title:Aging and disease
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journal_title:Aging and disease
pub_type: 杂志文章,评审
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journal_title:Aging and disease
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abstract::Cataract is a major cause of blindness worldwide, its complicated and unclear etiopathogenesis limit effective therapy. Here, we found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in lens epithelial cells and Yap conditional knockout (cKO) in the lens leads to cataract. Histologicall...
journal_title:Aging and disease
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journal_title:Aging and disease
pub_type: 杂志文章,评审
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journal_title:Aging and disease
pub_type: 杂志文章,评审
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journal_title:Aging and disease
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doi:10.14336/AD.2018.1129
更新日期:2019-10-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章,评审
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journal_title:Aging and disease
pub_type: 杂志文章
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2019.0610
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2018.0611
更新日期:2019-06-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.1027
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journal_title:Aging and disease
pub_type: 杂志文章
doi:
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2015.0505
更新日期:2015-11-17 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::It is currently well established that the immune system is activated in response to transient or focal cerebral ischemia. This acute immune activation occurs in response to damage, and injury, to components of the neurovascular unit and is mediated by the innate and adaptive arms of the immune response. The initial im...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2014.0500307
更新日期:2014-10-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2019.0402
更新日期:2020-02-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2015.0906
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journal_title:Aging and disease
pub_type: 杂志文章
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journal_title:Aging and disease
pub_type: 杂志文章
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journal_title:Aging and disease
pub_type: 杂志文章,评审
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更新日期:2020-07-23 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2019.0218
更新日期:2019-12-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章,评审
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2017.1016
更新日期:2018-12-04 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:10.14336/AD.2020.0106
更新日期:2020-10-01 00:00:00
abstract::Melatonin is a pleiotropically acting regulator molecule, which influences numerous physiological functions. Its secretion by the pineal gland progressively declines by age. Strong reductions of circulating melatonin are also observed in numerous disorders and diseases, including Alzheimer's disease, various other neu...
journal_title:Aging and disease
pub_type: 杂志文章
doi:
更新日期:2012-04-01 00:00:00
abstract::Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease. Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin and its aglycon baicalein are flavonoids extracted from Scutellaria baicalensis, an important traditional Chinese herb. In recent yea...
journal_title:Aging and disease
pub_type: 杂志文章,评审
doi:10.14336/AD.2017.0829
更新日期:2017-12-01 00:00:00
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journal_title:Aging and disease
pub_type: 杂志文章
doi:
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